Dafu Chen, Jiaxiang Zhou, Chengkai Lin, Junhong Li, Zhengya Zhu, Xuezhi Rao, Jianmin Wang, Jianfeng Li, Hongkun Chen, Fuan Wang, Xianlong Li, Manman Gao, Zhiyu Zhou, Yongming Xi, Shufen Li
BACKGROUND: The relationship between hormonal fluctuations in the reproductive system and the occurrence of low back pain (LBP) has been widely observed. However, the causal impact of specific variables that may be indicative of hormonal and reproductive factors, such as age at menopause (ANM), age at menarche (AAM), length of menstrual cycle (LMC), age at first birth (AFB), age at last live birth (ALB) and age first had sexual intercourse (AFS) on low back pain remains unclear. METHODS: This study employed Bidirectional Mendelian randomization (MR) using publicly available summary statistics from Genome Wide Association Studies (GWAS) and FinnGen Consortium to investigate the causal links between hormonal and reproductive factors on LBP...
2024: Frontiers in Endocrinology