Sara C Staubo, Ole Martin Fuskevåg, Mathias Toft, Ingeborg H Lie, Kirsti M J Alvik, Pål Jostad, Stein H Tingvoll, Hallvard Lilleng, Kristina Rosqvist, Elisabet Størset, Per Odin, Espen Dietrichs, Erik Sveberg Dietrichs
BACKGROUND AND PURPOSE: Impulse control disorders (ICDs) are common among Parkinson's disease patients using dopamine agonists. We wanted to determine whether ICD patients have higher dopamine agonist serum concentrations than those without any sign of ICD. METHODS: Patients who used either pramipexole or ropinirole depot once daily were screened for ICDs using the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale. Those who scored above the cut-off for one or more of the four defined ICDs (gambling, compulsive sexual behavior, compulsive shopping, and binge-eating) were compared in a case-control study to patients who scored zero points (no evidence of ICD) on the same items...
February 2024: European Journal of Neurology