Venu Thatikonda, Verena Supper, Johannes Wachter, Onur Kaya, Anju Kombara, Ceren Bilgilier, Madhwesh C Ravichandran, Jesse J Lipp, Rahul Sharma, Lukas Badertscher, Andrew S Boghossian, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Sarah Grosche, Ralph A Neumüller, Barbara Mair, Federico Mauri, Alexandra Popa
Transcription factors (TFs) are important mediators of aberrant transcriptional programs in cancer cells. In this study, we focus on TF activity (TFa) as a biomarker for cell-line-selective anti-proliferative effects, in that high TFa predicts sensitivity to loss of function of a given gene (i.e., genetic dependencies [GDs]). Our linear-regression-based framework identifies 3,047 pan-cancer and 3,952 cancer-type-specific candidate TFa-GD associations from cell line data, which are then cross-examined for impact on survival in patient cohorts...
April 30, 2024: Cell Reports