Zhiyou Dong, Ruihu Wu, Lijuan Liu, Shengquan Ai, Jinpeng Yang, Qianlan Li, Keyi Fu, Yunian Zhou, Hualin Fu, Ziyao Zhou, Haifeng Liu, Zhijun Zhong, Xianmeng Qiu, Guangneng Peng
Proteus mirabilis , a prevalent urinary tract pathogen and formidable biofilm producer, especially in Catheter-Associated Urinary Tract Infection, has seen a worrying rise in multidrug-resistant (MDR) strains. This upsurge calls for innovative approaches in infection control, beyond traditional antibiotics. Our research introduces bacteriophage (phage) therapy as a novel non-antibiotic strategy to combat these drug-resistant infections. We isolated P2-71, a lytic phage derived from canine feces, demonstrating potent activity against MDR P...
2024: Frontiers in Cellular and Infection Microbiology