X Zhao, H Li, L Jin, J Xue, Y Yao, W Pang, X Liu, W Wang, Q Han, B Zhang, X Zhao, Q Zhang, X Wu, Z Tan, X Zhang, X Su, C Zhang
OBJECTIVES: The present study aims to develop an effective risk-prediction score (RPS) to improve screening efficiency and contribute to secondary prevention of colorectal cancer (CRC). STUDY DESIGN: Screening for colorectal lesions. METHODS: 14,398 high-risk individuals aged 50-65 years were included. The baseline characteristics of participants with and without colorectal lesions (CL) were compared using a Chi-squared test. The overall population was randomly split into a training set and a test set in the ratio of 80% and 20%...
July 15, 2024: Public Health
Pinkal Desai, Ying Zhou, Justin Grenet, Samuel K Handelman, Cynthia M Crispino, Laura N Tarbay, Eric A Whitsel, Gail Roboz, Ana Barac, Michael Honigberg, Alexander Bick, Garnet Anderson, Jean Wactawski-Wende, Yasminka A Jakubek Swartzlander, Jason Bacon, Justin Wong, Xiaolong Ma, Paul Scheet, Zichan Li, Pashtoon Kasi, Ross Prentice, Paul Auer, JoAnn E Manson, Alexander Reiner, Michael Simon
BACKGROUND: Understanding the impact of clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs) on solid tumor risk and mortality can shed light on novel cancer pathways. METHODS: The authors analyzed whole genome sequencing data from the Trans-Omics for Precision Medicine Women's Health Initiative study (n = 10,866). They investigated the presence of CHIP and mCA and their association with the development and mortality of breast, lung, and colorectal cancers...
July 16, 2024: Cancer
Sono Ito, Yusuke Kinugasa, Shinichi Yamauchi, Hiroyuki Sato, Akihiro Hirakawa, Soichiro Ishihara, Akio Shiomi, Yukihide Kanemitsu, Takeshi Suto, Hiroki Takahashi, Michio Itabashi, Manabu Shiozawa, Masaya Hiyoshi, Takaya Kobatake, Koji Komori, Hiroyuki Egi, Heita Ozawa, Tomohiro Yamaguchi, Ryo Inada, Masaaki Ito, Yasumitsu Hirano, Akinobu Furutani, Yoshitaka Tanabe, Hideki Ueno, Masayuki Ohue, Koya Hida, Kazushige Kawai, Eiji Sunami, Hideyuki Ishida, Kay Uehara, Jun Watanabe, Masanori Hotchi, Atsushi Ishibe, Yasumasa Takii, Junichiro Hiro, Masakatsu Numata, Ichiro Takemasa, Takeshi Kato, Yoshihiro Kakeji, Akira Hirata, Yoichi Ajioka
BACKGROUND: The significance of resection of paraaortic lymph node metastasis in colorectal cancer is controversial. OBJECTIVE: To clarify the prognosis of colorectal cancer after paraaortic lymph node metastasis resection. DESIGN: Multicenter retrospective study. SETTINGS: Thirty-six institutions in Japan participated in this study. PATIENTS: Patients with resected and pathologically proven paraaortic lymph node metastasis of CRC between 2010 and 2015...
July 16, 2024: Diseases of the Colon and Rectum
H Guadalajara, M Leon-Arellano, J L Dominguez-Tristancho, D García-Olmo
This manuscript offers a detailed description of our successful tips for mastering transanal robotic surgery. It covers various aspects, including patient positioning, management of abdominal pressures to maintain a stable pneumorectum, platform positioning, camera alignment, trocar positioning to minimize collisions, instruments used, and approaches to tumor resection.
July 16, 2024: Techniques in Coloproctology
Justin C Brown, Shengping Yang, Stephanie L E Compton, Kristin L Campbell, Elizabeth M Cespedes Feliciano, Sara Quinney, Barbara Sternfeld, Bette J Caan, Jeffrey A Meyerhardt, Kathryn H Schmitz
BACKGROUND: The decline of physical function during chemotherapy predicts poor quality of life and premature death. It is unknown if resistance training prevents physical function decline during chemotherapy in colon cancer survivors. METHODS: This multicenter trial randomized 181 colon cancer survivors receiving postoperative chemotherapy to home-based resistance training or usual care control. Physical function outcomes included the short physical performance battery (SPPB), isometric handgrip strength, and the physical function subscale of the Medical Outcomes Short-Form 36-item questionnaire...
July 16, 2024: JNCI Cancer Spectrum
Thomas Samaille, Antoine Falcoz, Romain Cohen, Pierre Laurent-Puig, Thierry André, Julien Taieb, Edouard Auclin, Dewi Vernerey
BACKGROUND: We assessed the added value of incorporating carcinoembryonic antigen (CEA) to circulating tumor DNA (ctDNA) and pathological TN (pTN) stage for risk classification in stage 3 colon cancer (CC). PATIENTS AND METHODS: We retrospectively analyzed postoperative CEA values in patients with CC from the IDEA-France phase 3 trial. The relation between disease-free survival (DFS) and CEA was modeled through restricted cubic splines. Prognostic value of CEA, ctDNA, and pTN was assessed with the Kaplan-Meier method...
July 15, 2024: Oncologist
Yovita Tjhin, Bharti Kewlani, Harpreet K S I Singh, Nikhil Pawa
AIM: To give an insight into areas for future development and suggestions in the complexities of incorporation of AI into human colorectal cancer (CRC) care while bringing into focus the importance of clinicians' roles in patient care. METHODS: Existing literature around AI use in CRC care is reviewed and potential regulatory issues and medicolegal implications around its implementation in CRC multidisciplinary team meetings (MDTs) are identified. RESULTS: Challenges with patient privacy and confidentiality, patient consent, inequity and bias, patient autonomy, as well as AI system transparency and the liability and accountability issues arising from complications that arise from AI-aided clinical decisions are important focusses associated with the use of AI in CRC MDTs...
July 16, 2024: Colorectal Disease
Jinsong Zhou, Rong Fu, Juwei Zhang, Suhong Zhang, Zhifeng Lin, Zheng Lin, Xin Liu, Xiaolu Xu, Yulun Chen, Zhijian Hu
OBJECTIVES: This study aimed to explore the potential causal associations between serum uric acid (SUA) and the risk of colorectal cancer, colon cancer and rectal cancer. METHODS: Twenty-six SUA-related single nucleotide polymorphisms which were identified by a large meta-analysis of genome-wide association studies (GWASs) were used as instrumental variables in the two-sample Mendelian randomization (MR) study. Meta-analyses were used to synthesize the results of multiple GWASs which were extracted from the MRC Integrative Epidemiology Unit GWAS database for each type of cancer...
2024: Frontiers in Oncology
Esranur Aydın, Ünal Metin Tokat, Ashkan Adibi, Eylül Özgü, Şevval Nur Bilgiç, Mutlu Demiray
BACKGROUND: Metastatic colon adenocarcinoma presents significant challenges in treatment, particularly when resistant to standard therapies. Precision oncology, guided by multidisciplinary tumor boards (MTBs), offers a promising way for individualized therapeutic approaches. Integration of comprehensive genomic profiling (CGP) and minimal residual disease (MRD) testing strengthens treatment decision-making, yet challenges persist in identifying and overcoming resistance mechanisms. FLT3 amplification can be one of those resistance/escape mechanisms that needs to be targeted...
2024: Frontiers in Oncology
Weifei Yu, Jingxia Qiu, Ximing Jiang, Haofen Xie, Zejun Cai, Bin Yang
AIM: To investigate the grip strength of older patients with gastrointestinal tumours and analyse its explanatory factors. METHODS: A total of 170 older patients with gastrointestinal tumours admitted to the Gastrointestinal Surgery Department of a Grade-III hospital in the Zhejiang province from January 2022 to December 2022 were selected as the investigation participants. Among them, there were 102 cases of gastric cancer (60.0%) and 68 cases of colon cancer (40...
2024: International Journal of General Medicine
Rita Pinheiro Duque, Nuno Santos, Bárbara Freire, Carlos M Oliveira, João M Mendes, Juliana P Macedo, Francisco Sampaio
Lynch syndrome is the most common cause of hereditary colorectal cancer. It usually develops asymptomatically until symptoms related to colorectal carcinoma appear, such as gastrointestinal bleeding, abdominal pain, and changes in bowel habits and/or stool characteristics. Oftentime, when these clinical signs and symptoms are not present, the diagnosis becomes challenging. We present the clinical case of a 69-year-old woman, adopted, with no known previous history, who presented to the emergency department with low back pain, without irradiation, that had been going on for three days, associated with inflammatory signs in the right hip region...
June 2024: Curēus
Yifan Shi, Yuting Sun, Xiaoming Shen, Zenghui Yang, Binghua Xu, Chuanqing Bao
OBJECTIVE: Handgrip strength (HGS) and the high-sensitivity modified Glasgow prognostic score (HS-mGPS) are associated with the survival of patients with cancer. However, no studies have investigated the combined effect of HGS and HS-mGPS on the overall survival (OS) of patients with colon cancer. METHODS: Prospective follow-up data of colon cancer patients undergoing radical resection from April, 2016 to September, 2019 were retrospectively collected. We combined the HGS and HS-mGPS to create a new composite index, HGS-HS-mGPS...
2024: Frontiers in Nutrition
WeiZhou Wang, YunXue Zheng, ZhouXue Wu, Min Wu, Yue Chen, Yan Zhang, ShaoZhi Fu, JingBo Wu
BACKGROUND: The combination of immune checkpoint inhibitors with radiotherapy can enhance the immunomodulation by RT and reduce the growth of distant unirradiated tumors (abscopal effect); however, the results are still not very satisfactory. Therefore, new treatment options are needed to enhance this effect. Our previous study showed that the combination of Bifidobacterium (Bi) and its specific monoclonal antibody (mAb) could target and alleviate hypoxia at the tumor site and act as a radiosensitizer...
July 15, 2024: Journal of Translational Medicine
Nicolas Faundes-Gandolfo, Carlos Jara-Gutiérrez, Mario Párraga, Iván Montenegro, Waleska Vera, Marcela Escobar, Alejandro Madrid, Manuel Valenzuela-Valderrama, Joan Villena
BACKGROUND: The leaves of Kalanchoe pinnata (Lam.) Pers. (K. pinnata), a succulent plant native to tropical regions, are used as a medicinal alternative against cancer in several countries worldwide; however, its therapeutic potential to fight cancer has been little addressed. In this study, we analyzed the phytochemical content, antioxidant capacity, and selectivity of K. pinnata leaf ethanolic extract against different human cancer cell lines in vitro. METHODOLOGY: This study subjected the ethanolic extract to enzymatic assays to quantify the phytochemical content (phenolics, flavonoids, and anthraquinones) and its radical scavenging and iron-reducing capacities...
July 15, 2024: BMC complementary medicine and therapies
Carlos G Urzúa-Traslaviña, Tijs van Lieshout, Floranne Boulogne, Kevin Domanegg, Mahmoud Zidan, Olivier B Bakker, Annique Claringbould, Jeroen de Ridder, Wilbert Zwart, Harm-Jan Westra, Patrick Deelen, Lude Franke
BACKGROUND: The genetic background of cancer remains complex and challenging to integrate. Many somatic mutations within genes are known to cause and drive cancer, while genome-wide association studies (GWAS) of cancer have revealed many germline risk factors associated with cancer. However, the overlap between known somatic driver genes and positional candidate genes from GWAS loci is surprisingly small. We hypothesised that genes from multiple independent cancer GWAS loci should show tissue-specific co-regulation patterns that converge on cancer-specific driver genes...
July 15, 2024: BMC Medical Genomics
Tatiana V Karpinets, Yoshitsugu Mitani, Chia-Chi Chang, Xiaogang Wu, Xingzhi Song, Ivonne I Flores, Lauren K McDaniel, Yasmine M Hoballah, Fabiana J Veguilla, Renata Ferrarotto, Lauren E Colbert, Nadim J Ajami, Robert R Jenq, Jianhua Zhang, Andrew P Futreal, Adel K El-Naggar
Adenoid cystic carcinoma (ACC) is a rare, usually slow-growing yet aggressive head and neck malignancy. Despite its clinical significance, our understanding of the cellular evolution and microenvironment in ACC remains limited. We investigated the intratumoral microbiomes of 50 ACC tumor tissues and 33 adjacent normal tissues using 16S rRNA gene sequencing. This allowed us to characterize the bacterial communities within the ACC and explore potential associations between the bacterial community structure, patient clinical characteristics, and tumor molecular features obtained through RNA sequencing...
July 15, 2024: Scientific Reports
Mert Erciyestepe, Oğuzhan Selvi, Gülhan Dinç, Ahmet Emin Öztürk, Okan Aydın, Şermin Dinç Sonuşen, Tuğçe Kübra Güneş, Tugay Avcı, Sezai Vatansever, Emir Çelik, Muhammed Mustafa Atcı
INTRODUCTION: Our study delves into the intricate interplay of risk factors and the strategic selection of adjuvant therapy, scrutinizing their influence on recurrence and survival outcomes in stage IIA (T3N0M0) colon cancer patients. MATERIALS AND METHODS: The study examined the medical records of patients who underwent surgery for stage IIA colon cancer. Identification of stage IIA (pT3N0M0) colon cancer involved a comprehensive review of postoperative clinical records and histological reports...
July 15, 2024: Oncology
Shuang Wang, LinLing Gan, Lei Han, Ping Deng, Yihao Li, Dongxiao He, Haoze Chi, Liwei Zhu, Yuehui Li, Rui Long, Zongjie Gan
The vascular endothelial growth factor receptor (VEGFR) is a receptor tyrosine kinase that is regarded as an emerging target for abnormal angiogenesis diseases. In this study, novel naphthalene imidazo[1,2-b]pyridazine hybrids as VEGFR selective inhibitors were designed and synthesized using a scaffold hopping strategy based on ponatinib, a multitarget kinase inhibitor. Among the evaluated compounds, derivative 9k (WS-011) demonstrated the most potent inhibitory potency against VEGFR-2 (IC50  = 8...
July 15, 2024: Archiv der Pharmazie
Hong-Hin Cheong, Weimin Zuo, Jiarui Chen, Chon-Wai Un, Yain-Whar Si, Koon Ho Wong, Hang Fai Kwok, Shirley W I Siu
Anticancer peptides (ACPs) are promising future therapeutics, but their experimental discovery remains time-consuming and costly. To accelerate the discovery process, we propose a computational screening workflow to identify, filter, and prioritize peptide sequences based on predicted class probability, antitumor activity, and toxicity. The workflow was applied to identify novel ACPs with potent activity against colorectal cancer from the genome sequences of Candida albicans . As a result, four candidates were identified and validated in the HCT116 colon cancer cell line...
July 15, 2024: Journal of Chemical Information and Modeling
O I Kit, Yu A Gevorkyan, A M Karachun, N V Soldatkina, O K Bondarenko, V E Kolesnikov
OBJECTIVE: To evaluate surgical and oncological results of standard and extended lymph node dissection (D2 and D3) in patients with colon cancer. MATERIAL AND METHODS: We analyzed treatment outcomes in 74 patients with colon cancer stage T1-4aN0-2M0 who underwent right- and left-sided hemicolectomy, resection of sigmoid colon with standard and extended lymph node dissection (D2 and D3). RESULTS: Surgical approach and level of D3 lymph node dissection did not increase intra- and postoperative morbidity...
2024: Khirurgiia
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