Elena Fueyo-Marcos, Gema Lopez-Pernas, Coral Fustero-Torre, Marta Elena Antón, Fátima Al-Shahrour, Oscar Fernández-Capetillo, Matilde Murga
Antibodies targeting the PD-1 receptor and its ligand PD-L1 have shown impressive responses in some tumors of bad prognosis. We hypothesized that, since immunosuppressive cells might present several immune checkpoints on their surface, the selective elimination of PD-L1 expressing cells could be efficacious in enabling the activation of antitumoral immune responses. To address this question, we developed an inducible suicidal knock-in mouse allele of Pd-l1 (PD-L1ATTAC ) which allows for the tracking and specific elimination of PD-L1-expressing cells in adult tissues...
March 22, 2023: Aging
Jiaoyuan Li, Shifan Qin, Shanshan Zhang, Yifan Lu, Qian Shen, Liming Cheng, Rong Zhong
Serum 25-Hydroxyvitamin D (25(OH)D) has been demonstrated to be associated with risk of colorectal cancer (CRC). However, it remains unclear whether this association was modified by vitamin D-related polymorphisms. We evaluated association of serum 25(OH)D concentrations with CRC risk among 403,170 participants from UK Biobank Project. Two variants of vitamin D binding protein (VDBP), rs4588 and rs7041, were included to estimate the binding affinity of 25(OH)D to VDBP, and three variants of vitamin D receptor (VDR), rs11568820, rs2228570, and rs1544410, which may influence VDR activity, were also investigated...
March 22, 2023: International Journal of Cancer. Journal International du Cancer
Jiawei Wan, Xiujuan Yu, Jiao Liu, Jing Li, Tingyang Ai, Cong Yin, Hong Liu, Rui Qin
Ulcerative colitis (UC) is a growing health concern in humans, but it can be prevented by using special dietary strategies. Young stems and leaves of Brasenia schreberi (BS) are coated with a special polysaccharide hydrogel (BS mucilage) which can be beneficial for colon health. The aim of this study was to investigate the preventive effects of BS mucilage against UC in a DSS-treated mouse model. Although containing only 0.3% solid content, our research showed that BS mucilage effectively attenuated the disease activity index (DAI) and the spleen index and downregulated IL-1β, IL-18, IL-6 and CAT mRNA levels in DSS-treated mice, which is a promising UC alleviation function...
March 22, 2023: Food & Function
Rhonda M Brand, Beth Dudley, Eve Karloski, Ashley Zyhowski, Rebecca Raphael, Danielle Pitlor, E Jeffrey Metter, Reet Pai, Kenneth Lee, Randall E Brand, Shikhar Uttam
INTRODUCTION: Lynch syndrome (LS) is the most common hereditary cause of colorectal cancer (CRC), increasing lifetime risk of CRC by up to 70%. Despite this higher lifetime risk, disease penetrance in LS patients is highly variable and most LS patients undergoing CRC surveillance will not develop CRC. Therefore, biomarkers that can correctly and consistently predict CRC risk in LS patients are needed to both optimize LS patient surveillance and help identify better prevention strategies that reduce risk of CRC development in the subset of high-risk LS patients...
March 6, 2023: medRxiv
Ji Hyeong Song, Myung Sun Lee, Eun Young Cha, Kyung Ha Lee, Ji Yeon Kim, Jin Soo Kim
PURPOSE: Apurinic/apyrimidinic endonuclease 1 (APE1) is a key enzyme involved in the base excision repair pathway. It also has redox activity and maintains various transcription factors in an active reduced state. APE1 may be associated with chemoresistance. In the present study, we first investigated the expression level of APE1 protein and its correlation with oncologic outcomes of oxaliplatin-based chemotherapy in patients with stage III colon cancer. Further, we investigated the effects of human APE1 siRNA on the sensitivity of oxaliplatin in SNU-C2A colon cancer cells...
June 2022: Korean J Clin Oncol
Jinseok Hwang, Donghyoun Lee, Jung Kyong Shin, Jae Hyuck Jang, Jung Wook Huh, Yoon Ah Park, Yong Beom Cho, Hee Cheol Kim, Seong Hyeon Yun, Woo Yong Lee, Ho-Kyung Chun
PURPOSE: Various clinical practice guidelines recommend at least 12 regional lymph nodes should be removed for resected colon cancer. According to a recent study, the lymph node yield (LNY) in colon cancer surgery in the last 20 years has tended to increase from 14.91 to 21.30. However, it is unclear whether these guidelines adequately reflect recent findings on the number of harvested lymph nodes in colon cancer surgery. The aim of this study is to assess the impact of an LNY of more than 25 on survival in right-sided colon cancer...
June 2022: Korean J Clin Oncol
Yaron Rudnicki, Sahael M Stapleton, Rishi Batra, Tong Gan, Kellie L Mathis, Scott R Kelley
AIM: Perianal Paget's disease (PAPD) is a rare disorder with a predisposition to anal and colorectal malignancies and an unclear prognosis. Our previous 25-year series demonstrated a non-aggressive nature. This study aims to describe our updated institutional experience. METHODS: This is a retrospective review of all patients diagnosed with primary PAPD from 1991 to 2021. A prospectively maintained institutional database was searched which included demographics, clinical and pathological manifestations, treatment methods, recurrence, oncological outcome and mortality...
March 21, 2023: Colorectal Disease
Kelly R Voigt, Lissa Wullaert, Cornelis Verhoef, Dirk J Grünhagen, Christian Ramakers
AIM: Follow-up after colorectal cancer requires frequent surveillance of the tumour marker carcinoembryonic antigen (CEA). Home-based blood sampling could be beneficial in terms of patients' well-being and societal cost-effectiveness. Blood sampling by venepuncture is unsuitable for home-based sampling. The aim of this feasibility study is to evaluate the long-term whole-blood stability of CEA. METHOD: In this prospective feasibility study capillary blood withdrawal was collected in a Hem-Col® microtube containing a patented stabilization buffer using an internal lithium standard to correct for dilution...
March 21, 2023: Colorectal Disease
Ruifang Sun, Yang Yang, Weidong Lü, Yanqi Yang, Yulong Li, Zhigang Liu, Dongmei Diao, Yang Wang, Su'e Chang, Mengnan Lu, Qiuyu Jiang, Bingling Dai, Xiaobin Ma, Chang'an Zhao, Moqi Lü, Juan Zhang, Caixia Ding, Na Li, Jian Zhang, Zhengtao Xiao, Dangxia Zhou, Chen Huang
The aim of the present study was to elucidate the evolutionary trajectory of colon cells from normal colon mucosa, to adenoma, then to carcinoma in the same microenvironment. Normal colon, adenoma and carcinoma tissues from the same patient were analyzed by single-cell sequencing, which perfectly simulated the process of time-dependent colon cancer due to the same microenvironment. A total of 22 cell types were identified. Results suggest the presence of dominant clones of same cells including C2 goblet cell, epithelial cell subtype 1 (Epi1), enterocyte cell subset 0 (Entero0), and Entero5 in carcinoma...
March 21, 2023: Cell & Bioscience
Mônica Silva Monteiro de Castro, Gabriela Drummond Marques da Silva, Iara Veloso Oliveira Figueiredo, Wanessa Debôrtoli de Miranda, Helvécio Miranda Magalhães Júnior, Fausto Pereira Dos Santos, Rômulo Paes de Sousa
BACKGROUND: Litigation for health care, also known as health judicialization, is frequent in Brazil. It involves recourse to the court system to access health services. The study aimed to evaluate whether cancer patients in Belo Horizonte, Minas Gerais, Brazil, increased their overall survival by increasing access to certain drugs or treatments through litigation, controlling for the effect of demographic and disease-related variables. METHODS: A retrospective cohort study was conducted...
March 21, 2023: BMC Public Health
Takahiro Hirano, Makiko Negishi, Yoshiki Kuwatsuru, Masafumi Arai, Ryozo Wakabayashi, Naoko Saito, Ryohei Kuwatsuru
BACKGROUND: Administrative claims data are a valuable source for clinical studies; however, the use of validated algorithms to identify patients is essential to minimize bias. We evaluated the validity of diagnostic coding algorithms for identifying patients with colorectal cancer from a hospital's administrative claims data. METHODS: This validation study used administrative claims data from a Japanese university hospital between April 2017 and March 2019. We developed diagnostic coding algorithms, basically based on the International Classification of Disease (ICD) 10th codes of C18-20 and Japanese disease codes, to identify patients with colorectal cancer...
March 21, 2023: BMC Health Services Research
Roupen Djinbachian, Marie-Lyssa Lafontaine, Talia Dufault, Edgard Medawar, Michel Boivin, Mickael Bouin, Daniel von Renteln
BACKGROUND AND AIMS: Serrated lesions (SL) have been associated with significant risks of developing colorectal cancer (CRC). Data on synchronous findings after SL detection during colonoscopy is limited. Study aim was to evaluate the rate of synchronous advanced neoplasia (S-AN) and synchronous CRC (S-CRC) in colonoscopies where SLs were detected. METHODS: We conducted a retrospective study of screening aged patients 45-74year with colorectal SL (sessile serrated polyp [SSP] or traditional serrated adenoma [TSA]) detected during an elective colonoscopy...
March 21, 2023: Surgical Endoscopy
Tsubasa Sakurai, Tomohiro Yamaguchi, Takashi Sakamoto, Takahiro Amano, Toshiki Mukai, Yukiharu Hiyoshi, Toshiya Nagasaki, Takashi Akiyoshi, Yosuke Fukunaga
Conventional laparoscopic or robotic surgery for right-sided colon cancer often requires intraoperative repositioning and removal of the bowel. Changing positions during robotic surgery can be troublesome and robotic removal of the small intestine carries a risk of unexpected injury because robotic devices have a strong grasping force and no sense of touch. Herein, we introduce a novel mobilization of the medial approach without changing the position for robotic right hemicolectomy. Using this technique, mobilization is performed in counterclockwise succession, allowing all mobilizations and bowel removal to be completed sequentially, without positional change...
March 21, 2023: Surgery Today
Pallavi Gurung, Junmo Lim, Rajeev Shrestha, Yong-Wan Kim
We hypothesized that photodynamic therapy (PDT) with Chlorin e6 (Ce6) enhances antitumor abscopal effects via inhibition of the programmed cell death-1/programmed death-ligand 1 (PD-1/PD-L1) immune checkpoint. By using syngeneic melanoma and pancreatic tumor mouse models, we studied the Ce6-PDT-induced immune responses in local and distant tumor microenvironments. In addition, the Ce6-PDT's target in the PD-1/PD-L1 interaction was analyzed in MC38-hPD-L1 colon cancer and PD-1 expressing Jurkat T cell coculture...
March 21, 2023: Scientific Reports
Eduardo Davi Lima da Silva, Flaviana Alves Dos Santos, Júlia Teixeira de Oliveira, Fabio Vieira Dos Santos, Francisco Jaime Bezerra Mendonça Junior, Maria do Carmo Oliveira de Lima, Maira Galdino da Rocha Pitta, Moacyr Barreto de Jesus de Melo Rego, Michelly Cristiny Pereira
INTRODUCTION: Thiophene derivatives have been widely studied as promising options for the treatment of solid tumors. Previous studies have shown that thiophene derivatives have antileishmanial activity and cytotoxic activity against breast, colon, and ovarian cancer cells. METHOD: In our study, we evaluated the anticancer activities of three aminothiophene derivatives: SB-44, SB-83, and SB-200, in prostate and cervical adenocarcinoma cells. Several in vitro methods were performed, including cytotoxicity, clonogenic migration, mutagenic, and cleaved Poly (ADP-ribose) polymerase (PARP) assays and annexin V staining...
March 21, 2023: Anti-cancer Agents in Medicinal Chemistry
Divya Naresh, Ali Baqar, Afaq Khan
Schwannomas are nerve sheath tumours that can be found throughout the body along peripheral nerves. Primary schwannomas of the colon are very rare. They are usually benign and their surgical resection is considered curative. They are, however, difficult to diagnose preoperatively and therefore tend to be overtreated with major colorectal surgery.
March 21, 2023: BMJ Case Reports
Yi-Chuan Yu, Pedram Paragomi, Aizhen Jin, Renwei Wang, Robert E Schoen, Woon-Puay Koh, Jian-Min Yuan, Hung N Luu
BACKGROUND: Colorectal cancer (CRC) is common cancer with a high mortality rate. Low-carbohydrate diet (LCD) score holistically evaluates the LCD pattern from carbohydrate, protein, and fat intake. Epidemiologic data of LCD-CRC association are sparse. METHODS: We evaluated the associations between LCD (i.e., total, animal- and plant-based) and CRC risk in the Singapore Chinese Health Study, a population-based prospective cohort study including 61,321 Chinese in Singapore who were 45-74 years old at baseline...
March 21, 2023: Cancer Epidemiology, Biomarkers & Prevention
Fang Cheng, Victor Chérouvrier Hansson, Grigorios Georgolopoulos, Katrin Mani
Glypicans (GPC1-6) are associated with tumorigenic processes and their involvement in neoplastic behavior has been discussed in different cancer types. Here, a cancer-wide GPC expression study, using clinical cancer patient data in The Cancer Genome Atlas, reveals net upregulation of GPC1 and GPC2 in primary solid tumors, whereas GPC3 , GPC5 and GPC6 display lowered expression pattern compared to normal tissues. Focusing on GPC1 , survival analyses of the clinical cancer patient data reveal statistically significant correlation between high expression of GPC1 and poor prognosis in 10 particular cancer types i...
March 21, 2023: Oncotarget
Raj Singh, Greg Bowden, David Mathieu, Haley K Perlow, Joshua D Palmer, Shahed Elhamdani, Matthew Shepard, Yun Liang, Ahmed M Nabeel, Wael A Reda, Sameh R Tawadros, Khaled Abdelkarim, Amr M N El-Shehaby, Reem M Emad, Ahmed Hesham Elazzazi, Ronald E Warnick, Yair M Gozal, Megan Daly, Brendan McShane, Marcel Addis-Jackson, Gokul Karthikeyan, Sian Smith, Piero Picozzi, Andrea Franzini, Tehila Kaisman-Elbaz, Huai-Che Yang, Zhishuo Wei, Andrew Legarreta, Judith Hess, Kelsey Templeton, Stylianos Pikis, Georgios Mantziaris, Gabriela Simonova, Roman Liscak, Selcuk Peker, Yavuz Samanci, Veronica Chiang, Ajay Niranjan, Charles R Kersh, Cheng-Chia Lee, Daniel M Trifiletti, L Dade Lunsford, Jason P Sheehan
BACKGROUND: There are limited data regarding outcomes for patients with gastrointestinal (GI) primaries and brain metastases treated with stereotactic radiosurgery (SRS). OBJECTIVE: To examine clinical outcomes after SRS for patients with brain metastases from GI primaries and evaluate potential prognostic factors. METHODS: The International Radiosurgery Research Foundation centers were queried for patients with brain metastases from GI primaries managed with SRS...
March 21, 2023: Neurosurgery
Guangyue Zhao, Guoqing Xiang, Xiaoru Hu, Yun Qiao, Shiyang Ma, Ye Tian, Xiaozuo Gao, Fang Liu, Xiaohan Li, Gang Shi
OBJECTIVE: Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome worldwide. Due to the decreasing family size in Liaoning province. The Bethesda and Amsterdam II criteria have lower sensitivity and specificity and are not suitable for the local population. Immunohistochemistry screening for mutations in DNA mismatch repair (MMR) in newly diagnosed colorectal cancer can improve the detection rate of LS. METHODS: All newly diagnosed colorectal cancer patients who underwent surgery between January 2018 and June 2020 at Cancer Hospital of China Medical University and Shengjing Hospital of China Medical University from Liaoning China were included retrospectively, and the ratio of universal LS screening by immunohistochemistry, MMR protein deficiency (dMMR) ratio, MLH1 loss, MSH2 loss, MSH6 loss, and PMS2 loss was analyzed...
March 20, 2023: European Journal of Cancer Prevention
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