keyword
https://read.qxmd.com/read/38536911/select-ezh2-inhibitors-enhance-viral-mimicry-effects-of-dnmt-inhibition-through-a-mechanism-involving-nfat-ap-1-signaling
#1
JOURNAL ARTICLE
Alison A Chomiak, Rochelle L Tiedemann, Yanqing Liu, Xiangqian Kong, Ying Cui, Ashley K Wiseman, Kate E Thurlow, Evan M Cornett, Michael J Topper, Stephen B Baylin, Scott B Rothbart
DNA methyltransferase inhibitor (DNMTi) efficacy in solid tumors is limited. Colon cancer cells exposed to DNMTi accumulate lysine-27 trimethylation on histone H3 (H3K27me3). We propose this Enhancer of Zeste Homolog 2 (EZH2)-dependent repressive modification limits DNMTi efficacy. Here, we show that low-dose DNMTi treatment sensitizes colon cancer cells to select EZH2 inhibitors (EZH2is). Integrative epigenomic analysis reveals that DNMTi-induced H3K27me3 accumulates at genomic regions poised with EZH2. Notably, combined EZH2i and DNMTi alters the epigenomic landscape to transcriptionally up-regulate the calcium-induced nuclear factor of activated T cells (NFAT):activating protein 1 (AP-1) signaling pathway...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536816/iqgap1-and-nwasp-promote-human-cancer-cell-dissemination-and-metastasis-by-regulating-%C3%AE-1-integrin-via-fak-and-mrtf-srf
#2
JOURNAL ARTICLE
Camilla Cerutti, Serena Lucotti, Sofia T Menendez, Nicolas Reymond, Ritu Garg, Ignacio A Romero, Ruth Muschel, Anne J Ridley
Attachment of circulating tumor cells to the endothelial cells (ECs) lining blood vessels is a critical step in cancer metastatic colonization, which leads to metastatic outgrowth. Breast and prostate cancers are common malignancies in women and men, respectively. Here, we observe that β1-integrin is required for human prostate and breast cancer cell adhesion to ECs under shear-stress conditions in vitro and to lung blood vessel ECs in vivo. We identify IQGAP1 and neural Wiskott-Aldrich syndrome protein (NWASP) as regulators of β1-integrin transcription and protein expression in prostate and breast cancer cells...
March 26, 2024: Cell Reports
https://read.qxmd.com/read/38536483/cacna2d1-regulates-the-progression-and-influences-the-microenvironment-of-colon-cancer
#3
JOURNAL ARTICLE
Hiroyuki Inoue, Atsushi Shiozaki, Toshiyuki Kosuga, Hiroki Shimizu, Michihiro Kudou, Tomohiro Arita, Hirotaka Konishi, Shuhei Komatsu, Yoshiaki Kuriu, Takeshi Kubota, Hitoshi Fujiwara, Yukiko Morinaga, Eiichi Konishi, Eigo Otsuji
BACKGROUND: Calcium voltage-gated channel auxiliary subunit alpha 2/delta 1 (CACNA2D1), a gene encoding a voltage-gated calcium channel, has been reported as an oncogene in several cancers. However, its role in colon cancer (CC) remains unclear. This study aimed to investigate the function of CACNA2D1 and its effect on the microenvironment in CC. METHODS: Immunohistochemistry (IHC) analysis was performed on samples collected from 200 patients with CC who underwent curative colectomy...
March 27, 2024: Journal of Gastroenterology
https://read.qxmd.com/read/38535948/the-impact-of-atmospheric-cadmium-exposure-on-colon-cancer-and-the-invasiveness-of-intestinal-stents-in-the-cancerous-colon
#4
JOURNAL ARTICLE
Shuai Zhang, Ruikang Li, Jing Xu, Yan Liu, Yanjie Zhang
BACKGROUND: Inhalation exposure to carcinogenic metals such as cadmium (Cd) is a significant global health concern linked to various cancers. However, the precise carcinogenic mechanism underlying inhalation exposure remains elusive. METHODS: In this study, CT26 mouse colon cancer (CC) cells were implanted into BALB/c mice to establish CC mouse models. Some of the CC mice were implanted with intestinal stents. The mice were exposed to atomized oxygen and nitrogen (O2 /N2 ) gas containing Cd...
March 14, 2024: Toxics
https://read.qxmd.com/read/38535894/prognostic-impact-of-primary-tumour-location-after-curative-resection-in-stage-i-iii-colorectal-cancer-a-single-centre-retrospective-study
#5
JOURNAL ARTICLE
Manabu Inoue, Yukihide Kanemitsu, Shunsuke Tsukamoto, Konosuke Moritani, Yasuyuki Takamizawa, Hiroyuki Daiko
OBJECTIVE: The relationship of tumour site with post-recurrence course and outcome after primary surgery in resectable colorectal cancer is unclear. This study investigated the prognostic impact of primary tumour location following radical resection without preoperative treatment in Stage I-III colorectal cancer. METHODS: We analyzed 3770 patients with Stage I-III colorectal cancer who underwent curative resection at our hospital during 2000-15. We defined the right-sided colon as the cecum, ascending colon and transverse colon, and the left-sided colon as the descending colon, sigmoid and rectosigmoid junction...
March 26, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38535769/the-relationship-between-liver-volume-clinicopathological-characteristics-and-survival-in-patients-undergoing-resection-with-curative-intent-for-non-metastatic-colonic-cancer
#6
JOURNAL ARTICLE
Josh McGovern, Charles Mackay, Rhiannon Freireich, Allan M Golder, Ross D Dolan, Paul G Horgan, David Holroyd, Nigel B Jamieson, Donald C McMillan
INTRODUCTION: The prognostic value of CT-derived liver volume in terms of cancer outcomes is not clear. The aim of the present study was to examine the relationship between liver area on a single axial CT-slice and the total liver volume in patients with colonic cancer. Furthermore, we examine the relationship between liver volume, determined using this novel method, clinicopathological variables and survival. METHODS: Consecutive patients who underwent potentially curative surgery for colonic cancer were identified from a prospectively maintained database...
February 28, 2024: Tomography: a Journal for Imaging Research
https://read.qxmd.com/read/38534987/targeting-solute-carrier-transporters-slcs-as-a-therapeutic-target-in-different-cancers
#7
REVIEW
Ravi Bharadwaj, Swati Jaiswal, Erandi E Velarde de la Cruz, Ritesh P Thakare
Solute carrier (SLC) transporters constitute a vast superfamily of transmembrane proteins tasked with regulating the transport of various substances such as metabolites, nutrients, ions, and drugs across cellular membranes. SLC transporters exhibit coordinated expression patterns across normal tissues, suggesting a tightly regulated regulatory network governing normal cellular functions. These transporters are crucial for the transport of various metabolites, including carbohydrates, proteins, lipids, and nucleic acids...
March 21, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534916/optimization-of-aqueous-extraction-of-polyphenols-from-cuminum-cyminum-seeds-using-response-surface-methodology-and-assessment-of-biological-activity
#8
JOURNAL ARTICLE
Hana El Tannir, Diana Houhou, Espérance Debs, Mohamed Koubaa, Adla Jammoul, Bilal Azakir, Mahmoud I Khalil, Nada El Darra, Nicolas Louka
(1) Background: Cumin seeds, extracted from the plant Cuminum cyminum , are abundant in phenolic compounds and have been extensively researched for their chemical makeup and biological effects. The objective of this research is to enhance the water extraction of polyphenols through the water bath (WB) technique and to evaluate the antiradical, antibacterial, and anticancer effects of the extract. (2) Methods: Response Surface Methodology was used to find the best parameters to extract polyphenols. Three experimental parameters, time, temperature, and solid-liquid ratio, were tested...
March 21, 2024: BioTech (Basel)
https://read.qxmd.com/read/38534438/the-trpv6-calcium-channel-and-its-relationship-with-cancer
#9
REVIEW
Yifang Wang, Xiaoling Deng, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Declan William Ali, Marek Michalak, Cefan Zhou, Xing-Zhen Chen, Jingfeng Tang
Transient receptor potential vanilloid-6 (TRPV6) is a cation channel belonging to the TRP superfamily, specifically the vanilloid subfamily, and is the sixth member of this subfamily. Its presence in the body is primarily limited to the skin, ovaries, kidney, testes, and digestive tract epithelium. The body maintains calcium homeostasis using the TRPV6 channel, which has a greater calcium selectivity than the other TRP channels. Several pieces of evidence suggest that it is upregulated in the advanced stages of thyroid, ovarian, breast, colon, and prostate cancers...
March 5, 2024: Biology
https://read.qxmd.com/read/38534182/systematic-scoping-review-use-of-the-faecal-immunochemical-test-residual-buffer-to-enhance-colorectal-cancer-screening
#10
REVIEW
Timothy McAuliffe, Joseph C Anderson, Robin J Larson, Douglas J Robertson
BACKGROUND: The faecal immunochemical test (FIT) is an inexpensive and convenient modality to screen for colorectal cancer. However, its one-time sensitivity for detecting colorectal cancer and cancer precursors is limited. There is growing interest in using the non-haemoglobin contents of FIT residual buffer to enhance colonic neoplasia detection. AIM: To establish from the literature a framework to catalogue candidate biomarkers within FIT residual buffer for non-invasive colorectal cancer screening...
March 27, 2024: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/38534052/multispecialty-management-of-metastatic-colon-adenocarcinoma-involving-the-extraocular-muscles-primary-excision-and-simultaneous-treatment-of-strabismus-with-a-review-of-the-literature
#11
JOURNAL ARTICLE
Fereshteh Azad, Tassapol Singalavanija, Robert Beaulieu, Federica Mingardo, Steven M Archer, Victor Maurice Elner, Hakan Demirci
Metastatic colon adenocarcinoma involving the extraocular muscles is extremely rare. It usually develops following the diagnosis of the systemic disease and therefore, management and treatment require a multispecialty approach. Within this manuscript, we provide a summary of cases of orbital metastasis secondary to colon cancer. We further discuss a detailed case of a 42-year-old male patient who developed recent-onset diplopia in the left gaze. Orbital CT imaging showed a localized, well-circumscribed enlargement of the right medial rectus muscle...
March 21, 2024: Ophthalmic Plastic and Reconstructive Surgery
https://read.qxmd.com/read/38533987/paradoxical-activation-of-oncogenic-signaling-as-a-cancer-treatment-strategy
#12
JOURNAL ARTICLE
Matheus Henrique Dias, Anoek Friskes, Siying Wang, Joao M Fernandes Neto, Frank van Gemert, Soufiane Mourragui, Chrysa Papagianni, Hendrik J Kuiken, Sara Mainardi, Daniel Alvarez-Villanueva, Cor Lieftink, Ben Morris, Anna Dekker, Emma van Dijk, Lieke H S Wilms, Marcelo S da Silva, Robin A Jansen, Antonio Mulero-Sanchez, Elke Malzer, August Vidal, Cristina Santos, Ramon Salazar, Rosangela A M Wailemann, Thompson E P Torres, Giulia De Conti, Jonne A Raaijmakers, Petur Snaebjornsson, Shengxian Yuan, Wenxin Qin, John S Kovach, Hugo A Armelin, Hein Te Riele, Alexander van Oudernaarden, Haojie Jin, Roderick L Beijersbergen, Alberto Villanueva, Rene H Medema, Rene Bernards
Cancer homeostasis depends on a balance between activated oncogenic pathways driving tumorigenesis and engagement of stress-response programs that counteract the inherent toxicity of such aberrant signaling. While inhibition of oncogenic signaling pathways has been explored extensively, there is increasing evidence that overactivation of the same pathways can also disrupt cancer homeostasis and cause lethality. We show here that inhibition of Protein Phosphatase 2A (PP2A) hyperactivates multiple oncogenic pathways and engages stress responses in colon cancer cells...
March 27, 2024: Cancer Discovery
https://read.qxmd.com/read/38533822/vascularized-tissue-on-mesh-assisted-platform-vt-map-a-novel-approach-for-diverse-organoid-size-culture-and-tailored-cancer-drug-response-analysis
#13
JOURNAL ARTICLE
Jungseub Lee, Sangmin Jung, Hye Kyoung Hong, Hyeonsu Jo, Stephen Rhee, Ye-Lin Jeong, Jihoon Ko, Yong Beom Cho, Noo Li Jeon
This study presents the vascularized tissue on mesh-assisted platform (VT-MAP), a novel microfluidic in vitro model that uses an open microfluidic principle for cultivating vascularized organoids. Addressing the gap in 3D high-throughput platforms for drug response analysis, the VT-MAP can host tumor clusters of various sizes, allowing for precise, size-dependent drug interaction assessments. Key features include capability for forming versatile co-culture conditions (EC, fibroblasts and colon cancer organoids) that enhance tumor organoid viability and a perfusable vessel network that ensures efficient drug delivery and maintenance of organoid health...
March 27, 2024: Lab on a Chip
https://read.qxmd.com/read/38533761/the-influence-of-microwave-ablation-parameters-on-the-positioning-of-trocar-in-different-cancerous-tissues-a-numerical-study
#14
JOURNAL ARTICLE
Vellavalapalli Satish, Ramjee Repaka
The present study analyzed the microwave ablation of cancerous tumors located in six major cancer-prone organs and estimated the significance of input power and treatment time parameters in the apt positioning of the trocar into the tissue during microwave ablation. The present study has considered a three-dimensional two-compartment tumour-embedded tissue model. FEA based COMSOL Multiphysics software with inbuilt bioheat transfer, electromagnetic waves, heat transfer in solids and fluids, and laminar flow physics has been used to obtain the numerical results...
March 27, 2024: Electromagnetic Biology and Medicine
https://read.qxmd.com/read/38533538/cxcr4-targeted-macrophage-derived-biomimetic-hybrid-vesicle-nanoplatform-for-enhanced-cancer-therapy-through-codelivery-of-manganese-and-doxorubicin
#15
JOURNAL ARTICLE
Yeonwoo Jang, Young Seok Cho, April Kim, Xingwu Zhou, Yujin Kim, Ziye Wan, James J Moon, Hansoo Park
Immune-cell-derived membranes have garnered significant attention as innovative delivery modalities in cancer immunotherapy for their intrinsic immune-modulating functionalities and superior biocompatibilities. Integrating additional parental cell membranes or synthetic lipid vesicles into cellular vesicles can further potentiate their capacities to perform combinatorial pharmacological activities in activating antitumor immunity, thus providing insights into the potential of hybrid cellular vesicles as versatile delivery vehicles for cancer immunotherapy...
March 27, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38533503/unraveling-the-causal-role-of-immune-cells-in-gastrointestinal-tract-cancers-insights-from-a-mendelian-randomization-study
#16
JOURNAL ARTICLE
Yu-Xiang Wang, Chao-Ping Zhou, Da-Tian Wang, Jun Ma, Xue-Hu Sun, Yao Wang, Ya-Ming Zhang
BACKGROUND: Despite early attempts, the relationship between immune characteristics and gastrointestinal tract cancers remains incompletely elucidated. Hence, rigorous and further investigations in this domain hold significant clinical relevance for the development of novel potential immunotherapeutic targets. METHODS: We conducted a two-sample Mendelian randomization (MR) analysis using the tools available in the "TwoSampleMR" R package. The GWAS data for these 731 immune traits were sourced from the GWAS Catalog database...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38533237/hot-avulsion-versus-argon-plasma-coagulation-for-the-management-of-the-non-ensnarable-polyp-a-multicenter-randomized-controlled-trial
#17
JOURNAL ARTICLE
Chloe Attree, Ravinder Ogra, Ian F Yusoff, Alan C Moss, Angela Jacques, Gregor Brown, Sina Alexander, Marios Efthymiou, Spiro Raftopoulos
BACKGROUND AND AIM: Snare resection of nonlifting colonic lesions often requires supplemental techniques. We compared the success rates of neoplasia eradication using hot avulsion and argon plasma coagulation in colonic polyps when complete snare polypectomy had failed. METHODS: Polyps that were not completely resectable by snare polypectomy were randomized to argon plasma coagulation or hot avulsion for completion of resection. Argon plasma coagulation was delivered using a forward shooting catheter, using a nontouch technique (flow 1...
March 2024: JGH Open: An Open Access Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38532592/-application-value-of-laparoscopic-double-stapler-firings-and-double-stapling-technique-combined-with-rectal-eversion-and-total-extra-abdominal-resection-in-the-sphincter-preserving-resection-of-low-rectal-cancer
#18
JOURNAL ARTICLE
H Liang, K Q Wu, Q W Fan, W Zheng, H Zhang, J W Bai, J M Li, J Q Chen, C Zhang
Objectives: To investigate the application value of laparoscopic double stapler firings and double stapling technique combined with rectal eversion and total extra-abdominal resection (LDER) in the anal preservation treatment of low rectal cancer. Methods: Inclusion criteria: (1) age was 18-70; (2) the distance of the lower tumor edge from the anal verge was 4-5 cm; (3) primary tumor with a diameter ≤3 cm; (4) preoperative staging of T1~2N1~2M0; (5) "difficult pelvis", defined as ischial tuberosity diameter<10 cm or body mass index>25 kg/m2 ; (6) patients with strong intention for sphincter preservation; (7) no preoperative treatment (e...
March 25, 2024: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38532103/identification-of-unique-rectal-cancer-specific-subtypes
#19
JOURNAL ARTICLE
Batuhan Kisakol, Anna Matveeva, Manuela Salvucci, Alexander Kel, Elizabeth McDonough, Fiona Ginty, Daniel B Longley, Jochen H M Prehn
BACKGROUND: Existing colorectal cancer subtyping methods were generated without much consideration of potential differences in expression profiles between colon and rectal tissues. Moreover, locally advanced rectal cancers at resection often have received neoadjuvant chemoradiotherapy which likely has a significant impact on gene expression. METHODS: We collected mRNA expression profiles for rectal and colon cancer samples (n = 2121). We observed that (i) Consensus Molecular Subtyping (CMS) had a different prognosis in treatment-naïve rectal vs...
March 26, 2024: British Journal of Cancer
https://read.qxmd.com/read/38531501/effects-of-moderate-ethanol-exposure-on-risk-factors-for-cardiovascular-disease-and-colorectal-cancer-in-adult-wistar-rats
#20
JOURNAL ARTICLE
Anna J Kwon, Lani Morales, Louise Chatagnier, Jacqueline Quigley, Jeremy Pascua, Natalie Pinkowski, Susan M Brasser, Mee Young Hong
While past studies have provided evidence linking excessive alcohol consumption to increased risk for cardiovascular diseases (CVDs) and colorectal cancer (CRC), existing data on the effects of moderate alcohol use on these conditions have produced mixed results. The purpose of this study was to investigate the effects of moderate alcohol consumption on risk factors associated with the development of CVDs and CRC in adult rats. Twenty-four, 14-month-old, non-deprived male Wistar rats were randomly assigned to either an ethanol group, which consisted of voluntary access to a 20% (v/v) ethanol solution on alternate days, or a water control group (n = 12/group) for 13 weeks...
March 24, 2024: Alcohol
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