keyword
https://read.qxmd.com/read/38343837/development-and-validation-of-a-federated-learning-framework-for-detection-of-subphenotypes-of-multisystem-inflammatory-syndrome-in-children
#21
Naimin Jing, Xiaokang Liu, Qiong Wu, Suchitra Rao, Asuncion Mejias, Mitchell Maltenfort, Julia Schuchard, Vitaly Lorman, Hanieh Razzaghi, Ryan Webb, Chuan Zhou, Ravi Jhaveri, Grace M Lee, Nathan M Pajor, Deepika Thacker, L Charles Bailey, Christopher B Forrest, Yong Chen
BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C) is a severe post-acute sequela of SARS-CoV-2 infection. The highly diverse clinical features of MIS-C necessities characterizing its features by subphenotypes for improved recognition and treatment. However, jointly identifying subphenotypes in multi-site settings can be challenging. We propose a distributed multi-site latent class analysis (dMLCA) approach to jointly learn MIS-C subphenotypes using data across multiple institutions...
January 27, 2024: medRxiv
https://read.qxmd.com/read/38326932/thyroid-hormone-may-predict-treatment-failure-in-kawasaki-disease
#22
JOURNAL ARTICLE
Yuichiro Hashida, Yoichi Mino, Keisuke Okuno, Hitoshi Uemasu, Shinji Sakata, Masanobu Fujimoto, Noriyuki Namba
BACKGROUND: In systemic inflammatory conditions, inflammatory cytokines can cause low thyroid hormone levels. There are no reports discussing the relation between thyroid hormone levels and response to treatment for Kawasaki disease. METHODS: We investigated 67 patients who underwent treatment in the acute phase of Kawasaki disease. We divided patients into two groups based on their response to initial intravenous immunoglobulin (IVIG) treatment: the responder group (n = 40), and the non-responder group (n = 27)...
2024: Pediatrics International: Official Journal of the Japan Pediatric Society
https://read.qxmd.com/read/38321737/critical-considerations-on-interpreting-n-terminal-pro-brain-natriuretic-peptide-levels-in-kawasaki-disease-authors-reply
#23
JOURNAL ARTICLE
Priyankar Pal
No abstract text is available yet for this article.
February 15, 2024: Indian Pediatrics
https://read.qxmd.com/read/38321736/critical-considerations-on-interpreting-n-terminal-pro-brain-natriuretic-peptide-levels-in-kawasaki-disease
#24
JOURNAL ARTICLE
Fida Ali Al-Ghailani, Gowda Parameshwara
No abstract text is available yet for this article.
February 15, 2024: Indian Pediatrics
https://read.qxmd.com/read/38319657/age-dependent-variations-in-kawasaki-disease-incidence-in-japan
#25
JOURNAL ARTICLE
Laurel L DeHaan, Charles D Copeland, Jennifer A Burney, Yosikazu Nakamura, Mayumi Yashiro, Chisato Shimizu, Koichi Miyata, Jane C Burns, Daniel R Cayan
IMPORTANCE: The etiology of Kawasaki disease (KD) remains elusive, with immunologic and epidemiologic data suggesting different triggers in individuals who are genetically susceptible. KD remains the most common cause of acquired heart disease in pediatric patients, and Japan is the country of highest incidence, with an increasing number of cases. OBJECTIVE: To investigate whether an analysis of the epidemiologic KD record in Japan stratified by age and prefecture (subregion) may yield new clues regarding mechanisms of exposure to etiologic agents associated with KD...
February 5, 2024: JAMA Network Open
https://read.qxmd.com/read/38310292/risk-factors-and-an-early-predictive-model-for-kawasaki-disease-shock-syndrome-in-chinese-children
#26
JOURNAL ARTICLE
Mingming Zhang, Congying Wang, Qirui Li, Hongmao Wang, Xiaohui Li
BACKGROUND: Kawasaki disease shock syndrome (KDSS), though rare, has increased risk for cardiovascular complications. Early diagnosis is crucial to improve the prognosis of KDSS patients. Our study aimed to identify risk factors and construct a predictive model for KDSS. METHODS: This case-control study was conducted from June, 2015 to July, 2023 in two children's hospitals in China. Children initially diagnosed with KDSS and children with Kawasaki disease (KD) without shock were matched at a ratio of 1:4 by using the propensity score method...
February 3, 2024: Italian Journal of Pediatrics
https://read.qxmd.com/read/38310210/assessing-pattern-of-the-pediatric-multisystem-inflammatory-syndrome-pmis-in-children-during-the-covid-19-pandemic-experience-from-the-emergency-department-of-tertiary-care-center-of-a-low-middle-income-country
#27
JOURNAL ARTICLE
Saleem Akhtar, Iqra Anis, Nirdosh Ashok Kumar, Muhammad Tayyab Ihsan, Ahmed Raheem, Surraiya Bano
BACKGROUND: Pediatric Multisystem Inflammatory Syndrome (PMIS) is a hyperinflammatory condition affecting multiple organs in children, often resembling incomplete Kawasaki Disease during later phases of COVID-19 infection. Data on PMIS in low-middle-income countries, particularly in emergency department settings, is limited. OBJECTIVES: This prospective observational study at Aga Khan University Hospital, Karachi, aimed to determine the frequency, clinical presentation patterns, and laboratory parameters of children with PMIS visiting the emergency department during the COVID-19 pandemic...
February 3, 2024: BMC Pediatrics
https://read.qxmd.com/read/38287358/kawasaki-disease-in-neonates-a-case-report-and-literature-review
#28
REVIEW
Mingjun Shen, Die Liu, Fang Ye, Jing Zhang, Jun Wang
BACKGROUND: Kawasaki disease (KD) is an acute systemic vasculitis of unknown etiology that affects infants and young children but is extremely rare in neonates, especially afebrile KD. We present a case of KD without fever in a neonate and review the literature on KD in neonates. CASE PRESENTATION: A newborn female was hospitalized because her peripheral blood leukocytes increased for half a day. The admission diagnosis was considered neonatal sepsis and bacterial meningitis...
January 29, 2024: Pediatric Rheumatology Online Journal
https://read.qxmd.com/read/38281860/the-efficacy-and-safety-of-intravenous-immunoglobulin-infusion-in-12%C3%A2-h-for-the-initial-treatment-of-kawasaki-disease
#29
JOURNAL ARTICLE
Satoshi Asano, Naoya Fukushima, Kenichiro Yamada
BACKGROUND: Approximately 10-20 % of individuals develop a recrudescent or persistent fever after intravenous immunoglobulin (IVIG) infusion for the initial treatment of Kawasaki disease. The aim of this study was to evaluate the efficacy and safety of the initial IVIG treatment of Kawasaki disease based on duration of infusion. METHODS: This retrospective, single-center study included 53 patients with Kawasaki disease who were initially treated with 2 g/kg of IVIG by means of a single infusion from June 2018 to August 2019...
January 23, 2024: Pediatrics and Neonatology
https://read.qxmd.com/read/38274908/unusual-manifestations-of-kawasaki-disease-in-the-covid-era-a-case-series-and-review-of-the-literature
#30
Maria Kostara, Anastasios Serbis, Maria Pavlou, Eleni Kotanidou, Sofia Tsabouri, Antonios Vlahos, Alexandros Makis, Ekaterini Siomou
Kawasaki disease (KD) is an acute medium-vessel vasculitis, mainly affecting infants older than six months and children under five years. It predisposes to the development of coronary artery aneurysms and constitutes the leading cause of acquired heart disease in children. Its diagnosis is based on clinical criteria, namely, fever lasting for ≥ five days together with at least four of the five principal clinical features of the disease. Occasionally, children with KD present with fever, but they fulfill only some of the five principal criteria, and this is described as incomplete KD...
December 2023: Curēus
https://read.qxmd.com/read/38273388/serum-levels-of-pdgf-cc-as-a-potential-biomarker-for-the-diagnosis-of-kawasaki-disease
#31
JOURNAL ARTICLE
Jing Zhang, Penghui Yang, Yihao Liu, Zhuo Chen, Jinhui Wu, Siqi Feng, Qijian Yi
BACKGROUND: Kawasaki disease (KD) is an acute systemic vasculitis of unknown etiology that predominantly affects children, and no specific diagnostic biomarkers for KD are available. Platelet-derived growth factor CC (PDGF-CC) is a peptide with angiogenic properties that has been amply demonstrated to play a critical role in the cardiovascular system. This study aimed to investigate the serum expression of PDGF-CC in children with KD and to evaluate the ability of PDGF-CC to diagnose KD...
January 25, 2024: Italian Journal of Pediatrics
https://read.qxmd.com/read/38273368/new-insight-into-the-intravenous-immunoglobulin-treatment-in-multisystem-inflammatory-syndrome-in-children-and-adults
#32
REVIEW
Chih-Jen Chen, Hsu-Yen Kao, Ching-Hua Huang, Chia-Jung Li, Cheng-Hsien Hung, Su-Boon Yong
Within 6 months of the coronavirus pandemic, a new disease entity associated with a multisystem hyperinflammation syndrome as a result of a previous infection with the SARS-CoV-2 virus is increasingly being identified in children termed Multisystem Inflammatory Syndrome in Children (MIS-C) and more recently in adults(MIS-A). Due to its clinical similarity with Kawasaki Disease, some institutions have used intravenous immunoglobulins and steroids as first line agents in the management of the disease. We seek to find how effective intravenous immunoglobulin therapy is across these two disease entities...
January 25, 2024: Italian Journal of Pediatrics
https://read.qxmd.com/read/38271561/interaction-between-genetic-susceptibility-and-covid-19-pathogenesis-in-pediatric-multisystem-inflammatory-disorders-the-role-of-immune-responses
#33
JOURNAL ARTICLE
Li-Na Chen, Zhang-Xuan Shou, Xue Jin
Numerous studies have highlighted the emergence of coronavirus disease (COVID-19) symptoms reminiscent of Kawasaki disease in children, including fever, heightened multisystem inflammation, and multiorgan involvement, posing a life-threatening complication. Consequently, extensive research endeavors in pediatric have aimed to elucidate the intricate relationship between COVID-19 infection and the immune system. COVID-19 profoundly impacts immune cells, culminating in a cytokine storm that particularly inflicts damage on the pulmonary system...
January 25, 2024: Viral Immunology
https://read.qxmd.com/read/38269467/-multisystem-inflammatory-syndrome-in-children-in-the-context-of-coronavirus-disease-2019-pandemic
#34
JOURNAL ARTICLE
Bin Zhou, Yu-Kun Huang, Shao-Xian Hong, Fu-Yong Jiao, Kai-Sheng Xie
Multisystem inflammatory syndrome in children (MIS-C) is a complex syndrome characterized by multi-organ involvement that has emerged in the context of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak. The clinical presentation of MIS-C is similar to Kawasaki disease but predominantly presents with fever and gastrointestinal symptoms, and severe cases can involve toxic shock and cardiac dysfunction. Epidemiological findings indicate that the majority of MIS-C patients test positive for SARS-CoV-2 antibodies...
January 15, 2024: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://read.qxmd.com/read/38262814/the-impact-of-inappropriate-steroid-exposure-before-the-diagnosis-of-kawasaki-disease
#35
JOURNAL ARTICLE
Chanyoung Chung, Hoon Ko, Joung-Hee Byun, Tae Hong Kim, Hyungtae Kim, Kwang Ho Choi, Hyoung-Doo Lee
BACKGROUND: Kawasaki disease (KD) is a systemic inflammatory disease characterized by vasculitis. In South Korea, some pediatric doctors empirically prescribe steroids to control febrile pediatric patients. This study aimed to evaluate the clinical characteristics of patients with KD after steroid exposure. METHODS: This was a single-center, retrospective, observational study. This study included patients (aged ≤15 years) between January 2020 and July 2022...
January 4, 2024: Pediatrics and Neonatology
https://read.qxmd.com/read/38245705/hemolytic-anemia-associated-with-intravenous-immunoglobulin-in-kawasaki-disease
#36
JOURNAL ARTICLE
Eun Jung Cheon, Jun Suk Oh
BACKGROUND: The administration of high-dose intravenous immunoglobulin (IVIG) is a standard treatment for the management of Kawasaki disease (KD). IVIG is known to be a highly effective and safe treatment. CASE PRESENTATION: We report the development of hemolytic anemia in seven children receiving repeated doses of IVIG. The children were aged 3-44 months and included 4 girls and 3 boys. All children received 10% IVIG and a second course of immunoglobulin because they did not respond to the first course of immunoglobulin...
January 20, 2024: BMC Pediatrics
https://read.qxmd.com/read/38240765/efficacy-and-safety-of-infliximab-in-the-treatment-of-kawasaki-disease-a-systematic-review-and-meta-analysis
#37
JOURNAL ARTICLE
Lihe Wang, Milan He, Wei Wang, Shiya Li, Guoxiao Zhao
Infliximab is a monoclonal antibody specifically binding tumor necrosis factor-alpha and has been approved for the treatment of several inflammatory disorders. However, the efficacy of infliximab in primary treatment of Kawasaki disease (KD) or retreatment of intravenous immunoglobulin (IVIG)-resistant KD in children is controversial. Therefore, we conducted a meta-analysis to compare the efficacy of infliximab alone or in combination with IVIG to IVIG. Eligible randomized and non-randomized trials were retrieved by searching literature databases prior to May 31, 2023...
January 19, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38233123/human-adipose-tissue-derived-stem-cells-inhibit-coronary-artery-vasculitis-in-a-mouse-model-of-kawasaki-disease
#38
JOURNAL ARTICLE
Ryohei Fukunaga, Takahiro Ueda, Ryosuke Matsui, Toshikazu Itabashi, Ryuji Fukazawa, Noriko Nagi-Miura, Yasuhiko Itoh
BACKGROUND: Adipose tissue-derived mesenchymal stem cells (ADSCs) are used for the treatment of various diseases because of their rapid proliferation and high anti-inflammatory and tissue repair properties. Kawasaki disease is a systemic vasculitis with coronary arteritis and aneurysms occurring in pediatric patients. In this study, we examined serologically and pathologically whether the administration of human ADSCs (hADSCs) to a mouse model of Kawasaki disease could suppress vasculitis...
January 16, 2024: Journal of Nippon Medical School
https://read.qxmd.com/read/38216359/reliability-of-the-risser-grade-for-assessment-of-bone-maturity-in-pediatric-scoliosis-cases-investigation-using-standing-and-supine-whole-spine-radiograph
#39
JOURNAL ARTICLE
Takahiro Mui, Hideki Shigematsu, Masaki Ikejiri, Sachiko Kawasaki, Yasuhito Tanaka
BACKGROUND: Although several radiography-based systems for assessing skeletal maturity are available to clinicians, the classical Risser grading system remains a clinical gold standard. For scoliosis follow-up, a standing whole-spine radiograph is usually used. However, in our clinical practice, we have occasionally encountered cases in which ossification of the iliac crest is seen differently in the standing and supine whole-spine radiography. Here, we aimed to clarify the reliability of the Risser+ grading system for supine versus standing position radiographs...
January 11, 2024: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://read.qxmd.com/read/38204335/updated-case-definition-of-mis-c-and-implications-for-clinical-care
#40
JOURNAL ARTICLE
Megan Day-Lewis, Laura Berbert, Annette Baker, Audrey Dionne, Jane W Newburger, Mary Beth F Son
OBJECTIVES: A broad, surveillance case definition was implemented when multisystem inflammatory syndrome in children (MIS-C) emerged in 2020. In 2023, a revised MIS-C case definition was constructed to improve specificity and reduce misclassification with other pediatric inflammatory conditions. This study aims to describe the impact of the updated definition on the classification of patients with MIS-C and Kawasaki Disease (KD). METHODS: Patients hospitalized from March 2020 to November 2022 with clinician-diagnosed KD and MIS-C at a single center were studied retrospectively...
January 11, 2024: Pediatrics
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