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JOURNAL ARTICLE
Ronit R Dalmat, Rebecca A Ziebell, Aruna Kamineni, Amanda I Phipps, Noel S Weiss, Erica S Breslau, Douglas A Corley, Beverly B Green, Ethan A Halm, Theodore R Levin, Joanne E Schottinger, Jessica Chubak
BACKGROUND: Few empirical data are available to inform older adults' decisions about whether to screen or continue screening for colorectal cancer (CRC) based on their prior history of screening, particularly among individuals with a prior negative exam. METHODS: Using a retrospective cohort of older adults receiving healthcare at three Kaiser Permanente integrated healthcare systems in Northern California (KPNC), Southern California (KPSC), and Washington (KPWA), we estimated the cumulative risk of CRC incidence and mortality among older adults who had a negative colonoscopy ten years earlier, accounting for death from other causes...
September 13, 2022: Cancer Epidemiology, Biomarkers & Prevention
#42
JOURNAL ARTICLE
Andrew M Hersh, A Daniel Davidar, Carly Weber-Levine, Divyaansh Raj, Safwan Alomari, Brendan F Judy, Nicholas Theodore
Significant advancements in the treatment of spinal cord injury (SCI) were developed in the setting of military conflicts, partly due to the large numbers of injuries sustained by service members. No effective SCI treatment options existed into the early 20th century, and soldiers who sustained these injuries were usually considered untreatable. Extensive progress was made in SCI treatment during and after World War II, as physical therapy was increasingly encouraged for patients with SCI, multidisciplinary teams oversaw care, pathophysiology was better understood, and strategies were devised to prevent wound infection and pressure sores...
September 2022: Neurosurgical Focus
#43
REVIEW
Gordon Mao, Srujan Kopparapu, Yike Jin, A Daniel Davidar, Andrew M Hersh, Carly Weber-Levine, Nicholas Theodore
Ehlers-Danlos syndrome (EDS) is a rare hereditary condition that can result in ligamentous laxity and hypermobility of the cervical spine. A subset of patients can develop clinical instability of the craniocervical junction associated with pain and neurological dysfunction, potentially warranting treatment with occipitocervical fixation (OCF). Surgical decision-making in patients with EDS can be complicated by difficulty distinguishing from hypermobility inherent in the disease and true pathological instability necessitating intervention...
December 2022: Spine Journal: Official Journal of the North American Spine Society
#44
REVIEW
Andrew M Hersh, Carly Weber-Levine, Kelly Jiang, Lisa Young, Max Kerensky, Denis Routkevitch, Yohannes Tsehay, Alexander Perdomo-Pantoja, Brendan F Judy, Daniel Lubelski, Nicholas Theodore, Amir Manbachi
Elastography is an imaging technology capable of measuring tissue stiffness and consistency. The technology has achieved widespread use in the workup and management of diseases of the liver, breast, thyroid, and prostate. Although elastography is increasingly being applied in neurosurgery, it has not yet achieved widespread adoption and many clinicians remain unfamiliar with the technology. Therefore, we sought to summarize the range of applications and elastography modalities available for neurosurgery, report its effectiveness in comparison with conventional imaging methods, and offer recommendations...
August 4, 2022: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
#45
REVIEW
Carly Weber-Levine, Brendan F Judy, Andrew M Hersh, Tolulope Awosika, Yohannes Tsehay, Timothy Kim, Alejandro Chara, Nicholas Theodore
OBJECTIVE: The authors systematically reviewed current evidence for the utility of mean arterial pressure (MAP), intraspinal pressure (ISP), and spinal cord perfusion pressure (SCPP) as predictors of outcomes after traumatic spinal cord injury (SCI). METHODS: PubMed, Cochrane Reviews Library, EMBASE, and Scopus databases were queried in December 2020. Two independent reviewers screened articles using Covidence software. Disagreements were resolved by a third reviewer...
June 3, 2022: Journal of Neurosurgery. Spine
#46
JOURNAL ARTICLE
Alexander Perdomo-Pantoja, Hesham Mostafa Zakaria, Ann Liu, Yohannes Tsehay, Carly Weber-Levine, Gordon Mao, Nicholas Theodore
BACKGROUND AND IMPORTANCE: Although catheter-related complications in intrathecal drug delivery systems are relatively common, vascular myelopathy secondary to occlusion of the artery of Adamkiewicz (AoA) from an abutting intrathecal catheter has not yet been reported. In this study, we present a case of this extremely rare presentation, which resolved after decompression of the artery. CLINICAL PRESENTATION: A 39-year-old woman presented with lower extremity weakness and paresthesia...
August 1, 2022: Operative Neurosurgery (Hagerstown, Md.)
#47
Aasma Shaukat, Theodore R Levin
No abstract text is available yet for this article.
August 2022: Nature Reviews. Gastroenterology & Hepatology
#48
JOURNAL ARTICLE
Theodore E Harrison, Jannice Bowler, K Dean Reeves, Todd N Levins, An-Lin Cheng
Platelet-rich plasma (PRP) and hypertonic dextrose solutions are commonly used injectates in regenerative medicine, sometimes used simultaneously. The effects of hypertonic dextrose on platelet lysis and activation have not been previously reported. We tested the effects of escalating dextrose concentration on cell counts and cell volume of platelets and red cells in PRP and whole blood (WB). A prompt partial reduction in platelet count occurred with all dextrose admixtures with either PRP or whole blood, consistent with partial lysis...
May 2022: Curēus
#49
JOURNAL ARTICLE
Amanda Marie Moore, Anne Catherine Holding, Shelby Levine, Theodore Powers, Richard Koestner
Social distancing (SD) was an effective way of reducing virus transmission during the deadly and highly infectious COVID-19 pandemic. Using a prospective longitudinal design, the present study explored how the Big 5 traits relate to variations in SD in a sample of university students (n = 285), and replicated these findings using informant reports. Self-determination theory's concepts of autonomous motivation and intrinsic community values were explored as potential mechanisms linking traits to SD. Individuals who were higher on trait agreeableness and conscientiousness engaged in more SD because they more effectively internalized the importance and value of the guidelines as a function of their concerns about the welfare of their communities...
June 15, 2022: Motivation and Emotion
#50
REVIEW
Hiroko Matsumoto, Afrain Z Boby, Rishi Sinha, Megan L Campbell, Chun Wai Hung, Fay C Gbolo, Gerard F Marciano, Sonya Levine, Adam N Fano, Matthew E Simhon, Theodore Quan, Nicole M Bainton, Ameeka George, Amber S Mizerik, Benjamin D Roye, David P Roye, Michael G Vitale
BACKGROUND: The 24-question Early-Onset Scoliosis Questionnaire (EOSQ-24) is a proxy measure assessing health-related quality of life (HRQoL) among patients with early-onset scoliosis (EOS). There exists an increasing need to assess HRQoL through a child's own perspective, particularly for older children and adolescents with EOS. The purpose of this study was to develop and validate a self-reported questionnaire, the Early-Onset Scoliosis Self-Report Questionnaire (EOSQ-SELF), to assess HRQoL in older children and adolescents with EOS...
August 3, 2022: Journal of Bone and Joint Surgery. American Volume
#51
JOURNAL ARTICLE
Jeffrey K Lee, Angela Y Lam, Christopher D Jensen, Amy R Marks, Jessica Badalov, Evan Layefsky, Kevin Kao, Ngoc J Ho, Joanne E Schottinger, Nirupa R Ghai, Cheryl M Carlson, Ethan A Halm, Beverly Green, Dan Li, Douglas A Corley, Theodore R Levin
BACKGROUND: The COVID-19 pandemic has impacted clinical services globally, including colorectal cancer (CRC) screening and diagnostic testing. We investigated the pandemic's impact on fecal immunochemical test (FIT) screening, colonoscopy utilization, and colorectal neoplasia detection across 21 medical centers in a large integrated healthcare organization. METHODS: We performed a retrospective cohort study in Kaiser Permanente Northern California patients ages 18-89 years in 2019 and 2020 and measured changes in the numbers of mailed, completed, and positive FITs; colonoscopies, and cases of colorectal neoplasia detected by colonoscopy in 2020 versus 2019...
May 14, 2022: Gastroenterology
#52
REVIEW
Aasma Shaukat, Theodore R Levin
Despite strong evidence of effectiveness, colorectal cancer (CRC) screening remains underused. Currently, there are several options for CRC screening, each with its own performance characteristics and considerations for practice. This Review aims to cover current CRC screening guidelines and highlight future blood-based and imaging-based options for screening. In current practice, the leading non-invasive option is the faecal immunochemical test (FIT) based on its high specificity, good sensitivity, low cost and ease of use in mailed outreach programmes...
August 2022: Nature Reviews. Gastroenterology & Hepatology
#53
JOURNAL ARTICLE
Andrew B Hawkey, Erica Pippen, Bruny Kenou, Zade Holloway, Theodore A Slotkin, Frederic J Seidler, Edward D Levin
Diazinon is an organophosphate pesticide that has a history of wide use. Developmental exposures to organophosphates lead to neurobehavioral changes that emerge early in life and can persist into adulthood. However, preclinical studies have generally evaluated changes through young adulthood, whereas the persistence or progression of deficits into middle age remain poorly understood. The current study evaluated the effects of maternal diazinon exposure on behavior and neurochemistry in middle age, at 1 year postpartum, comparing the results to our previous studies of outcomes at adolescence and in young adulthood (4 months of age) (Hawkey 2020)...
April 19, 2022: Toxicology
#54
JOURNAL ARTICLE
Sophia A Doerr, Carly Weber-Levine, Andrew M Hersh, Tolulope Awosika, Brendan Judy, Yike Jin, Divyaansh Raj, Ann Liu, Daniel Lubelski, Craig K Jones, Haris I Sair, Nicholas Theodore
OBJECTIVE: Damage to the thoracolumbar spine can confer significant morbidity and mortality. The Thoracolumbar Injury Classification and Severity Score (TLICS) is used to categorize injuries and determine patients at risk of spinal instability for whom surgical intervention is warranted. However, calculating this score can constitute a bottleneck in triaging and treating patients, as it relies on multiple imaging studies and a neurological examination. Therefore, the authors sought to develop and validate a deep learning model that can automatically categorize vertebral morphology and determine posterior ligamentous complex (PLC) integrity, two critical features of TLICS, using only CT scans...
April 2022: Neurosurgical Focus
#55
REVIEW
Yohannes Tsehay, Carly Weber-Levine, Timothy Kim, Alejandro Chara, Safwan Alomari, Tolulope Awosika, Ann Liu, Jeffrey Ehresman, Kurt Lehner, Brian Hwang, Andrew M Hersh, Ian Suk, Eli Curry, Fariba Aghabaglou, Yinuo Zeng, Amir Manbachi, Nicholas Theodore
Spinal cord injury (SCI) is a devastating condition that affects about 17,000 individuals every year in the United States, with approximately 294,000 people living with the ramifications of the initial injury. After the initial primary injury, SCI has a secondary phase during which the spinal cord sustains further injury due to ischemia, excitotoxicity, immune-mediated damage, mitochondrial dysfunction, apoptosis, and oxidative stress. The multifaceted injury progression process requires a sophisticated injury-monitoring technique for an accurate assessment of SCI patients...
March 26, 2022: Spine Journal: Official Journal of the North American Spine Society
#56
JOURNAL ARTICLE
Amelia J McFarland, Pradipta R Ray, Salman Bhai, Benjamin D Levine, Theodore J Price
Sedentary lifestyle, chronic disease, or microgravity can cause muscle deconditioning that then has an impact on other physiological systems. An example is the nervous system, which is adversely affected by decreased physical activity resulting in increased incidence of neurological problems such as chronic pain. We sought to better understand how this might occur by conducting RNA sequencing experiments on muscle biopsies from human volunteers in a 5-week bed-rest study with an exercise intervention arm. We also used a computational method for examining ligand-receptor interactions between muscle and human dorsal root ganglion (DRG) neurons, the latter of which play a key role in nociception and are generators of signals responsible for chronic pain...
February 2022: Physiological Reports
#57
JOURNAL ARTICLE
Sara R Alcorn, Christen R Elledge, Anna W LaVigne, Lawrence Kleinberg, Thomas J Smith, Adam S Levin, Jacob Fiksel, Scott Zeger, Todd McNutt, Theodore L DeWeese, Jean L Wright
RATIONALE, AIMS AND OBJECTIVES: In the management of symptomatic bone metastases, current practice guidelines do not provide clear methodology for selecting palliative radiotherapy (RT) regimens based on specific patient and disease features. Decision support aids may offer an effective means for translating the complex data needed to render individualised treatment decisions, yet no such tools are available for use in this setting. Thus, we describe the development of the Bone Metastases Ensemble Trees for Survival-Decision Support Platform (BMETS-DSP), which aims to optimise selection of evidence-based, individualised palliative RT regimens...
January 28, 2022: Journal of Evaluation in Clinical Practice
#58
MULTICENTER STUDY
Michael Xiang, Ting Martin Ma, Ricky Savjani, Erqi L Pollom, R Jeffrey Karnes, Tristan Grogan, Jessica K Wong, Giovanni Motterle, Jeffrey J Tosoian, Bruce J Trock, Eric A Klein, Bradley J Stish, Robert T Dess, Daniel E Spratt, Avinash Pilar, Chandana Reddy, Rebecca Levin-Epstein, Trude B Wedde, Wolfgang A Lilleby, Ryan Fiano, Gregory S Merrick, Richard G Stock, D Jeffrey Demanes, Brian J Moran, Hartwig Huland, Phuoc T Tran, Santiago Martin, Rafael Martinez-Monge, Daniel J Krauss, Eyad I Abu-Isa, Ridwan Alam, Zeyad Schwen, Thomas M Pisansky, C Richard Choo, Daniel Y Song, Stephen Greco, Curtiland Deville, Todd McNutt, Theodore L DeWeese, Ashley E Ross, Jay P Ciezki, Paul C Boutros, Nicholas G Nickols, Prashant Bhat, David Shabsovich, Jesus E Juarez, Natalie Chong, Patrick A Kupelian, Matthew B Rettig, Nicholas G Zaorsky, Alejandro Berlin, Jonathan D Tward, Brian J Davis, Robert E Reiter, Michael L Steinberg, David Elashoff, Eric M Horwitz, Rahul D Tendulkar, Derya Tilki, Johannes Czernin, Andrei Gafita, Tahmineh Romero, Jeremie Calais, Amar U Kishan
IMPORTANCE: Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) can detect low-volume, nonlocalized (ie, regional or metastatic) prostate cancer that was occult on conventional imaging. However, the long-term clinical implications of PSMA PET/CT upstaging remain unclear. OBJECTIVES: To evaluate the prognostic significance of a nomogram that models an individual's risk of nonlocalized upstaging on PSMA PET/CT and to compare its performance with existing risk-stratification tools...
December 1, 2021: JAMA Network Open
#59
JOURNAL ARTICLE
Theodore A Slotkin, Edward D Levin, Frederic J Seidler
The legalization and increasing availability of cannabis products raises concerns about the impact on offspring of users, and little has appeared on the potential contribution of paternal use. We administered cannabis extract to male rats prior to mating, with two different 28-day exposures, one where there was a 56-day interval between the end of exposure and mating ("Early Cannabis"), and one just prior to mating ("Late Cannabis"); the extract delivered 4 mg/kg/day of the main psychoactive component, Δ9-tetrahydrocannabinol...
November 24, 2021: Toxicological Sciences: An Official Journal of the Society of Toxicology
#60
REVIEW
Andrew Hersh, Smruti Mahapatra, Carly Weber-Levine, Tolulope Awosika, John N Theodore, Hesham M Zakaria, Ann Liu, Timothy F Witham, Nicholas Theodore
Augmented reality (AR) navigation refers to novel technologies that superimpose images, such as radiographs and navigation pathways, onto a view of the operative field. The development of AR navigation has focused on improving the safety and efficacy of neurosurgical and orthopedic procedures. In this review, the authors focus on 3 types of AR technology used in spine surgery: AR surgical navigation, microscope-mediated heads-up display, and AR head-mounted displays. Microscope AR and head-mounted displays offer the advantage of reducing attention shift and line-of-sight interruptions inherent in traditional navigation systems...
October 2021: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
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