Rui Xie, Jingyu Xu, Yufeng Xiao, Jilin Wu, Hanxing Wan, Bo Tang, Jingjing Liu, Yahan Fan, Suming Wang, Yuyun Wu, Tobias Xiao Dong, Michael X Zhu, John M Carethers, Hui Dong, Shiming Yang
Although dietary calcium intake has long been recommended for disease prevention, the influence of calcium in development of cancer in the upper gastrointestinal tract has not been explored. Here, we assess the roles of calcium and calcium-sensing receptor (CaSR) in gastric cancer development. CaSR expression was enhanced in gastric cancer specimens, which positively correlated with serum calcium concentrations, tumor progression, poor survival, and male gender in gastric cancer patients. CaSR and transient receptor potential cation channel subfamily V member 4 (TRPV4) were colocalized in gastric cancer cells, and CaSR activation evoked TRPV4-mediated Ca2+ entry...
December 1, 2017: Cancer Research