Manavotam Singh, Nitin Malik, Vijaywant Brar, Patrick T Bering, Cyrus Hadadi, Farooq H Sheikh, Phillip H Lam
Sustained ventricular tachycardia and ventricular fibrillation (VF) are life-threatening arrhythmias which remain highly prevalent in patients with advanced heart failure. These ventricular arrhythmias may impair the support provided by continuous-flow left ventricular assist devices (CF-LVADs) and lead to frequent hospitalizations, antiarrhythmic medication use, external defibrillations, and need for heart transplantation. We report a case in which a patient with a CF-LVAD and an implantable cardioverter defibrillator at end-of-life presented with asymptomatic low-flow alarms and was found to have VF of unknown duration...
January 23, 2021: Journal of Cardiovascular Electrophysiology
Andrew Chatfield, Janarthanan Sathananthan, David A Wood, John G Webb
The next generation SAPIEN 3 Ultra (Edwards Lifesciences, CA, USA) builds on the success of the SAPIEN 3 (S3) transcatheter heart valve. The textured polyethylene terephthalate external skirt is 40% taller than the S3 valve skirt. The Edwards Commander delivery system and Edwards eSheath remain unchanged from S3 with proven results regarding valve deliverability and low rates of vascular complications.
January 20, 2021: Future Cardiology
Mohamed Abdelwahab, Priyesh Patel, Cherian K Kandathil, Harsh Wadhwa, Sam P Most
OBJECTIVES/HYPOTHESIS: To evaluate the lateral nasal wall stability, nasal function, and cosmesis when creating an aesthetically pleasing nasal tip subunit utilizing lateral crus (LC) altering procedures. STUDY DESIGN: Retrospective cohort. METHODS: In this retrospective cohort study, cosmetic rhinoplasty patients undergoing LC procedures with available lateral wall insufficiency (LWI) scores were included. An LWI grading system was used to evaluate internal (zone 1) and external (zone 2) nasal valves objectively...
January 18, 2021: Laryngoscope
Anh Tong, Quang Long Pham, Vatsal Shah, Akshay Naik, Paul Abatemarco, Roman Voronov
Cell culturing experiments are ubiquitous to the study of biology, development of new medical treatments, and the biomanufacturing industry. However, there are still major technological barriers limiting the advancement of knowledge and ballooning the experimental costs associated with these systems. For example, currently, it is difficult to perform nondisruptive monitoring and control of the cells in the cultured samples. This often necessitates the use of sacrificial assays and results in product inconsistency...
March 9, 2020: ACS Biomaterials Science & Engineering
Shi Sum Poon, Joseph George, Daniel Obaid, Pankaj Kumar
Background: Iatrogenic right coronary artery (RCA) injury is a rare complication of tricuspid valve annuloplasty. Given that surgical intervention is increasingly favoured for tricuspid regurgitation, it is of great importance to recognize potential complications following tricuspid valve surgery. Case summary: A 72-year-old man underwent surgical mitral and tricuspid valve repair. The early post-operative course was complicated by recurrent ventricular fibrillation episodes...
December 2020: European Heart Journal. Case Reports
Quentin Chatelain, Andrea Carcaterra, Florian Rey, Haran Burri
Background : Infective endocarditis with paravalvular abscess can be complicated by atrioventricular block (AVB), but junctional ectopic tachycardia (JET) has as yet never been described. Case summary : A 68-year-old male recently admitted with Staphylococcal aureus endocarditis of his aortic valve bioprosthesis, presented with a regular tachycardia at 240 b.p.m. with a pre-existent right bundle branch block pattern. Haemodynamic collapse necessitated electrical cardioversion, following which high-grade AVB was observed...
December 2020: European Heart Journal. Case Reports
Xueying Huang, Long Deng, Heng Zuo, Chun Yang, Yunhu Song, Mary Lesperance, Dalin Tang
BACKGROUND: Patient-specific active fluid-structure interactions (FSI) model is a useful approach to non-invasively investigate the hemodynamics in the heart. However, it takes a lot of effort to obtain the proper external force boundary conditions for active models, which heavily restrained the time-sensitive clinical applications of active computational models. METHODS: The simulation results of 12 passive FSI models based on 6 patients' pre-operative and post-operative CT images were compared with corresponding active models to investigate the differences in hemodynamics and cardiac mechanics between these models...
January 12, 2021: Biomedical Engineering Online
Yoshihiro Suematsu, Satoshi Nishi, Daisuke Arima, Akihiro Yoshimoto
BACKGROUND: Acute aortic dissection (AAD) is a life-threatening condition which can lead to coronary, brachiocephalic or branch vessel malperfusion, as well as aortic valve insufficiency, or aortic rupture. Mortality of surgical treatment in high-risk or elderly patients with Type A AAD (TAAAD) still remains high, and treatment for such patients remains controversial. We report a successful treatment of TAAAD with a communicating false lumen in a 60-year-old man with acute hemi-cerebral malperfusion...
January 11, 2021: Journal of Cardiothoracic Surgery
Marek J Jasinski, Karol Miszalski-Jamka, Kinga Kosiorowska, Radoslaw Gocol, Izabella Wenzel-Jasinska, Grzegorz Bielicki, Mikolaj Berezowski, Marceli Lukaszewski, Andrzej Kansy, Marek A Deja
BACKGROUND: The incompetent bicuspid aortic valve (BAV) can be replaced or repaired using various surgical techniques. This study sought to assess the efficacy of external annuloplasty and postoperative reverse remodelling using cardiac magnetic resonance (CMR) and compare the results of external and subcommissural annuloplasty. METHODS: Out of a total of 200 BAV repair performed between 2004 and 2018, 21 consecutive patients (median age 54 years) with regurgitation requiring valve repair with annuloplasty without concomitant aortic root surgery were prospectively referred for CMR and transthoracic echocardiography (TTE) one year after the operation...
January 6, 2021: BMC Cardiovascular Disorders
A Cavallo, E Gasparotti, P Losi, I Foffa, T Al Kayal, E Vignali, S Celi, G Soldani
The valve replacement therapy is the standard treatment for severe heart valve diseases. Nowadays, two types of commercial prosthesis are available: mechanical and biological, but both of them have severe limitations. Moreover, alternative therapeutic approach for valve replacement, based on minimally invasive techniques (MIAVR), motivates the search for new valve materials. In this study a polyurethane-based self-expandable tri-leaflets heart valve compatible with MIAVR procedure is proposed. The device is based on the development, fabrication and characterization of three different elements: the leaflets, the polymeric stent for supporting the leaflets, and the external metallic stent for anchoring the valve to the native aortic root...
December 25, 2020: Journal of the Mechanical Behavior of Biomedical Materials
Laura Hemming, Peer Bhatti, Jennifer Shaw, Gillian Haddock, Daniel Pratt
Suicide and violence are prevalent within male prisons in the UK. It has been suggested that alexithymia may be associated with both suicide and violence. Alexithymia can be defined as an inability to identify or discuss emotions. The present study aimed to qualitatively explore male prisoners' experiences of alexithymia and how these experiences may relate to suicide and violence. Fifteen male prisoners were recruited from two prisons in the North West of England. All participants had experienced suicidal and/or violent thoughts and/or behaviors in the past 3 months, and all screened positive on an established measure of alexithymia...
2020: Frontiers in Psychiatry
Efstathios T Detorakis, Adan Villamarin, Sylvain Roy, Stephane Bigler, Georgios Bontzos, Constantinos Stergiopulos, Nikos Stergiopulos
Introduction: The eyeWatch™ is a novel device in glaucoma surgery aiming at the control of aqueous flow through the use of an external magnetic control unit. We propose the modification of this approach through the use of an injectable perforated tube rather than a plated valve. Materials and methods: Procedures were performed at the Department of Ophthalmology of the University of Crete. Three blind painful eyes of three patients were included. All patients were operated under topical anesthesia...
May 2020: Journal of Current Glaucoma Practice
Shunsuke Matsushima, Shota Hasegawa, Hironori Matsuhisa, Yoshihiro Oshima
Progressive aortic regurgitation can occur in pediatric patients due to root dilation with conotruncal anomalies or cusp prolapse associated with a ventricular septal defect. It is treated using various approaches influenced by personal preferences and institutional experience. We applied geometrical concepts developed for adult aortic valve repair to pediatric valves. The basal ring and sinotubular junction are downsized in relation to the geometric height of the cusp by external suture annuloplasty. The length of the cusp free margin is then adjusted with central plication, guided by measuring the effective height of the cusp...
December 3, 2020: Multimedia Manual of Cardiothoracic Surgery: MMCTS
Nobuki Takeuchi, Shunsuke Nakajima, Koki Yoshida, Ryuji Kawano, Yutaka Hori, Hiroaki Onoe
Programmable materials have artificially designed physical shapes responding to external stimuli, as well as high design capability and high flexibility. Here, we propose a microfiber-shaped programmable material with an axial pattern of stimuli-responsive (SR) and nonresponsive hydrogels. The SR pre-gel solution was mixed to sodium alginate pre-gel solution for instantaneous gelation with ionic crosslinking and solidified on a nonresponsive hydrogel microfiber with a valve-controlled microfluidic system. A design of microfiber-shaped programmable material (patterned position of SR regions) could be flexibly altered by changing a coded sequence program...
December 3, 2020: Soft Robotics
Akiko Yawata, Takanori Tsujimura, Ryosuke Takeishi, Jin Magara, Li Yu, Makoto Inoue
Coughing, huffing and swallowing protect the airway from aspiration. This study was conducted to compare the physical properties of voluntary coughing, huffing and swallowing in healthy subjects. Ten healthy men were asked to huff, cough and swallow repeatedly. Electromyograms (EMGs) were recorded from the left side of the external oblique (EO), sternocleidomastoid, suprahyoid (SH) and thyrohyoid muscles. Airflow was recorded using a face mask with two-way non-rebreathing valves. The expiratory velocity of huffing and coughing and the SH EMG of all actions presented high intraclass correlation coefficients (> 0...
2020: PloS One
Daniele Camilli, Alessandro Platone, Massimo Ruggeri, Sergio Furgiuele
Evaluation of the outcomes of OSES (oval-shaped external support), a novel device for external valvuloplasty of the great saphenous vein (GSV) for the conservative treatment of superficial venous insufficiency. Between 2012 and 2015, 30 patients underwent external valvuloplasty of the GSV for a total of 32 limbs. Patients were subjected to clinical and instrumental follow-up by a half-year ultrasound for a minimum of 36 months. The main endpoints were the recurrence of varicose disease, persistent or recurrent venous reflux, and venous thrombosis...
December 2020: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
Magdi H Yacoub, Ahmed Afifi, Hatem Hosny, Mohamed Nagy, Nairouz Shehata, Mazen Abou Gamrah, Amr El Sawy, Walid Simry, Ahmed Mahgoub, Nadine Francis, Hussam El Nashar, Yuan-Tsan Tseng, Soha Romeih, Heba Aguib
BACKGROUND: Preserving dynamism, and recreation of sinuses in the Dacron graft are thought to be important for optimising results of aortic valve conserving operations. METHODS: We here describe a novel technique which preserves dynamism and recreates the sinotubular junction, as well as tailors 3 sinuses of defined longitudinal and transverse curvatures in a straight Dacron tube, during operation, the technique has been used in 6 patients with varied aortic root pathology...
November 27, 2020: Annals of Thoracic Surgery
Yashodeep Patil, Kevin Dotseth, Theodore Shapiro, Dhakshenan Pushparajan, Stephen Binderup, James R Horn, Venumadhav Korampally
This paper presents a new approach towards the design of paper based autonomous microfluidic devices. Autonomy in the device operation is achieved through the incorporation of mechanically actuated microfluidic switches that are versatile in their design and may be configured to be simple time triggered ON or OFF switches or more complex switches that can be timed to be in multiple states (timed ON, followed by timed OFF). These switches are self-contained and require no external power for their operation, deriving their functionality solely through stored elastic energy...
November 27, 2020: Biomedical Microdevices
Emanuele Catena, Riccardo Colombo, Alessandra Volontè, Beatrice Borghi, Paola Bergomi, Davide Ottolina, Tommaso Fossali, Elisa Ballone, Roberto Rech, Antonio Castelli, Donato Mele
BACKGROUND: Survival after cardiac arrest depends on prompt and effective cardiopulmonary resuscitation (CPR). Transesophageal echocardiography (TEE) can be applied to evaluate the effectiveness of chest compression-decompression maneuvers in the setting of cardiac arrest undergoing CPR. The efficacy of chest compression can be continuously assessed by TEE that can improve the effectiveness of CPR guiding the rescuer to optimize or correct chest compression and decompression by directly examining the movements of the cardiac walls and valve leaflets...
November 27, 2020: Journal of Echocardiography
Richard Saczkowski, Fabio Zulauf, Saverio Spada
INTRODUCTION: Vacuum assisted venous drainage (VAVD) requires the sealing of the hard-shell venous reservoir, thereby creating circumstances where reservoir pressurization may occur. Manufacturers utilize integrated pressure relief valves (IPRV) to mitigate pressurization risk; however, accidents have been reported even with these devices. We have undertaken a performance evaluation of IPRV's in a large number of hard-shell venous reservoirs. METHODS: Reservoirs were sealed and gas insufflated while measuring reservoir internal pressure...
November 27, 2020: Perfusion
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