Carlo Maria Bellanca, Egle Augello, Anna Flavia Cantone, Rosaria Di Mauro, Giuseppe Antonino Attaguile, Vincenza Di Giovanni, Guido Attilio Condorelli, Giulia Di Benedetto, Giuseppina Cantarella, Renato Bernardini
The European Medicine Agency (EMA) has defined Adverse Drug Reactions (ADRs) as "a noxious and unintended response to a medicine", not including poisoning, accidental, or intentional overdoses. The ADR occurrence differs based on the approach adopted for defining and detecting them, the characteristics of the population under study, and the research setting. ADRs have a significant impact on morbidity and mortality, particularly among older adults, and represent a financial burden for health services. Between 30% and 60% of ADRs might be predictable and preventable, emerging as a result of inappropriate prescription, drug chemistry inherent toxicity, cell-specific drug toxicity, age- and sex-related anomalies in drug absorption, distribution, metabolism, and elimination (ADME), and drug-drug interactions (DDIs) in combination therapies or when a patient is treated with different drugs for concomitant disorders...
November 1, 2023: Pharmaceuticals