Henintsoa Murielle Rakotomalala, Andriatsihoarana Voahary Nasandratriniavo Ramahandrisoa, Malala Razakanaivo, Ny Ony Andrianandrasana, Florine Rafaramino
The management of breast cancer during pregnancy is a challenge for physicians due to mother´s desire to carry the pregnancy to term despite the need for chemotherapy. This study reports the case of a 37-year-old multiparous woman at 20 weeks and 4 days of amenorrhea (WA). She was hospitalized for dyspnoea (stage IV according to New York Heart Association (NYHA) classification). The patient had a syndrome of heavy left pleural effusion and bilateral mastitis. The diagnosis of metastatic breast cancer was retained based on cytological examination of pleural fluid and breast cytoponction revealing galactophoric carcinoma...
2021: Pan African Medical Journal
Tchin Darré, Mazamaesso Tchaou, Toukilnan Djiwa, Baguilane Douaguibe, Akila Bassowa, Solange Adani-Ifé, Ayikoé Kossi Amavi, Bidamin N'Timon, Abdoulatif Amadou, Panakinao Simgban, Bingo K N'Bortche, Koffi Amégbor, Abdoul-Samadou Aboubakari, Gado Napo-Koura
Background: Breast cancer is the most common cancer in women, and its incidence and mortality rates are expected to increase significantly over the next few years, particularly in developing countries. The aim of this study was to describe the epidemiological, clinical, radiological, histopathological, and prognostic aspects of breast cancer in Togo. Materials and methods: We retrospectively analyzed at our Department of Pathology of Lomé all cases of breast cancer in women confirmed by histology over a period of 20 years (2000-2019)...
2021: Breast Cancer: Basic and Clinical Research
Anne Menz, Rifka Bauer, Martina Kluth, Clara Marie von Bargen, Natalia Gorbokon, Florian Viehweger, Maximilian Lennartz, Cosima Völkl, Christoph Fraune, Ria Uhlig, Claudia Hube-Magg, Noémi De Wispelaere, Sarah Minner, Guido Sauter, Simon Kind, Ronald Simon, Eike Burandt, Till Clauditz, Patrick Lebok, Frank Jacobsen, Stefan Steurer, Waldemar Wilczak, Till Krech, Andreas H Marx, Christian Bernreuther
To evaluate cytokeratin 19 expression in normal and cancerous tissues, 15,977 samples from 122 tumor types and 608 samples of 76 normal tissue types were analyzed by immunohistochemistry. In normal tissues, CK19 expression occurred in epithelial cells of most glandular organs but was strictly limited to the basal cell layer of non-keratinizing squamous epithelium and absent in the skin. CK19 expression in ≥90% of cases was seen in 34% of the tumor entities including the adenocarcinomas of the pancreas (99...
June 5, 2021: Human Pathology
Umberto Basso, Antonella Facchinetti, Elisabetta Rossi, Marco Maruzzo, Vincenza Conteduca, Michele Aieta, Francesco Massari, Anna Paola Fraccon, Claudia Mucciarini, Teodoro Sava, Matteo Santoni, Cristina Pegoraro, Emilia Durante, Maurizio Nicodemo, Alessandra Perin, Alessandra Bearz, Carlo Gatti, Pasquale Fiduccia, Alberto Diminutto, Carmen Barile, Ugo De Giorgi, Rita Zamarchi, Vittorina Zagonel
BACKGROUND: Circulating Tumor Cells (CTCs) correlate with adverse prognosis in breast, colorectal, lung and prostate cancer patients. Little data is available for Renal Cell Carcinoma (RCC). MATERIALS AND METHODS: We designed a multicenter prospective observational study to assess the correlation between CTC counts and Progression Free Survival (PFS) in metastatic RCC patients treated with an anti-angiogenic tyrosine kinase inhibitor as a first-line regimen; Overall Survival (OS) and response were secondary objectives...
June 2, 2021: Oncologist
Alfred Kayira, Master R O Chisale, Frank W Sinyiza, Chikondi S Chimbatata, Paul U Kaseka, Pocha S Kamudumuli, Joseph Wu, Balwani C Mbakaya
Breast cancer is one of the major public health problem in developing countries. In Malawi, cancer of the breast among females is among the top four accounting for 4.9%. The study determined the histopathologic profile of breast cancer in Northern Malawi from July 2013 to June 2018. A record based retrospective cross-sectional study was conducted at Mzuzu Central Hospital. We reviewed 202 histopathological results of breast specimens during the study period. Data was analyzed using STATA version 14.0. Out of 202 clinically diagnosed breast lesions/tumours, 102 (50...
February 2021: African Journal of Reproductive Health
Marta Piras, Martina Panebianco, Matteo Garibaldi, Michela Roberto, Gioia Merlonghi, Patrizia Pellegrini, Paolo Marchetti
INTRODUCTION: Dermatomyositis (DM) is an idiopathic inflammatory myopathy (IIM) mainly characterized by subacute muscle weakness and skin rash sometimes associated with malignancy. CASE PRESENTATION: A 61-year-old female was admitted to our hospital because of progressive proximal muscular weakness, heliotropic rash and left breast rash. Muscle biopsy findings were consistent with dermatomyositis (DM). A full panel of myositis associated (MAA) and specific antibodies (MSA) revealed the presence of anti-nuclear antibodies (1:160, speckled), Anti-Ro52 and anti TIF1-γ antibodies...
May 24, 2021: Current Oncology
Soumya Deep Roy, Soham Das, Devroop Kar, Friedhelm Schwenker, Ram Sarkar
Breast cancer, like most forms of cancer, is a fatal disease that claims more than half a million lives every year. In 2020, breast cancer overtook lung cancer as the most commonly diagnosed form of cancer. Though extremely deadly, the survival rate and longevity increase substantially with early detection and diagnosis. The treatment protocol also varies with the stage of breast cancer. Diagnosis is typically done using histopathological slides from which it is possible to determine whether the tissue is in the Ductal Carcinoma In Situ (DCIS) stage, in which the cancerous cells have not spread into the encompassing breast tissue, or in the Invasive Ductal Carcinoma (IDC) stage, wherein the cells have penetrated into the neighboring tissues...
May 23, 2021: Sensors
H Shaker, Nar Leena, V Mayers, F Koussa, A Deshpande
INTRODUCTION: Day-case surgery is safe and efficacious for most breast surgical procedures. Limited data exist on its use in immediate breast reconstruction. We present our experience of day-case management of mastectomy with immediate pre-pectoral implant-based reconstruction (IBR). METHODS: Data were collected on 47 patients who underwent day-case skin-sparing (SSM) or nipple-sparing (NSM) mastectomy with pre-pectoral IBR between October 2017 and September 2019...
June 2021: Annals of the Royal College of Surgeons of England
Runzhi Zhu, Yanjie Tu, Jingxia Chang, Haixia Xu, Jean C Li, Wang Liu, Ahn-Dao Do, Yuxia Zhang, Jinhu Wang, Benyi Li
Background: Liver cancer is a leading cause of cancer death worldwide, and novel prognostic factor is needed for early detection and therapeutic responsiveness monitoring. The orphan nuclear receptor NR0B2 was reported to suppress liver cancer development in a mouse model, and its expression levels were reduced in liver cancer tissues and cell lines due to hypermethylation within its promoter region. However, it is not clear if NR0B2 expression is associated with cancer survival or disease progression and how NR0B2 gene expression is regulated at the molecular level...
2021: Frontiers in Oncology
Heba Allah M Alsheikh, Brandon J Metge, Chae-Myeong Ha, Dominique C Hinshaw, Mateus S V Mota, Sarah C Kammerud, Tshering Lama-Sherpa, Noha Sharafeldin, Adam R Wende, Rajeev S Samant, Lalita A Shevde
Obesity and diabetes cumulatively create a distinct systemic metabolic pathophysiological syndrome that predisposes patients to several diseases including breast cancer. Moreover, diabetic and obese women with breast cancer show a significant increase in mortality compared to non-obese and/or non-diabetic women. We hypothesized that these metabolic conditions incite an aggressive tumor phenotype by way of impacting tumor cell-autonomous and tumor cell non-autonomous events. In this study, we established a type 2 diabetic mouse model of triple-negative mammary carcinoma and investigated the effect of a glucose lowering therapy, metformin, on the overall tumor characteristics and immune/metabolic microenvironment...
May 27, 2021: Cancer Letters
Hendrika M Duivenvoorden, Natasha K Brockwell, Cameron J Nowell, Kaylene J Simpson, Belinda S Parker
Understanding how cancer cells interact with the surrounding microenvironment early in breast cancer development can provide insight into the initiation and progression of invasive breast cancers. The myoepithelial cell layer surrounding breast ducts acts as a physical barrier in early breast cancer, preventing cancer cells from invading the surrounding stroma. Changes to the expression profile and properties of myoepithelial cells have been implicated in progression to invasive carcinoma. Identifying the molecular drivers of myoepithelial cell-mediated tumour suppression may offer new approaches to predict and block the earliest stages of cancer invasion...
May 28, 2021: Scientific Data
Ethan J Brock, Ryan M Jackson, Julie L Boerner, Quanwen Li, Meredith A Tennis, Bonnie F Sloane, Raymond R Mattingly
Breast ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive ductal carcinoma (IDC). It is still unclear which DCIS will become invasive and which will remain indolent. Patients often receive surgery and radiotherapy, but this early intervention has not produced substantial decreases in late-stage disease. Sprouty proteins are important regulators of ERK/MAPK signaling and have been studied in various cancers. We hypothesized that Sprouty4 is an endogenous inhibitor of ERK/MAPK signaling and that its loss/reduced expression is a mechanism by which DCIS lesions progress toward IDC, including triple-negative disease...
2021: PloS One
R Ciérvide, Á Montero, G Potdevin, J García, M G Aranda, B Álvarez, K Rossi, M López, O Hernando, J Valero, E Sánchez, X Chen, R Alonso, P F Letón, C Rubio
PURPOSE: To explore the feasibility of image-guided and respiratory-gated Stereotactic Body Radiation Therapy (SBRT) for Accelerated Partial Breast Irradiation (APBI) in patients with very early breast cancer. MATERIAL AND METHODS: Selected patients with early breast carcinoma after breast-conserving surgery were enrolled in this phase II trial. A fiducial marker was percutaneously placed close to surgical bed and five external fiducials were set on the skin. A CT scan for planning was acquired at free breathing...
May 27, 2021: Clinical & Translational Oncology
William J Gradishar, Meena S Moran, Jame Abraham, Rebecca Aft, Doreen Agnese, Kimberly H Allison, Sarah L Blair, Harold J Burstein, Chau Dang, Anthony D Elias, Sharon H Giordano, Matthew P Goetz, Lori J Goldstein, Sara A Hurvitz, Steven J Isakoff, Rachel C Jankowitz, Sara H Javid, Jairam Krishnamurthy, Marilyn Leitch, Janice Lyons, Jennifer Matro, Ingrid A Mayer, Joanne Mortimer, Ruth M O'Regan, Sameer A Patel, Lori J Pierce, Hope S Rugo, Amy Sitapati, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, Erica M Stringer-Reasor, Melinda L Telli, John H Ward, Kari B Wisinski, Jessica S Young, Jennifer L Burns, Rashmi Kumar
The NCCN Guidelines for Breast Cancer include up-to-date guidelines for clinical management of patients with carcinoma in situ, invasive breast cancer, Paget disease, phyllodes tumor, inflammatory breast cancer, male breast cancer, and breast cancer during pregnancy. These guidelines are developed by a multidisciplinary panel of representatives from NCCN Member Institutions with breast cancer-focused expertise in the fields of medical oncology, surgical oncology, radiation oncology, pathology, reconstructive surgery, and patient advocacy...
May 1, 2021: Journal of the National Comprehensive Cancer Network: JNCCN
A O Jasper, E A Onohwakpor, A Akhator
Patients with high-risk conditions for surgery may benefit from some form of regional block when neuroaxial regional blocks may be life threatening. Despite the increased use of ultrasound-guided peripheral regional blocks internationally, local infiltration and targeted nerve blocks aided by knowledge of anatomical landmarks remain helpful in these two patients presented. A 48-year old woman, presented with bleeding left breast mass, mild respiratory distress, and radiological features of lung metastases (Carcinoma of the breast stage 4)...
May 2021: Nigerian Journal of Clinical Practice
Feng Li, Zihua Zeng, Dale Hamilton, Youli Zu, Zheng Li
Noninvasive in vivo imaging to measure the expression of EpCAM, a biomarker overexpressed in the majority of carcinoma tumors and metastatic lesions, is highly desirable for accurate tumor staging and therapy evaluation. Here, we report the use of an aptamer radiotracer to enable tumor-specific EpCAM-targeting PET imaging. Oligonucleotide aptamers are small molecular ligands that specifically bind with high affinity to their target molecules. For specific tumor imaging, an aptamer radiotracer was formulated by chelating a 64 Cu isotope and DOTA-PEGylated aptamer sequence to target EpCAM...
May 20, 2021: Bioconjugate Chemistry
Oliver Stoetzer, Dorit Di Gioia, Rolf Dieter Issels, Sultan Abdel-Rahman, Ulrich Mansmann, Lars Hartwin Lindner, Oleg Gluz, Rachel Würstlein, Michael Braun, Moritz Hamann, Franz Edler von Koch, Nadia Harbeck, Christoph Salat
Background: Patients with triple-negative primary breast cancer (TNBC) who have residual invasive carcinoma after neoadjuvant chemotherapy have poor prognosis. Proven adjuvant approaches to reduce the risk of recurrence and improve outcome in patients with non-pathological complete response (non-pCR) are limited. Methods: From our institutional registry, a consecutive case series of patients with operable, unilateral, primary invasive noninflammatory early TNBC of stage I-IIIB and pathologically verified residual cancer cells (no pathological complete response) after neoadjuvant chemotherapy underwent adjuvant treatment with gemcitabine plus cisplatin combined with regional hyperthermia...
April 2021: Breast Care
Yunfeng Ding, Yonghong Liu, Dong-Kee Lee, Zhangwei Tong, Xiaobin Yu, Yi Li, Yong Xu, Rainer B Lanz, Bert W O'Malley, Jianming Xu
HER2-positive (HER2+ ) breast cancers (BrCs) contain approximately equal numbers of ERα+ HER2+ and ERα- HER2+ cases. An enduring obstacle is the unclear cell lineage-related characteristics of these BrCs. Although ERα+ HER2+ BrCs could lose ERα to become ERα- HER2+ BrCs, direct evidence is missing. To investigate ERα dependencies and their implications during BrC growth and metastasis, we generated ERαCre RFP-T mice that produce an RFP-marked ERα+ mammary gland epithelial cell (MGEC) lineage. RCAS virus-mediated expression of Erbb2, a rodent Her2 homolog, first produced comparable numbers of ERα+ RFP+ Erbb2+ and ERα- RFP- Erbb2+ MGECs...
May 25, 2021: Proceedings of the National Academy of Sciences of the United States of America
Asmaa M El-Rasikh, Haithem A M Farghali, Hisham A Abdelrahman, Mostafa Elgaffary, Shaymaa Abdelmalek, Ibrahim A Emam, Magdy A Ghoneim, Salah A Selim
Feline mammary carcinoma (FMC) shows great similarities to human breast cancer in the cellular and molecular levels. So, in cats as in humans, the role of immune responses is indicated to detect and follow up the development of tumors. As a new breast cancer therapeutic approach, Plasmonic Photothermal Therapy (PPTT) is an effective localized treatment for canine and feline mammary-carcinoma. Its systemic effect has not been inquired yet and needs many studies to hypothesis how the PPTT eradicates tumor cells...
May 17, 2021: Scientific Reports
Daniel Cheng, Jennifer Baynosa, Chad Cross, Daniel Kirgan, Shelley J Williams, Charles St Hill
BACKGROUND: Our objective is to evaluate the effect of distance to facility on the use of breast conservation therapy and reconstruction for early stage breast cancer. METHODS: Utilizing the National Cancer Database, we identified females, age <65, with Stage I invasive ductal carcinoma from 2004 to 2015. Using logistic regression, we compared radiation, mastectomy, and reconstruction treatment patterns. A subgroup analysis was performed within the mountain region (MR)...
April 30, 2021: American Journal of Surgery
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