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JOURNAL ARTICLE
Yutang Li, Dezhi Cao, Junda Qu, Wei Wang, Xinhui Xu, Lingyu Kong, Jianxiang Liao, Wenhan Hu, Kai Zhang, Jihan Wang, Chunlin Li, Xiaofeng Yang, Xu Zhang
OBJECTIVE: Scalp high-frequency oscillations (sHFOs) are a promising non-invasive biomarker of epilepsy. However, the visual marking of sHFOs is a time-consuming and subjective process, existing automatic detectors based on single-dimensional analysis have difficulty with accurately eliminating artifacts and thus do not provide sufficient reliability to meet clinical needs. Therefore, we propose a high-performance sHFOs detector based on a deep learning algorithm. METHODS: An initial detection module was designed to extract candidate high-frequency oscillations...
April 16, 2024: IEEE Transactions on Neural Systems and Rehabilitation Engineering
#42
JOURNAL ARTICLE
Jürgen Panholzer, Amadeus Hauser, Nadia Thamm, Gudrun Gröppel, Kurosch Yazdi-Zorn, Tim J von Oertzen
OBJECTIVE: We studied the impact of depressive symptoms on adverse effects (AEs) in people with epilepsy (PWE) on antiseizure medication (ASM) therapy. An effect of depression on the AE burden has already been reported. We studied the correlation of various depressive symptoms with specific AEs to assess which AEs are especially prone to being confounded by particular depressive symptoms. METHODS: PWE filled in a variety of questionnaires including the "Neurological Disorder Depression Inventory for Epilepsy" (NDDI-E), "Emotional Thermometers 4" (ET4) and "Liverpool Adverse Events Profile" (LAEP)...
April 16, 2024: Epilepsia Open
#43
REVIEW
A Szoke, B Pignon, O Godin, A Ferchiou, R Tamouza, M Leboyer, F Schürhoff
PURPOSE OF REVIEW: A global study of multimorbidity in schizophrenia, especially of the association with physical conditions, might offer much needed etiological insights. RECENT FINDINGS: Our review suggests that life-style factors and medication related to schizophrenia are only part of the explanation of the increase in risk for cardiovascular, metabolic, pulmonary disorders, and some cancers. Positive associations with autoimmune disorders (with the exception of rheumatoid arthritis) and epilepsy are promising avenues of research but to date have not been fully exploited...
April 16, 2024: Current Psychiatry Reports
#44
JOURNAL ARTICLE
Naoki Ikegaya, Thandar Aung, Arka Mallela, Jasmine L Hect, Arianna Damiani, Jorge A Gonzalez-Martinez
In patients with drug-resistant epilepsy (DRE) who are not candidates for resective surgery, various thalamic nuclei, including the anterior, centromedian, and pulvinar nuclei, have been extensively investigated as targets for neuromodulation. However, the therapeutic effects of different targets for thalamic neuromodulation on various types of epilepsy are not well understood. Here, we present a 32-year-old patient with multifocal bilateral temporoparieto-occipital epilepsy and bilateral malformations of cortical development (MCDs) who underwent bilateral stereoelectroencephalographic (SEEG) recordings of the aforementioned three thalamic nuclei bilaterally...
April 16, 2024: Epilepsia
#45
JOURNAL ARTICLE
Alberth Jonnathan Carreño-González, José Luiz Liberato, Marcus Vinicius Batista Celani, Norberto Peporine Lopes, João Luís Callegari Lopes, Leonardo Gobbo-Neto, Andreia Cristina Karklin Fontana, Wagner Ferreira Dos Santos
Epilepsy is a condition marked by sudden, self-sustained, and recurring brain events, showcasing unique electro-clinical and neuropathological phenomena that can alter the structure and functioning of the brain, resulting in diverse manifestations. Antiepileptic drugs (AEDs) can be very effective in 30% of patients in controlling seizures. Several factors contribute to this: drug resistance, individual variability, side effects, complexity of epilepsy, incomplete understanding, comorbidities, drug interactions, and no adherence to treatment...
April 16, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
#46
JOURNAL ARTICLE
Dong Ah Lee, Taeik Jang, Jaeho Kang, Seongho Park, Kang Min Park, Min Kang, Park
We investigated the differences in functional connectivity based on the source-level electroencephalography (EEG) analysis between stroke patients with and without post-stroke epilepsy (PSE). Thirty stroke patients with PSE and 35 stroke patients without PSE were enrolled. EEG was conducted during a resting state period. We used a Brainstorm program for source estimation and the connectivity matrix. Data were processed according to EEG frequency bands. We used a BRAPH program to apply a graph theoretical analysis...
April 16, 2024: Brain Topography
#47
Michał Sobstyl, Magdalena Konopko, Aleksandra Wierzbicka
No abstract text is available yet for this article.
April 16, 2024: Epileptic Disorders: International Epilepsy Journal with Videotape
#48
JOURNAL ARTICLE
Anthony D Jimenez, Margaret Gopaul, Hannah Asbell, Seyhmus Aydemir, Maysaa M Basha, Ayush Batra, Charlotte Damien, Gregory S Day, Onome Eka, Krista Eschbach, Safoora Fatima, Madeline C Fields, Brandon Foreman, Elizabeth E Gerard, Teneille E Gofton, Hiba A Haider, Stephen T Hantus, Sara Hocker, Amy Jongeling, Mariel Kalkach Aparicio, Padmaja Kandula, Peter Kang, Karnig Kazazian, Marissa A Kellogg, Minjee Kim, Jong Woo Lee, Lara V Marcuse, Christopher M McGraw, Wazim Mohamed, Janet Orozco, Cederic Pimentel, Vineet Punia, Alexandra M Ramirez, Claude Steriade, Aaron F Struck, Olga Taraschenko, Andrew K Treister, Ji Yeoun Yoo, Sahar Zafar, Daniel J Zhou, Deepti Zutshi, Nicolas Gaspard, Lawrence J Hirsch, Aurelie Hanin
Febrile infection-related epilepsy syndrome (FIRES) is a subset of new onset refractory status epilepticus (NORSE) that involves a febrile infection prior to the onset of the refractory status epilepticus. It is unclear whether FIRES and non-FIRES NORSE are distinct conditions. Here, we compare 34 patients with FIRES to 30 patients with non-FIRES NORSE for demographics, clinical features, neuroimaging, and outcomes. Because patients with FIRES were younger than patients with non-FIRES NORSE (median = 28 vs...
April 16, 2024: Epilepsia
#49
JOURNAL ARTICLE
Ulrich Specht, Denise Lahr, Theodor W May, Pascal Speicher, Heiko Hausfeld, Ingrid Coban, Birgitt Müffelmann, Christian G Bien, Anne Hagemann
OBJECTIVES: To evaluate the efficacy of a specialized inpatient rehabilitation program in patients with newly diagnosed epilepsy (NDE), who had been referred within 1 year after diagnosis. METHODS: We performed an open, prospective, controlled study comparing a 1-year follow-up assessment of patients with NDE after completing a rehabilitation program at an epilepsy center (rehabilitation group) with a control group of patients with similar epilepsy duration, but without rehabilitation in the first year after diagnosis...
April 16, 2024: Epilepsia
#50
REVIEW
Andres M Kanner, Enrique Carrazana, Heidi M Munger Clary, Adrian L Rabinowicz, Edward Faught
The diagnosis of epilepsy is associated with loss of predictability, which invariably results in the fear of when and if future seizures will occur. For a subset of patients with epilepsy (PWE), there may be a pathological persistent fear of seizure occurrence, resulting in limitations to daily activities through avoidant behaviors. Paradoxically, the research of anticipatory anxiety of seizures (AAS; also referred to as seizure phobia) has been practically nonexistent and, not surprisingly, this condition remains underrecognized by clinicians...
April 16, 2024: Epileptic Disorders: International Epilepsy Journal with Videotape
#51
REVIEW
Philippe Gélisse, William O Tatum, Arielle Crespel, Peter W Kaplan
In the case of suspicion of nonconvulsive status epilepticus (NCSE), reactivity on electroencephalograms (EEGs) can provide valuable diagnostic information. Reactivity refers to responses to auditory or somatosensory stimulation, with changes in amplitude and frequency of background activity. Because of self-perpetuating processes and the failure of self-terminating mechanisms, status epilepticus is unlikely to cease when patients spontaneously move, and it cannot typically be stopped by external stimulation (i...
April 16, 2024: Epilepsia
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JOURNAL ARTICLE
Thijs van Dalen, Jessica F Kirkham, Aswin Chari, Felice D'Arco, Friederike Moeller, Christin Eltze, J Helen Cross, Martin M Tisdall, Rachel C Thornton
OBJECTIVE: The objective was to analyze seizure semiology in pediatric frontal lobe epilepsy patients, considering age, to localize the seizure onset zone for surgical resection in focal epilepsy. METHODS: Fifty patients were identified retrospectively, who achieved seizure freedom after frontal lobe resective surgery at Great Ormond Street Hospital. Video-electroencephalography recordings of preoperative ictal seizure semiology were analyzed, stratifying the data based on resection region (mesial or lateral frontal lobe) and age at surgery (≤4 vs >4)...
April 16, 2024: Annals of Neurology
#53
JOURNAL ARTICLE
Maria F De la Cerda-Vargas, Mattia Russel Pantalone, Cecilia Söderberg Nauclér, Rafael Medrano-Guzman, Kathrine Jauregui Renaud, Barbara Nettel Rueda, Ma de Jesus Reynoso-Sanchez, Brenda Lopez-Quintana, Marco A Rodriguez-Florido, Iris A Feria-Romero, Rogelio R Trejo-Rosales, Rocio L Arreola-Rosales, Jose A Candelas-Rangel, Pedro Navarro-Dominguez, Elizabeth Meza-Mata, Melisa A Muñoz-Hernandez, F K Segura-Lopez, Marisela Del Rocio Gonzalez-Martinez, Hector A Delgado-Aguirre, Bayron A Sandoval-Bonilla
INTRODUCTION: Previous studies have reported a correlation between a high-grade CMV-infection and an unfavorable prognosis in glioblastoma (GB). Coversely, epilepsy has been associated with a more favorable outcome in GB patients. Despites epilepsy and CMV share similar molecular mechanisms in GB tumoral microenvironment, the correlation between Tumor-Related-Epilepsy (TRE) and CMVinfection remains unexplored. The aim of our study is to examine the correlation between the dregree of CMV infection and seizure types on the survival of TRE Adult-type-diffuse-glioma...
April 15, 2024: Heliyon
#54
JOURNAL ARTICLE
Qian Zheng, Yong-Ran Cheng, Mingwei Wang, Xuntai Ma, Lan Ye, Zucai Xu, Zhanhui Feng
Several COVID-19 vaccines have been approved for emergency use according to China's immunization programs. These vaccines has created hope for patients with epilepsy, because the vaccines can help to reduce their risk of becoming infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of this study was to investigate the COVID-19 vaccine safety in patients with epilepsy. Here, we assessed the time of symptom control and the features of adverse events of seizure patients following their COVID-19 vaccinations...
April 15, 2024: Heliyon
#55
JOURNAL ARTICLE
Jennifer Katherine Ballesteros Tapias, Diana Isabel Conde Hurtado, Luz Helena Castaño, Adriana Martínez Pérez
Twelve patients between 18 and 53 years of age were included. MAD plus nutritional supplementation was administered to 75% ( n = 10) of the participants, one (8.3%) received MAD alone, and 16.7 ( n = 2) received Classic Ketogenic Diet (cKD) plus nutritional supplementation. Oral nutritional supplementation, administered in the outpatient setting, provided patients with between 31 and 55% of the total caloric value. In the first month of KDT treatment, 83.3% ( n = 10) of patients reduced the number of weekly seizures by 40% (median)...
April 15, 2024: Nutritional Neuroscience
#56
REVIEW
Nikita P Ilyin, Elena V Petersen, Tatyana O Kolesnikova, Konstantin A Demin, Sergey L Khatsko, Kirill V Apuhtin, Allan V Kalueff
High prevalence of human brain disorders necessitates development of the reliable peripheral biomarkers as diagnostic and disease-monitoring tools. In addition to clinical studies, animal models markedly advance studying of non-brain abnormalities associated with brain pathogenesis. The zebrafish (Danio rerio) is becoming increasingly popular as an animal model organism in translational neuroscience. These fish share some practical advantages over mammalian models together with high genetic homology and evolutionarily conserved biochemical and neurobehavioral phenotypes, thus enabling large-scale modeling of human brain diseases...
February 2024: Biochemistry. Biokhimii︠a︡
#57
JOURNAL ARTICLE
Yilun Chen, Stefanie P Cappucci, Jennifer A Kim
Posttraumatic epilepsy (PTE) is a complication of traumatic brain injury that can increase morbidity, but predicting which patients may develop PTE remains a challenge. Much work has been done to identify a variety of risk factors and biomarkers, or a combination thereof, for patients at highest risk of PTE. However, several issues have hampered progress toward fully adapted PTE models. Such issues include the need for models that are well-validated, cost-effective, and account for competing outcomes like death...
April 15, 2024: Seminars in Neurology
#58
REVIEW
N Jing, X-T Gao, H Ding, Y-N Wang, Y-W Zhang, G Liang, G-M Zhu
BACKGROUND: Substantial observational evidence suggests an association between neuropsychiatric conditions and Venous Thromboembolism (VTE). However, the causal relationship between these two conditions requires further investigation. Therefore, we employed a two-sample Mendelian Randomization (MR) approach to assess bidirectional causal effects between four neuropsychiatric conditions and VTE, Deep Vein Thrombosis (DVT), and Pulmonary Embolism (PE). METHODS: Genetic variants associated with four neuropsychiatric conditions, including Schizophrenia (SCH), Major Depressive Disorder (MDD), Bipolar Disorder (BD), and Epilepsy, as well as VTE, DVT, and PE were selected...
April 13, 2024: Journal of Vascular Surgery. Venous and Lymphatic Disorders
#59
JOURNAL ARTICLE
Daniel Uher, Gerhard S Drenthen, Benedikt A Poser, Paul A M Hofman, Louis G Wagner, Rick H G J van Lanen, Christianne M Hoeberigs, Albert J Colon, Olaf E M G Schijns, Jacobus F A Jansen, Walter H Backes
BACKGROUND AND PURPOSE: Higher magnetic field strength introduces stronger magnetic field inhomogeneities in the brain, especially within temporal lobes, leading to image artifacts. Particularly, T2-weighted fluid-attenuated inversion recovery (FLAIR) images can be affected by these artifacts. Here, we aimed to improve the FLAIR image quality in temporal lobe regions through image processing of multiple contrast images via machine learning using a neural network. METHODS: Thirteen drug-resistant MR-negative epilepsy patients (age 29...
April 13, 2024: Magnetic Resonance Imaging
#60
JOURNAL ARTICLE
Rongqi Hong, Tingting Zheng, Vincenzo Marra, Dongping Yang, Jian K Liu
Epilepsy is a complex disease spanning across multiple scales, from ion channels in neurons to neuronal circuits across the entire brain. Over the past decades, computational models have been used to describe the pathophysiological activity of the epileptic brain from different aspects. Traditionally, each computational model can aid in optimizing therapeutic interventions, therefore, providing a particular view to design strategies for treating epilepsy. As a result, most studies are concerned with generating specific models of the epileptic brain that can help us understand the certain machinery of the pathological state...
April 15, 2024: Journal of Neural Engineering
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