Andres M Kanner, Rohit Shankar, Nils G Margraf, Bettina Schmitz, Elinor Ben-Menachem, Josemir W Sander
Epilepsy is one of the most common neurologic conditions. Its clinical manifestations are not restricted to seizures but often include cognitive disturbances and psychiatric disorders. Prospective population-based studies have shown that people with epilepsy have an increased risk of developing mood disorders, and people with a primary mood disorder have an increased risk of developing epilepsy. The existence of common pathogenic mechanisms in epilepsy and mood disorders may explain the bidirectional relation between these two conditions...
March 4, 2024: Annals of General Psychiatry
Yerin Kang, Sieun Kim, Yunah Jung, Dai Sik Ko, Hyun-Woo Kim, Jung-Pil Yoon, Sunghwan Cho, Tae-Jin Song, Kihun Kim, Eunjeong Son, Yun Hak Kim
BACKGROUND: Epilepsy, characterized by recurrent unprovoked seizures, poses significant challenges to affected individuals globally. While several established risk factors for epilepsy exist, the association with cigarette smoking remains debated. This study aims to conduct systematic review and meta-analysis to elucidate the potential association between smoking and the likelihood of epilepsy. METHODS: The search was performed on March 31st, 2023, using the Medline, Embase, Web of Science, Scopus, and ScienceDirect...
March 4, 2024: BMC Medicine
Yuqiu Zheng, Yingfang She, Zhengwei Su, Kanghui Huang, Shuda Chen, Liemin Zhou
TDP2 gene encodes tyrosyl DNA phosphodiesterase 2, an enzyme required for effective repair of the DNA double-strand breaks (DSBs). Spinocerebellar ataxia autosomal recessive 23 (SCAR23) is a rare disease caused by the pathogenic mutation of TDP2 gene and characterized by intellectual disability, progressive ataxia and refractory epilepsy. Thus far, merely nine patients harboring five different variants (c.425 + 1G > A; c.413_414delinsAA, p. Ser138*; c.400C > T, p...
March 4, 2024: Neurological Sciences
Julia Böhnke, Antonia Zapf, Katharina Kramer, Philipp Weber, André Karch, Nicole Rübsamen
OBJECTIVE: In this study we evaluate how to estimate diagnostic test accuracy (DTA) correctly in the presence of longitudinal patient data (i.e., repeated test applications per patient). STUDY DESIGN AND SETTING: We used a nonparametric approach to estimate sensitivity and specificity of three tests for different target conditions with varying characteristics (i.e., episode length and disease-free intervals between episodes): 1) systemic inflammatory response syndrome (n = 36), 2) depression (n = 33), and 3) epilepsy (n = 30)...
March 1, 2024: Journal of Clinical Epidemiology
Simeon M Wong, Rohit Sharma, Ahmed Abushama, Ayako Ochi, Hiroshi Otsubo, George M Ibrahim
BACKGROUND: In this study, we examined the utility of simultaneous scalp and stereotactic intracranial electroencephalography (SSIEEG) in epilepsy patients. Although SSIEEG offers valuable insights into epilepsy and cognitive function, its routine use is uncommon. Challenges include interpreting post-craniotomy scalp EEG due to surgically implanted electrodes. NEW METHOD: We describe our methodology for conducting SSIEEG recordings. To simulate the potential impact on EEG interpretation, we computed the leadfield of scalp electrodes with and without burrholes using Finite Element Analysis to compare the resulting sensitivity volume and waveforms of simulated intracranial signals between skulls with and without burrholes...
March 1, 2024: Journal of Neuroscience Methods
Erum Shariff, Saima Nazish, Rizwana Shahid, Azra Zafar, Zakia M Yasawy, Norah A AlKhaldi, Danah AlJaafari, Nehad M Soltan, Foziah Alshamrani, Mohammed AlShurem, Aishah Ibrahim Albakr, Feras AlSulaiman, Rana Alameri, Majed Alabdali
BACKGROUND: The occurrence of seizures following a stroke is a well-recognized complication associated with a significant increase in morbidity and mortality. Despite the numerous studies examining outcomes and risk factors related to post-stroke seizures (PSS), there remains a lack of clarity regarding the clinical characteristics, treatment, and PSS recurrence (PSSR) rates in patients experiencing their initial episode of PSS. PURPOSE: This study aimed to determine the risk factors for developing recurrent seizures after first PSS and their effects on functional outcomes and mortality...
February 27, 2024: Clinical Neurology and Neurosurgery
Fahad A Bashiri, Khalid Hundallah, Raidah Al-Baradie, Ali Al-Otaibi, Omar Ismayl, Mohamed Elhadi AlMalik, Osama Y Muthaffar, Amna Al Futaisi, Daniah Kurdi, Asmaa Al Tawari, Daad AlSowat, Shatha Al Shafi, Ayman Ali, Lynn M AlHajjar, Abdullah Aldakhil
Despite the availability of international recommendations for the management of Infantile Epileptic Spasms Syndrome (IESS), there is a lack of recommendations adapted to the local context of clinical practice of pediatric neurology in the Gulf Cooperation Council (GCC) countries. By an initiative from the Saudi Pediatric Neurology Society (SPNS), a literature review was performed and an expert panel comprised of 13 pediatric neurologists from all GCC countries (Saudi Arabia, Kuwait, Bahrain, Oman, Qatar, and the United Arab Emirates) was subsequently convened to discuss all issues related to the management and diagnosis practices of IESS in the GCC...
February 23, 2024: Seizure: the Journal of the British Epilepsy Association
Xiyu Feng, Rory J Piper, Freya Prentice, Jonathan D Clayden, Torsten Baldeweg
Epilepsy is increasingly recognised as a brain network disorder and many studies have investigated functional connectivity (FC) in children with epilepsy using functional MRI (fMRI). This systematic review of fMRI studies, published up to November 2023, investigated profiles of FC changes and their clinical relevance in children with focal epilepsy compared to healthy controls. A literature search in PubMed and Web of Science yielded 62 articles. We categorised the results into three groups: 1) differences in correlation-based FC between patients and controls; 2) differences in other FC measures between patients and controls; and 3) associations between FC and disease variables (for example, age of onset), cognitive and seizure outcomes...
February 28, 2024: Seizure: the Journal of the British Epilepsy Association
Xizhong Zhou, Qiuli Liu, Mingwei Huang
No abstract text is available yet for this article.
February 20, 2024: Seizure: the Journal of the British Epilepsy Association
Heng Liu, Duoli Chen, Chengxiang Liu, Peng Liu, Hua Yang, Hong Lu
BACKGROUND: Benign epilepsy with centrotemporal spikes (BECTS) is a common childhood epilepsy syndrome, accompanied by behavioral problems and cognitive impairments. Previous studies of BECTS-related brain structures applied univariate analysis and showed inconsistent results. And neurotransmitter patterns associated with brain structural alterations were still unclear. METHODS: Structural images of twenty-one drug-naïve children with BECTS and thirty-five healthy controls (HCs) were scanned...
March 2, 2024: Pediatric Research
Phillip L Pearl
No abstract text is available yet for this article.
February 20, 2024: European Journal of Paediatric Neurology: EJPN
Rui Bao, Wei-Shi Zhang, Yi-Feng Zha, Zhen-Zhen Zhao, Jie Huang, Jia-Lin Li, Tong Wang, Yu Guo, Jin-Jun Bian, Jia-Feng Wang
OBJECTIVES: Opioid-free anaesthesia (OFA) has emerged as a promising approach for mitigating the adverse effects associated with opioids. The objective of this study was to evaluate the impact of OFA on postoperative nausea and vomiting (PONV) following video-assisted thoracic surgery. DESIGN: Single-centre randomised controlled trial. SETTING: Tertiary hospital in Shanghai, China. PARTICIPANTS: Patients undergoing video-assisted thoracic surgery were recruited from September 2021 to June 2022...
March 1, 2024: BMJ Open
Bartlomiej Chybowski, Petr Klimes, Jan Cimbalnik, Vojtech Travnicek, Petr Nejedly, Martin Pail, Laure Peter-Derex, Jeff Hall, François Dubeau, Pavel Jurak, Milan Brazdil, Birgit Frauscher
OBJECTIVE: Interictal biomarkers of the epileptogenic zone (EZ) and their use in machine learning models open promising avenues for improvement of epilepsy surgery evaluation. Currently, most studies restrict their analysis to short segments of intracranial EEG (iEEG). METHODS: We used 2381 hours of iEEG data from 25 patients to systematically select 5-minute segments across various interictal conditions. Then, we tested machine learning models for EZ localization using iEEG features calculated within these individual segments or across them and evaluated the performance by the area under the precision-recall curve (PRAUC)...
February 18, 2024: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Song Su, Fen Zhao, Hongwei Zhang, Yi Liu, Zilong Li, Huan Zhang, Yaping Wang, Fang Fang, Yong Liu
Epilepsy affects ∼ 65 million people worldwide. Status epilepticus can lead to life-threatening if untreated. In this study, peripheral blood mononuclear cells were isolated from a young patient patient bearing a Nitrogen Perntease Regulator Like 2 Protein (NPRL2) mutation and suffering from Epilepsy verified by clinical and genetic diagnosis. Induced pluripotent stem cells (iPSCs) were established by a non-integrative method, using plasmids carrying OCT4, SOX2, KLF4, BCL-XL and C-MYC. The established iPSCs presented typical pluripotent cells morphology, normal karyotype, and potential to differentiate into three germ layers...
February 28, 2024: Stem Cell Research
Ushtar Amin, Selim R Benbadis
The diagnosis of seizures and seizure mimics relies primarily on the history, but history has well-known limitations. Video recordings of events are a powerful extension of the history because they allow neurologists to view the events in question. In addition, they are readily available in situation, whereas the gold standard of EEG-video is not. That includes underserved or rural areas, and events that are too infrequent to be captured during a few days of EEG-video monitoring. Brief cellphone videos have been shown to be valuable to suggest or guide the correct diagnosis...
March 1, 2024: Epilepsy & Behavior: E&B
Tobias Haeusermann, Emily Yang Liu, Kristina Celeste Fong, Daniel Dohan, Winston Chiong
This study explored illness experiences and decision-making among patients with epilepsy who underwent two different types of surgical interventions: resection versus implantation of the NeuroPace Responsive Neurostimulation System (RNS). We recruited 31 participants from a level four epilepsy center in an academic medical institution. We observed 22 patient clinic visits (resection: n = 10, RNS: n = 12) and conducted 18 in-depth patient interviews (resection: n = seven, RNS: n = 11); most visits and interviews included patient caregivers...
March 1, 2024: Epilepsy & Behavior: E&B
Anjik Ghosh, Sean Quinlan, Patrick A Forcelli
BACKGROUND: Many anti-seizure medications (ASMs) trigger neuronal cell death when administered during a confined period of early life in rodents. Prototypical ASMs used to treat early-life seizures such as phenobarbital induce this effect, whereas levetiracetam does not. However, most prior studies have examined the effect of ASMs in naïve animals, and the degree to which underlying brain injury interacts with these drugs to modify cell death is poorly studied. Moreover, the degree to which drug-induced neuronal cell death differs as a function of sex is unknown...
February 4, 2024: Epilepsy Research
Aurélie Hanin, Eyal Muscal, Lawrence J Hirsch
Several pieces of evidence suggest immune dysregulation could trigger the onset and modulate sequelae of new onset refractory status epilepticus (NORSE), including its subtype with prior fever known as febrile infection-related epilepsy syndrome (FIRES). Consensus-driven recommendations have been established to guide the initiation of first- and second-line immunotherapies in these patients. Here, we review the literature to date on second-line immunotherapy for NORSE/FIRES, presenting results from 28 case reports and series describing the use of anakinra, tocilizumab, or intrathecal dexamethasone in 75 patients with NORSE...
March 2, 2024: Epilepsia
D Ryan King, Mustafa Demirtas, Mikhail Tarasov, Heather L Struckman, Xiaolei Meng, Drew Nassal, Nicolae Moise, Alec Miller, Dennison Min, Andrew M Soltisz, Midhun N K Anne, Patrícia A Alves Dias, Jacy L Wagnon, Seth H Weinberg, Thomas J Hund, Rengasayee Veeraraghavan, Przemysław B Radwański
BACKGROUND: Sudden unexpected death in epilepsy (SUDEP) is a fatal complication experienced by otherwise healthy epilepsy patients. Dravet syndrome (DS) is an inherited epileptic disorder resulting from loss of function of the voltage-gated sodium channel, NaV 1.1, and is associated with particularly high SUDEP risk. Evidence is mounting that NaV s abundant in the brain also occur in the heart, suggesting that the very molecular mechanisms underlying epilepsy could also precipitate cardiac arrhythmias and sudden death...
February 15, 2024: JACC. Clinical Electrophysiology
Caroline Sévoz-Couche, Wupeng Liao, Hazel Y C Foo, Isabelle Bonne, Thong Beng Lu, Caris Tan Qi Hui, Wendy Yen Xian Peh, Shi-Cheng Yen, W S Fred Wong
BACKGROUND AND PURPOSE: Asthma is characterized by airway inflammation, mucus hypersecretion, and airway hyperresponsiveness. The use of nicotinic agents to mimic the cholinergic anti-inflammatory pathway (CAP) controls experimental asthma. Yet, the effects of vagus nerve stimulation (VNS)-induced CAP on allergic inflammation remain unknown. EXPERIMENTAL APPROACH: BALB/c mice were sensitized and challenged with house dust mite (HDM) extract and treated with active VNS (5 Hz, 0...
March 2, 2024: British Journal of Pharmacology
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