Janaki Sheth, Ariel Tankus, Michelle Tran, Nader Pouratian, Itzhak Fried, William Speier
OBJECTIVE: Brain-Computer Interfaces (BCI) may help patients with faltering communication abilities due to neurodegenerative diseases produce text or speech by direct neural processing. However, their practical realization has proven difficult due to limitations in speed, accuracy, and generalizability of existing interfaces. The goal of this study is to evaluate the BCI performance of a robust speech decoding system that translates neural signals evoked by speech to a textual output...
April 9, 2021: Biomedical Physics & Engineering Express
Jithangi Wanigasinghe, Carukshi Arambepola, Shalini Sri Ranganathan, Kasun Jayasundara, Ashangi Weerasinghe, Piyumi Wickramarachchi
BACKGROUND: This article explores the role of initial treatment on control of spasms and other epilepsies at four years in children previously treated for West syndrome. METHODS: The Sri Lanka Infantile Spasm Study is a prospective clinical trial evaluating response to intra-muscular adrenocorticotropic hormone (ACTH) versus oral prednisolone. A previous report documented response through age 12 months. This article provides four-year follow-up data. RESULTS: At age four years, 65 of the original 97 were available for follow-up; another 13 had died, and 19 moved and could not be contacted...
March 8, 2021: Pediatric Neurology
F E Uçan Tokuç, F Genç, A Erdal, Y Biçer Gömceli
No abstract text is available yet for this article.
March 22, 2021: Seizure: the Journal of the British Epilepsy Association
Nathália Stela Visoná de Figueiredo, Larissa Botelho Gaça, Idaiane Batista Assunção-Leme, Lenon Mazetto, Maria Teresa Fernandes Castilho Garcia, Gabriel Barbosa Sandim, Neide Barreira Alonso, Ricardo Silva Centeno, Gerardo Maria de Araújo Filho, Andrea Parolin Jackowski, Henrique Carrete Júnior, Elza Márcia Targas Yacubian
Depression is the most frequent psychiatric comorbidity in patients with mesial temporal lobe epilepsy (MTLE) and hippocampal sclerosis (HS). This study aimed to confirm whether patients with comorbid depression have different volumetric patterns on magnetic resonance imaging, analysing the influence of HS sides. Psychiatrists conducted semi-structured interviews with 75 patients, who were divided into non-depression group (NDG, n = 52) and depression group (DG, n = 23), and compared with 98 controls. The FreeSurfer software was used in the volumetric analysis of the estimated total intracranial volume (eTIV), bilateral cortical and subcortical regions of interest (ROIs), and for presence of left (L-, n = 41) or right (R-, n = 34) MTLE-HS...
March 19, 2021: Psychiatry Research. Neuroimaging
Katharina Schönhoff, Eva-Lotta von Rüden, Ines Koska, Isabel Seiffert, Heidrun Potschka
Experimental and clinical data suggest an impact of serotonergic signaling on seizure susceptibility and epilepsy-associated psychiatric comorbidities. Previous µPET studies revealed increased binding of 5-HT1A receptor ligand [18 F]MPPF in two rat models with spontaneous recurrent seizures. These findings raised the question whether these alterations are due to altered 5-HT1A receptor expression or a modification of extracellular serotonin concentrations. 5-HT1A receptor expression rates were quantitatively analyzed in rat brain tissue from an electrical and a chemical post-status epilepticus model...
April 6, 2021: Neuroscience
(no author information available yet)
No abstract text is available yet for this article.
April 2021: Epilepsia
(no author information available yet)
No abstract text is available yet for this article.
April 2021: Epilepsia
(no author information available yet)
No abstract text is available yet for this article.
April 2021: Epilepsia
Borbála A Lőrincz, Agustina Anson, Stephan Handschuh, Alexander Tichy, Conor Rowan, Balázs B Lőrincz, Rita Garamvölgyi
Hippocampal changes in epilepsy may manifest as hippocampal atrophy/sclerosis. A recent human study suggests that the demonstration of hippocampal volume loss is more reliable using quantitative evaluation methods. The aim of the present study was to obtain volumetric data in both epileptic and healthy dogs, to compare hippocampal volumes in both groups, and to compare subjective and volumetric assessment. Volumetric measurements of the hippocampi, lateral ventricles and hemispheria were performed in 31 epileptic and 15 control dogs...
April 8, 2021: Acta Veterinaria Hungarica
Elaine Lu, Nataliya Pyatka, Christopher J Burant, Martha Sajatovic
BACKGROUND AND PURPOSE: Mental illness is disproportionately common in people with epilepsy (PWE). This systematic literature review identified original research articles that reported the prevalence of psychiatric comorbidities based upon clinical assessments in a sample of PWE and assessed the clinical features of the populations found in studies included in our review of mental health comorbidity. METHODS: The included articles were written in English and published from 2008 to 2018, and focused on adults aged ≥18 years who had psychiatric diagnoses determined in clinical assessments, such as those found in medical records, clinician psychiatric evaluations, structured diagnostic interviews, and mental health screening questionnaires specific for a psychiatric disorder...
April 2021: Journal of Clinical Neurology
Hire Hersi, Jukka T Saarinen, Jani Raitanen, Jukka Peltola
OBJECTIVES: To investigate the interaction among the efficacy, tolerability and overall effectiveness of the first antiseizure medication in patients 16 years or older with newly diagnosed epilepsy. MATERIALS AND METHODS: The study included 584 patients who were referred to the Tampere University Hospital between 1 January 1995 and 31 December 2005 and were diagnosed with epilepsy. All individuals were retrospectively followed up until 31 December 2006, until reaching at least one year of seizure freedom, or until death if before the cut-off date...
April 9, 2021: Acta Neurologica Scandinavica
Zhujun Zhu, Sihong Wang, Qi Cao, Gang Li
Circular RNAs (circRNAs) have key roles in a variety of neurological diseases, including epilepsy. This objective of this study was to perform the functional exploration and mechanism investigation of circRNA Ubiquilin1 (circUBQLN1) in epilepsy. Epilepsy cell model was established by the treatment of Mg2+ -free in human neurons-hippocampal (HN-h) cells. The quantitative real-time polymerase chain reaction (qRT-PCR) was used for the expression analysis of circUBQLN1, linear-UBQLN1, microRNA-155 (miR-155), and sex-determining region Y-box 7 (SOX7)...
April 9, 2021: Journal of Molecular Neuroscience: MN
Marjo K Hytönen, Riika Sarviaho, Christopher B Jackson, Pernilla Syrjä, Tarja Jokinen, Kaspar Matiasek, Marco Rosati, Cristina Dallabona, Enrico Baruffini, Ileana Quintero, Meharji Arumilli, Geoffray Monteuuis, Jonas Donner, Marjukka Anttila, Anu Suomalainen, Laurence A Bindoff, Hannes Lohi
We investigated the clinical, genetic, and pathological characteristics of a previously unknown severe juvenile brain disorder in several litters of Parson Russel Terriers. The disease started with epileptic seizures at 6-12 weeks of age and progressed rapidly to status epilepticus and death or euthanasia. Histopathological changes at autopsy were restricted to the brain. There was severe acute neuronal degeneration and necrosis diffusely affecting the grey matter throughout the brain with extensive intraneuronal mitochondrial crowding and accumulation of amyloid-β (Aβ)...
April 9, 2021: Human Genetics
Carsten Mim, Guy Perkins, Gerhard Dahl
Pannexin 1 (Panx1) plays a decisive role in multiple physiological and pathological settings, including oxygen delivery to tissues, mucociliary clearance in airways, sepsis, neuropathic pain, and epilepsy. It is widely accepted that Panx1 exerts its role in the context of purinergic signaling by providing a transmembrane pathway for ATP. However, under certain conditions, Panx1 can also act as a highly selective membrane channel for chloride ions without ATP permeability. A recent flurry of publications has provided structural information about the Panx1 channel...
May 3, 2021: Journal of General Physiology
Anna Staniszewska, Agnieszka Mąka, Urszula Religioni, Dominik Olejniczak, Grzegorz Juszczyk, Rafał Gierczyński, Andrzej Marcinkiewicz
BACKGROUND: Drivers suffering from epilepsy are commonly regarded as a threat to road safety. However, inability to use their own means of transport very often implies specific professional effects and lowers the quality of life. The aim of this study was to analyze the driving status of patients with epilepsy in Poland. MATERIAL AND METHODS: The prospective study was performed using an independent questionnaire developed by the authors, consisting of 4 parts: 1) socio-demographic information, 2) clinical information, 3) driving information, and 4) opinions about patients with epilepsy as drivers...
March 30, 2021: Medycyna Pracy
Renzo Guerrini, Carmen Barba
Introduction : Focal Cortical Dysplasias (FCDs) represent the most common etiology in pediatric drug-resistant focal epilepsies undergoing surgical treatment. The localization, extent and histopathological features of FCDs are considerably variable. Somatic mosaic mutations of genes that encode proteins in the PI3K-AKTmTOR pathway, which also includes the tuberous sclerosis associated genes TSC1 and TSC2 , have been implicated in FCD type II in a substantial subset of patients. Surgery is the principal therapeutic option for FCD-related epilepsy...
April 9, 2021: Expert Review of Neurotherapeutics
G V Kalmykova, Zh Yu Chefranova, V F Rybnikova, K O Zubova
OBJECTIVE: To study the possibility of using the polypeptide drug cortexin for the treatment of cognitive, emotional and behavioral disorders in children and adolescents with epilepsy and to assess the efficacy and safety of the drug in this group of patients. MATERIALS AND METHODS: Eighty-six patients (41 girls and 45 boys) were examined at the age of 3 to 17 y.o. Cortexin was used along with antiepileptic drugs. Clinical and pathopsychological methods were administered...
2021: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
N V Chebanenko, V P Zykov, I B Komarova, A A Vergizova, A A Egozheva
A clinical case of a genetically confirmed diagnosis of alternating hemiplegia associated with epilepsy is presented. The combination of two types of seizures in a child made it difficult to make a diagnosis. The result of video-EEG monitoring made it possible to understand that a child showed both epileptic seizures and non-epileptic seizures simultaneously with different periodicities. The mutation in the ATP1A3 gene was verified with genome-wide sequencing and targeted therapy was prescribed in a timely manner...
2021: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
E D Belousova
The article is a short review of an observational study that proves the good efficacy and tolerability of perampanel suspension in the adjunctive treatment of epilepsy in children over 4 years of age. The study demonstrated a high level of 50% responders: 47% with focal seizures, 65% with transition of focal seizures to bilateral tonic-clonic seizures, 65% with primary generalized tonic-clonic seizures. Cessation of seizures was achieved in 12%, 19% and 55% of patients, respectively. The most common side-effects were fatigue (26%), nasopharyngitis (19%), lightheadedness, irritability, fever (13% each), and vomiting (11%)...
2021: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
V A Karlov, P N Vlasov, A B Kozhokaru, A S Orlova
OBJECTIVE: To evaluate the efficacy and tolerability of extended release carbamazepine (finlepsin-retard and tegretol CR) in adult patients with new-onset focal epilepsy (FE) with the assessment of epileptiform activity index (EAI). MATERIAL AND METHODS: The study included 62 patients (38 (61.3%) men and 24 (38.7%) women) with new-onset FE aged ≥18 years (mean age 42.9±18.4 years). All patients underwent video-ECG-monitoring with EAI assessment at each visit...
2021: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
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