Domenica Battaglia, Daniela Chieffo, Simona Lucibello, Carla Marini, Valentina Sibilia, Davide Mei, Francesca Darra, Francesca Offredi, Elena Fontana, Nicola Specchio, Simona Cappelletti, Tiziana Granata, Francesca Ragona, Mara Patrini, Maria G Baglietto, Giulia Prato, Annarita Ferrari, Federico Vigevano, Eugenio Mercuri, Bernardo Dalla Bernardina, Renzo Guerrini, Charlotte Dravet, Francesco Guzzetta
The objective of this study was to identify developmental trajectories of developmental/behavioral phenotypes and possibly their relationship to epilepsy and genotype by analyzing developmental and behavioral features collected prospectively and longitudinally in a cohort of patients with Dravet syndrome (DS). Thirty-four patients from seven Italian tertiary pediatric neurology centers were enrolled in the study. All patients were examined for the SCN1A gene mutation and prospectively assessed from the first years of life with repeated full clinical observations including neurological and developmental examinations...
January 18, 2021: Brain & Development