Nicola Specchio, Rima Nabbout, Eleonora Aronica, Stephane Auvin, Arianna Benvenuto, Luca de Palma, Martha Feucht, Floor Jansen, Katarzyna Kotulska, Harvey Sarnat, Lieven Lagae, Sergiusz Jozwiak, Paolo Curatolo
No abstract text is available yet for this article.
May 17, 2024: European Journal of Paediatric Neurology: EJPN
Fan Wu, Xinna Ji, Yanyan Gao, Wanting Liu, Yuanfang Lu, Aiyun Yang, Jianhua Wang, Qian Chen, Xue Zhang
The NF1 gene is related to neurofibromatosis type 1 (NF1), which is an autosomal dominant disorder associated with multisystem involvement and epilepsy susceptibility. A human induced pluripotent stem cell (iPSC) line was derived from a pediatric patient with NF1 and epilepsy, harboring a heterozygous NF1 gene mutation. The iPSC line exhibits high levels of pluripotency markers, maintains the NF1 gene mutation, and demonstrates the capacity to undergo differentiation potential in vitro into three germ layers...
May 15, 2024: Stem Cell Research
Ruslan Akhmedullin, Gaziz Kyrgyzbay, Darkhan Kimadiev, Zhasulan Utebekov
BACKGROUND: The epidemiology of psychogenic non-epileptic seizures (PNES) is still unclear. Although approximately 14 million people need neurosurgical care annually, there is a dearth of thorough analysis on PNES occurrence following surgery. This study seeks to estimate the proportion of newly diagnosed PNES. METHODS: We conducted a literature search of the PubMed, Ovid, CINAHL, and Cochrane Library databases up to December 2023. We identified studies using an observational design on the occurrence of PNES in patients who underwent intracranial surgery, and confirmed diagnosis using video-EEG...
May 1, 2024: Seizure: the Journal of the British Epilepsy Association
Mokshal H Porwal, Abrahim N Razzak, Vinay Kumar, Ahmed Z Obeidat, Umesh Sharma
BACKGROUND: Pharmacovigilance systems such as the FDA Adverse Event Reporting System (FAERS), are established models for adverse event surveillance that may have been missed during clinical trials. We aimed to analyze twenty-five anti-seizure medications (ASMs) in FAERS to assess for increased reporting of suicidal and self-injurious behavior. METHODS: Twenty-five ASMs were analyzed: brivaracetam, cannabidiol, carbamazepine, clobazam, clonazepam, diazepam, eslicarbazepine, felbamate, gabapentin, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, perampanel, phenobarbital, phenytoin, pregabalin, primidone, rufinamide, stiripentol, tiagabine, topiramate, valproate, vigabatrin, zonisamide...
May 17, 2024: Epilepsy Research
M R Trimble, D Hesdorffer, H Hećimović, N Osborne
In this paper we look at non-pharmaceutical treatments for intractable epilepsy based on neurophysiological methods especially with EEG analysis. In summary, there are a number of limbic and thalamo-cortical related structures involved in the processing of musical emotion (exposure), including the amygdala (arousal, expression of mood, fear), hippocampus (memory, regulation of HPA axis, stress), parahippocampal gyrus (recognition, memory retrieval), insula (valence), temporal poles (connectivity), ventral striatum (expectation and experience of reward), orbitofrontal cortex (valence) and cingulate cortex (autonomic regulation)...
May 17, 2024: Epilepsy & Behavior: E&B
Cibelle de Melo Bastos Cavalcante, Kellysson Bruno Oliveira, Fernanda Maria Araújo de Souza, Milenna Maria Jatobá Hasten Reiter, Bianca Rodrigues Melo da Silva, Keylla Lavínia da Silva Oliveira, Marcos Vinicius Dos Santos Sales, Amanda Larissa Dias Pacheco, Edite Santos Siqueira, Maisa de Araújo Costa, José Gomes Dos Santos Neto, Rayssa Gabriely Duarte Torres, Ana Catarina R Leite, Igor Santana de Melo, Sônia Salgueiro Machado, Marcelo Duzzioni, Daniel Leite Góes Gitaí, Olagide Wagner de Castro
Crack cocaine is a highly addictive and potent stimulant drug. Animal studies have shown that the cholinergic system plays a role in neurotoxicity induced by cocaine or its active metabolites inhalation. Behavioral alterations associated with crack cocaine use include hyperactivity, depressed mood, and decreased seizure threshold. Here we evaluate the acetylcholinesterase (AChE) and reactive oxygen species (ROS) activity, behavioral profile, and the threshold for epileptic seizures in rats that received intrahippocampal pilocarpine (H-PILO) followed by exposure to crack cocaine (H-PILO + CRACK)...
May 17, 2024: Epilepsy & Behavior: E&B
Pınar Bengi Boz, Kezban Aslan-Kara, Mehmet Taylan Peköz
INTRODUCTION: Epilepsy accounts for a substantial part of the global burden of disability. This study aimed to investigate the employment history of people with epilepsy in Türkiye, evaluate the role of education level in employment and epilepsy burden, and compare epilepsy employment data in different societies according to sociodemographic index data. METHODS: This prospective study included 420 people 16-76 years of age who were diagnosed with epilepsy according to the criteria of the International League Against Epilepsy...
May 17, 2024: Epilepsy & Behavior: E&B
Zhao Hu, Lu Tang, Xiaowei Xu, Yiqiang Zhan
OBJECTIVE: The study aimed to investigate the association between physical activity and the four dimensions of psychosocial status in adults with epilepsy. METHODS: The data of individuals with epilepsy utilized in this cross-sectional study were derived from the 2022 National Health Interview Survey(NHIS). Physical activity was analyzed based on walking, moderate or vigorous intensity physical activity and the 2018 Physical Activity Guidelines (PAG) for Americans...
May 17, 2024: Epilepsy & Behavior: E&B
Lisa M Clifford, Erin M Flynn, Shannon L Brothers, Shanna Guilfoyle, Avani C Modi
Youth with epilepsy (YWE) are at elevated risk for anxiety, yet anxiety is often undetected and understudied in this population. Most research on anxiety in YWE is based on parent proxy-report and broad-band measures with limited sensitivity. The aim of the current study was to: 1) examine rates of anxiety symptoms in YWE using a diagnosis-specific, self-report measure of anxiety symptoms, 2) assess differences in anxiety symptoms by sociodemographic and medical variables, and 3) evaluate changes in anxiety symptoms following a brief behavioral health intervention delivered within an interdisciplinary epilepsy clinic visit...
May 17, 2024: Epilepsy & Behavior: E&B
G Bruschi, L Pellegrino, A L Bisogno, F Ferreri, B Kassabian, D Seppi, S Favaretto, M Corbetta, F Dainese
INTRODUCTION: Status epilepticus (SE) is a medical emergency associated with a significant risk of disability and death. The treatment of SE follows a step-wise approach, with limited data on ideal antiseizure medications (ASMs) for refractory and super refractory SE (RSE/SRSE). Perampanel (PER), an AMPA receptor antagonist, has shown promise in animal models but still has limited data in humans. This study tried to evaluate optimal dosage and safety of PER in RSE and SRSE patients. MATERIALS AND METHODS: We retrospectively analysed 17 adult patients with RSE (1) or SRSE (16) treated with PER...
May 17, 2024: Epilepsy & Behavior: E&B
Philippe Gélisse, Selim R Benbadis, Arielle Crespel, William O Tatum
Normal EEG variants, especially the epileptiform variants, can be challenging to interpret because they often have sharp contours and may be confused with "epileptic" interictal activities. However, they can be recognized by the fact that "most spikes or sharp wave discharges of clinical import are followed by a slow wave or a series of slow deflections" (Maulsby, 1971). If there is no wave after the spike, electroencephalographers should be suspicious of artifacts and normal EEG variants. Most normal EEG variants display a single rhythm with the same frequency within the pattern and the morphology remains stable throughout the entire EEG recording with repetition of the same pattern...
May 18, 2024: Journal of Neurology
Dongjun Guo, Lirong Han, Christin M Godale, Nicholas R Rensing, Steve C Danzer, Michael Wong
OBJECTIVE: The mechanistic target of rapamycin (mTOR) pathway has been implicated in promoting epileptogenesis in animal models of acquired epilepsy, such as posttraumatic epilepsy (PTE) following traumatic brain injury (TBI). However, the specific anatomical regions and neuronal populations mediating mTOR's role in epileptogenesis are not well defined. In this study, we tested the hypothesis that mTOR activation in dentate gyrus granule cells promotes neuronal death, mossy fiber sprouting, and PTE in the controlled cortical impact (CCI) model of TBI...
May 18, 2024: Epilepsia
Rini Pauly, Layla Johnson, F Alex Feltus, Emily L Casanova
Homo sapiens and Neanderthals underwent hybridization during the Middle/Upper Paleolithic age, culminating in retention of small amounts of Neanderthal-derived DNA in the modern human genome. In the current study, we address the potential roles Neanderthal single nucleotide polymorphisms (SNP) may be playing in autism susceptibility in samples of black non-Hispanic, white Hispanic, and white non-Hispanic people using data from the Simons Foundation Powering Autism Research (SPARK), Genotype-Tissue Expression (GTEx), and 1000 Genomes (1000G) databases...
May 17, 2024: Molecular Psychiatry
Rohit Prem Kumar, Vijay Sivan, Hanin Bachir, Syed A Sarwar, Francis Ruzicka, Geoffrey R O'Malley, Paulo Lobo, Ilona Cazorla Morales, Nicholas D Cassimatis, Jasdeep S Hundal, Nitesh V Patel
INTRODUCTION: Neurosurgery emphasizes the criticality of accurate differential diagnoses, with diagnostic delays posing significant health and economic challenges. As large language models (LLMs) emerge as transformative tools in healthcare, this study seeks to elucidate their role in assisting neurosurgeons with the differential diagnosis process, especially during preliminary consultations. METHODS: This study employed three chat-based LLMs, ChatGPT (versions 3...
May 15, 2024: World Neurosurgery
J Domingo Sánchez, Jorge Gómez-Carpintero, Juan F González, J Carlos Menéndez
The therapeutic use of the traditional drugs against epilepsy has been hindered by their toxicity and low selectivity. These limitations have stimulated the design and development of new generations of antiepileptic drugs. This review explores the molecular targets and synthesis of the antiepileptic drugs that have entered the market in the 21st century, with a focus on manufacturer synthesis.
May 4, 2024: European Journal of Medicinal Chemistry
Boulenouar Mesraoua, Francesco Brigo, Simona Lattanzi, Emilio Perucca, Musab Ali, Ali A Asadi-Pooya
Safe delivery and optimal peripartum and postpartum care in women with epilepsy (WWE) is a major concern which has received limited attention in recent years. A diagnosis of epilepsy per se is not an indication for a planned cesarean section or induction of labor, even though epidemiological studies indicate that cesarean delivery is more common among WWE compared to the general population. Pregnancy in WWE is associated with an increased risk of obstetrical complications and increased perinatal morbidity and mortality, and these risks may be greater among WWE taking ASMs...
May 16, 2024: Epilepsy & Behavior: E&B
Pia Parekh, Hannah Wheless, Cameryn Freglette, Jacqueline French, Chris Morrison, Jacob Pellinen
OBJECTIVE: A previous investigation of people with newly diagnosed focal epilepsy participating in the Human Epilepsy Project 1 (HEP1) revealed an association between learning difficulties and structural brain differences, suggesting an underlying relationship prior to seizure onset. To investigate physicians' practices of documentation learning difficulties during clinical encounters, we conducted a review of initial epileptologist encounter notes from HEP1 participants who self-reported early life learning difficulties separately as part of study enrollment...
May 16, 2024: Epilepsy & Behavior: E&B
Kristijonas Puteikis, Rūta Mameniškienė
BACKGROUND: The conceptual definition of epilepsy has been changing over decades and remains debatable. We assessed how artificial intelligence (AI) conceives epilepsy and its impact on a person's life through verbal and visual material. METHODS: We asked the Chat Generative Pre-Trained Transformer (ChatGPT, OpenAI) to define epilepsy and its impact. Prompts from ChatGPT were transferred to another AI tool DALL·E 2 (Open AI) to generate visual images based on verbal input...
May 16, 2024: Epilepsy & Behavior: E&B
Sarah Metzger, Jessica Lee, Lindley McDavid
Epilepsy affects millions of people and when medications are insufficient to maintain seizure control, individuals are diagnosed with refractory epilepsy (RE). Medical ketogenic diet therapy (KDT), a diet high in fat and low in carbohydrates and sufficient in protein, is a well-established treatment for RE. However, compliance is one of the main reasons for discontinuation of KDT and, with pediatric RE patients, the ability of informal caregivers, typically family members, to maintain diet adherence is vital for successful KDT treatment...
May 16, 2024: Epilepsy & Behavior: E&B
Ting Zhao, Xuefei Zhang, Xiaoxiao Cui, Songxue Su, Lei Li, Yanan Chen, Na Wang, Lei Sun, Jianyuan Zhao, Jiewen Zhang, Xiong Han, Jing Cao
BACKGROUND: Epilepsy is a chronic disabling disease poorly controlled by available antiseizure medications. Oridonin, a bioactive alkaloid with anti-inflammatory properties and neuroprotective effects, can inhibit the increased excitability of neurons caused by glutamate accumulation at the cellular level. However, whether oridonin affects neuronal excitability and whether it has antiepileptic potential has not been reported in animal models or clinical studies. METHOD: Pentylenetetrazol was injected into mice to create a model of chronic epilepsy...
May 16, 2024: International Immunopharmacology
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