Wei Guo, Lin Jia, Ling Xie, Juliann G Kiang, Yangyang Wang, Fengfei Sun, Zunwen Lin, Enwen Wang, Yida Zhang, Peigen Huang, Ting Sun, Xiao Zhang, Zhengying Bian, Tiejun Tang, Jingtian Guo, Soldano Ferrone, Xinhui Wang
Irradiation (IR) induces immunogenic cell death (ICD) in tumors, but it rarely leads to the abscopal effect (AE); even combining IR with immune checkpoint inhibitors has shown only anecdotal success in inducing AEs. In this study, we aimed to enhance the IR-induced immune response and generate reproducible AEs using the anti-alcoholism drug, disulfiram (DSF), complexed with copper (DSF/Cu) to induce tumor ICD. We measured ICD in vitro and in vivo. In mouse tumor models, DSF/Cu was injected intratumorally followed by localized tumor IR, creating an in situ cancer vaccine...
April 27, 2024: Cell Death & Disease