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JOURNAL ARTICLE
Pierre A Geoffroy, Valentina Decio, Philippe Pirard, Olivier Bouaziz, Emmanuelle Corruble, Viviane Kovess-Masfety, Michel Lejoyeux, Jonathan Messika, Baptiste Pignon, Vittorio Perduca, Nolwenn Regnault, Sarah Tebeka
INTRODUCTION: Although hospitalisation for COVID-19 is associated with a higher post-discharge risk of mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD), this risk has not been compared to that following hospitalisation for a reason other than COVID-19. METHODS: Using data from France's National Health Data System (SNDS) database, we compared patients hospitalised for mood disorders in the 12 months following COVID-19/another reason hospitalisation...
January 14, 2024: Journal of Affective Disorders
#22
JOURNAL ARTICLE
Gwénaël Le Teuff, Nathalie Cozic, Jean-Christophe Boyer, Valérie Boige, Robert B Diasio, Julien Taieb, Didier Meulendijks, Claire Palles, Matthias Schwab, Maarten Deenen, Carlo R Largiadèr, Anthony Marinaki, Barbara A Jennings, Yvonne Wettergren, Antonello Di Paolo, Eva Gross, Barna Budai, Stephen P Ackland, André B P van Kuilenburg, Howard L McLeod, Gérard Milano, Fabienne Thomas, Marie-Anne Loriot, David Kerr, Jan H M Schellens, Pierre Laurent-Puig, Qian Shi, Jean-Pierre Pignon, Marie-Christine Etienne-Grimaldi
BACKGROUND: Dihydropyrimidine dehydrogenase (DPD) deficiency is the main known cause of life-threatening fluoropyrimidine (FP)-induced toxicities. We conducted a meta-analysis on individual patient data to assess the contribution of deleterious DPYD variants *2A/D949V/*13/HapB3 (recommended by EMA) and clinical factors, for predicting G4-5 toxicity. METHODS: Study eligibility criteria included recruitment of Caucasian patients without DPD-based FP-dose adjustment...
January 15, 2024: British Journal of Cancer
#23
JOURNAL ARTICLE
Frédéric Pignon, Emilie Guilbert, Samuel Mandin, Nicolas Hengl, Mohamed Karrouch, Bruno Jean, Jean-Luc Putaux, Thomas Gibaud, Sebastien Manneville, Theyencheri Narayanan
HYPOTHESIS: Rodlike cellulose nanocrystals (CNCs) exhibit significant potential as building blocks for creating uniform, sustainable materials. However, a critical hurdle lies in the need to enhance existing or devise novel processing that provides improved control over the alignment and arrangement of CNCs across a wide spatial range. Specifically, the challenge is to achieve orthotropic organization in a single-step processing, which entails creating non-uniform CNC orientations to generate spatial variations in anisotropy...
January 4, 2024: Journal of Colloid and Interface Science
#24
JOURNAL ARTICLE
Luna Gargani, Cosimo Bruni, Giancarlo Todiere, Nicola Riccardo Pugliese, Giulia Bandini, Silvia Bellando-Randone, Serena Guiducci, Gennaro D'Angelo, Corrado Campochiaro, Giacomo De Luca, Chiara Stagnaro, Massimo Lombardi, Lorenzo Dagna, Alessia Pepe, Yannick Allanore, Alberto Moggi-Pignone, Marco Matucci-Cerinic
BACKGROUND: Cardiac involvement in systemic sclerosis (SSc) affects the prognosis of the disease. Echocardiography is the first line imaging tool to detect cardiac involvement, but it is not able to routinely detect myocardial fibrosis. Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) is the gold standard for replacement myocardial fibrosis assessment, but its availability is currently limited. AIM: We aimed to assess the clinical and instrumental parameters that would be useful for predicting the presence of LGE-CMR, to achieve a better selection of patients with SSc that could benefit from third-level CMR imaging...
December 23, 2023: Journal of Clinical Medicine
#25
JOURNAL ARTICLE
Clément Dondé, Nathalie Coulon, Hugo Turbé, Myrtille Andre, Laurent Boyer, Delphine Capdevielle, Isabelle Chereau, Romane Dassing, Jean-Michel Dorey, Caroline Dubertret, Sylvain Leignier, Pierre-Michel Llorca, David Misdrahi, Christine Passerieux, Baptiste Pignon, Romain Rey, Benoît Schorr, Franck Schürhoff, Mathieu Urbach, Guillaume Fond, Jasmina Mallet
BACKGROUND: Childhood Attention-deficit/hyperactivity disorder (C-ADHD) is a neurodevelopmental disorder, associated with an increased risk of subsequent schizophrenia. The objective of the present study was to determine the prevalence of C-ADHD in schizophrenia and the clinical and cognitive characteristics associated with C-ADHD history in schizophrenia. METHODS: 569 subjects with schizophrenia (74 % men, mean age 30.8) were included in ten expert centers at a national level and tested with a comprehensive battery of clinician-rated, patient-reported scales and cognitive tests...
December 19, 2023: Schizophrenia Research
#26
JOURNAL ARTICLE
Giulia Bandini, Alessia Alunno, Filipe O Pinheiro, Corrado Campochiaro, Ilaria Galetti, Pietro Matucci-Cerinic, Barbara Ruaro, Khadija El Aoufy, Maria R Melis, Alberto Moggi Pignone, Silvia Bellando Randone, Lorenzo Dagna, Marco Matucci-Cerinic, Zsuzsanna H McMahan, Michael Hughes
OBJECTIVE: Proton pump inhibitors (PPIs) are widely prescribed to treat gastroesophageal reflux disease (GERD) in Systemic Sclerosis (SSc). However, not all patients adequately respond to the treatment, and there are frequent concerns about the safety of long-term use of PPIs. Our aim was to identify the main problems/complaints of SSc patients on PPIs, as well as understand their unmet needs. METHODS: SSc patients treated with PPIs were invited through international patient associations and social media to participate in an online survey...
December 18, 2023: Arthritis Care & Research
#27
JOURNAL ARTICLE
Sarah Tebeka, Laure Carcaillon-Bentata, Valentina Decio, Caroline Alleaume, Nathalie Beltzer, Anne Gallay, Cédric Lemogne, Baptiste Pignon, Tatjana T Makovski, Joël Coste
No abstract text is available yet for this article.
December 13, 2023: European Psychiatry: the Journal of the Association of European Psychiatrists
#28
JOURNAL ARTICLE
Giulia Trotta, Victoria Rodriguez, Diego Quattrone, Edoardo Spinazzola, Giada Tripoli, Charlotte Gayer-Anderson, Tom P Freeman, Hannah E Jongsma, Lucia Sideli, Monica Aas, Simona A Stilo, Caterina La Cascia, Laura Ferraro, Daniele La Barbera, Antonio Lasalvia, Sarah Tosato, Ilaria Tarricone, Giuseppe D'Andrea, Andrea Tortelli, Franck Schürhoff, Andrei Szöke, Baptiste Pignon, Jean-Paul Selten, Eva Velthorst, Lieuwe de Haan, Pierre-Michel Llorca, Paulo Rossi Menezes, Cristina M Del Ben, Jose Luis Santos, Manuel Arrojo, Julio Bobes, Julio Sanjuán, Miquel Bernardo, Celso Arango, James B Kirkbride, Peter B Jones, Alexander Richards, Bart P Rutten, Jim Van Os, Isabelle Austin-Zimmerman, Zhikun Li, Craig Morgan, Pak C Sham, Evangelos Vassos, Chloe Wong, Richard Bentall, Helen L Fisher, Robin M Murray, Luis Alameda, Marta Di Forti
BACKGROUND: Childhood adversity and cannabis use are considered independent risk factors for psychosis, but whether different patterns of cannabis use may be acting as mediator between adversity and psychotic disorders has not yet been explored. The aim of this study is to examine whether cannabis use mediates the relationship between childhood adversity and psychosis. METHODS: Data were utilised on 881 first-episode psychosis patients and 1231 controls from the European network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study...
November 2023: Psychological Medicine
#29
JOURNAL ARTICLE
Baptiste Pignon, Emmanuel Wiernik, Sofiane Kab, Joane Matta, Anne Toussaint, Bernd Löewe, Mathilde Horn, Ali Amad, Thomas Fovet, Clément Gouraud, Charles Ouazana-Vedrines, Victor Pitron, Marcel Goldberg, Marie Zins, Cédric Lemogne
OBJECTIVE: The 12-item Somatic Symptom Disorder-B Criteria Scale (SSD-12) is a self-reported questionnaire designed to assess the B criteria of the DSM-5 somatic symptom disorder. In this cross-sectional study, we aimed to examine the psychometric properties of the SSD-12 French version and associated health outcomes. METHODS: Participants were volunteers from the population-based CONSTANCES cohort who reported at least one new symptom that occurred between March 2020 and January 2021...
November 29, 2023: Journal of Psychosomatic Research
#30
REVIEW
Baptiste Pignon, Andrei Szöke, Benson Ku, Maria Melchior, Franck Schürhoff
In the present qualitative literature review, we summarise data on psychotic disorders and urbanicity, focusing particularly on recent findings. Longitudinal studies of the impact of urbanicity on the risk for psychotic disorders have consistently shown a significant association, with a relative risk between 2 and 2.5. However, most of the original studies were conducted in Western Europe, and no incidence studies were conducted in low- and middle-income countries. European studies suggest that neighbourhood-level social fragmentation and social capital may partly explain this association...
December 2023: Dialogues in Clinical Neuroscience
#31
JOURNAL ARTICLE
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S Yom, Catherine Fortpied, Johannes Langendijk, Jan B Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
BACKGROUND: A single institution retrospective study suggested that head and neck squamous cell cancer (HNSCC) patients receiving radiotherapy (RT) during "dark" season (fall/winter) may have better outcomes than those treated during "light" season (spring/summer), possibly secondary to seasonal variations in cell cycle progression. We investigated the impact of season of RT in two large, multi-institutional, prospective datasets of randomized trials. METHODS: Individual patient data from the MACH-NC and MARCH meta-analyses were analyzed...
November 11, 2023: Radiotherapy and Oncology
#32
JOURNAL ARTICLE
David Misdrahi, Maud Dupuy, Yecodji Dansou, Laurent Boyer, Fabrice Berna, Delphine Capdevielle, Isabelle Chereau, Nathalie Coulon, Thierry D'Amato, Caroline Dubertret, Sylvain Leignier, Pierre Michel Llorca, Christophe Lançon, Jasmina Mallet, Christine Passerieux, Baptiste Pignon, Romain Rey, Franck Schürhoff, Joel Swendsen, Mathieu Urbach, Andrei Szöke, Ophélia Godin, Guillaume Fond
Schizophrenia is characterized by the most salient medication adherence problems among severe mental disorders, but limited prospective data are available to predict and improve adherence in this population. This investigation aims to identify predictors of medication adherence over a 1-year period in a large national cohort using clustering analysis. Outpatients were recruited from ten Schizophrenia Expert Centers and were evaluated with a day-long standardized battery including clinician and patient-rated medication adherence measures...
November 7, 2023: Translational Psychiatry
#33
JOURNAL ARTICLE
David Malka, Benjamin Verret, Matthieu Faron, Rosine Guimbaud, Caroline Caramella, Julien Edeline, Marie-Pierre Galais, Leïla Bengrine-Lefevre, Denis Smith, Eric Dupont-Bierre, Thierry De Baere, Diane Goéré, Peggy Dartigues, Ludovic Lacroix, Valérie Boige, Maximiliano Gelli, Jean-Pierre Pignon, Michel Ducreux
BACKGROUND: The efficacy and tolerability of hepatic arterial infusion (HAI) oxaliplatin plus systemic 5-fluorouracil and cetuximab as frontline treatment in patients with colorectal liver metastases (CRLM) are unknown. METHODS: In this multicenter, single-arm phase II study, patients with CRLM not amenable to curative-intent resection or requiring complex/major liver resection, and no prior chemotherapy for metastatic disease, received HAI oxaliplatin and intravenous 5-fluorouracil, leucovorin and cetuximab, every two weeks until disease progression, limiting toxicity or at least 3 months after complete response or curative-intent resection/ablation...
October 28, 2023: European Journal of Cancer
#34
JOURNAL ARTICLE
Lorenzo Metilli, Héloïse Ugo, William Chèvremont, Cyril Picard, Frédéric Pignon
Metal-organic-frameworks (MOFs) are promising materials for addressing critical issues such as petrochemical separation, water purification, energy storage and drug delivery. Their large-scale deployment, however, is hampered by a limited processability due to their powdery nature. Recently, the hybridization of MOFs with biopolymers has emerged as a greener, biocompatible strategy to shape MOFs composites into more processable membranes, films, and porous materials. In this work, cellulose nanocrystals (CNCs) were used in combination with ZIF-8 (a widely used synthetic zeolite) to produce hybrid composites through ultrafiltration...
October 20, 2023: Soft Matter
#35
JOURNAL ARTICLE
Guillaume Fond, Jasmina Mallet, Mathieu Urbach, Michael Eriksen Benros, Michael Berk, Martina Billeci, Laurent Boyer, Christoph U Correll, Michele Fornaro, Jayashri Kulkarni, Marion Leboyer, Pierre-Michel Llorca, David Misdrahi, Romain Rey, Franck Schürhoff, Marco Solmi, Iris E C Sommer, Stephen M Stahl, Baptiste Pignon, Fabrice Berna
QUESTION: This umbrella review and guidelines aimed to provide evidence to support the rational choice of selected adjunctive therapies for schizophrenia. STUDY SELECTION AND ANALYSIS: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and World Federation of Societies of Biological Psychiatry (WFSBP)-grading recommendations, 63 randomised control trials (RCTs) (of which 4219 unique participants have completed the RCTs) and 29 meta-analyses were analysed...
October 2023: BMJ Ment Health
#36
JOURNAL ARTICLE
Dorra Elhaj Mahmoud, Mariem Hanachi, Hajar Yaakoub, Simon Blanchard, Pascale Pignon, Oussama Souiai, Yves Delneste, Jean-Philippe Bouchara, Nicolas Papon, Anaïs Hérivaux
Fungal infections caused by Scedosporium species are rising among immunocompromised and immunocompetent patients. Within the immunocompetent group, patients with cystic fibrosis (pwCF) are at high risk of developing a chronic airway colonization by these molds. While S. apiospermum is one of the major species encountered in the lungs of pwCF, S. dehoogii has rarely been reported. The innate immune response is believed to be critical for host defense against fungal infections. However, its role has only recently been elucidated and the immune mechanisms against Scedosporium species are currently unknown...
October 11, 2023: Cytokine
#37
JOURNAL ARTICLE
Adewole S Adamson, Bradford E Jackson, Christopher D Baggett, Nancy E Thomas, Alex B Haynes, Michael P Pignone
BACKGROUND: Previous studies of hospital-based patients with metastatic melanoma suggest sociodemographic factors, including insurance type, may be associated with the receipt of systemic treatments. OBJECTIVES: To examine whether insurance type is associated with the receipt of systemic treatment among patients with melanoma in a broad cohort of patients in North Carolina. METHODS: We conducted a retrospective cohort study between 2011 and 2017 of patients with stages III-IV melanoma using data from the North Carolina Central Cancer Registry linked to Medicare, Medicaid, and private health insurance claims across the state...
September 13, 2023: Medical Care
#38
JOURNAL ARTICLE
Emma Monge, Thomas M Donnelly, Thomas Coutant, R Avery Bennett, Charly Pignon
OBJECTIVE: Describe lateral ear canal resection and bulla osteotomy with marsupialization (LECARBOM) in rabbits with otitis media (OM), and report outcomes, complications, bacteria cultured from middle ears, and their antimicrobial susceptibility testing (AST) results. STUDY DESIGN: Retrospective clinical case series; single referral hospital. ANIMALS: Forty-two rabbits with naturally occurring OM. METHODS: Medical records (2011-2021) of rabbits with CT-confirmed OM undergoing surgery were reviewed for outcomes, complications, bacteria cultured from middle ears, and AST...
August 27, 2023: Veterinary Surgery
#39
JOURNAL ARTICLE
Baptiste Pignon, Valentina Decio, Philippe Pirard, Olivier Bouaziz, Emmanuelle Corruble, Pierre A Geoffroy, Viviane Kovess-Masfety, Marion Leboyer, Cédric Lemogne, Jonathan Messika, Vittorio Perduca, Franck Schürhoff, Nolwenn Regnault, Sarah Tebeka
COVID-19, like other infectious diseases, may be a risk factor for psychotic disorders. We aimed to compare the proportions of hospitalizations for psychotic disorders in the 12 months following discharge from hospital for either COVID-19 or for another reason in the adult general population in France during the first wave of the pandemic. We conducted a retrospective longitudinal nationwide study using the national French administrative healthcare database. Psychotic disorders were first studied as a whole, and then chronic and acute disorders separately...
August 3, 2023: Molecular Psychiatry
#40
JOURNAL ARTICLE
Alberto Varela-Feijoo, Philippe Djemia, Tetsuharu Narita, Frédéric Pignon, Armelle Baeza-Squiban, Valentina Sirri, Alain Ponton
In order to get better knowledge of mechanical properties from microscopic to macroscopic scale of biopolymers, viscoelastic bulk properties of aqueous solutions of sodium alginate were studied at different scales by combining macroscopic shear rheology (Hz), diffusing-wave spectroscopy microrheology (kHz-MHz) and Brillouin spectroscopy (GHz). Structural properties were also directly probed by small-angle X-ray scattering (SAXS). The results demonstrate a change from polyelectrolyte behavior to neutral polymer behavior by increasing polymer concentration with the determination of characteristic sizes (persistence length, correlation length)...
July 25, 2023: Soft Matter
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