Yue Yang, Ting Yan, Qiang Han, Meiyu Zhang, Yijun Zhang, Yuan Luo, Lai Wei, Pengcheng Li, Enhua Wang
Zinc-finger protein 326 (ZNF326) activity has been reported in different tumors, but its expression and possible mechanism of action in colorectal cancer are not known. In this study, we applied immunohistochemistry to detect the expression of ZNF326 in colorectal tissues. Next, we used a ZNF326 expression plasmid and small interfering (si) RNA-ZNF326 (siZNF326) to transfect colorectal cancer cell lines in order to determine the effect of ZNF326 on cell migration and as well as its potential role in promoting epithelial-mesenchymal transition (EMT)...
July 22, 2021: Pathology, Research and Practice
Takahiro Anzai, Shinji Saijou, Yoshitsugu Ohnuki, Hiroshi Kurosawa, Masahiro Yasunaga, Yasuhiro Matsumura
TMEM180, a novel colon cancer-specific protein with a 12-transmembrane topology, is upregulated at low oxygen. Previously, we established a humanized monoclonal antibody against TMEM180 aimed at clinical trials. Prior to such trials, it is necessary to clarify the function of TMEM180 in cancer. To compare SW480 human colon cancer cells and their TMEM180-knockdown derivatives, we analyzed proliferation and oxygen consumption, and also performed phosphorylation proteomics, metabolomics, and next-generation sequencing (NGS)...
July 28, 2021: Translational Oncology
S Mohiuddin, B C Reeves, N J Smart, W Hollingworth
AIM: Parastomal hernia (PSH) is a common problem following colostomy. Using prophylactic mesh during end colostomy creation may reduce PSH incidence, but concerns exist regarding the optimal type of mesh, potential long-term complications, and cost-effectiveness of its use. We evaluated the cost-effectiveness of mesh prophylaxis to prevent PSH in patients undergoing end colostomy for rectal cancer. METHODS: We developed a decision-analytical model, stratified by rectal cancer stages I-IV, to estimate the lifetime costs, quality-adjusted life-years (QALYs) and net monetary benefits (NMBs) of synthetic, biologic and no mesh from a UK NHS perspective...
July 31, 2021: Colorectal Disease
Subashini Chandrapalan, Sofie Bosch, Heena Tyagi, Emma Daulton, Joaquín Cubiella, Jordi Guardiola, Peter Kimani, Chris Mulder, James Covington, Krishna Persaud, Tim G J de Meij, Donato F Altomare, Herman Brenner, Nanne K H de Boer, Luigi Ricciardiello, Ramesh P Arasaradnam
No abstract text is available yet for this article.
August 2021: Alimentary Pharmacology & Therapeutics
George B Hanna, Amanda J Cross
No abstract text is available yet for this article.
August 2021: Alimentary Pharmacology & Therapeutics
Marianne Rodrigues Fernandes, Juliana Carla Gomes Rodrigues, Elizabeth Ayres Fragoso Dobbin, Lucas Favacho Pastana, Danielle Feio da Costa, Williams Fernandes Barra, Antônio André Conde Modesto, Paula Baraúna de Assumpção, Artur Luiz da Costa Silva, Sidney Emanuel Batista Dos Santos, Rommel Mario Rodriguez Burbano, Paulo Pimentel de Assumpção, Ney Pereira Carneiro Dos Santos
PURPOSE: Fluoropyrimidines are one of the most used drug class to treat cancer patients, although they show high levels of associated toxicity. This study analyzed 33 polymorphisms in 17 pharmacogenes involved with the pharmacogenomics of fluoropyrimidines, in gastrointestinal cancer patients undergoing fluoropyrimidine-based treatment in the Brazilian Amazon. METHODS: The study population was composed of 216 patients, 92 of whom have an anatomopathological diagnosis of gastric cancer and 124 of colorectal cancer...
July 31, 2021: Cancer Chemotherapy and Pharmacology
Giulia Scaglioni, Nicoletta Cavazza
OBJECTIVE: To assess a three-factor version of the Emotional Barriers to Bowel Screening (EBBS) scale; analyze the scale's psychometric properties; and investigate the associations of fecal disgust, embarrassment, and fear with colorectal cancer (CRC) screening avoidance. METHODS: Retrospective design: We asked participants to rate negative emotions associated with CRC screenings as well as whether they had ever attended a fecal occult blood test. SAMPLE: 268 Italian adults aged 45-74 years...
July 30, 2021: Psycho-oncology
Xiaoding Shen, Yong Wang, Rui Zhao, Qianyi Wan, Yutao Wu, Lihao Zhao, Xiaoting Wu
PURPOSE: Observational studies have reported an association between metabolic syndrome (MetS) and colorectal cancer risk with inconsistent risk estimates. We conducted this meta-analysis to evaluate the risk of colorectal cancer in individuals with MetS. METHODS: PubMed, Embase, and Web of Science were searched for related studies from database inception to 21 January 2021. Risk estimates for colorectal cancer were extracted from individual articles and pooled using a fixed-effect or random-effect model according to the heterogeneity...
July 31, 2021: International Journal of Colorectal Disease
Dong Chen, Xuanwen Bao, Ruyi Zhang, Yongfeng Ding, Min Zhang, Benfeng Li, Hangyu Zhang, Xiaolin Li, Zhou Tong, Lulu Liu, Xiaohu Zhou, Saisai Wang, Xiaofei Cheng, Yi Zheng, Jian Ruan, Weijia Fang, Peng Zhao
BACKGROUND: Colorectal neuroendocrine carcinomas (CRNECs) are highly aggressive tumours with poor prognosis and low incidence. To date, the genomic landscape and molecular pathway alterations have not been elucidated. METHODS: Tissue sections and clinical information of CRNEC (n = 35) and CR neuroendocrine tumours (CRNETs) (n = 25) were collected as an in-house cohort (2010-2020). Comprehensive genomic and expression panels (AmoyDx® Master Panel) were applied to identify the genomic and genetic alterations of CRNEC...
July 30, 2021: British Journal of Cancer
Eleftherios Trivizakis, Georgios S Ioannidis, Ioannis Souglakos, Apostolos H Karantanas, Maria Tzardi, Kostas Marias
Colorectal cancer (CRC) constitutes the third most commonly diagnosed cancer in males and the second in females. Precise histopathological classification of CRC tissue pathology is the cornerstone not only for diagnosis but also for patients' management decision making. An automated system able to accurately classify different CRC tissue regions may increase diagnostic precision and alleviate clinical workload. However, tissue classification is a challenging task due to the variability in morphological and textural characteristics present in histopathology images...
July 30, 2021: Scientific Reports
Yanyan Chen, Mengxi Huang, Xiaolong Liu, Yadi Huang, Chao Liu, Jialong Zhu, Gongbo Fu, Zengjie Lei, Xiaoyuan Chu
Alternative splicing (AS) is an important event that contributes to posttranscriptional gene regulation. This process leads to several mature transcript variants with diverse physiological functions. Indeed, disruption of various aspects of this multistep process, such as cis- or trans- factor alteration, promotes the progression of colorectal cancer. Therefore, targeting some specific processes of AS may be an effective therapeutic strategy for treating cancer. Here, we provide an overview of the AS events related to colorectal cancer based on research done in the past 5 years...
July 30, 2021: Cell Death & Disease
Xingqin Zhou, Yazhou Chang, Jing Qian, Chaoyan Shen, Jie Han, Hongyu Zhao, Renan Chang
BACKGROUND The impact of therapeutic drug management (TDM) on reducing toxicity and improving efficacy in colorectal cancer (CRC) patients receiving fluorouracil-based chemotherapy is still unclear. MATERIAL AND METHODS A total of 207 patients (Study Group n=54, Historical Group n=153) with metastatic colorectal cancer were enrolled. All of them received 6 administrations of the 5-FU based regimens. Initial 5-FU dosing of all patients was calculated using body surface area (BSA). In the Study Group, individual exposure during each cycle was measured using a nanoparticle immunoassay, and the 5-FU blood concentration was calculated using the area under the curve (AUC)...
July 31, 2021: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Christelle Harly, Stephen Paul Joyce, Charlotte Domblides, Thomas Bachelet, Vincent Pitard, Charlotte Mannat, Angela Pappalardo, Lionel Couzi, Sonia Netzer, Layal Massara, Emilie Obre, Omar Hawchar, Lydia Lartigue, Stéphane Claverol, Carla Cano, Jean-François Moreau, Isabelle Mahouche, Isabelle Soubeyran, Rodrigue Rossignol, Benoit Viollet, Carrie R Willcox, Fiyaz Mohammed, Benjamin E Willcox, Benjamin Faustin, Julie Déchanet-Merville
Human γδ T cells contribute to tissue homeostasis and participate in epithelial stress surveillance through mechanisms that are not well understood. Here, we identified ephrin type-A receptor 2 (EphA2) as a stress antigen recognized by a human Vγ9Vδ1 TCR. EphA2 is recognized coordinately by ephrin A to enable γδ TCR activation. We identified a putative TCR binding site on the ligand-binding domain of EphA2 that was distinct from the ephrin A binding site. Expression of EphA2 was up-regulated upon AMP-activated protein kinase (AMPK)-dependent metabolic reprogramming of cancer cells, and coexpression of EphA2 and active AMPK in tumors was associated with higher CD3 T cell infiltration in human colorectal cancer tissue...
July 30, 2021: Science Immunology
Pokhraj Prakashchandra Suthar, Khushboo Gupta, Jagadeesh S Singh
Panitumumab is a new humanized anti-epidermal growth factor receptor (EGFR) monoclonal antibody (mAb) approved for the treatment of advanced colorectal cancer. There is an increase in the use of this drug due to a good response rate and possible secondary resection in advance colorectal cancer. Here we present 18 F-FDG PET/CT imaging findings of cardiac arrhythmia in a patient receiving Panitumumab for the treatment of metastatic infiltrating rectal adenocarcinoma. Cardiotoxicity is a known adverse effect associated with Panitumumab...
July 30, 2021: Journal of Nuclear Medicine Technology
Gi-Hoon Nam, Minsu Kwon, Hanul Jung, Eunbyeol Ko, Seong A Kim, Yoonjeong Choi, Su Jeong Song, Seohyun Kim, Yeji Lee, Gi Beom Kim, Jihoon Han, Jiwan Woo, Yakdol Cho, Cherlhyun Jeong, Seung-Yoon Park, Thomas M Roberts, Yong Beom Cho, In-San Kim
BACKGROUND: Statins preferentially promote tumor-specific apoptosis by depleting isoprenoid such as farnesyl pyrophosphate and geranylgeranyl pyrophosphate. However, statins have not yet been approved for clinical cancer treatment due, in part, to poor understanding of molecular determinants on statin sensitivity. Here, we investigated the potential of statins to elicit enhanced immunogenicity of KRAS -mutant ( KRAS mut ) tumors. METHODS: The immunogenicity of treated cancer cells was determined by western blot, flow cytometry and confocal microscopy...
July 2021: Journal for Immunotherapy of Cancer
Hege Berg Henriksen, Dena Helene Alavi, Rune Blomhoff
BACKGROUND & AIMS: High quality and precise methods are needed when monitoring changes in body composition among colorectal cancer (CRC) patients and healthy subjects. The aim of this study was to estimate precision of the Dual-energy X-ray absorptiometry (Lunar iDXA, GE Healthcare software enCORE version 16) in measuring body composition in CRC patients and healthy subjects. METHODS: Precision error of iDXA in measuring body composition was investigated in the current study...
August 2021: Clinical Nutrition ESPEN
Frédérick Barreau, Céline Tisseyre, Sandrine Ménard, Audrey Ferrand, Marie Carriere
The gastrointestinal tract is a complex interface between the external environment and the immune system. Its ability to control uptake across the mucosa and to protect the body from damage of harmful substances from the lumen is defined as the intestinal barrier function (IBF). The IBF involves four elements: the intestinal microbiota, the mucus layer, the epithelium and the immune system. Its dysfunction is linked with human diseases including inflammatory, metabolic, infectious, autoimmune and neurologic disorders...
July 30, 2021: Particle and Fibre Toxicology
Hui Li, Jie Liu, Yiqin Lai, Sha Huang, Liang Zheng, Nanfen Fan
BACKGROUND: Colorectal cancer (CRC) is considered as one of the commonest tumors and is the major reason of cancer-related deaths around the world. Plentiful evidences have validated that long non-coding RNAs (lncRNAs) play a significant part in various cancers, including CRC. LINC01559 is implicated in the development of various cancers. However, the detailed function of LINC01559 in CRC has not been illustrated. METHODS: LINC01559 expression was examined via RT-qPCR, and a series of functional experiments were conducted to explore the role of LINC01559 in CRC progression...
June 8, 2021: Pathology, Research and Practice
Qing Xie, Zhen Li, Yang Liu, Dawei Zhang, Meng Su, Hiroaki Niitsu, Robert J Coffey, Mingfeng Bai
Abscopal effect is an attractive cancer therapeutic effect referring to tumor regression at a location distant from the primary treatment site. Immunogenic cell death (ICD) offers a mechanistic link between the primary and remote therapeutic effects by activating favorable anti-tumor immune responses. In this study, we induced ICD in colorectal cancer (CRC) cell lines in vitro and in vivo by targeting the 18 kDa translocator protein (TSPO), a mitochondrial receptor overexpressed in CRC. Photodynamic therapy (PDT) using a TSPO-targeted photosensitizer, IR700DX-6T, caused effective apoptotic cell death in fourteen CRC cell lines...
July 27, 2021: Acta Biomaterialia
Siyu Wang, Yue Song, Kunxia Cao, Lingxiao Zhang, Xuedong Fang, Fangfang Chen, Shouhua Feng, Fei Yan
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. The primary treatment for CRC is surgical resection, along with chemotherapy in more advanced or inoperable cases. There is a growing interest to complement both curative and palliative treatment with immunotherapies such as the programmed cell death-1 (PD-1) and PD-ligand 1 (PDL1) checkpoint inhibitors and transforming growth factor (TGF) β inhibitors. However, the clinical outcomes of current immunotherapeutic strategies are limited by tumor heterogeneity and drug resistance...
July 27, 2021: Acta Biomaterialia
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