P L S Uson Junior, D Riegert-Johnson, L Boardman, J Kisiel, L Mountjoy, N Patel, B Lizaola-Mayo, M J Borad, D Ahn, M B Sonbol, J Jones, J A Leighton, S Gurudu, H Singh, M Klint, K L Kunze, M A Golafshar, E D Esplin, R L Nussbaum, A K Stewart, T Bekaii-Saab, N J Samadder
BACKGROUND & AIM: Hereditary factors play a role in the development of colorectal cancer (CRC). Identification of germline predisposition can have implications on treatment and cancer prevention. To determine prevalence of pathogenic germline variants (PGV) in CRC patients using an universal testing approach, association with clinical outcomes and the uptake of family variant testing. DESIGN: We undertook a prospective multi-site study of germline sequencing using an >80 gene NGS platform among CRC patients (not selected for age or family history) receiving care at Mayo Clinic Cancer Centers between April 1, 2018 and March 31, 2020...
April 12, 2021: Clinical Gastroenterology and Hepatology