Dmitri Mouradov, Paul Greenfield, Shan Li, Eun-Jung In, Claire Storey, Anuratha Sakthianandeswaren, Peter Georgeson, Daniel D Buchanan, Robyn L Ward, Nicholas J Hawkins, Iain Skinner, Ian T Jones, Peter Gibbs, Chenkai Ma, Yi Jin Liew, Kim Y C Fung, Oliver M Sieber
BACKGROUND & AIMS: Dysbiosis of gut microbiota is linked to the development of colorectal cancer (CRC). However, microbiota-based stratification of CRC tissue and how this relates to clinico-molecular characteristics and prognosis remains to be clarified. METHODS: Tumour and normal mucosa from 423 stage I-IV patients were profiled by bacterial 16S rRNA gene sequencing. Tumours were characterised for microsatellite instability (MSI), CpG island methylator phenotype (CIMP), APC, BRAF, KRAS, PIK3CA, FBXW7, SMAD4 and TP53 mutations; subsets for chromosome instability (CIN), mutation signatures and consensus molecular subtypes (CMS)...
March 16, 2023: Gastroenterology