keyword
https://read.qxmd.com/read/38758911/the-role-of-preoperative-fpr-and-far-in-prognostic-evaluation-of-stages-ii-and-iii-radical-colorectal-cancer-a-single-center-retrospective-study
#1
JOURNAL ARTICLE
Hang Yan, Tao Liu, Ruyi Yu, Dong Xia
The inflammatory and nutritional states of body are 2 important causes associated with the initiation and progression of colorectal cancer (CRC). The aim of this study is to investigate the prognostic evaluation value of preoperative fibrinogen-to-prealbumin ratio (FPR) and preoperative fibrinogen-to-albumin ratio (FAR) in CRC. The clinical data of 350 stages II and III patients with CRC who received radical resection were retrospectively analyzed. All patients were followed up for 5 years to observe the overall survival and disease-free survival of 5 years and analyze the relationship between preoperative FPR and FAR and prognosis of all enrolled patients...
May 17, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38758803/correction-up-regulation-of-91h-promotes-tumor-metastasis-and-predicts-poor-prognosis-for-patients-with-colorectal-cancer
#2
Qiwen Deng, Bangshun He, Tianyi Gao, Yuqin Pan, Huiling Sun, Yeqiong Xu, Rui Li, Houqun Ying, Feng Wang, Xian Liu, Jie Chen, Shukui Wang
[This corrects the article DOI: 10.1371/journal.pone.0103022.].
2024: PloS One
https://read.qxmd.com/read/38758606/colon-age-a-metric-for-whether-and-how-to-screen-male-veterans-for-early-onset-colorectal-cancer
#3
JOURNAL ARTICLE
Thomas F Imperiale, Laura J Myers, Barry C Barker, Timothy E Stump, Joanne K Daggy
We aimed to develop a metric for estimating risk for early-onset colorectal cancer (EOCRC) to help decide whether and how to screen persons < age 50. We used risk prediction models derived and validated on male Veterans to calculate the relative risks (RRs) for 6 scenarios: one low-risk scenario (no risk factors present), four intermediate risk scenarios (some factors present), and one high-risk scenario (all factors present) for three age groups (35-39, 40-44, and 45-49 years). For each scenario, we estimated absolute CRC risk using SEER CRC incidence rates and each scenario's RR...
May 17, 2024: Cancer Prevention Research
https://read.qxmd.com/read/38758457/common-skin-cancers-and-their-association-with-other-non-cutaneous-primary-malignancies-a-review-of-the-literature
#4
REVIEW
Lindsay Holic
It has long been recognized that a history of skin cancer puts one at risk for additional primary skin cancers. However, more variable data exists for the risk of developing a non-cutaneous primary cancer following a diagnosis of skin cancer. The data are most variable for Basal Cell Carcinoma (BCC), the most common and least aggressive type of skin cancer. While early studies imply that BCC does not impart a larger risk of other primary non-cutaneous cancers, more recent studies with larger populations suggest otherwise...
May 17, 2024: Medical Oncology
https://read.qxmd.com/read/38758433/application-of-machine-learning-model-to-optimize-colonic-adenoma-detection-in-india
#5
JOURNAL ARTICLE
Nitin Jagtap, Rakesh Kalapala, Hardik Rughwani, Aniruddha Pratap Singh, Pradev Inavolu, Mohan Ramchandani, Sundeep Lakhtakia, P Manohar Reddy, Anuradha Sekaran, Manu Tandan, Zaheer Nabi, Jahangeer Basha, Rajesh Gupta, Sana Fathima Memon, G Venkat Rao, Prateek Sharma, D Nageshwar Reddy
AIMS: There is limited data on the prevalence and risk factors of colonic adenoma from the Indian sub-continent. We aimed at developing a machine-learning model to optimize colonic adenoma detection in a prospective cohort. METHODS: All consecutive adult patients undergoing diagnostic colonoscopy were enrolled between October 2020 and November 2022. Patients with a high risk of colonic adenoma were excluded. The predictive model was developed using the gradient-boosting machine (GBM)-learning method...
May 17, 2024: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/38757886/study-on-the-evaluative-value-of-abdominal-multi-slice-spiral-ct-examination-for-distant-metastasis-and-regional-lymph-node-metastasis-in-colorectal-cancer
#6
JOURNAL ARTICLE
Lin Wang, Cunliang Bai, Qiangmei Wu, Yaping Ma, Wenling Li, Xia Nan, Xiaoju Zhao, Shaoyu Wang, Xiaoyun Cheng
No abstract text is available yet for this article.
May 16, 2024: Minerva surgery
https://read.qxmd.com/read/38757843/splenic-flexure-mobilization-in-left-sided-colonic-and-rectal-resections-a-meta-analysis-and-meta-regression-of-factors-associated-with-anastomotic-leak-and-complications
#7
REVIEW
Sameh Hany Emile, Justin Dourado, Peter Rogers, Nir Horesh, Zoe Garoufalia, Rachel Gefen, Steven D Wexner
AIM: Splenic flexure mobilization (SFM) is commonly performed during left-sided colon and rectal resections. The aim of the present systematic review was to assess the outcomes of SFM in left-sided colon and rectal resections and the risk factors for complications and anastomotic leak (AL). METHOD: This study was a PRISMA-compliant systematic review. PubMed, Scopus and Web of Science were searched for studies that assessed the outcomes of sigmoid and rectal resections with or without SFM...
May 17, 2024: Colorectal Disease
https://read.qxmd.com/read/38757745/exploring-guolin-qigong-mind-body-exercise-for-improving-cancer-related-fatigue-in-cancer-survivors-a-mixed-method-randomized-controlled-trial-protocol
#8
RANDOMIZED CONTROLLED TRIAL
Sara L K Low, Gwo Fuang Ho, Bingkai Liu, Eng-Siew Koh, Yutong Fei, Chiah Shean Teo, Xiaoshu Zhu
BACKGROUND: Cancer-related fatigue and its associated symptoms of sleep disorder and depression are prevalent in cancer survivors especially among breast, lung, and colorectal cancer survivors. While there is no gold standard for treating cancer-related fatigue currently, studies of mind-body exercises such as Qigong have reported promise in reducing symptoms. This study was designed to evaluate the feasibility and effect of Guolin Qigong on cancer-related fatigue and other symptoms in breast, lung and colorectal cancer survivors while exploring their perceptions and experiences of Guolin Qigong intervention...
2024: Integrative Cancer Therapies
https://read.qxmd.com/read/38757734/mechanical-shear-flow-regulates-the-malignancy-of-colorectal-cancer-cells
#9
JOURNAL ARTICLE
Yu-Ting Tseng, Ching-Chung Tsai, Ping-Chen Chen, Bo-Yan Lin, Sodio C N Hsu, Shu-Ping Huang, Bin Huang
Colorectal cancer (CRC) is notable for its high mortality and high metastatic characteristics. The shear force generated by bloodstream provides mechanical signals regulating multiple responses of cells, including metastatic cancer cells, dispersing in blood vessels. We, therefore, studied the effect of shear flow on circulating CRC cells in the present study. The CRC cell line SW620 was subjected to shear flow of 12.5 dynes/cm2 for 1 and 2 h separately. Resulting elevated caspase-9 and -3 indicated that shear flow initiated the apoptosis of SW620...
May 17, 2024: Kaohsiung Journal of Medical Sciences
https://read.qxmd.com/read/38757622/selenoi-functions-as-a-key-modulator-of-ferroptosis-pathway-in-colitis-and-colorectal-cancer
#10
JOURNAL ARTICLE
Xin Huang, Xu Yang, Mingxin Zhang, Tong Li, Kongdi Zhu, Yulan Dong, Xingen Lei, Zhengquan Yu, Cong Lv, Jiaqiang Huang
Ferroptosis plays important roles both in normal physiology and multiple human diseases. It is well known that selenoprotein named glutathione peroxidase 4 (GPX4) is a crucial regulator for ferroptosis. However, it remains unknown whether other selenoproteins responsible for the regulation of ferroptosis, particularly in gut diseases. In this study, it is observed that Selenoprotein I (Selenoi) prevents ferroptosis by maintaining ether lipids homeostasis. Specific deletion of Selenoi in intestinal epithelial cells induced the occurrence of ferroptosis, leading to impaired intestinal regeneration and compromised colonic tumor growth...
May 17, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38757452/serum-ferritin-and-risk-of-colonic-neoplasia-implications-for-the-workup-and-treatment-of-iron-deficiency
#11
REVIEW
Adam L Urback, Kylee Martens, Hannah Stowe McMurry, Anil Sharma, Caitlin Citti, Thomas G DeLoughery, Joseph J Shatzel
Iron deficiency is the most common extraintestinal sign of colonic neoplasia, including colorectal cancer (CRC) and other lower gastrointestinal pathology. Both upper endoscopy and colonoscopy is usually recommended in the work-up of patients with unexplained iron deficiency, particularly in men and postmenopausal women. As the incidence of early-onset CRC (age <50 years) rises in the United States, there is an increasing need to identify risk predictors to aid in the early detection of CRC. It remains unknown if serum ferritin (SF), and what specific threshold, can be used as a marker to stratify those at risk for CRC and other lower gastrointestinal pathology...
May 16, 2024: European Journal of Haematology
https://read.qxmd.com/read/38757413/inhibition-of-oxidative-stress-of-biancaea-sappan-l-tod-from-java
#12
JOURNAL ARTICLE
Yovita Viona Tiono, Agustinus Hadi Prasetyo, Martha P Wulanjati, Michael Wink, Agustina Dwi Retno Nurcahyanti
Increased reactive oxygen species and advanced glycation end products are often associated with human ageing and degenerative diseases. Biancaea sappan L serves as a medicinal plant and a healthy drinks ingredient in Java. However, the pharmacological investigation of the plant native to this island is still lacking in depth. In the current study, DNA barcoding using the marker gene maturase K ( matK ), evaluation of the chemical composition, total phenolic content (TPC) and antioxidant properties, antiglycation, anti-β-amyloid, anti-inflammatory, and selective cytotoxic activities were performed ...
May 17, 2024: Natural Product Research
https://read.qxmd.com/read/38757343/daunorubicin-induces-gli1%C3%A2-dependent-apoptosis-in-colorectal-cancer-cell-lines
#13
JOURNAL ARTICLE
Bo Ram Kim, Dae Yeong Kim, Na Ly Tran, Bu Gyeom Kim, Sun Il Lee, Sang Hee Kang, Byung Yook Min, Wooyoung Hur, Sang Cheul Oh
Daunorubicin, also known as daunomycin, is a DNA‑targeting anticancer drug that is used as chemotherapy, mainly for patients with leukemia. It has also been shown to have anticancer effects in monotherapy or combination therapy in solid tumors, but at present it has not been adequately studied in colorectal cancer (CRC). In the present study, from a screening using an FDA‑approved drug library, it was found that daunorubicin suppresses GLI‑dependent luciferase reporter activity. Daunorubicin also increased p53 levels, which contributed to both GLI1 suppression and apoptosis...
June 2024: International Journal of Oncology
https://read.qxmd.com/read/38757097/the-relationship-of-kras-expression-with-kras-status-prognosis-and-tumor-infiltrated-t-lymphocytes-in-colorectal-cancer
#14
JOURNAL ARTICLE
Yebohao Zhou, Ziwei Zeng, Ze Li, Lei Ruan, Hao Xie, Fujin Ye, Liang Huang, Huashan Liu, Liang Kang
BACKGROUND: The significance of Kirsten rat sarcoma viral oncogene (KRAS) mutation in colorectal cancer (CRC) is well established; yet, its association with KRAS expression and prognosis warrants further investigation. While high KRAS expression is commonly linked with poorer prognosis in other cancers, its role in CRC remains relatively understudied. OBJECTIVE: To explore the correlation between KRAS expression, KRAS status, prognosis, and tumor-infiltrating T lymphocyte density in CRC...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38757002/the-business-case-for-quality-estimating-lives-saved-and-harms-avoided-in-a-value-based-purchasing-model
#15
JOURNAL ARTICLE
Peter Amico, Elizabeth E Drye, Peter Lee, Carolee Lantigua, Dana Gelb Safran
Ever-increasing concern about the cost and burden of quality measurement and reporting raises the question: How much do patients benefit from provider arrangements that incentivize performance improvements? We used national performance data to estimate the benefits in terms of lives saved and harms avoided if US health plans improved performance on 2 widely used quality measures: blood pressure control and colorectal cancer screening. We modeled potential results both in California Marketplace plans, where a value-based purchasing initiative incentivizes improvement, and for the US population across 4 market segments (Medicare, Medicaid, Marketplace, commercial)...
May 2024: Health Aff Sch
https://read.qxmd.com/read/38756650/kras-g12c-inhibitor-combination-therapies-current-evidence-and-challenge
#16
REVIEW
Hirotaka Miyashita, Shumei Kato, David S Hong
Although KRAS G12C inhibitors have proven that KRAS is a "druggable" target of cancer, KRAS G12C inhibitor monotherapies have demonstrated limited clinical efficacy due to primary and acquired resistance mechanisms. Multiple combinations of KRAS G12C inhibitors with other targeted therapies, such as RTK, SHP2, and MEK inhibitors, have been investigated in clinical trials to overcome the resistance. They have demonstrated promising efficacy especially by combining KRAS G12C and EGFR inhibitors for KRAS G12C-mutated colorectal cancer...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38756644/efficacy-and-safety-of-trifluridine-tipiracil-plus-bevacizumab-versus-trifluridine-tipiracil-monotherapy-for-refractory-metastatic-colorectal-cancer-a-retrospective-cohort-study
#17
JOURNAL ARTICLE
Rong-Rong Li, Hui-Jun Zhou, De-Yu Zeng, Shao-Feng Jiang, Wu Liu, Petter Frühling, Zhen-Yang Liu
BACKGROUND: Several studies demonstrated trifluridine/tipiracil (TAS-102) plus bevacizumab (BEV) had better efficacy than the monotherapy of TAS-102 in refractory metastatic colorectal cancer (mCRC). However, it remains unclear whether Chinese population can benefit from this combination or not. Hence, we conducted this retrospective cohort study to compare the efficacy and safety between TAS-102 plus BEV with TAS-102 monotherapy in refractory mCRC. METHODS: This retrospective cohort study enrolled patients (any age) with refractory mCRC from Hunan Cancer Hospital...
April 30, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38756629/efficacy-and-safety-of-gemcitabine-plus-raltitrexed-or-s-1-versus-standard-third-line-therapies-in-metastatic-colorectal-cancer-a-retrospective-cohort-study
#18
JOURNAL ARTICLE
Jialong Tao, Yingtian Zhang, Yanjie Wang, Sijia Huang, Wenwen Gao, Liya Dai, Zhengyang Feng, Chenchen Jiao, Yusong Zhang
BACKGROUND: After the failure of standard first- and second-line treatments, including oxaliplatin, irinotecan, and 5-fluorouracil (5-FU) combined with targeted drugs, the currently recommended third-line regimens for metastatic colorectal cancer (mCRC) include TAS-102, regorafenib, and fruquintinib. However, these regimens have the drawbacks of mediocre efficacy, substantive side effects, and high cost. Therefore, more effective, economical regimens with fewer side effects are needed in clinical practice...
April 30, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38756628/survival-in-metastatic-microsatellite-stable-colorectal-cancer-correlated-with-tumor-mutation-burden-and-mutations-identified-by-next-generation-sequencing
#19
JOURNAL ARTICLE
Nicholas Taflin, Lyndsey Sandow, Rajat Thawani, Shangyuan Ye, Adel Kardosh, Christopher L Corless, Emerson Y Chen
BACKGROUND: Next-generation sequencing (NGS) identifies mutations and molecular abnormalities within tumors, including tumor mutation burden (TMB). If a solid tumor has high TMB, immune checkpoint inhibitors (ICIs) are approved as an option for treatment. Studies have been inconclusive regarding how effective ICI are in treating patients with colorectal cancer (CRC), and it is unclear if high TMB is a good prognostic marker for CRC. We collected data from NGS of CRC and correlated survival to both TMB and mutations of interest, as well as investigated the efficacy of ICI...
April 30, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38756626/construction-and-validation-of-a-nomogram-for-predicting-disease-free-survival-after-radical-resection-of-rectal-cancer-using-perioperative-inflammatory-indicators
#20
JOURNAL ARTICLE
Jiayi Sun, Xinzhi Zhong, Xiangqi Yin, Huimin Wu, Lei Li, Ruiling Yang
BACKGROUND: Colorectal cancer is a common digestive tract malignancy that seriously affects patients' quality of life and survival time. Surgery is the main treatment modality, but postoperative prognosis varies greatly. This study sought to explore the impact of perioperative inflammatory indicators on disease-free survival (DFS) in patients after radical resection of rectal cancer and to construct a nomogram for clinical reference. METHODS: A retrospective analysis was performed on 304 primary rectal adenocarcinoma patients who underwent laparoscopic radical resection of rectal cancer at the Affiliated Hospital of Xuzhou Medical University from May 1, 2018 to September 30, 2020...
April 30, 2024: Journal of Gastrointestinal Oncology
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