Kalyan Sreeram, Randell Seaton, Mark K Greenwald, Mandana Kamgar, Hadeel Assad, Tara Baird, Ann G Schwartz, Julie Ruterbusch, Michael S Simon
PURPOSE: Improved life expectancy has increased the likelihood for long-term complications from chemotherapy among cancer survivors. One burdensome complication is chemotherapy-induced peripheral neuropathy (CIPN). We evaluated rates of CIPN outcomes in the Detroit Research on Cancer Survivorship (ROCS) cohort. METHODS: The population included 1,034 African American (AA) survivors who received chemotherapy for breast, colorectal, lung or prostate cancer. CIPN prevalence was based on initial occurrence of worsening of self-reported pain, numbness or tingling after chemotherapy...
March 19, 2023: Cancer Causes & Control: CCC
Rafael Jiménez-Izquierdo, Rosario Morrugares, Lucía Suanes-Cobos, Alejandro Correa-Sáez, Martín Garrido-Rodríguez, Laura Cerero-Tejero, Omar M Khan, Susana de la Luna, Rocío Sancho, Marco A Calzado
FBXW7 is a member of the F-box protein family, which functions as the substrate recognition component of the SCF E3 ubiquitin ligase. FBXW7 is a main tumor suppressor due to its ability to control proteasome-mediated degradation of several oncoproteins such as c-Jun, c-Myc, Cyclin E1, mTOR, and Notch1-IC. FBXW7 inactivation in human cancers results from a somatic mutation or downregulation of its protein levels. This work describes a novel regulatory mechanism for FBXW7 dependent on the serine/threonine protein kinase DYRK2...
March 18, 2023: Cell Death & Disease
Sixue Wang, Shuangya Deng, Xiaoxin Jin, Weidong Chen, Xiaobo Wang, Haiyan Zhan, Xiaoling Fang, Jie Fu
AIMS: One of the main factors hampering the long-term prognosis of colorectal cancer (CRC) patients is distant metastasis. However, the driving factors of CRC metastasis have not been clarified at the single-cell level, which limits the in-depth study of accurate prediction and prevention of CRC metastasis to improve the prognosis. MATERIALS AND METHODS: Heterogeneities in the tumor microenvironment (TME) between metastatic and nonmetastatic CRC were investigated by single-cell RNA (scRNA) sequencing data...
March 16, 2023: Life Sciences
Youli Chen, Tianhui Chen, Jing-Yuan Fang
Although gastrointestinal (GI) cancers pose a great challenge to public health, data are scant for understanding the burden of GI cancers in China. We aimed to provide an updated estimate of the burden of major GI cancers in China over three decades. According to the GLOBOCAN 2020 database, 1,922,362 GI cancer cases were newly diagnosed and 1,497,388 deaths occurred in China in 2020, with the highest incidence in colorectal cancer (555,480 new cases; 23.90/100,000 age-standardized incidence rate [ASIR]) and the highest mortality in liver cancer (391,150 deaths; 17...
March 16, 2023: Cancer Letters
Dmitri Mouradov, Paul Greenfield, Shan Li, Eun-Jung In, Claire Storey, Anuratha Sakthianandeswaren, Peter Georgeson, Daniel D Buchanan, Robyn L Ward, Nicholas J Hawkins, Iain Skinner, Ian T Jones, Peter Gibbs, Chenkai Ma, Yi Jin Liew, Kim Y C Fung, Oliver M Sieber
BACKGROUND & AIMS: Dysbiosis of gut microbiota is linked to the development of colorectal cancer (CRC). However, microbiota-based stratification of CRC tissue and how this relates to clinico-molecular characteristics and prognosis remains to be clarified. METHODS: Tumour and normal mucosa from 423 stage I-IV patients were profiled by bacterial 16S rRNA gene sequencing. Tumours were characterised for microsatellite instability (MSI), CpG island methylator phenotype (CIMP), APC, BRAF, KRAS, PIK3CA, FBXW7, SMAD4 and TP53 mutations; subsets for chromosome instability (CIN), mutation signatures and consensus molecular subtypes (CMS)...
March 16, 2023: Gastroenterology
Hao-Lu Sun, Qiu-Ying Ma, He-Ge Bian, Xiao-Ming Meng, Juan Jin
The gastrin-releasing peptide receptor (GRPR), a member of the G protein-coupled receptors (GPCRs), binds to ligands such as gastrin-releasing peptide (GRP) and plays a variety of biological roles. GRP/GRPR signalling is involved in the pathophysiological processes of many diseases, including inflammatory diseases, cardiovascular diseases, neurological diseases, and various cancers. In the immune system, the unique function of GRP/GRPR in neutrophil chemotaxis suggests that GRPR can be directly stimulated through GRP-mediated neutrophils to activate selective signalling pathways, such as PI3K, PKC, and MAPK, and participate in the occurrence and development of inflammation-related diseases...
March 16, 2023: Biomedicine & Pharmacotherapy
Pedja Cuk, Randi Maria Simonsen, Selab Sherzai, Thomas Buchbjerg, Per Vadgaard Andersen, Søren Salomon, Pia Iben Pietersen, Sören Möller, Issam Al-Najami, Mark Bremholm Ellebaek
BACKGROUND: There is a potential benefit on long-term outcomes following complete mesocolic excision (CME) for right-sided colon cancer when compared to conventional colectomy. This study aims to analyze the learning curve and short-term outcomes of laparoscopic CME with intracorporeal anastomosis (ICA) for right-sided colon cancer in the hands of experienced colorectal surgeons. METHODS: A two-center cohort study of consecutive patients undergoing right-sided colectomy from September 2021 to May 2022 at two tertiary colorectal centers in Denmark...
March 18, 2023: Journal of Surgical Oncology
Nasir Zaheer Ahmad, Muhammad Azam, Candice Neezeth Fraser, John Calvin Coffey
BACKGROUND: Methylene blue staining of the resected specimen has been described as an alternative to the conventional palpation and visual inspection method to improve lymph node harvest. This meta-analysis evaluates the usefulness of this technique in surgery for rectal cancer, particularly after neoadjuvant therapy. METHODS: Randomized controlled trials (RCTs) comparing lymph node harvest in methylene blue-stained rectal specimens to those of unstained specimens were identified from the Medline, Embase, and Cochrane databases...
March 18, 2023: Techniques in Coloproctology
Wei Wei, Juanhong Wang, Pu Huang, Siqi Gou, Daihua Yu, Lei Zong
Tumor necrosis factor-alpha (TNF-α) is a potent pro-inflammatory factor that plays an important role in establishing a complicated connection between inflammation and cancer. TNF-α promotes tumor proliferation, migration, invasion, and angiogenesis according to numerous studies. Studies have shown the significant role of STAT3, a downstream transcription factor of another important inflammatory cytokine, IL-6 in the development and progression of different tumors especially colorectal cancer. In the present study, we investigated whether TNF-α has a role in proliferation and apoptosis of colorectal cancer cells through STAT3 activation...
March 18, 2023: Immunogenetics
Nadiah Abu, Nurul Ainaa Adilah Rus Bakarurraini, Siti Nurmi Nasir, Muhiddin Ishak, Rashidah Baharuddin, Rahman Jamal, Nurul Syakima Ab Mutalib
Background: Cancer testis antigens (CTAs) are a class of immune-stimulating antigens often overexpressed in many types of cancers. The usage of the CTAs as immunotherapy targets have been widely investigated in different cancers including melanoma, hematological malignancies, and colorectal cancer. Studies have indicated that the epigenetic regulation of the CTAs such as the methylation status may affect the expression of the CTAs. However, the report on the methylation status of the CTAs is conflicting. The general methylation profile of the CTAs, especially in colorectal cancer, is still elusive...
March 14, 2023: Iranian Journal of Immunology: IJI
Muhammad Musaab Munir, Selamawit Woldesenbet, Laura Alaimo, Zorays Moazzam, Henrique A Lima, Yutaka Endo, Joal Beane, Alex Kim, Mary Dillhoff, Jordan Cloyd, Aslam Ejaz, Timothy M Pawlik
BACKGROUND: Area-level social determinants of health (SDoH) impact access to cancer care and prevention. Little is known about the factors that underlie the impact of residential privilege on county-level cancer screening uptake. METHODS: Population-based cross-sectional study examining county-level data was obtained from the Centers for Disease Control and Prevention's PLACES database, American Community Survey and the County Health Rankings and Roadmap database...
March 18, 2023: Journal of Surgical Oncology
Mufaddal Kazi, Suman Ankathi, Avanish Saklani
No abstract text is available yet for this article.
March 18, 2023: Colorectal Disease
Yuichiro Tsukada, Eric Rullier, Takuya Shiraishi, Maylis Capdepont, Takeshi Sasaki, Bertrand Celerier, Quentin Denost, Masaaki Ito
AIM: The standard strategy for clinical T3 rectal cancer without enlarged lateral lymph nodes is preoperative chemoradiotherapy (CRT) followed by total mesorectal excision (TME) in Western countries and TME with bilateral lateral pelvic lymph node dissection (LPLND) in Japan. This study compared surgical, pathological and oncological results of these two strategies. METHOD: Patients who underwent preoperative CRT followed by TME in France (CRT + TME group) and those who underwent TME with LPLND in Japan (TME + LPLND group) for clinical T3 rectal adenocarcinoma without enlarged lateral lymph nodes from 2010 to 2016 were retrospectively analysed...
March 18, 2023: Colorectal Disease
Mo Liu, Shi-Jun Liu, Ming-Jun Chen, Tingting Ning
BACKGROUND: To develop a new modality of colorectal cancer screening based on chronic disease management (CDM) to improve the participation rate of screening, and maximize the benefits of limited resources. METHODS: Patients under CDM were assigned to screening intervention group (SI) and screening control group1 (SC1), residents from natural community were assigned to screening control group2 (SC2). A parallel controlled community intervention study was performed...
March 17, 2023: BMC Gastroenterology
Atsuko Deguchi, Miho Watanabe-Takahashi, Taishi Mishima, Tsutomu Omori, Umeharu Ohto, Nobuto Arashiki, Fumio Nakamura, Kiyotaka Nishikawa, Yoshiro Maru
The tumor-elicited inflammation is closely related to tumor microenvironment during tumor progression. S100A8, an endogenous ligand of Toll-like receptor 4 (TLR4), is known as a key molecule in the tumor microenvironment and premetastatic niche formation. We firstly generated a novel multivalent S100A8 competitive inhibitory peptide (divalent peptide3A5) against TLR4/MD-2, using the alanine scanning. Divalent peptide3A5 suppressed S100A8-mediated interleukin-8 and vascular endothelial growth factor production in human colorectal tumor SW480 cells...
March 17, 2023: Cancer Gene Therapy
Yichao Liang, Di Wu, Qiao Qu, Zhilong Li, Hongzhuan Yin
MORC family CW-type zinc finger 4 (MORC4) possessing nuclear matrix binding domains has been observed to be involved in multiple cancer development. By digging three gene expression omnibus (GEO) gene microarrays (GSE110223, GSE110224 and GSE24514), we found that MORC4 was overexpressed in colorectal cancer (CRC) samples (log2 Fold change >1, p < 0.05). We aimed to investigate the role of MORC4 in CRC malignant behaviors, with an emphasis on polycomb group ring finger 1 (PCGF1)/cyclin-dependent kinase inhibitor 1A (CDKN1A) axis...
March 17, 2023: Cancer Gene Therapy
Harry Frederick Dean, Emily Britton, Emily Farrow, Sameerah Abdel-Khaleq, Natasha Lakin, Molly Bradbury, Tim Cook
BACKGROUND: Acute diverticulitis (AD) is a common cause of presentation to emergency surgical services. Follow-up with endoluminal investigation to exclude colorectal cancer (CRC) remains controversial. Guidelines are increasingly moving to a more restrictive follow-up based on severity of disease and age. The purpose of this observational study was to assess the prevalence of CRC in AD patients and the impact of follow-up on endoscopy services. METHODS: Patients admitted with a diagnosis of AD over a 2-year period were reviewed...
March 17, 2023: Surgical Endoscopy
Shuen-Ern Chin, Fang-Ting Wan, Jasmine Ladlad, Koy-Min Chue, Eng-Kiong Teo, Cui-Li Lin, Fung-Joon Foo, Frederick H Koh
BACKGROUND: Colonoscopies have long been the gold standard for detection of pre-malignant neoplastic lesions of the colon. Our previous study tried real-time artificial intelligence (AI)-aided colonoscopy over a three-month period and found significant improvements in collective and individual endoscopist's adenoma detection rates compared to baseline. As an expansion, this study evaluates the 1-year performance of AI-aided colonoscopy in the same institution. METHODS: A prospective cohort study was conducted in a single institution in Singapore...
March 17, 2023: Surgical Endoscopy
Xin Liu, Yi Fang, Xinting Lv, Chenghong Hu, Guorong Chen, Lingxi Zhang, Bo Jin, Lijiang Huang, Wu Luo, Guang Liang, Yi Wang
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, which has been shown to increase the incidence of colorectal cancer. Recent studies have highlighted the role of ubiquitination, a post-translational modification, in the occurrence and development of colonic inflammation. Ovarian tumor deubiquitinase 6 A (OTUD6A) is a deubiquitinating enzyme, which regulates cell proliferation and tumorigenesis. In this study, we investigated the expression and role of OTUD6A in IBD...
March 17, 2023: Cell Death and Differentiation
Ce Tang, Haiyang Sun, Motohiko Kadoki, Wei Han, Xiaoqi Ye, Yulia Makusheva, Jianping Deng, Bingbing Feng, Ding Qiu, Ying Tan, Xinying Wang, Zehao Guo, Chanyan Huang, Sui Peng, Minhu Chen, Yoshiyuki Adachi, Naohito Ohno, Sergio Trombetta, Yoichiro Iwakura
Dectin-1 (gene Clec7a), a receptor for β-glucans, plays important roles in the host defense against fungi and immune homeostasis of the intestine. Although this molecule is also suggested to be involved in the regulation of tumorigenesis, the role in intestinal tumor development remains to be elucidated. In this study, we find that azoxymethane-dextran-sodium-sulfate-induced and ApcMin -induced intestinal tumorigenesis are suppressed in Clec7a-/- mice independently from commensal microbiota. Dectin-1 is preferentially expressed on myeloid-derived suppressor cells (MDSCs)...
March 17, 2023: Nature Communications
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