Rocío Navarro, Antonio Tapia-Galisteo, Laura Martín-García, Carlos Tarín, Cesáreo Corbacho, Gonzalo Gómez-López, Esther Sánchez-Tirado, Susana Campuzano, Araceli González-Cortés, Paloma Yáñez-Sedeño, Marta Compte, Luis Álvarez-Vallina, Laura Sanz
The crosstalk between cancer cells and the tumor microenvironment has been implicated in cancer progression and metastasis. Fibroblasts and immune cells are widely known to be attracted to and modified by cancer cells. However, the role of pericytes in the tumor microenvironment beyond endothelium stabilization is poorly understood. Here, we report that pericytes promoted colorectal cancer (CRC) cell proliferation, migration, invasion, stemness and chemoresistance in vitro, as well as tumor growth in a xenograft CRC model...
August 7, 2020: Molecular Oncology
Mazen Hasan, Sreedhar M Reddy, Nupur K Das
Ferritinophagy is a form of selective autophagy responsible for degrading intracellular ferritin, mediated by nuclear receptor coactivator 4 (NCOA4). NCOA4 plays significant roles in systemic iron homeostasis, and its disruption leads to simultaneous anemia and susceptibility to iron overload. The importance of iron colorectal cancer pathogenesis is well studied, however the role of ferritinophagy in colon cancer cell growth has not been assessed. Disruption of ferritinophagy via NCOA4 knockout leads to only marginal differences in growth under basal and iron-restricted conditions...
August 7, 2020: Cell Biology International
Jammbe Z Musoro, Samantha C Sodergren, Corneel Coens, Alessia Pochesci, Mitsumi Terada, Madeleine T King, Mirjam Ag Sprangers, Mogens Groenvold, Kim Cocks, Galina Velikova, Hans-Henning Flechtner, Andrew Bottomley
BACKGROUND: The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) assesses health related quality of life of patients in cancer trials. There are currently no minimally important difference (MID) guidelines for the EORTC QLQ-C30 for colorectal cancer (CRC). METHODS: The data were obtained from three published EORTC trials that treated CRC patients using chemotherapy. Potential anchors were selected from clinical variables based on their correlation with EORTC QLQ-C30 scales...
August 7, 2020: Colorectal Disease
Nancy N Baxter, Rinku Sutradhar, Fahima Dossa, Longdi Fu, Paula Rochon, Alice C Wei, Erin D Kennedy, Craig C Earle
AIM: In patients with incurable metastatic colorectal cancer (mCRC), primary tumour resection is debated; however, patients with intact primaries may be at higher risk of complications requiring surgery when receiving treatment with bevacizumab. We estimated the risk of non-elective colorectal surgery in patients undergoing bevacizumab therapy for mCRC and evaluated the association between intact primary tumours and risk of non-elective surgery METHODS: We designed a population-based, retrospective cohort study using administrative and cancer registry data in Ontario, Canada...
August 7, 2020: Colorectal Disease
B Zhou, F Yi, Y Chen, C-H Li, Y-S Cheng, K Yang
OBJECTIVE: We aimed at investigating the expression of Long non-coding RNA (LncRNA) PGM5-AS1 and its facilitating effects on proliferation and invasion of colorectal cancer by sponging miR-100-5p. PATIENTS AND METHODS: qRT-PCR was performed to detect the expressions of PGM5-AS1 and SMAD4 in human colorectal cancer tissues and cells. CCK-8 assay was performed to evaluate the SW403 cells proliferation and transwell assay was performed to evaluate the SW403 cells migration...
August 2020: European Review for Medical and Pharmacological Sciences
J Dai, Y Zhuang, M Tang, Q Qian, J-P Chen
OBJECTIVE: The aim of this study is to explore the regulatory mechanism of circRNA UBAP2 (circUBAP2) in colorectal cancer (CRC). PATIENTS AND METHODS: The expression levels of circUBAP2, miR-199a, and VEGFA in tissues and cell lines were detected by RT-qPCR. The cell proliferation was examined by CCK-8 and colony formation assays. The migration and invasion abilities were evaluated by wound healing and transwell assays, respectively. Bioinformatics analysis and Luciferase activity assay were applied to determine the interaction between genes...
August 2020: European Review for Medical and Pharmacological Sciences
Z-G Gu, G-H Shen, J-H Lang, W-X Huang, Z-H Qian, J Qiu
The article "Effects of long non-coding RNA URHC on proliferation, apoptosis and invasion of colorectal cancer cells, by Z.-G. Gu, G.-H. Shen, J.-H. Lang, W.-X. Huang, Z.-H. Qian, J. Qiu, published in Eur Rev Med Pharmacol Sci 2018; 22 (6): 1658-1664-DOI: 10.26355/eurrev_201803_14577-PMID: 29630109" has been withdrawn from the authors. The Publisher apologizes for any inconvenience this may cause.
August 2020: European Review for Medical and Pharmacological Sciences
Xiao-Yu Zhou, Bing Luo, Ze-Kun Jiang, Ying-Kang Xie, Feng-Cong Wu, Jiong-Qiang Huang, Jing-Song Chen
More than 50% of colorectal cancer (CRC) deaths are attributed to metastasis, and the liver is the most common distant metastatic site of CRC. The molecular mechanisms underlying CRC liver metastasis are very complicated and remain largely unknown. Accumulated evidence has shown that non-coding RNAs (NcRNAs) play critical roles in tumor development and progression. Here we reviewed the roles and underlying mechanisms of NcRNAs in CRC liver metastasis.
August 7, 2020: Molecular and Cellular Biochemistry
Samira Negrichi, Salima Taleb
Colorectal carcinoma (CRC) is the second most common cancer diagnosed in Algeria. The incidence and the mortality rate of CRC have increased so that the nation now ranks third in Africa in both these variables. Many environmental and genetic factors are suspected to play an important role in the development of the disease. This study aimed to identify the risk factors for CRC in Algeria. We performed a case-control study in five Medical Oncology Services in this region: Tebessa, Batna, Annaba, Setif, and Constantine, from 2016 to 2019...
August 7, 2020: Environmental Science and Pollution Research International
Susanne Klein-Scory, Ingo Wahner, Marina Maslova, Yosef Al-Sewaidi, Michael Pohl, Thomas Mika, Swetlana Ladigan, Roland Schroers, Alexander Baraniskin
Treatment options for patients with metastatic colorectal cancer (mCRC) are limited. This particularly affects the largest group of patients with RAS mutations, who are considered ineligible for therapy with antiEGFR antibodies. In this liquid biopsy-based study, we performed the first in-depth analysis of the RAS mutational status in initially RAS-mutated patients during first-line therapy. RAS status of twelve patients with initially RAS-mutated mCRC was monitored longitudinally in 69 liquid biopsy samples...
2020: Frontiers in Oncology
Mahboubeh Enteghami, Mahsa Ghorbani, Mina Zamani, Hamid Galehdari
Colorectal cancer (CRC) is one of the most common types of cancer in world and has a high rate of mortality. The majority of cases of CRC are sporadic; however, factors such as age, a family history of inflammatory diseases, diet, lifestyle and genetics increase the risk. HOX genes and lncRNAs are two classes of genes, and alterations in the expression levels of these genes are significantly associated with numerous different types of cancer. In the present study, the expression levels of HOXC10 , HOXC-AS3 , HOTAIR , HOXC13 and HOXC13-AS in tumor tissues were compared with normal healthy tissues in patients with CRC...
September 2020: Biomedical Reports
Tingrui Ge, Ping Xiang, Haibing Mao, Shumin Tang, Jinyi Zhou, Yonggang Zhang
Colorectal cancer (CRC) is one of the major threats to human health worldwide. In the treatment of CRC, chemoresistance affects the efficacy of platinum-based therapies. Oxaliplatin is one of the most commonly used first-line medications for the treatment of CRC; however, chemoresistance is common among patients receiving oxaliplatin treatment, which significantly decreases its therapeutic efficacy. The present study focused on the roles of microRNA (miR)-96 in the oxaliplatin resistance of CRC cells and the underlying mechanisms...
September 2020: Experimental and Therapeutic Medicine
Sofy Permana, Reyudzky Putri Fityanti, Eviana Norahmawati, Agustin Iskandar, Erika Desy Anggraini Mulyadi, Agustina Tri Endharti
Ulcerative colitis is a major risk factor that increases the occurrence of colorectal cancer. In colorectal cancer due to colitis, intestinal inflammation plays an important role which causes DNA damage. The aim of this study is to investigate the anticancer effect of coelomic fluid of Eisenia fetida (CFEF) and cetuximab combinations. Colitis associated colon cancer was induced in BALB/c mice by DSS/AOM. The mice were randomly divided into six groups: group 1 received vehicle (control), groups 2-6 received DSS/AOM, groups 3-5 received cetuximab + CFEF (30, 60, or 120 mg/kgBW), and group 6 received CFEF only...
2020: Evidence-based Complementary and Alternative Medicine: ECAM
Eduardo Orrego-González, Luisa Londoño-Tobón, José Ardila-González, Diego Polania-Tovar, Ana Valencia-Cárdenas, Alberto Velez-Van Meerbeke
Objective: Colorectal cancer represents a heavy burden for health systems worldwide, being the third most common cancer worldwide. Despite the breakthroughs in medicine, current chemotherapeutic options continue to have important side effects and may not be effective in preventing disease progression. Cannabinoids might be substances with possible therapeutic potential for cancer because they can attenuate the side effects of chemotherapy and have antiproliferative and antimetastatic effects...
2020: Evidence-based Complementary and Alternative Medicine: ECAM
Di-Er Sun, Shu-Yuan Ye
Despite numerous advances in cancer treatment, the global prevalence and cancer-related mortality remain high. Understanding tumor initiation and progression mechanisms are critical as it will lead to the development of interventions for improving the prognosis of cancer patients. The roles of long noncoding RNAs (lncRNAs) in cancer have attracted immense research interest. Growing evidence indicates that lncRNA regulator of reprogramming (linc-ROR), a well-studied RNA, regulates the progression of various cancers, such as lung cancer (LC), hepatocellular carcinoma (HCC), breast cancer (BC), colorectal cancer (CRC), pancreatic cancer (PC), papillary thyroid carcinoma (PTC), or esophageal squamous cell carcinoma (ESCC)...
2020: Cancer Management and Research
Yongkang An, Shuangxi Zhang, Jing Zhang, Qing Yin, Haitao Han, Fang Wu, Xiangan Zhang
Background: NLIPMT, as a tumor suppressive lncRNA, has only been investigated in breast cancer, while its roles in other types of cancer remain unknown. This study aimed to explore the role of NLIPMT in colorectal cancer (CRC). Methods: Expression levels of NLIPMT and TGF-β1 in two types of CRC tissue (Non-tumor tissues and tumor tissues) were measured and compared by qRT-PCR and paired t -test, respectively. Correlations between the expression of NLIPMT and TGF-β1 were analyzed by performing linear regression...
2020: Cancer Management and Research
Marissa Lam, Caroline Lum, Sarah Latham, Sam Tipping Smith, Hans Prenen, Eva Segelov
Despite advances, patients with metastatic colorectal cancer (mCRC) still have poor long-term survival. Identification of molecular subtypes is important to guide therapy through standard treatment pathways and holds promise for the development of new treatments. Following standard first- and second-line chemotherapy plus targeted agents, many patients retain a reasonable performance status, and thus are seeking further effective treatment to extend life and maintain symptom control. The challenge lies in selecting the most appropriate therapy in the third- and fourth-line settings, from a range of options including the relatively new oral agents TAS-102 and regorafenib, or rechallenge with previous chemotherapy or anti-epidermal growth factor receptor (anti-EGFR) monoclonal antibodies (mAB)...
2020: Cancer Management and Research
Lijuan Yin, Jinhua Li
Purpose: Central venous catheters (CVCs) have been demonstrated as a feasible method for chemotherapy delivery in colorectal cancer patients. The objective of our study was to explore the preference of colorectal cancer patients (89%) in our institution for port catheters (PCs) through comparing the costs and complications between peripherally inserted central venous catheters (PICCs) and PCs. Methods: Overall, 777 colorectal cancer patients (89%) were eligible for central venous catheter (CVC) insertions from January 1, 2017, to January 1, 2019...
2020: Cancer Management and Research
Liang Wang, Jun Yang, Jian Huang, Zheng-Qi Wen, Ning Xu, Xuan Liu, Jian-Hua Zhang, Wen-Liang Li
Objective: Colorectal cancer (CRC) is one of the most common malignant tumors in the digestive tract, which accounts for 10% of all the malignant tumors in the world. The aim of this study was to identify key genes and miRNAs in CRC diagnosis, prognosis, and therapy and to further explore the potential molecular mechanisms of CRC. Methods: The infiltration and metastasis of neutrophils in primary colorectal cancer tissue and paracancerous tissue were observed by immunohistochemical staining...
2020: Cancer Management and Research
Tianyu Yu, Lingling Tong, Yu Ao, Genmao Zhang, Yunpeng Liu, Hejia Zhang
Background: Thyroid cancer is a very common endocrine cancer worldwide. How long noncoding RNA (lncRNA) regulates thyroid cancer is elusive. LncRNA MFI2-AS1 has been demonstrated to initiate colorectal cancer. Nevertheless, the role of MFI2-AS1 in thyroid cancer remains unknown. This study aims to determine the roles of MFI2-AS1 in thyroid cancer. Methods: qRT-PCR was used to determine the expression of MFI2-AS1 in thyroid cancer tissues and cells. Proliferation was determined by using CCK8 and colony formation assays...
2020: OncoTargets and Therapy
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