Yam Prasad Aryal, Sanjiv Neupane, Tae-Young Kim, Eui-Seon Lee, Nitin Kumar Pokhrel, Chang-Yeol Yeon, Ji-Youn Kim, Chang-Hyeon An, Seo-Young An, Eui-Kyun Park, Jung-Hong Ha, Jae-Kwang Jung, Hitoshi Yamamoto, Sung-Won Cho, Sanggyu Lee, Do-Yeon Kim, Tae-Yub Kwon, Youngkyun Lee, Wern-Joo Sohn, Jae-Young Kim
FUSE binding protein 1 ( Fubp1 ), a regulator of the c-Myc transcription factor and a DNA/RNA-binding protein, plays important roles in the regulation of gene transcription and cellular physiology. In this study, to reveal the precise developmental function of Fubp1 , we examined the detailed expression pattern and developmental function of Fubp1 during tooth morphogenesis by RT-qPCR, in situ hybridization, and knock-down study using in vitro organ cultivation methods. In embryogenesis, Fubp1 is obviously expressed in the enamel organ and condensed mesenchyme, known to be important for proper tooth formation...
October 29, 2020: International Journal of Molecular Sciences