Zhaleh Mohsenifar, Samira Behrad, Fatemeh Mashhadi Abbas
BACKGROUND Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumor with a mesenchymal component, showing sarcomatous features and epithelial nests resembling ameloblastic fibroma (AF). CASE REPORT We report a case of AFS showing epithelial dysplasia arising in a recurrent AF in the left mandible after 3 years in a 26-year-old man, which is regarded as an uncommon histopathologic finding in AFS. We also emphasize the comprehensive clinical, radiographic, and histopathologic evaluation, and immunohistochemical staining of this patient...
2015: American Journal of Case Reports
Fereydoun Pourdanesh, Mansoureh Mohamadi, Mohammad Moshref, Omid Soltaninia
Ameloblastic fibrosarcoma is a mixed odontogenic tumor that can originate de novo or from a transformed ameloblastic fibroma. This report describes the case of a 34-year-old woman with a recurrent, rapidly growing, debilitating lesion. This lesion appeared as a large painful mandibular swelling that filled the oral cavity and extended to the infratemporal fossa. The lesion had been previously misdiagnosed as ameloblastoma. Twenty months after final surgery and postoperative chemotherapy, lung metastases were diagnosed after she reported respiratory signs and symptoms...
October 2015: Journal of Oral and Maxillofacial Surgery
Susanne A Gatz, Khin Thway, Henry Mandeville, Cyrus Kerawala, David MacVicar, Julia Chisholm
Ameloblastic fibro-odontosarcoma (AFOS) is an extremely rare malignant odontogenic tumor. Complete surgical excision is the treatment of choice. Deaths due to disease recurrence and/or progression are documented. Here, we report the case of a 15-year-old female with multiple recurrent AFOS. She responded to chemotherapy with ifosfamide and doxorubicin consolidated by stereotactic reirradiation using cyberknife and remained in complete remission 14 months from the end of reirradiation therapy. Chemotherapy with ifosfamide and doxorubicin should be considered in advanced cases of AFOS...
November 2015: Pediatric Blood & Cancer
Il-Kyu Kim, Sang-Pill Pae, Hyun-Young Cho, Hyun-Woo Cho, Ji-Hoon Seo, Dong-Hwan Lee, In-Shu Park
Odontogenic carcinosarcoma is an extremely rare malignant odontogenic tumor with only a few reported cases. It is characterized by a true mixed tumor showing malignant cytology of both epithelial and mesenchymal components. It has been assumed to arise from pre-existing lesions such as ameloblastoma, ameloblastic fibroma, and ameloblastic fibrosarcoma. To date, the reported cases have exhibited considerably aggressive clinical behavior. The case of an odontogenic carcinosarcoma in the mandible of a 61-year-old male is described herein...
June 2015: Journal of the Korean Association of Oral and Maxillofacial Surgeons
Al Haitham Al Shetawi, Erin H Alpert, Daniel Buchbinder, Mark L Urken
Odontogenic sarcomas and their subtypes are very rare tumors. The authors' objectives were to report an additional case of ameloblastic fibrosarcoma, review the clinicopathologic features, discuss their treatment approach, and complete a thorough review of the literature.
August 2015: Journal of Oral and Maxillofacial Surgery
Sílvia F Sousa, Ricardo S Gomez, Marina G Diniz, Vanessa F Bernardes, Flávia F C Soares, João Artur R Brito, Sophie Liu, Hélder Antônio R Pontes, Constantine A Stratakis, Carolina C Gomes
The surgical treatment of some odontogenic tumors often leads to tooth and maxillary bone loss as well as to facial deformity. Therefore, the identification of genes involved in the pathogenesis of odontogenic tumors may result in alternative molecular therapies. The PRKAR1A gene displays a loss of protein expression as well as somatic mutations in odontogenic myxomas, an odontogenic ectomesenchymal neoplasm. We used a combination of quantitative RT-PCR (qRT-PCR), immunohistochemistry, loss of heterozygosity (LOH) analysis, and direct sequencing of all PRKAR1A exons to assess if this gene is altered in mixed odontogenic tumors...
June 2015: Endocrine-related Cancer
Abelardo Loya-Solis, Karla Judith González-Colunga, Cynthia M Pérez-Rodríguez, Natalie Sofía Ramírez-Ochoa, Luis Ceceñas-Falcón, Oralia Barboza-Quintana
Ameloblastic fibrosarcoma is an uncommon odontogenic tumor composed of a benign epithelial component and a malignant ectomesenchymal component most frequently seen in the third and fourth decades of life. It mainly presents as a painful maxillary or mandibular swelling. Radiographs show a radiolucent mass with ill-defined borders. Radical surgical excision and long-term follow-up are the suggested treatment. We report the case of a 22-year-old female with a 2-month history of an asymptomatic swelling in her left mandible...
2015: Case Reports in Pathology
Yuan-Yuan Hu, Mo-Hong Deng, Ling-Ling Yuan, Yu-Ming Niu
Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic neoplasm of the jaw. AFS is characteristically composed of a benign odontogenic epithelium and a malignant mesenchymal component. The posterior region of the mandible is the predominantly occupied site. In the present report, a new case of AFS in a 22-year-old male that originated from ameloblastic fibroma was described. Histologically, the tumor showed biphasic components: Benign epithelium and a malignant mesenchymal component. Immunochemical findings revealed that the tumor cells were positive for cluster of differentiation (CD) 34, vimentin, Ki-67 and p53, but negative for smooth muscle actin, S-100, CD68 and desmin...
November 2014: Experimental and Therapeutic Medicine
C J Nortjé
No abstract text is available yet for this article.
April 2014: SADJ: Journal of the South African Dental Association
Michel Wassef
No abstract text is available yet for this article.
June 2014: Annales de Pathologie
Akindayo O Akinyamoju, Adeola A Olusanya, Bukola F Adeyemi, B Kolude
Ameloblastic fibrosarcoma (AFS) is a rare odontogenic malignancy with benign epithelial and malignant ectomesenchymal components. About 66 cases have been reported in the medical literature. We therefore report an additional case as well as a review of literature to add to the existing knowledge on this rare lesion.
September 2013: Journal of Oral and Maxillofacial Pathology: JOMFP
Maryam Khalili, Pouyan Amini Shakib
Ameloblastic fibrosarcoma (AFS) is a rare malignant mixed odontogenic tumor which is usually considered as the malignant counterpart of ameloblastic fibroma. Only mesenchymal component represents sarcomatous alterations and ameloblast-like epithelial nest remains bland in AFS. Here, we report a case of AFS in a 26-year-old man in the maxilla, which was regarded as an uncommon location for this tumor. After 2 years follow up, no evidence of recurrence was noted. We also emphasize on comprehensive clinical, radiographic, and histopathologic evaluation of such patients rather than immunohistochemical staining to make an accurate diagnosis...
January 2013: Dental Research Journal
S M Gilani, A Raza, B M Al-Khafaji
INTRODUCTION: Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumor. It can arise de novo, however one-third of cases may arise from a recurrent ameloblastic fibroma, in which case they appear to present at an older age. CASE REPORT: A 16-year-old female presented with one month history of right mandibular mass. Computerized tomography (CT) scan showed a large destructive mass. A biopsy of the mass was performed. Histologically, it consisted of a mixed epithelial-mesenchymal odontogenic neoplasm composed of benign islands of well-differentiated ameloblastic epithelium within a malignant fibrous stroma consisting of spindle cells or fibroblasts with a brisk mitotic activity...
February 2014: European Annals of Otorhinolaryngology, Head and Neck Diseases
Ravikumar S Kulkarni, Amitabh Sarkar, Sandeep Goyal
Ameloblastic fibroma (AF) is an uncommon mixed neoplasm of odontogenic origin frequently seen in the second decade of life. It mainly presents as an intrabony lesion but can even occur peripherally. Histologically, our case showed hypercellular areas, an uncommon feature seen in typical AF. Whether this benign lesion is treated by mode of enucleation and curettage or by extensive surgery is still a topic of debate. An extensive surgical treatment is suggested as the initial approach due to its high recurrence rate (18%) and the greater chances of recurrent AFs transforming into ameloblastic fibrosarcoma (45%), together with a long-term followup...
2013: Case Reports in Dentistry
M Martínez Martínez, A Mosqueda-Taylor, R Carlos, W Delgado-Azañero, O P de Almeida
OBJECTIVE: The aim of this study was to show the epidemiological features of 25 malignant odontogenic tumors (MOT) in Latin America. MATERIALS AND METHODS: We retrieved 25 cases of MOT out of 2142 odontogenic tumors, from four oral diagnostic centers in Latin America, and described the main clinical and pathological characteristics. RESULTS: A total of 19 cases were carcinomas, including eight ameloblastic carcinomas, five primary intra-osseous squamous cell carcinomas, three clear cell odontogenic carcinomas and three ghost cell odontogenic carcinomas...
May 2014: Oral Diseases
Esther Manor, Elena Kan, Lipa Bodner
Background. Ameloblastic fibroodontoma (AFO) is a rare mixed odontogenic tumor with epithelial and mesenchymal components. AFO presents as a painless swelling in the mandible or maxilla. Radiographs show a well-defined radiolucent area containing various amounts of radiopaque material of irregular size and form. The common treatment is enucleation. It is not an aggressive tumor but recurrence and malignant transformation are possible. Methods. An AFO of the mandible of a 3-year-old female is reported. Panoramic radiograph and CT scan revealed a unilocular lesion with radiopaque center and radiolucent margins...
2012: Case Reports in Dentistry
Girish B Giraddi, Vipul Garg
Ameloblastic fibroma and related lesions constitute a group of lesions, which range in biologic behaviour from true neoplasms to hamartomas. This group of lesions is also sometimes referred to as mixed odontogenic tumors and usually includes ameloblastic fibroma, ameloblastic fibrodentinoma and ameloblastic fibro-odontoma. Despite numerous efforts however, there is still considerable confusion concerning the nature and interrelationship of these mixed odontogenic tumors and related lesions. The malignant counterpart of these lesions namely aameloblastic fibrosarcoma, ameloblastic dentinosarcoma and ameloblastic odontosarcoma respectively are said to arise secondarily in their benign counterpart or de novo...
January 2012: Contemporary Clinical Dentistry
Roseanna Noordhoek, Marvin E Pizer, Daniel M Laskin
No abstract text is available yet for this article.
December 2012: Journal of Oral and Maxillofacial Surgery
Jonathan Lai, Nick Blanas, Kevin Higgins, Hagen Klieb
No abstract text is available yet for this article.
August 2012: Journal of Oral and Maxillofacial Surgery
Clarice F Galvão, Carolina C Gomes, Marina G Diniz, Pablo A Vargas, Alfredo M B de Paula, Adalberto Mosqueda-Taylor, Adriano M Loyola, Ricardo S Gomez
Although molecular alterations are reported in different types of odontogenic tumours, their pathogenesis remains to be established. Loss of heterozygosity (LOH) studies allow the identification of minimal regions of deletions of known or putative tumour suppressor genes, the losses of which may promote neoplastic growth. The purpose of this study was to investigate LOH in a set of odontogenic mixed tumours. Tumour suppressor gene loci on 3p, 9p, 11p, 11q and 17p chromosomes were analysed in five samples of ameloblastic fibroma (AF), three samples of ameloblastic fibro-odontoma (AFO) and three samples of ameloblastic fibrosarcoma (AFS)...
May 2012: Journal of Oral Pathology & Medicine
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