Marko Kavčič, Aida Zečkanović, Janez Jazbec, Marusa Debeljak
No abstract text is available yet for this article.
November 2020: Klinische Pädiatrie
Paolo Marchetti, Andrea Botticelli, Antonio Paolo Ascierto, Giuseppe Curigliano, Diana Giannarelli
BACKGROUND: Ipilimumab and Nivolumab, targeting the molecules CTLA-4, PD-1, respectively,have shown efficacy against several types of cancer. Despite these results, only a small percentage of patients maintains a long-lasting effect. Even Ipilimumab, in combination with nivolumab, has demonstrated a significant clinical benefit in multiple tumor types. However, no trial has been designed with the primary endpoint to compare the efficacy of nivolumab plus ipilimumab combined, compared to nivolumab alone...
November 25, 2020: Journal of Translational Medicine
Patrick Druwé, Koenraad G Monsieurs, James Gagg, Shinji Nakahara, Michael N Cocchi, Gábor Élő, Hans van Schuppen, Evan Avraham Alpert, Anatolij Truhlář, Sofie A Huybrechts, Nicolas Mpotos, Peter Paal, Conrad BjØrshol, Theodoros Xanthos, Luc-Marie Joly, Markus Roessler, Conor Deasy, Hildigunnur Svavarsdóttir, Jouni Nurmi, Radoslaw Owczuk, Pascual Piñera Salmeron, Diana Cimpoesu, Pablo Aguilera Fuenzalida, Violetta Raffay, Johan Steen, Johan Decruyenaere, Peter De Paepe, Ruth Piers, D Dominique Benoit
INTRODUCTION: Cardiopulmonary resuscitation (CPR) in patients with a poor prognosis increases the risk of perception of inappropriate care leading to moral distress in clinicians. We evaluated whether perception of inappropriate CPR is associated with intention to leave the job among emergency clinicians. METHODS: A cross-sectional multi-centre survey was conducted in 24 countries. Factors associated with intention to leave the job were analysed by conditional logistic regression models...
November 20, 2020: Resuscitation
Bingke Liu, Junming Cao, Junzhi Li, La Li, Duo Chen, Siqi Zhang, Dong Cai, Wei Han
Traditional cobalt selenides as active materials in lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs) would suffer from drastic volume expansions and large stacking effects, leading to a low cycling stability. In this work, we utilized a facile template method for preparing Co3 Se4 @N-CN (CSNC) that encapsulated Co3 Se4 nanoparticles into 3D interconnected nitrogen-doped carbon network (N-CN). Satisfactorily, it possesses excellent cycling stability with enhanced lithium and sodium energy storage capacity...
November 3, 2020: Journal of Colloid and Interface Science
J A Guzman-Cottrill, D K Henderson, H Babcock, S Haessler, M K Hayden, A R Murthy, C Rock, T Van Schooneveld, D J Weber, S B Wright, C A Forde, L K Logan, A N Malani
No abstract text is available yet for this article.
November 5, 2020: Infection Control and Hospital Epidemiology
Shan Lyu, Jie Li, Limin Yang, Xiaoliang Du, Xiaoyi Liu, Libo Chuan, Guoqiang Jing, Zhenyan Wang, Weiwei Shu, Chunjuan Ye, Qionglan Dong, Jun Duan, James B Fink, Zhancheng Gao, Zongan Liang
Background: Aerosol delivery via mechanical ventilation has been reported to vary significantly among different intensive care units (ICU). The optimal technique for using each aerosol generator may need to be updated with the available evidence. Methods: A 2-week prospective multicenter observational cohort study was implemented to record aerosol delivery for mechanically ventilated adult patients in Chinese ICUs. Our data included the type of aerosol device and its placement, ventilator type, humidification, and aerosolized medication administered...
September 2020: Annals of Translational Medicine
Jasmina B Timic, Jelena Kotur-Stevuljevic, Heiner Boeing, Dušanka Krajnovic, Brizita Djordjevic, Sladjana Sobajic
This study investigated the behavior of urban-living students related to the salty snacks consumption, and their contribution to salt daily intake. A cross-sectional survey on 1313 urban-living students (16-25 years, 61.4% university students and 38.6% high school students) used a pre-verified questionnaire created specifically for the study. The logistic regression analysis was performed to investigate the factors influencing snack consumption. The results of salt content and the snack consumption frequency were used to evaluate snack contribution to salt intake...
October 27, 2020: Nutrients
Sachin Mohan, Shaffer Mok, Thomas Judge
Purpose: Utilization of genetic databases to identify genes involved in ulcerative colitis (UC), Crohn's disease (CD), and their extra-intestinal manifestations. Methods: Protein coding genes involved in ulcerative colitis (3783 genes), Crohn's disease (3980 genes), uveitis (1043 genes), arthritis (5583 genes), primary sclerosing cholangitis (PSC) (1313 genes), and pyoderma gangrenosum (119 genes) were categorized using four genetic databases. These include Genecards: The Human Gene Database (www...
2020: Clinical and Experimental Gastroenterology
Quinette Abigail Louw, Karina Berner, Ritika Tiwari, Dawn Ernstzen, Diribsa Tsegaye Bedada, Marisa Coetzee, Usuf Chikte
RATIONALE, AIM AND OBJECTIVE: The physiotherapy profession did not escape the effects of racially based segregatory practises. While numerous strategies and initiatives have been employed to redress the inequities of the past, the extent of demographic transformation within the physiotherapy profession in South Africa remains uncertain. Transformation is defined in this article as an intentional change aimed at addressing inequalities and the ultimate goal is for population group and gender profiles of higher education graduates to be representative of the national epidemiological profile...
October 22, 2020: Journal of Evaluation in Clinical Practice
Ki Hong Choi, Young Bin Song, Dong Seop Jeong, Yong Ho Jang, David Hong, Sang Yoon Lee, Taeho Youn, Minjung Bak, Kyung Min Min, Joo Myung Lee, Taek Kyu Park, Jeong Hoon Yang, Joo-Yong Hahn, Jin-Ho Choi, Seung-Hyuk Choi, Su Ryeun Chung, Yang Hyun Cho, Kiick Sung, Wook Sung Kim, Hyeon-Cheol Gwon, Young Tak Lee
AIMS: The current study sought to evaluate whether long-term clinical outcomes according to the use of dual antiplatelet therapy (DAPT) or single antiplatelet therapy (SAPT) differed between acute coronary syndrome (ACS) and stable ischaemic heart disease (SIHD) patients who underwent coronary artery bypass grafting surgery (CABG). METHODS AND RESULTS: Between January 2001 and December 2017, 3199 patients with ACS (55.3%) and 2583 with SIHD (44.7%) who underwent isolated CABG were enrolled...
July 6, 2020: European Heart Journal. Cardiovascular Pharmacotherapy
Shirin Shahkoomahally, Ali Khadivi, Jeffrey K Brecht, Ali Sarkhosh
The global demand for pomegranate has led to increasing research and improvement of cultivars that produce higher antioxidant compounds. The current study was carried out to evaluate the bioactive constituents and physical properties of fourteen pomegranate genotypes grown in the subtropical region of Florida. There were differences in aril color among genotypes. The highest total anthocyanin content was found in 'Ariana', 'Molla Nepes', and 'Parfianka' genotypes. Furthermore, total anthocyanin content in peel ranged from 2...
October 6, 2020: Food Chemistry
Jing Wen, Anping Wang, Guangxu Liu, Meiping Wang, Yingting Zuo, Wei Li, Qi Zhai, Yiming Mu, Herbert Y Gaisano, Yan He, Jingtao Dou
BACKGROUND: Prediabetes has become a pandemic. This study aimed to identify a better predictor for the incidence of prediabetes, which we hypothesize to be the triglyceride-glucose (TyG) index, a simplified insulin resistance index. We compared its predictive value with the other common risk factors of prediabetes. METHODS: The participants of this analysis were derived from the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) study...
October 15, 2020: Lipids in Health and Disease
Vanessa L Cropley, Ye Tian, Kavisha Fernando, Sina Mansour L, Christos Pantelis, Luca Cocchi, Andrew Zalesky
BACKGROUND: This study aimed to investigate whether dimensional constructs of psychopathology relate to variation in patterns of brain development and to determine whether these constructs share common neurodevelopmental profiles. METHODS: Psychiatric symptom ratings from 9312 youths (8-21 years old) from the Philadelphia Neurodevelopmental Cohort were parsed into 7 independent dimensions of clinical psychopathology representing conduct, anxiety, obsessive-compulsive, attention, depression, bipolar, and psychosis symptoms...
August 1, 2020: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
James Peyton, Raymond Park, Steven J Staffa, Stefano Sabato, Thomas W Templeton, Mary Lyn Stein, Annery G Garcia-Marcinkiewicz, Edgar Kiss, John Edem Fiadjoe, Britta von Ungern-Sternberg, Franklin Chiao, Patrick Olomu, David Zurakowski, Pete G Kovatsis
BACKGROUND: The design of a videolaryngoscope blade may affect its efficacy. We classified videolaryngoscope blades as standard and non-standard shapes to compare their efficacy performing tracheal intubation in children enrolled in the Paediatric Difficult Intubation Registry. METHODS: Cases entered in the Registry from March 2017 to January 2020 were analysed. We compared the success rates of initial and eventual tracheal intubation, complications, and technical difficulties between the two groups and by weight stratification...
September 17, 2020: British Journal of Anaesthesia
Francesco Vassalli, Serge Masson, Jennifer Meessen, Iacopo Pasticci, Matteo Bonifazi, Luigi Vivona, Pietro Caironi, Mattia Busana, Lorenzo Giosa, Matteo Maria Macrì, Federica Romitti, Deborah Novelli, Michael Quintel, Roberto Latini, Luciano Gattinoni
OBJECTIVE: To investigate the behavior of pentraxin-3 (PTX3), troponin T (hsTnT), N-terminal pro-B type Natriuretic Peptide (NT-proBNP) in sepsis and their relationships with sepsis severity and oxygen transport/utilization impairment. DESIGN: Retrospective analysis of PTX3, hsTnT, NT-proBNP levels at day 1, 2 and 7 after admission in the intensive care unit in a subset of the ALBIOS database SETTING:: 40 Italian intensive care units. PATIENTS: 958 septic patients enrolled in the randomized clinical trial comparing albumin replacement plus crystalloids and crystalloids alone INTERVENTIONS:: The patients were divided in sextiles of lactate (marker of severity), ScvO2 (marker of oxygen transport) and fluid balance (marker of therapeutic strategy)...
May 14, 2020: Shock
Søren Birkeland, Thea Linkhorst, Anders Haakonsson, Michael John Barry, Sören Möller
BACKGROUND: Obtaining a sample that is representative of the group of interest is of utmost importance in questionnaire studies. In a survey using a state authorized web-portal for citizen communication with authorities, we wanted to investigate the view of adult men on patient involvement in health care decision-making regarding Prostate-Specific Antigen test for prostatic cancer. In this paper, we report on sample characteristics and representativeness of our sample in terms of personality and baseline involvement preferences...
September 10, 2020: BMC Health Services Research
Victoria W Dykstra, Teena Willoughby, Angela D Evans
INTRODUCTION: Lie-telling appears to peak during adolescence; however, previous research has not yet examined lie-telling frequency in adolescents' friendships. Increased lie-telling may be problematic given that honesty is crucial for trust within positive relationships, and more positive relationships lead to more positive well-being. The present study examined adolescents' lies to friends and longitudinal associations between lying, friendship quality, and depressive symptoms. METHODS: Canadian adolescents (Time 1: N = 1313, Mage  = 11...
September 7, 2020: Journal of Adolescence
YongLin He, Guangjie He, Qi-Qin Li, Wei Lin, Gao-Qin Yuan
Crassocephalum crepidioides (Benth.) S. Moore, native to tropical Africa, is an important invasive weed in many countries, seriously threatening the safety of agricultural ecosystem. During December 2018, 100% of C. crepidioides plants exhibited leaf spots in the Kudzu (Pueraria lobata) garden in Tianlin County, Baise City, Guangxi, China (24°40'20.42″N, 106°11'33.51″E), but Kudzu was not affected by this disease. The leaf spots appeared as small brown spots surrounded by a yellow-green halo initially, enlarged to subrotund or irregular in shape, slightly sunken, then developed as a dark brown to dark spot with grey-white necrotic center (Supplementary Fig...
September 10, 2020: Plant Disease
Yixi Tian, A C Thanos Bourtsalas, Shiho Kawashima, Siwei Ma, Nickolas J Themelis
In the U.S., about 27 million metric tons of municipal solid waste are used as fuel in Waste-to-Energy (WTE) power plants, generating about seven million tons of mixed bottom ash and fly ash (combined ash) annually, which are disposed of in landfills after metal separation. This study assessed the effect of using combined ash as a substitute of mined stone aggregates on the mechanical properties and leachability of cement mortar and concrete. The as-received combined ash was separated into three fractions: fine (<2 mm), medium (2-9...
September 3, 2020: Waste Management
Joseph L Domagalski, Eric Morway, Nancy L Alvarez, Juliet Hutchins, Michael R Rosen, Robert Coats
Lake Tahoe, a large freshwater lake of the eastern Sierra Nevada in California and Nevada, has 63 tributaries that are sources of nutrients and sediment to the lake. The Tahoe watershed is relatively small, and the surface area of the lake occupies about 38% of the watershed area (1313 km2 ). Only about 6% of the watershed is urbanized or residential land, and as part of a plan to maintain water clarity, wastewater is exported out of the basin. The lake's clarity has been diminishing due to algae and fine sediment, prompting development of management plans...
August 19, 2020: Science of the Total Environment
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