keyword
https://read.qxmd.com/read/38529083/laparoscopy-assisted-restorative-proctocolectomy-with-ileal-pouch-anal-anastomosis-in-middle-colic-artery-ligation-immediately-before-specimen-removal
#41
JOURNAL ARTICLE
Keiji Matsuda, Yojiro Hashiguchi, Tamuro Hayama, Kurara Hayashi, Toshiya Miyata, Kentaro Asako, Yoshihisa Fukushima, Ryu Shimada, Kensuke Kaneko, Keijiro Nozawa, Hiroki Ochiai, Takatsugu Yamamoto
INTRODUCTION: Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the surgical procedure for ulcerative colitis (UC). Intestinal ischemia may occur if the main blood vessels are ligated at an early stage of this surgery. Considering that the blood flow in the large intestine can be maintained by preserving the middle colic artery, we have used a new IPAA method: ligating the middle colic artery immediately before removal of the specimens ("M-method"). Here, we evaluated the M-method's clinical outcomes...
2024: Inflammatory Intestinal Diseases
https://read.qxmd.com/read/38528846/efficacy-of-orthoplastic-management-in-the-treatment-of-traumatic-popliteal-artery-injury
#42
JOURNAL ARTICLE
Yuta Izawa, Kentaro Futamura, Hiroko Murakami, Kazuo Sato, Yoshihiko Tsuchida
BACKGROUND: Popliteal artery injury (PAI) is a challenging condition. Even with appropriate initial treatment and reconstruction of the associated injuries, extensive soft-tissue necrosis may occur, requiring lower leg amputation. There are no reports on the effectiveness of orthoplastic surgery in treating traumatic PAI. However, orthoplastic surgery is also considered very effective in PAI treatment, which requires delicate handling of soft-tissue and blood vessels. This study aimed to examine the treatment outcomes of traumatic PAI at a trauma center with the capacity for orthoplastic management...
March 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38528651/real-world-evaluation-of-the-off-the-shelf-precannulated-inner-branched-endograft-for-pararenal-aortic-aneurysms
#43
JOURNAL ARTICLE
Theodosios Bisdas, Neophytos Zambas, Marios Zertalis, Panagiotis Theodorides, Nikolaos Iatrou, Christos Dimopoulos, Nikolas Charalambous
PURPOSE: To analyze the early performance and efficacy of the first commercially available off-the-shelf precannulated multibranched endograft in the endovascular repair of pararenal abdominal aortic aneurysms (PAAAs). The device received European marketing approval in late 2020. MATERIALS AND METHODS: Between January 2021 and June 2023, a retrospective analysis of prospectively collected data from all consecutive patients with pAAAs undergoing implantation of the E-nside precannulated inner-branched endograft was conducted in 2 centers...
March 25, 2024: Journal of Endovascular Therapy
https://read.qxmd.com/read/38528270/portal-venous-contrast-enhancement-ratio-of-the-adrenal-glands-and-spleen-as-prognostic-marker-of-mortality-in-patients-with-acute-mesenteric-ischemia
#44
JOURNAL ARTICLE
Felix Pfister, Matthias Mehdorn, Christoph Schwartner, Daniel Seehofer, Hans-Michael Tautenhahn, Manuel Florian Struck, Timm Denecke, Hans-Jonas Meyer
PURPOSE: Contrast enhancement of the adrenal gland defined by computed tomography (CT) was previously analyzed as a prognostic factor for critically ill patients in various diseases. However, no study investigated this quantitative parameter in patients with acute mesenteric ischemia. Therefore, the aim of this study was to evaluate the prognostic value of the contrast enhancement of the adrenal glands in patients with clinically suspected AMI. METHODS: All patients with clinically suspected AMI were retrospectively assessed between 2016 and 2020...
March 25, 2024: Abdominal Radiology
https://read.qxmd.com/read/38528196/nonocclusive-mesenteric-ischemia-nomi-on-roux-limb-after-biliary-reconstruction-successfully-treated-by-interventional-radiology-ivr
#45
JOURNAL ARTICLE
Makoto Kawamoto, Yoshihiro Miyasaka, Nobuhiko Koreeda, Yousuke Hirano, Ryotaro Yamamoto, Masato Watanabe
Nonocclusive mesenteric ischemia (NOMI) is a life-threatening disorder. Early diagnosis is challenging because NOMI lacks specific symptoms. A 52-year-old man who received extended cholecystectomy with Roux-en-Y hepaticojejunostomy for gallbladder cancer (GBC) presented to our hospital with nausea and vomiting. Neither tender nor peritoneal irritation sign was present on abdominal examination. Blood test exhibited marked leukocytosis (WBC:19,800/mm3). A contrast-enhanced abdominal computed tomography (CT) scan revealed remarkable wall thickening and lower contrast enhancement effect localized to Roux limb...
March 25, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38528175/insulin-and-glycolysis-dependency-of-cardioprotection-by-nicotinamide-riboside
#46
JOURNAL ARTICLE
Y Xiao, Q Wang, H Zhang, R Nederlof, D Bakker, B A Siadari, M W Wesselink, B Preckel, N C Weber, M W Hollmann, B V Schomakers, M van Weeghel, C J Zuurbier
Decreased nicotinamide adenine dinucleotide (NAD+ ) levels contribute to various pathologies such as ageing, diabetes, heart failure and ischemia-reperfusion injury (IRI). Nicotinamide riboside (NR) has emerged as a promising therapeutic NAD+ precursor due to efficient NAD+ elevation and was recently shown to be the only agent able to reduce cardiac IRI in models employing clinically relevant anesthesia. However, through which metabolic pathway(s) NR mediates IRI protection remains unknown. Furthermore, the influence of insulin, a known modulator of cardioprotective efficacy, on the protective effects of NR has not been investigated...
March 25, 2024: Basic Research in Cardiology
https://read.qxmd.com/read/38528077/nuciferine-reduces-vascular-leakage-and-improves-cardiac-function-in-acute-myocardial-infarction-by-regulating-the-pi3k-akt-pathway
#47
JOURNAL ARTICLE
Wei Xie, Shumin Chen, Wenzhe Wang, Xichun Qin, Chuiyu Kong, Dongjin Wang
The destruction of the microvascular structure and function can seriously affect the survival and prognosis of patients with acute myocardial infarction (AMI). Nuciferine has a potentially beneficial effect in the treatment of cardiovascular disease, albeit its role in microvascular structure and function during AMI remains unclear. This study aimed to investigate the protective effect and the related mechanisms of nuciferine in microvascular injury during AMI. Cardiac functions and pathological examination were conducted in vivo to investigate the effect of nuciferine on AMI...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38527707/circular-rna-circefnb2-promotes-cell-injury-after-cerebral-infarction-by-sponging-mir-202-5p-and-regulating-traf3-expression
#48
JOURNAL ARTICLE
Limin Tu, Wei Cheng, Xudong Wang, Zhixin Li, Xing Li
BACKGROUND: Exogenous neural cell transplantation may be therapeutic for stroke, cerebral ischemic injury. Among other mechanisms, increasing findings indicated circular RNAs (circRNAs) regulate the pathogenesis progression of cerebral ischemia. Mmu_circ_0015034 (circEfnb2) was upregulated in focal cortical infarction established by middle cerebral artery occlusion (MCAO) in mice. Our study was designed to probe the molecular mechanism of circEfnb2 in the oxygen-glucose deprivation/reperfusion (OGD/R)-induced neuronal damage in cerebral ischemia...
March 23, 2024: Transplant Immunology
https://read.qxmd.com/read/38527629/machine-learning-to-identify-a-composite-indicator-to-predict-cardiac-death-in-ischemic-heart-disease
#49
JOURNAL ARTICLE
Alessandro Pingitore, Chenxiang Zhang, Cristina Vassalle, Paolo Ferragina, Patrizia Landi, Francesca Mastorci, Rosa Sicari, Alessandro Tommasi, Cesare Zavattari, Giuseppe Prencipe, Alina Sîrbu
BACKGROUND: Machine learning (ML) employs algorithms that learn from data, building models with the potential to predict events by aggregating a large number of variables and assessing their complex interactions. The aim of this study is to assess ML potential in identifying patients with ischemic heart disease (IHD) at high risk of cardiac death (CD). METHODS: 3987 (mean age 68 ± 11) hospitalized IHD patients were enrolled. We implemented and compared various ML models and their combination into ensembles...
March 23, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38527567/shikonin-attenuates-cerebral-ischemia-reperfusion-injury-via-inhibiting-nod2-rip2-nf-%C3%AE%C2%BAb-mediated-microglia-polarization-and-neuroinflammation
#50
JOURNAL ARTICLE
Ya Yang, Yuxiang Fei, Xuejiao Xu, Jun Yao, Jianing Wang, Chao Liu, Haiyan Ding
OBJECTIVES: Microglia-mediated neuroinflammation plays a crucial role in the pathophysiological process of multiple neurological disorders such as ischemic stroke, which still lacks effective therapeutic agents. Shikonin possesses anti-inflammatory and neuroprotective properties. However, its underlying mechanism remains elusive. This study aimed to investigate whether Shikonin confers protection against cerebral ischemia/reperfusion (I/R) injury by modulating microglial polarization and elucidate the associated mechanisms...
March 23, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/38527232/predictive-model-for-estimating-the-risk-of-epilepsy-after-aneurysmal-subarachnoid-hemorrhage-the-rise-score
#51
JOURNAL ARTICLE
Daniel Campos-Fernandez, Marc Rodrigo-Gisbert, Laura Abraira, Manuel Quintana Luque, Manel Santafé, Sofia Lallana, Elena Fonseca, Manuel Toledo, Darío F Gándara, Fuat Arikan, Alejandro Tomasello, Jacint X Sala Padró, Merce Falip, Pablo López-Ojeda, Andreu Gabarrós, Anna Sánchez, Estevo Santamarina
BACKGROUND AND OBJECTIVES: The occurrence of seizures after aneurysmal subarachnoid hemorrhage (aSAH) is associated with a poorer functional and cognitive prognosis and less favorable quality of life. It would be of value to promptly identify patients at risk of epilepsy to optimize follow-up protocols and design preventive strategies. Our aim was to develop a predictive score to help stratify epilepsy risk in patients with aSAH. METHODS: This is a retrospective, longitudinal study of all adults with aSAH admitted to our center (2012-2021)...
April 23, 2024: Neurology
https://read.qxmd.com/read/38527149/radial-versus-femoral-access-for-mechanical-thrombectomy-in-patients-with-stroke-a-noninferiority-randomized-clinical-trial
#52
JOURNAL ARTICLE
David Hernandez, Manuel Requena, Marta Olivé-Gadea, Marta de Dios, Laura Ludovica Gramegna, Marian Muchada, Álvaro García-Tornel, Francesco Diana, Federica Rizzo, Eila Rivera, Marta Rubiera, Carlos Piñana, Marc Rodrigo-Gisbert, David Rodríguez-Luna, Jorge Pagola, Tomás Carmona, Jesús Juega, Noelia Rodríguez-Villatoro, Carlos Molina, Marc Ribo, Alejandro Tomasello
BACKGROUND: Transfemoral access is predominantly used for mechanical thrombectomy in patients with stroke with a large vessel occlusion. Following the interventional cardiology guidelines, routine transradial access has been proposed as an alternative, although its safety and efficacy remain controversial. We aim to explore the noninferiority of radial access in terms of final recanalization. METHODS: The study was an investigator-initiated, single-center, evaluator-blinded, noninferiority randomized clinical trial...
April 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38527141/-stroke-literature-synopses-preclinical
#53
JOURNAL ARTICLE
Kathiresh Kumar Mani, Farida Sohrabji
No abstract text is available yet for this article.
April 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38527023/retinoic-acid-attenuates-ischemic-injury-induced-activation-of-glial-cells-and-inflammatory-factors-in-a-rat-stroke-model
#54
JOURNAL ARTICLE
Ju-Bin Kang, Hyun-Kyoung Son, Murad-Ali Shah, Phil-Ok Koh
Stroke is a leading cause of death and long-term disability which can cause oxidative damage and inflammation of the neuronal cells. Retinoic acid is an active metabolite of vitamin A that has various beneficial effects including antioxidant and anti-inflammatory effects. In this study, we investigated whether retinoic acid modulates oxidative stress and inflammatory factors in a stroke animal model. A middle cerebral artery occlusion (MCAO) was performed on adult male rats to induce focal cerebral ischemia...
2024: PloS One
https://read.qxmd.com/read/38526820/an-integrated-strategy-to-evaluate-active-substances-of-astragali-radix-carthami-flos-combination-on-the-treatment-of-cerebral-ischemia-reperfusion-injury-based-on-tqsm-polypharmacokinetics-and-pharmacodynamics
#55
JOURNAL ARTICLE
Qiang Zeng, Chang Li, Shouchao Xu, Yu He
As a classic herb pair, Astragali Radix-Carthami Flos (AR-CF) has revealed good biological activity in the treatment of cerebral ischemia/reperfusion injury (CI/RI), which remained to be further clarified together with the underlying efficacy related compounds for material basis. In this study, the nine formulations were obtained by L9 (34) orthogonal array design of four active fractions (saponin and flavonoid extracted from AR, safflower yellow and safflower red extracted from CF). The concentrations of eleven components and the levels of four biochemical indicators in rat plasma were continuously detected after intragastric administration of nine formulations, respectively...
December 15, 2023: Journal of Food and Drug Analysis
https://read.qxmd.com/read/38526753/diagnostic-accuracy-of-murray-law-based-quantitative-flow-ratio-in-patients-with-severe-aortic-stenosis-undergoing-transcatheter-aortic-valve-replacement
#56
JOURNAL ARTICLE
Fukuishi Yuta, Hiroyuki Kawamori, Takayoshi Toba, Takashi Hiromasa, Satoru Sasaki, Tomoyo Hamana, Hiroyuki Fujii, Yuto Osumi, Seigo Iwane, Tetsuya Yamamoto, Shota Naniwa, Yuki Sakamoto, Koshi Matsuhama, Ken-Ichi Hirata, Hiromasa Otake
BACKGROUND: Murray law-based quantitative flow ratio (μQFR) is a novel computational method that enables accurate estimation of fractional flow reserve (FFR) using a single angiographic projection. However, its diagnostic value in patients with severe aortic stenosis (AS) remains unclear. METHOD: We included 25 consecutive patients who underwent transcatheter aortic valve replacement (TAVR) for severe AS with intermediate or greater (30-90%) coronary artery disease (CAD)...
March 25, 2024: Heart and Vessels
https://read.qxmd.com/read/38526708/role-of-c-ebp-homologous-protein-in-vascular-stenosis-after-carotid-artery-injury
#57
JOURNAL ARTICLE
Lin Teng, Qin Qin, Zi-Yi Zhou, Fei Zhou, Cun-Yu Cao, Chao He, Jia-Wang Ding, Jian Yang
The study aims to explore the fluctuating expression of C/EBP Homologous Protein (CHOP) following rat carotid artery injury and its central role in vascular stenosis. Using in vivo rat carotid artery injury models and in vitro ischemia and hypoxia cell models employing human aortic endothelial cells (HAECs) and vascular smooth muscle cells (T/G HA-VSMCs), a comprehensive investigative framework was established. Histological analysis confirmed intimal hyperplasia in rat models. CHOP expression in vascular tissues was assessed using Western blot and immunohistochemical staining, and its presence in HAECs and T/G HA-VSMCs was determined through RT-PCR and Western blot...
March 25, 2024: Biochemical Genetics
https://read.qxmd.com/read/38526587/an-auxiliary-strategy-of-partial-least-squares-regression-in-pharmacokinetic-pharmacodynamic-studies-a-case-of-application-of-guhong-injection-in-myocardial-ischemia-reperfusion-rats
#58
JOURNAL ARTICLE
Hai-Yang Chen, Chang Li, Chong-Yu Shao, Yu-Jia Wu, Hai-Tong Wan, Yu He
Guhong injection (GHI) has been applied in the therapy of cardio-cerebrovascular disease in clinic, but there is no report about the pharmacokinetic/pharmacodynamic (PK/PD) research on GHI treating myocardial ischemia/reperfusion (MI/R) injury in rats. In this study, eight compounds of GHI in plasma, including N-acetyl-L-glutamine (NAG), chlorogenic acid (CGA), hydroxysafflor yellow A (HSYA), p-coumaric acid ( pCA), rutin, hyperoside, kaempferol-3-O-rutinoside, and kaempferol-3-O-glucoside, were quantified by LC-MS/MS...
March 15, 2024: Journal of Food and Drug Analysis
https://read.qxmd.com/read/38526305/bovine-aortic-arch-with-an-aberrant-left-vertebral-artery-in-a-3-year-old-boy-with-vacterl-association-a-case-report
#59
JOURNAL ARTICLE
Jesús Martínez-García, Sara F Ordorica-Sandoval, Erick Rivera-Sainz, Manuel A Beltrán-Salas, Nidia León-Sicairos, Adrian Canizalez-Roman
BACKGROUND The VACTEREL association is an acronym that includes vertebral malformations (V), anal atresia (A), cardiac defects (C), tracheoesophageal fistula (TE), renal defects (R), and limb malformations (L). The aortic arch is the section between the ascending aorta and the descending aorta, where some variants have been described, such as the right aortic arch and bovine aortic arch, among others. A rare presentation in the Natsis classification is the "type X" where a bovine aortic arch and anomalous origin of the left vertebral artery are present...
March 11, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38526284/cav3-2-channel-regulates-cerebral-ischemia-reperfusion-injury-a-promising-target-for-intervention
#60
JOURNAL ARTICLE
Feibiao Dai, Chengyun Hu, Xue Li, Zhetao Zhang, Hongtao Wang, Wanjun Zhou, Jiawu Wang, Qingtian Geng, Yongfei Dong, Chaoliang Tang
JOURNAL/nrgr/04.03/01300535-202419110-00028/figure1/v/2024-03-08T184507Z/r/image-tiff Calcium influx into neurons triggers neuronal death during cerebral ischemia/reperfusion injury. Various calcium channels are involved in cerebral ischemia/reperfusion injury. Cav3.2 channel is a main subtype of T-type calcium channels. T-type calcium channel blockers, such as pimozide and mibefradil, have been shown to prevent cerebral ischemia/reperfusion injury-induced brain injury. However, the role of Cav3.2 channels in cerebral ischemia/reperfusion injury remains unclear...
November 1, 2024: Neural Regeneration Research
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