Yuxing Wang, Xiaohua Pan, Yanjun Li, Ru Wang, Yuanyuan Yang, Baichun Jiang, Gongping Sun, Changshun Shao, Molin Wang, Yaoqin Gong
Tamoxifen (TAM) resistance is a significant clinical challenge in endocrine therapies for estrogen receptor (ER)-positive breast cancer patients. Cullin 4B (CUL4B), which acts as a scaffold protein in CUL4B-RING ubiquitin ligase complexes (CRL4B), is frequently overexpressed in cancer and represses tumor suppressors through diverse epigenetic mechanisms. However, the role and the underlying mechanisms of CUL4B in regulating drug resistance remain unknown. Here, we showed that CUL4B promotes TAM resistance in breast cancer cells through a miR-32-5p/ER-α36 axis...
February 27, 2021: Journal of Pathology
Jia-Chun Ma, Xiao-Rong Zhong, Ting Luo, Zhong-Zheng Xiang, Jia-Yuan Li, Chuanxu Luo, Xi Yan, Ping He, Ting-Lun Tian, Fang Liu, Lei Liu, Hong Zheng
No abstract text is available yet for this article.
February 26, 2021: Annals of Surgical Oncology
Michael M Jonczyk, Abhishek Chatterjee
No abstract text is available yet for this article.
February 26, 2021: Annals of Surgical Oncology
Elena Tsangaris, Andrea L Pusic, Manraj N Kaur, Sophocles Voineskos, Louise Bordeleau, Toni Zhong, Raghavan Vidya, Justin Broyles, Anne F Klassen
BACKGROUND: To assess the impact of animation deformity on health-related quality of life, a content-specific, valid, and reliable patient-reported outcome measure is needed. This report describes the development and validation of the BREAST-Q Animation Deformity scale. METHODS: Women with breast cancer who had an implant-based reconstruction provided data. In phase 1 (January 2017 and December 2018), qualitive and cognitive patient interviews and expert input were used to develop and refine scale content...
February 26, 2021: Annals of Surgical Oncology
Yu Li, Yuantao Wang, Wanpeng Zhang, Xinchen Wang, Lu Chen, Shuping Wang
Poly (ADP-ribose) polymerase (PARP) inhibitors offer a significant clinical benefit for triple-negative breast cancers (TNBCs) with BRCA1/2 mutation. However, the narrow clinical indication limits the development of PARP inhibitors. Phosphoinositide 3-kinase (PI3K) inhibition sensitizes BRCA-proficient TNBC to PARP inhibition, which broadens the indication of PARP inhibitors. Previously researches have reported that PI3K inhibition induced the defect of homologous recombination (HR) mediated repair by downregulating the expression of BRCA1/2 and Rad51...
February 26, 2021: Scientific Reports
Afrah E Mohammed, Hana Sonbol, Suaad Saleh Alwakeel, Modhi O Alotaibi, Sohailah Alotaibi, Nouf Alothman, Rasha Saad Suliman, Hanadi Talal Ahmedah, Rizwan Ali
Soil is considered an extensively explored ecological niche for microorganisms that produce useful biologically active natural products suitable for pharmaceutical applications. The current study aimed at investigating biological activities and metabolic profiles of three fungal strains identified from different desert sites in Saudi Arabia. Soil fungal isolates were collected from AlQasab, Tabuk, and Almuzahimiyah in Saudi Arabia and identified. Furthermore, their antibacterial activity was investigated against Staphylococcus aureus, Enterococcus faecalis, Klebsiella pneumonia, and Escherichia coli in blood, nutrient, and Sabouraud dextrose agars...
February 26, 2021: Scientific Reports
Fang Zheng, Jianing Chen, Xiaoqian Zhang, Zifeng Wang, Jiewen Chen, Xiaorong Lin, Hongyan Huang, Wenkui Fu, Jing Liang, Wei Wu, Bo Li, Herui Yao, Hai Hu, Erwei Song
Hypoxia-inducible factor-1 (HIF-1) is a master driver of glucose metabolism in cancer cells. Here, we demonstrate that a HIF-1α anti-sense lncRNA, HIFAL, is essential for maintaining and enhancing HIF-1α-mediated transactivation and glycolysis. Mechanistically, HIFAL recruits prolyl hydroxylase 3 (PHD3) to pyruvate kinase 2 (PKM2) to induce its prolyl hydroxylation and introduces the PKM2/PHD3 complex into the nucleus via binding with heterogeneous nuclear ribonucleoprotein F (hnRNPF) to enhance HIF-1α transactivation...
February 26, 2021: Nature Communications
Weibin Yang, Xuan Wu, Fan Zhou
BACKGROUND Breast cancer, a common malignant tumor, has been considered as the leading cause of cancer-related death in women. Collagen type X alpha 1 (COL10A1) is overexpressed in breast cancer. The current study was designed to determine the functional involvement and regulatory mechanism of COL10A1 on the growth and metastasis of breast cancer. MATERIAL AND METHODS COL10A1 and Prolyl 4-hydroxylase beta polypeptide (P4HB) expressions in normal tissues and tumor tissues of breast cancer patients were obtained from the GEPIA dataset...
February 27, 2021: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
John R Jeffers, Emilia M Pinto, Jerold E Rehg, Michael R Clay, Jinling Wang, Geoffrey Neale, Richard J Heath, Guillermina Lozano, Enzo Lalli, Bonald C Figueiredo, Alberto S Pappo, Carlos Rodriguez-Galindo, Wenan Chen, Stanley Pounds, Raul C Ribeiro, Gerard P Zambetti
The TP53-R337H founder mutation exists at a high frequency throughout southern Brazil and represents one of the most common germline TP53 mutations reported to date. It was identified in pediatric adrenocortical tumors in families with a low incidence of cancer. The R337H mutation has since been found in association with early-onset breast cancers and Li-Fraumeni syndrome (LFS). To study this variability in tumor susceptibility, we generated a knockin mutant p53 mouse model (R334H). Endogenous murine p53-R334H protein was naturally expressed at high levels in multiple tissues and was functionally compromised in a tissue- and stress-specific manner...
February 26, 2021: Cancer Research
Jianhua Wu, Zhuchao Zhou
BACKGROUND: Accumulating studies have demonstrated that microRNAs (miRNAs) are involved in the progression of various cancers. This study aimed to investigate the potential clinical and functional role of miR-432 in breast cancer. MATERIALS AND METHODS: We evaluated the expression of miR-432 in 117 breast cancer samples and paired nontumor tissue samples, as well as 4 breast cancer cell lines using RT-qPCR analysis. Kaplan-Meier survival curve and multivariate Cox regression analysis were used to evaluate the prognostic significance of miR-432 in breast cancer patients...
January 23, 2021: Clinical Breast Cancer
Laxman Pandey, Rajesh Pasricha, Deepa Joseph, Rachit Ahuja, Yanpothung Yanthan, Pankaj Kumar Garg, Manoj Gupta
BACKGROUND: The use of complementary and alternative medicine (CAM) is widespread among cancer patients in India. The present study elucidated usage patterns of CAM and the factors responsible for its adoption among patients with cancer, and the therapeutic impact of CAM. OBJECTIVE: The present study elucidated usage patterns of CAM and the factors responsible for its adoption among the patients with cancer, and the therapeutic impact of CAM. METHODS: This was a questionnaire-based study, conducted among patients with cancer in a tertiary care hospital in a sub-Himalayan city...
February 23, 2021: Journal of Ayurveda and Integrative Medicine
Lucie G Hallenstein, Carol Sorensen, Lorraine Hodgson, Shelly Wen, Justin Westhuyzen, Carmen Hansen, Andrew T J Last, Julan V Amalaseelan, Shehnarz Salindera, William Ross, Allan D Spigelman, Thomas P Shakespeare, Noel J Aherne
BACKGROUND: Guidelines for referral to cancer genetics service for women diagnosed with triple negative breast cancer have changed over time. This study was conducted to assess the changing referral patterns and outcomes for women diagnosed with triple negative breast cancer across three regional cancer centres during the years 2014-2018. METHODS: Following ethical approval, a retrospective electronic medical record review was performed to identify those women diagnosed with triple negative breast cancer, and whether they were referred to a genetics service and if so, the outcome of that genetics assessment and/or genetic testing...
February 26, 2021: Hereditary Cancer in Clinical Practice
Jason D Domogauer, Sonia M de Toledo, Roger W Howell, Edouard I Azzam
BACKGROUND: Cancer-associated fibroblasts (CAFs) are a major component of the cancer stroma, and their response to therapeutic treatments likely impacts the outcome. We tested the hypothesis that CAFs develop unique characteristics that enhance their resistance to ionizing radiation. METHODS: CAFs were generated through intimate coculture of normal human fibroblasts of skin or lung origin with various human cancer cell types using permeable microporous membrane inserts...
February 26, 2021: Cell Communication and Signaling: CCS
Emilia Virginia Lima Curvelo Fontes, Nataliê Almeida Silva, Lister Arruda Modesto Dos Santos, Vitorino Modesto Dos Santos
The scarcely reported hematogenous rectal metastases from breast cancer are rare and the diagnosis is challenging. They may be recognized before, concomitantly with, or after the diagnosis of the primary site of breast cancer. Invasive lobular cancer is the histological type more frequently described, and most of the affected patients have a late diagnosis. Tardive recognition is associated with poor outcomes, despite the management options. Endoscopic and imaging evaluations, mainly magnetic resonance studies, are useful, but the anatomopathological findings are mandatory to confirm the diagnostic hypothesis...
February 1, 2021: Archives of Iranian Medicine
Hsing-Ying Ho, Vincent Chin-Hung Chen, Bor-Show Tzang, Ching-Chuan Hsieh, Wen-Ke Wang, Yi-Ping Weng, Ya-Ting Hsu, Han-Pin Hsaio, Jun-Cheng Weng, Yi-Lung Chen
Depression is a common comorbid disorder associated with breast cancer, and it can have considerable physical and psychological impacts. Circulating cytokines have been proposed as a potential tool to predict depression in various diseases; however, limited studies have specifically examined it in breast cancer. In this study, we examined and compared the prediction ability of various circulating cytokines for depression in patients with breast cancer. Eighty-three patients with a new diagnosis of breast cancer not receiving chemotherapy were recruited; among them, 15 patients had depression and 68 did not have depression...
February 17, 2021: Journal of Psychiatric Research
Neftali Vazquez, Alma Lopez, Victoria Cuello, Michael Persans, Erin Schuenzel, Wendy Innis-Whitehouse, Megan Keniry
Cancer cells almost universally harbor constitutively active Phosphatidylinositol-3 Kinase (PI3K) Pathway activity via mutation of key signaling components and/or epigenetic mechanisms. Scores of PI3K Pathway inhibitors are currently under investigation as putative chemotherapeutics. However, feedback and stem cell mechanisms induced by PI3K Pathway inhibition can lead to reduced treatment efficacy. To address therapeutic barriers, we examined whether JAKi would reduce stem gene expression in a setting of PI3K Pathway inhibition in order to improve treatment efficacy...
February 17, 2021: Cancer Treatment and Research Communications
Sandrine Parisse-Di Martino, Christelle Faure, Thomas Mognetti
PURPOSE: Ultrasound is the recommended modality to assess axillary lymph node involvement in breast cancer; nevertheless, 18 F-fluorodeoxyglucose (18 F-FDG) integrated positron emission tomography/computed tomography (PET/CT) diagnostic efficiency, to identify suspicious lesions, is also considered. We aim to report discrepancies in ultrasound and 18 F-FDG PET/CT results. METHODS: This single-centered retrospective analysis selected consecutive patients with invasive ductal biopsy-proven breast cancer, for whom divergent 18 F-FDG PET/CT and axillary ultrasound imaging (and/or core needle biopsy if available) had been performed, and described clinical, histological, imaging, and surgery data...
February 20, 2021: Cancer Treatment and Research Communications
Qi Su, Jingjing Wang, Qing Wu, Asmat Ullah, Mohsin Ahmad Ghauri, Ammar Sarwar, Li Chen, Feng Liu, Yanmin Zhang
BACKGROUND: Breast cancer is the most common female cancer worldwide. Large hypoxic area is one of the features of tumor microenvironment. Highly activated hypoxia-induced pathways positively correlate with poor clinical response to chemo- and radiotherapy and high mortality in breast cancer patients. PURPOSE: We explore the effect of sanguinarine on hypoxia-induced activation of Ephrin type-B receptor 4 (EphB4) and hypoxia inducible factor-1α (HIF-1α) pathways in breast cancer...
February 9, 2021: Phytomedicine
Meng-Xue Wei, Jia-Ying Yu, Xin-Xin Liu, Xue-Qiang Li, Meng-Wei Zhang, Pei-Wen Yang, Jin-Hui Yang
For the first time, eight novel artemisinin-piperazine-furane ether hybrids (5a-h) were efficiently synthesized and investigated for their in vitro cytotoxic activity against some human cancer and benign cells. The absolute configuration of hybrid 5c was determined by X-ray crystallographic analysis. Hybrids 5a-h exhibited more pronounced growth-inhibiting action on hepatocarcinoma cell lines than their parent dihydroartemisinin (DHA) and the reference cytosine arabinoside (ARA). The hybrid 5a showed the best cytotoxic activity against human hepatocarcinoma cells SMMC-7721 (IC50  = 0...
February 16, 2021: European Journal of Medicinal Chemistry
Hae Ju Han, Woong Sub Byun, Gyu Ho Lee, Won Kyung Kim, Kyungkuk Jang, Sehun Yang, Jewon Yang, Min Woo Ha, Suckchang Hong, Jeeyeon Lee, Jongheon Shin, Ki Bong Oh, Sang Kook Lee, Hyeung-Geun Park
Disruptor of telomeric silencing-1 like (DOT1L) is a histone H3 methyltransferase which specifically catalyzes the methylation of histone H3 lysine-79 residue. Recent findings demonstrate that DOT1L is abnormally overexpressed and the upregulated DOT1L evokes the proliferation and metastasis in human breast cancer cells. Therefore, the DOT1L inhibitor is considered a promising strategy to treat breast cancers. Non-nucleoside DOT1L inhibitors, selenopsammaplin A and its analogues, were firstly reported in the present study...
February 11, 2021: Bioorganic & Medicinal Chemistry
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