Adrian Constantin, Dragos Predescu, Ruxandra Ciofu, Florin Achim, Silviu Constantinoiu
Breast cancer is one of the most severe health issues globally, but the therapy advancements and the constant adaptation of treatment protocols radically changed its prognoses. This article review of the literature from a surgical perspective, thus allowing for the optimum detection and placement of its role and benefits in the surgical and oncology therapeutics. The role of surgery becomes controversial, with sometimes "pretentious" techniques, hard to quantify benefits and challenges that require a thorough assessment prior to opting for surgery...
March 2021: Chirurgia
Dan Hershko
The indications for the use of neoadjuvant chemotherapy (NAC) for the management of breast cancer have broadened immensely in recent years. Initially intended mostly for inoperable breast cancers, this modality has then became the standard of care for locally advanced cancers. This treatment allowed safe surgical margin resection and in many patients with large tumors it allowed breast conserving surgery, avoiding the need for mastectomy. As clinical experience with NAC has increased along with the introduction of novel medications and better understanding of tumor biology, the indications for its use have become even more common for the treatment of some subtypes of early breast cancer...
March 2021: Chirurgia
Alexandru Blidaru
When at the end of last year Professor Traian Patrascu asked me to coordinate an issue of the journal "Chirurgia" dedicated to breast cancer, I was both surprised and intrigued. For two reasons: firstly it seemed to me so little time had passed since the previous issue about this disease and perhaps there weren't many new things to say and secondly I believed that the only topic worth discussing nowadays was the disease that overshadowed anything else: COVID-19. Nevertheless I realized that he was right...
March 2021: Chirurgia
Lana Van Damme, Jasper Van Hoorick, Philip Blondeel, Sandra Van Vlierberghe
Nowadays, breast implants, lipofilling, and microsurgical free tissue transfer are the most often applied procedures to repair soft tissue defects resulting from mastectomies/lumpectomies following breast cancer. Due to the drawbacks and limitations associated with these conventional clinical practices, there is a need for alternative reconstructive strategies. The development of biomimetic materials able to promote cell proliferation and adipogenic differentiation has gained increasing attention in the context of adipose reconstructive purposes...
May 5, 2021: Biomacromolecules
Bhupinder Pal, Yunshun Chen, François Vaillant, Bianca D Capaldo, Rachel Joyce, Xiaoyu Song, Vanessa L Bryant, Jocelyn S Penington, Leon Di Stefano, Nina Tubau Ribera, Stephen Wilcox, Gregory B Mann, Anthony T Papenfuss, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader
To examine global changes in breast heterogeneity across different states, we determined the single-cell transcriptomes of > 340,000 cells encompassing normal breast, preneoplastic BRCA1+/- tissue, the major breast cancer subtypes, and pairs of tumors and involved lymph nodes. Elucidation of the normal breast microenvironment revealed striking changes in the stroma of post-menopausal women. Single-cell profiling of 34 treatment-naive primary tumors, including estrogen receptor (ER)+ , HER2+ , and triple-negative breast cancers, revealed comparable diversity among cancer cells and a discrete subset of cycling cells...
May 5, 2021: EMBO Journal
Christine Winter, Klaus Jung
Public databases featuring original, raw data from "Omics" experiments enable researchers to perform meta-analyses by combining either the raw data or the summarized results of several independent studies. In proteomics, high-throughput protein expression data is measured by diverse techniques such as mass spectrometry, 2-D gel electrophoresis or protein arrays yielding data of different scales. Therefore, direct data merging can be problematic, and combining the summarized data of the individual studies can be advantageous...
2021: Methods in Molecular Biology
Bertrand Porro, Marie-José Durand, Audrey Petit, Mélanie Bertin, Yves Roquelaure
PURPOSE: To propose a conceptual framework of the return to work (RTW) of breast cancer survivors (BCS) according to the transactional perspective. METHODS: The Technique for Research of Information by Animation of a Group of Experts was implemented. For each determinant in an initial list established from the literature, experts selected for the consensus exercise were firstly asked to indicate their agreement level individually, via an online questionnaire. Determinants obtaining an agreement level of 80% or over during this first phase were retained...
May 5, 2021: Journal of Cancer Survivorship: Research and Practice
Hannah Collacott, Vikas Soekhai, Caitlin Thomas, Anne Brooks, Ella Brookes, Rachel Lo, Sarah Mulnick, Sebastian Heidenreich
BACKGROUND: As the number and type of cancer treatments available rises and patients live with the consequences of their disease and treatments for longer, understanding preferences for cancer care can help inform decisions about optimal treatment development, access, and care provision. Discrete choice experiments (DCEs) are commonly used as a tool to elicit stakeholder preferences; however, their implementation in oncology may be challenging if burdensome trade-offs (e.g. length of life versus quality of life) are involved and/or target populations are small...
May 5, 2021: Patient
Russell S Witte, Ehab A Tamimi
In recent years, there has been a progressive trend towards less invasive technologies for detecting metastatic cancer and guiding therapy with the goal of lower morbidity, better outcomes, and superior cosmetic appearance than traditional methods. This mini-review examines three emerging noninvasive hybrid technologies for detecting primary cancer, metastasis and guiding thermal therapy. Real-time thermoacoustic imaging and thermometry potentially provides valuable and critical feedback for guiding focused microwave ablation therapy...
May 5, 2021: Clinical & Experimental Metastasis
Aurora S Blucher, Gordon B Mills, Yiu Huen Tsang
Precision treatment for breast cancers has made several notable advances in recent decades, but challenges of tumor heterogeneity, drug resistance, and aggressive recurrence and metastases remain. To meet and overcome these challenges, we must refine our understanding of breast subtypes and treatment biomarkers according to the knowledge afforded across the spectrum of 'omics assays. A critical aspect of harnessing this knowledge into actionable biomarkers for treatment decision relies on our ability to integrate knowledge across data types and leverage our insight in evidence-based clinical trials...
May 5, 2021: Clinical & Experimental Metastasis
Yoshiaki Shoji, Satoru Furuhashi, Daniel F Kelly, Anton J Bilchik, Dave S B Hoon, Matias A Bustos
Brain metastasis (BM) frequently occurs in patients with cutaneous melanoma, lung, and breast cancer; although, BM rarely arises from cancers of the gastrointestinal tract (GIT). The reported incidence of GIT cancer BM is less than 4%. In the last few years, effective systemic therapy has prolonged the survival of GIT patients and consequently, the incidence of developing BM is rising. Therefore, the epidemiology and biology of BM arising from GIT cancer requires a more comprehensive understanding. In spite of the development of new therapeutic agents for patients with metastatic GIT cancers, survival for patients with BM still remains poor, with a median survival after diagnosis of less than 4 months...
May 5, 2021: Clinical & Experimental Metastasis
Rachel Martini, Lisa Newman, Melissa Davis
Breast cancer (BC) remains a leading cause of death among women today, and mortality among African American women in the US remains 40% higher than that of their White counterparts, despite reporting a similar incidence of disease over recent years. Previous meta-analyses and studies of BC mortality highlight that tumor characteristics, rather than socio-economic factors, drive excess mortality among African American women with BC. This is further complicated by the heterogeneity of BC, where BC can more appropriately be defined as a collection of diseases rather than a single disease...
May 5, 2021: Clinical & Experimental Metastasis
S David Nathanson, Michael Detmar, Timothy P Padera, Lucy R Yates, Danny R Welch, Thomas C Beadnell, Adam D Scheid, Emma D Wrenn, Kevin Cheung
Invasive breast cancer tends to metastasize to lymph nodes and systemic sites. The management of metastasis has evolved by focusing on controlling the growth of the disease in the breast/chest wall, and at metastatic sites, initially by surgery alone, then by a combination of surgery with radiation, and later by adding systemic treatments in the form of chemotherapy, hormone manipulation, targeted therapy, immunotherapy and other treatments aimed at inhibiting the proliferation of cancer cells. It would be valuable for us to know how breast cancer metastasizes; such knowledge would likely encourage the development of therapies that focus on mechanisms of metastasis and might even allow us to avoid toxic therapies that are currently used for this disease...
May 5, 2021: Clinical & Experimental Metastasis
Bo Pan, Dongyi Zhao, Yaqian Liu, Na Li, Chen Song, Ning Li, Xuelu Li, Zuowei Zhao
Malignant pleural effusion (MPE) presents a severe medical condition in patients with advanced breast cancer (BC). We applied organoid culture technology to culture preoperative puncture specimen and corresponding surgical specimen-derived tumor cells from early BC patients and pleural effusion-derived tumor cells from advanced BC patients with MPE to study whether in vitro models could predict therapies of clinical patients. We successfully expanded pleural effusion-derived tumor organoids from 1 advanced triple-negative breast cancer (TNBC) patient with MPE which had been continuously propagated for more than 3 months...
May 5, 2021: In Vitro Cellular & Developmental Biology. Animal
David W Lim, Kelly A Metcalfe
No abstract text is available yet for this article.
May 5, 2021: Annals of Surgical Oncology
Jana de Boniface, Robert Szulkin, Anna L V Johansson
Importance: Cohort studies show better survival after breast-conserving surgery (BCS) with postoperative radiotherapy (RT) than after mastectomy (Mx) without RT. It remains unclear whether this is an independent effect or a consequence of selection bias. Objective: To determine whether the reported survival benefit of breast conservation is eliminated by adjustment for 2 pivotal confounders, comorbidity and socioeconomic status. Design, Setting, and Participants: Cohort study using prospectively collected national data...
May 5, 2021: JAMA Surgery
Lisa A Newman
No abstract text is available yet for this article.
May 5, 2021: JAMA Surgery
Maria Susana Barboza da Silva, Maria Gaby Rivero de Gutiérrez, Elisabeth Níglio de Figueiredo, Márcia Barbieri, Carlos Frank Viga Ramos, Maria Cristina Gabrielloni
OBJECTIVE: to assess the implementation of actions for early detection of breast cancer in Primary Care and to verify the adequacy of these actions with the Ministry of Health recommendations. METHOD: a cross-sectional study conducted from September 2017 to March 2018 with 736 women registered in Basic Health Units in two municipalities in Acre. For data collection, a validated questionnaire was used. In statistical analysis, the chi-square test or Fisher's exact test was applied...
2021: Revista Brasileira de Enfermagem
Matteo Martinato, Giulia Lorenzoni, Tommaso Zanchi, Alessia Bergamin, Alessia Buratin, Danila Azzolina, Dario Gregori
BACKGROUND: Regular physical activity (PA) contributes to the primary and secondary prevention of several chronic diseases and reduces the risk of premature death. Physical inactivity is a modifiable risk factor for cardiovascular disease and a variety of chronic disorders such as diabetes, obesity, hypertension, bone and joint diseases (eg, osteoporosis and osteoarthritis), depression, and colon and breast cancer. Population aging and the related increase in chronic diseases have a major impact on the health care systems of most Western countries and will produce an even more significant effect in the future...
May 5, 2021: JMIR MHealth and UHealth
Aswathi R Hegde, Ruchira Raychaudhuri, Abhijeet Pandey, Guruprasad Kalthur, Srinivas Mutalik
This review focuses on the various formulation approaches that have been explored to achieve localized delivery in breast cancer. The rationale behind the necessity of localized drug delivery has been extensively reviewed. The review also emphasizes the various possible routes for achieving localized drug delivery. Particularly, different types of nanoplatforms like lipid-based drug carriers, polymeric particles, hydrogels, drug conjugates and other formulation strategies like microneedles and drug-eluting implants, which have been used to increase tumor retention and subsequently halt tumor progression, have been deliberated here...
May 5, 2021: Nanomedicine
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