Athanasios A Panagiotopoulos, Chara Polioudaki, Sotirios G Ntallis, Dimitris Dellis, George Notas, Christos A Panagiotidis, Panayiotis A Theodoropoulos, Elias Castanas, Marilena Kampa
BACKGROUND: Nuclear translocation of large proteins is mediated through specific protein carriers, collectively named karyopherins (importins, exportins and adaptor proteins). Cargo proteins are recognized by importins through specific motifs, known as nuclear localization signals (NLS). However, only the NLS recognized by importin α and transportin (M9 NLS) have been identified so far METHODS: An unsupervised in silico approach was used, followed by experimental validation. RESULTS: We identified the sequence EKRKI(E/R)(K/L/R/S/T) as an NLS signal for importin 7 recognition...
January 19, 2021: Biochimica et Biophysica Acta. General Subjects