Ingrid O Travassos, Francyelli Mello-Andrade, Raíssa P Caldeira, Wanessa C Pires, Paula F F da Silva, Rodrigo S Correa, Tamara Teixeira, Alisson Martins-Oliveira, Alzir A Batista, Elisângela P de Silveira-Lacerda
Metal complexes based on ruthenium have established excellent activity with less toxicity and great selectivity for tumor cells. This study aims to assess the anticancer potential of ruthenium(II)/allopurinol complexes called [RuCl2 (allo)2 (PPh3 )2 ] (1) and [RuCl2 (allo)2 (dppb)] (2), where allo means allopurinol, PPh3 is triphenylphosphine and dppb, 1,4-bis(diphenylphosphino)butane. The complexes were synthesized and characterized by elemental analysis, IR, UV-Vis and NMR spectroscopies, cyclic voltammetry, molar conductance measurements, as well as the X-ray crystallographic analysis of complex 2...
April 10, 2021: Journal of Biological Inorganic Chemistry: JBIC