Breast cancer

Lizhe Zhu, Siyuan Jiang, Shibo Yu, Xiaoxu Liu, Shengyu Pu, Peiling Xie, Heyan Chen, Xiaoqin Liao, Ke Wang, Bin Wang
Patients with advanced breast cancer (BC) showed a higher incidence of regional and distant metastases. Sine oculis homeobox homolog 1 (SIX-1) has been confirmed to be a key tumorigenic and metastatic regulator in BC progression. Yet, molecular mechanisms behind SIX-1-induced BC metastases remain largely unknown. Here we found that SIX-1 was frequently up-regulated in BC and correlated with poor outcomes when tested in human BC tissue microarray. Then, we manipulated the expression of SIX-1 by via shRNA-mediated knockdown and lentivirus-mediated overexpression...
March 30, 2020: Journal of Cellular and Molecular Medicine
Xu Feng, Ranran Tang, Runjie Zhang, Huan Wang, Zhaodong Ji, Yang Shao, Shuoer Wang, Tianying Zhong, Yun Gu, Jiao Meng
Gynaecologic and breast cancers share some similarities at the molecular level. The aims of our study are to highlight the similarities and differences about IDO1, an important immune-related gene in female cancers. The NGS data from TCGA of cervical squamous cell carcinoma (CESC), ovarian serous cystadenocarcinoma (OV), uterine corpus endometrial carcinoma (UCEC), uterine carcinosarcoma (UCS) and breast invasive carcinoma (BRCA) were analysed to identify molecular features, and clinically significant and potential therapeutic targets of IDO1...
March 30, 2020: Journal of Cellular and Molecular Medicine
Deng-Xing Lun, Nai-Wang Chen, Jiang-Tao Feng, Xion-Gang Yang, Zhao-Wan Xu, Feng Li, Yong-Cheng Hu
OBJECTIVE: To characterize the visceral metastasis as a predictive tool for the survival of patients with spinal metastases through an exploratory meta-analysis. METHODS: Two investigators independently searched PubMed and Embase databases for eligible studies from 2000-2016. The effect estimates for the hazard ratio (HR) or risk ratio (RR) and 95% confidence interval (CI) were collected and pooled with a random- or fixed-effect model. RESULTS: In total, 18 eligible studies were retrieved with 5468 participants from nine countries...
March 29, 2020: Orthopaedic Surgery
Paulina M Gutkin, Sebastian Fernandez-Pol, Kathleen C Horst
Recurrence of breast cancer is a predominant fear for patients who were treated for breast cancer. Acute and late dermatologic effects of radiotherapy are not uncommon and could have similar characteristics to breast cancer recurrence. Thus, it is important to highlight key differences between the clinical and histologic presentations of radiation effects and recurrence. Herein, we present two patients who presented with late dermatologic effects of radiotherapy months to years after treatment, neither of whom had workup consistent with cancer recurrence...
March 29, 2020: International Wound Journal
Beatriu Reig, Laura Heacock, Alana Lewin, Nariya Cho, Linda Moy
The goals of imaging after neoadjuvant therapy for breast cancer are to monitor the response to therapy and facilitate surgical planning. MRI has been found to be more accurate than mammography, ultrasound, or clinical exam in evaluating treatment response. However, MRI may both overestimate and underestimate residual disease. The accuracy of MRI is dependent on tumor morphology, histology, shrinkage pattern, and molecular subtype. Emerging MRI techniques that combine functional information such as diffusion, metabolism, and hypoxia may improve MR accuracy...
March 29, 2020: Journal of Magnetic Resonance Imaging: JMRI
Neal Bhutiani, Adam C Hicks, Bin Huang, Quan Chen, Thomas C Tucker, Kelly M McMasters, Nicolás Ajkay
BACKGROUND AND OBJECTIVES: A previous analysis of breast cancer care after the 2014 Medicaid expansion in Kentucky demonstrated delays in treatment despite a 12% increase in insurance coverage. This study sought to identify factors associated with treatment delays to better focus efforts for improved breast cancer care. METHODS: The Kentucky Cancer Registry was queried for adult women diagnosed with invasive breast cancer between 2010 and 2016 who underwent up-front surgery...
March 29, 2020: Journal of Surgical Oncology
Jéssika de Oliveira Nascimento, Lara Caroline Anastacio Haro, Rafael da Silva Sá, Rebeca Espelho Storch
Several factors trigger the development of genetic mutations that are responsible for causing a neoplasm. Medulloblastoma is a malignant and invasive cerebellar neoplasm, that affects children and young adults. Mucinous carcinoma is a special type of breast cancer. Being a special atypical subtype of invasive carcinoma, it most frequently affects women of advanced age and represents 1 to 7% of all breast cancers. The reported case aims to show the rarity of the occurrence of desmoplastic medulloblastoma and mammary mucinous carcinoma in a young patient in a short period of time, in different sites, without direct anatomical attachment and without occurrence of metastasis...
February 2020: Revista Brasileira de Ginecologia e Obstetrícia
Addie Hill, Eutiquio Gutierrez, Jennifer Liu, Sarah Sammons, Gretchen Kimmick, Mina S Sedrak
Breast cancer is a disease of aging, and the incidence of breast cancer is projected to increase dramatically as the global population ages. The majority of breast cancers that occur in older adults are hormone-receptor positive, human epidermal growth factor receptor-2 (HER2)-negative phenotypes, with favorable tumor biology; yet, because of underrepresentation in clinical trials, less evidence is available to guide the complex care for this population. Providing care for older patients with metastatic breast cancer, with coexisting medical conditions, increased risk of treatment toxicity, and frailty, remains a clinical challenge in oncology...
March 30, 2020: Drugs & Aging
Wei Liu, Wei Li, Ziyao Li, Lei Shi, Peng Zhao, Zihong Guo, Jiawei Tian, Zhenzhen Wang
BACKGROUND: Sclerosing adenosis (SA) is a benign lesion with complicated pathological components and could mimic breast carcinoma in both clinical palpation and medical imaging findings. The present study was conducted to assess the value of ultrasound (US) characteristics in diagnosing SA and their differentiation from breast carcinoma. METHODS: We retrospectively reviewed the medical records of 305 women (347 lesions) with invasive ductal carcinoma (IDC) and 54 women with single SA lesion, who had breast excision between April 2016 and July 2018...
March 29, 2020: Breast Cancer Research and Treatment
Brian L Sprague, R Yates Coley, Karla Kerlikowske, Garth H Rauscher, Louise M Henderson, Tracy Onega, Christoph I Lee, Sally D Herschorn, Anna N A Tosteson, Diana L Miglioretti
Importance: Many US radiologists have screening mammography recall rates above the expert-recommended threshold of 12%. The influence of digital breast tomosynthesis (DBT) on the distribution of radiologist recall rates is uncertain. Objective: To evaluate radiologists' recall and cancer detection rates before and after beginning interpretation of DBT examinations. Design, Setting, and Participants: This cohort study included 198 radiologists from 104 radiology facilities in the Breast Cancer Surveillance Consortium who interpreted 251 384 DBT and 2 000 681 digital mammography (DM) screening examinations from 2009 to 2017, including 126 radiologists (63...
March 2, 2020: JAMA Network Open
William W Feng, Manabu Kurokawa
Breast cancer is one of the leading causes of death in women in the United States. In general, patients with breast cancer undergo surgical resection of the tumor and/or receive drug treatment to kill or suppress the growth of cancer cells. In this regard, small molecule kinase inhibitors serve as an important class of drugs used in clinical and research settings. However, the development of resistance to these compounds, in particular HER2 and CDK4/6 inhibitors, often limits durable clinical responses to therapy...
2020: Cancer Drug Resistance
Bei Li, Rongxin Geng, Qi Wu, Qian Yang, Si Sun, Shan Zhu, Zhiliang Xu, Shengrong Sun
The tumor microenvironment (TME) is a heterogeneous system that contributes to breast cancer progression. The Cancer Genome Atlas (TCGA) database provides global gene expression profiling data for further analysis of various malignancies, including breast cancer. Based on the ESTIMATE algorithm, immune and stromal scores were calculated according to immune or stromal components in the TME. We divided breast cancer cases into high- and low-score groups and identified differentially expressed genes (DEGs) that were significantly associated with overall survival...
2020: Frontiers in Oncology
Li Tang, Yuli Chen, Huanhuan Chen, Pan Jiang, Linping Yan, Dongping Mo, Xun Tang, Feng Yan
Triple-negative breast cancer (TNBC) is a highly metastatic breast cancer subtype, and the primary systemic treatment strategy involves conventional chemotherapy. DC-STAMP domain containing 1-antisense 1 ( DCST1-AS1 ) is a long non-coding RNA that promotes TNBC migration and invasion. Studying the role of DCST1-AS1 in promoting epithelial-mesenchymal transition (EMT) and chemoresistance will provide a new strategy for TNBC therapy. In the present study, we found that DCST1-AS1 regulates the expression or secretion of EMT-related proteins E-cadherin, snail family zinc finger 1 (SNAI1), vimentin, matrix metallopeptidase 2 (MMP2), and matrix metallopeptidase 9 (MMP9)...
2020: Frontiers in Oncology
Zhichao Zhang, Yawen Yao, Qing Yuan, Cao Lu, Xiangchun Zhang, Jinling Yuan, Kaixiao Hou, Chunyu Zhang, Zhongying Du, Xueyun Gao, Xiongsheng Chen
Rationale : Bone is the most frequent site for breast cancer metastasis, which accounts for the leading cause of death in advanced breast cancer patients. Serious skeletal-related events (SREs) caused by bone metastasis have a decisive impact on the life expectancy of breast cancer patients, making breast cancer almost incurable. Metastatic breast cancer cell induced pathological osteoclastogenesis is a key driver of bone metastasis and osteolytic bone lesions. We previously reported that gold clusters can prevent inflammation induced osteoclastogenesis and osteolysis in vivo ...
2020: Theranostics
Zhiyuan Wu, Sihan Li, Xuemei Tang, Yue Wang, Weiwei Guo, Guojun Cao, Kun Chen, Min Zhang, Ming Guan, Da Yang
Rationale : Loss of DNA damage repair (DDR) in the tumor is an established hallmark of sensitivity to DNA damaging agents such as chemotherapy. However, there has been scant investigation into gain-of-function alterations of DDR genes in cancer. This study aims to investigate to what extent copy number amplification of DDR genes occurs in cancer, and what are their impacts on tumor genome instability, patient prognosis and therapy outcome. Methods : Retrospective analysis was performed on the clinical, genomics, and pharmacogenomics data from 10,489 tumors, matched peripheral blood samples, and 1,005 cancer cell lines...
2020: Theranostics
Wenya Liu, Tonghui Cai, Lingjun Li, Hui Chen, Ruichao Chen, Minfen Zhang, Wei Zhang, Li Zhao, Hanzhen Xiong, Ping Qin, Xingcheng Gao, Qingping Jiang
Nasopharyngeal carcinoma (NPC), is one of the most common malignant tumor in southern China and southeast Asia. MYH10 is a coding gene of the NMMHC-IIB protein. Previous studies have shown that MYH10 expression was up-regulated in breast cancer, glioma and meningioma. Moreover, it was targeted by miR200 family. However, no relevant studies have been found in NPC. In present study, we found in 48 NPC specimens, MYH10 level was lower in most cancer areas than that in the adjacent normal tissue. Moreover, the depletion of MYH10 can promote the migration and invasion of NPC...
2020: Journal of Cancer
Huishan Wang, Li Wang, Lingyu Tang, Jing Luo, Hao Ji, Wen Zhang, Jian Zhou, Quanpeng Li, Lin Miao
Cholangiocarcinoma (CCA) development is an extremely complex process with alterations occurring in numerous genes. SNHG6, a validated lncRNA, has been reported to regulate the expression of multiple tumor-related genes in hepatocellular carcinoma, colorectal cancer and breast cancer. Here, we elucidated the function and possible molecular mechanisms of SNHG6 in human CCA cells. Our results proved that the expression SNHG6 was upregulated in CCA tissues and cell lines. Ectopic expression of SNHG6 promoted cell proliferation, cell cycle progression, migration, and angiogenesis in CCA cells, whereas knockdown of SNHG6 repressed these cellular processes...
2020: Journal of Cancer
Qiqi Xie, Wen Ou-Yang, Mingwei Zhang, Huimei Wang, Qiuyuan Yue
Background: Nucleolar and spindle-associated protein 1 (NUSAP1) was previously reported to be associated with poor prognosis in multiple cancers. In the present study, we comprehensively investigated the clinicopathological features and potential prognostic value of NUSAP1 in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC). Methods: The expression profiles of the genes were extracted from Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), Cancer Cell Line Encyclopedia (CCLE), Gene Expression Profiling Interactive Analysis (GEPIA), and The Human Protein Atlas databases...
2020: Journal of Cancer
Robert Wieder, Basit Shafiq, Nabil Adam
Background: African American women have not benefited equally from recently improved breast cancer survival. We investigated if this was true for all subsets. Methods: We identified 395,170 patients with breast adenocarcinoma from the SEER database from 1990 to 2011 with designated race, age, stage, grade, ER and PR status, marital status and laterality, as control. We grouped patients into two time periods, 1990-2000 and 2001-2011, three age categories, under 40, 40-69 and ≥ 70 years and two stage categories, I-III and IV...
2020: Journal of Cancer
Chao-Qun Wang, Chih-Hsin Tang, Huey-En Tzeng, Lulu Jin, Jin Zhao, Le Kang, Yan Wang, Gui-Nv Hu, Bi-Fei Huang, Xiaoni Li, Yong-Ming Zhao, Chen-Ming Su, Hong-Chuan Jin
The adipokine resistin is linked with obesity, inflammation and various cancers, including breast cancer. This study sought to determine whether certain polymorphisms in the gene encoding resistin, RETN, increase the risk of breast cancer susceptibility. We analyzed levels of resistin expression in breast cancer tissue and samples from The Cancer Genome Atlas database. We also examined associations between four RETN single nucleotide polymorphisms (SNPs; rs3745367, rs7408174, rs1862513 and rs3219175) and breast cancer susceptibility in 515 patients with breast cancer and 541 healthy women without cancer...
2020: Journal of Cancer
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