Nigus D Ambaye, Hua E Yu
STAT3 is attractive target for development of anti-cancer therapeutics as it is implicated in nearly all forms of human tumors. To identify novel leads, we screened a combinatorial peptide library displayed on the surface of M13 bacteriophage. After three rounds of biopanning, a dodecapeptide with the YYVSWPPDMMHY sequence was found to be enriched by 36 % while another with a short consensus motif was displayed in 20% of the phages. Binding analysis by isothermal titration calorimetry shows the most displayed peptide interacted with a Kd of 1...
July 13, 2020: Chemical Biology & Drug Design
Saadet Çömez, Özgül Karayurt
PURPOSE: The aim of the study was to examine the effects of web-based training that was structured in line with Roy's Adaptation Model on the "life quality" of women with breast cancer, and on the "spousal adjustment" of women and their spouses. METHOD: The study used a pretest-posttest, quasi-experimental controlled group design and 83 women with breast cancer and their spouses were enrolled. The data were collected at baseline and again three months later using the Functional Assessment of Cancer Therapy-breast cancer scale and the Dyadic Adjustment Scale as data collection tools...
April 9, 2020: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
Zhenghua Wang, Xiaoyu Wang, Yu Gao, Yuanyuan Wang, Minghao Xu, Qiuyue Han, Xinhan Zhao
BACKGROUND: Interleukin 7 receptor (IL-7R) is a member of the type I cytokine receptor family, which affects the occurrence of various tumors by forming a signaling complex with its ligand Interleukin 7 (IL-7). This study aimed to explore the potential relationships of IL-7R polymorphisms with breast cancer susceptibility in the Chinese Han women. METHODS: Five polymorphisms of IL-7R gene (rs969129, rs10213865, rs10053847, rs118137916, and rs6451231) form 553 patients and 550 healthy individuals among the Chinese Han women were genotyped using Agena MassARRAY platform...
July 10, 2020: International Immunopharmacology
Wen-Wen Cheng, Ze-Kun Wang, Huang-Fang Shangguan, Qiang Zhu, Hong-Yu Zhang
OBJECTIVE: The relationship between vitamin intake and the occurrence of cancer is controversial. The aim of this study was to examine the genetic associations between vitamins D, E, and B12 and five cancers (i.e., colorectal cancer, breast cancer, prostate cancer, malignant melanoma, and squamous cell carcinoma). METHODS: This study started from genome-wide association data for three vitamins (N = 11 238) and five cancers (N = 373 316). The study analyzed their associations using Mendelian randomization (MR) methods...
May 29, 2020: Nutrition
Ding Tang, Renyi Yan, Yuan Sun, Kuoyin Kai, Keli Chen, Juan Li
BACKGROUND: The tuber of Pinellia ternata has been used for a thousand years in China. P. ternata possessed the activities of anti-emetic, sedative-hypnotic, anti-cancer, anti-asthmatic, anti-tussive, and anti-inflammatory. It is the representative of expectorant medicines in Traditional Chinese Medicine (TCM). Phlegm is the pathological product and a new pathogenic factor of the metabolite, which is analogous to the damage of oxidative stress. PURPOSE: The objectives of the study were to investigate the protective activity and mechanism of ethanol extract of P...
July 2, 2020: Phytomedicine
Jyoti Tanwar, Samriddhi Arora, Rajender K Motiani
Ion channels in particular Calcium (Ca2+ ) channels play a critical role in physiology by regulating plethora of cellular processes ranging from cell proliferation, differentiation, transcriptional regulation and programmed cell death. One such physiologically important and highly Ca2+ selective channel family is Orai channels consisting of three homologs Orai1, Orai2 and Orai3. Orai channels are responsible for Ca2+ influx across the plasma membrane in response to decrease in Endoplasmic Reticulum (ER) Ca2+ stores...
June 26, 2020: Cell Calcium
Zafeiro Zisi, Panagiotis G Adamopoulos, Christos K Kontos, Andreas Scorilas
Alternative splicing is commonly involved in carcinogenesis, being highly implicated in differential expression of cancer-related genes. Recent studies have shown that the human CEACAM19 gene is overexpressed in malignant breast and ovarian tumors, possessing significant biomarker attributes. In the present study, 3' rapid amplification of cDNA ends (3' RACE) and next-generation sequencing (NGS) were used for the detection and identification of novel CEACAM19 transcripts. Bioinformatical analysis of our NGS data revealed novel splice junctions between previously annotated exons and ultimately new exons...
July 10, 2020: Genomics
Masahiro Hiraoka, Takashi Mizowaki, Yukinori Matsuo, Mitsuhiro Nakamura, Dirk Verellen
A gimbaled-head radiotherapy device was developed by industry-academic collaborations, with a concept of robust structures whilst maintaining high flexibilities, and its clinical application started in 2008. The unique structures with multi-image guidance functions initiated 2 new treatment modalities. One is dynamic tumor tracking radiotherapy with real time monitoring (DTTRM), which enables 4-D radiotherapy without prolongation of radiotherapy treatment time. This treatment has become clinically feasible for stereotactic body radiotherapy (SBRT) of lung cancers and liver tumors, and intensity-modulated radiotherapy (IMRT) for pancreatic cancers...
July 10, 2020: Radiotherapy and Oncology
Hyun Jung Hwang, Ye-Rim Lee, Donghee Kang, Hyung Chul Lee, Haeng Ran Seo, Ji-Kan Ryu, Yong-Nyun Kim, Young-Gyu Ko, Heon Joo Park, Jae-Seon Lee
The effects of senescence associated secretory phenotype (SASP) from therapy-induced senescent endothelial cells on tumor microenvironment (TME) remains to be clarified. Here, we investigated effects of ionizing radiation (IR)- and doxorubicin-induced senescent HUVEC on TME. MDA-MB-231 cancer cells treated with conditioned medium (CM) from senescent HUVEC or co-cultured with senescent HUVEC significantly increased cancer cell proliferation, migration, and invasion. We found that CXCL11 plays a principal role in the senescent CM-induced aggressive activities of MDA-MB-231 cells...
July 10, 2020: Cancer Letters
Asma Nazar, Ghulam Abbas, Syed Sikander Azam
Heat shock protein 90 (Hsp90) performs function in cellular activities together with other signaling pathways. Hsp90 is evolutionary conserved and universally articulated as a human cancer-causing agent involves in lung cancer, breast cancer followed by colon and rectum cancer. It emerged as an effective drug candidate and inhibition may affect several signaling pathways associated with cancer spreading. Therefore, in-silico approaches molecular docking, molecular dynamics simulation and binding free energy calculations were applied to have insights into the inhibition mechanism against Hsp90 to identify new cancer therapeutic drugs...
July 13, 2020: Journal of Chemical Information and Modeling
Younghun Jung, Jin Koo Kim, Eunsohl Lee, Frank C Cackowski, Ann M Decker, Paul H Krebsbach, Russell S Taichman
BACKGROUND: Epithelial stem cells (ESCs) demonstrate a capacity to maintain normal tissues homeostasis and ESCs with a deregulated behavior can contribute to cancer development. The ability to reprogram normal tissue epithelial cells into prostate or mammary stem-like cells holds great promise to help understand cell of origin and lineage plasticity in prostate and breast cancers in addition to understanding normal gland development. We previously showed that an intracellular chemokine, CXCL12γ induced cancer stem cells and neuroendocrine characteristics in both prostate and breast adenocarcinoma cell lines...
July 13, 2020: Prostate
Yuka Nozaki, Hitomi Motomura, Shoma Tamori, Yumiko Kimura, Chotaro Onaga, Shotaro Kanai, Yuka Ishihara, Ayaka Ozaki, Yasushi Hara, Yohsuke Harada, Yasunari Mano, Tsugumichi Sato, Keiko Sato, Kazunori Sasaki, Hitoshi Ishiguro, Shigeo Ohno, Kazunori Akimoto
Despite development of markers for identification of cancer stem cells, the mechanism underlying the survival and division of cancer stem cells in breast cancer remains unclear. Here we report that PKCλ expression was enriched in basal-like breast cancer, among breast cancer subtypes, and was correlated with ALDH1A3 expression (p = 0.016, χ2-test). Late stage breast cancer patients expressing PKCλhigh and ALDH1A3high had poorer disease-specific survival than those expressing PKCλlow and ALDH1A3low (p = 0...
2020: PloS One
Carissa Nadia Kuswanto, Jessica Sharp, Lesley Stafford, Penelope Schofield
BACKGROUND: This study investigated the role of posttraumatic growth (PTG) in moderating the associations between parenting efficacy and psychological distress, and between fear of cancer recurrence (FCR) and psychological distress, in mothers who are breast cancer survivors. METHODS: In this cross-sectional study, mothers who were breast cancer survivors (N = 91) completed the Depression, Anxiety and Stress Scale (DASS-21), Cancer-Related Parenting Self-Efficacy (CaPSE), Concerns About Cancer Recurrence (CARS) and Posttraumatic Growth Inventory Short Form (PTGI-SF)...
June 23, 2020: Journal of Affective Disorders
Gopal S Tandel, Antonella Balestrieri, Tanay Jujaray, Narender N Khanna, Luca Saba, Jasjit S Suri
MOTIVATION: Brain or central nervous system cancer is the tenth leading cause of death in men and women. Even though brain tumour is not considered as the primary cause of mortality worldwide, 40% of other types of cancer (such as lung or breast cancers) are transformed into brain tumours due to metastasis. Although the biopsy is considered as the gold standard for cancer diagnosis, it poses several challenges such as low sensitivity/specificity, risk during the biopsy procedure, and relatively long waiting times for the biopsy results...
July 2020: Computers in Biology and Medicine
Izzet Mehmet Akcay, Elifnaz Celik, Nihat Bugra Agaoglu, Gizem Alkurt, Tugba Kizilboga Akgun, Jale Yildiz, Feruze Enc, Gozde Kir, Sezin Canbek, Ali Kilic, Ebru Zemheri, Fikret Ezberci, Melike Özcelik, Gizem Dinler Doganay, Levent Doganay
Inherited pathogenic variants account for 5-10% of all breast cancer (BC) and colorectal cancer (CRC) cases. Here we sought to profile the pathogenic variants in 25 cancer susceptibility genes in Turkish population. Germline pathogenic variants were screened in 732 BC patients, 189 CRC patients, and 490 cancer-free elderly controls, using NGS-based multigene panel testing and MLPA testing. Pathogenic variants were detected in 17.2% of high-risk BC patients and 26.4% of high-risk CRC patients. More than 95% of these variants were clinically actionable...
July 13, 2020: International Journal of Cancer. Journal International du Cancer
Konrad Stępień, Karol Nowak, Paweł Pasieka, Konrad Warmuz, Adam Stępień, Jadwiga Nessler, Jarosław Zalewski
Takotsubo cardiomyopathy (TCM) represents an acute systolic left ventricular dysfunction typically triggered by severe psychological or physical stress. Oncological patients due to emotional distress of the diagnosis, proinflammatory and prothrombotic nature of cancer and also physical stress often following complex anticancer therapies are at high-risk of TCM. Moreover, there are also few reports of TCM associated with oncological treatment, mostly chemotherapy. Recent data from large registries indicate a surprisingly high incidence of malignancy in TCM, significant differences in clinical characteristics and unfavorable short- and long-term clinical outcomes in this specific group of patients...
2020: Folia Medica Cracoviensia
Joerg Heil, André Pfob, Hans-Peter Sinn, Geraldine Rauch, Paul Bach, Bettina Thomas, Benedikt Schaefgen, Sherko Kuemmel, Toralf Reimer, Markus Hahn, Marc Thill, Jens-Uwe Blohmer, John Hackmann, Wolfram Malter, Inga Bekes, Kay Friedrichs, Sebastian Wojcinski, Sylvie Joos, Stefan Paepke, Nina Ditsch, Achim Rody, Regina Große, Marion van Mackelenbergh, Mattea Reinisch, Maria Karsten, Michael Golatta
OBJECTIVE: We evaluated the ability of minimally invasive, image-guided vacuum-assisted biopsy (VAB) to reliably diagnose a pathologic complete response in the breast (pCR-B). SUMMARY BACKGROUND DATA: Neoadjuvant systemic treatment (NST) elicits a pathologic complete response in up to 80% of women with breast cancer. In such cases, breast surgery, the gold standard for confirming pCR-B, may be considered overtreatment. METHODS: This multicenter, prospective trial enrolled 452 women presenting with initial stage 1-3 breast cancer of all biological subtypes...
July 9, 2020: Annals of Surgery
Jennifer K Plichta, Samantha M Thomas, Amanda R Sergesketter, Rachel A Greenup, Laura H Rosenberger, Oluwadamilola M Fayanju, Gretchen Kimmick, Jeremy Force, Terry Hyslop, E Shelley Hwang
OBJECTIVE: We aim to identify prognostic groups within a de novo metastatic cohort, incorporating both anatomic and biologic factors. BACKGROUND: Staging for breast cancer now includes anatomic and biologic factors, although the guidelines for stage IV disease do not account for how these factors may influence outcomes. METHODS: Adults with de novo metastatic breast cancer were selected from the National Cancer DataBase (2010-2013). Recursive partitioning analysis was used to group patients with similar overall survival (OS) based on clinical T/N stage, tumor grade, ER, PR, HER2, number of metastatic sites, and presence of bone-only metastases...
July 9, 2020: Annals of Surgery
Emma Sewart, Nicholas L Turner, Elizabeth J Conroy, Ramsey I Cutress, Joanna Skillman, Lisa Whisker, Steven Thrush, Nicola Barnes, Chris Holcombe, Shelley Potter
OBJECTIVE: To explore the impact of PMRT on PROs of IBBR performed with and without mesh. SUMMARY OF BACKGROUND DATA: PMRT is increasingly given to improve breast cancer outcomes but can adversely impact complications after IBBR. Little; however, is known about the impact of PMRT on the PROs of IBBR, especially when mesh is used. METHODS: The implant Breast Reconstruction evAluation prospective cohort study recruited consecutive women undergoing immediate IBBR from 81 UK breast and plastic surgical units...
July 9, 2020: Annals of Surgery
Figen Erol Ursavaş, Özgül Karayurt
BACKGROUND: The side effects of local and systemic treatments for breast cancer negatively impact the body image, sexual functioning, and social life of women on treatment for breast cancer. One of the ways to help these women adapt to their disease and cope with the effects of the disease and the side effects of its treatment is through support groups. OBJECTIVE: The aim of this study was to investigate the effect of a support group intervention, guided by Roy's Adaptation Model, on sexual adaptation, body image, and perceived social support in women on treatment for cancer...
July 9, 2020: Cancer Nursing
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