Hossein Javid, Fatemeh Attarian, Toktam Saadatmand, Nastaran Rezagholinejad, Ali Mehri, Hamed Amiri, Mehdi Karimi-Shahri
The second leading cause of cancer death in women worldwide is breast cancer (BC), and despite significant advances in BC therapies, a significant proportion of patients develop metastasis and disease recurrence. Currently used treatments, like radiotherapy, chemotherapy, and hormone replacement therapy, result in poor responses and high recurrence rates. Alternative therapies are therefore needed for this type of cancer. Cancer patients may benefit from immunotherapy, a novel treatment strategy in cancer treatment...
March 26, 2023: Journal of Cellular Biochemistry
Mingyuan He, Yue Hou, Liqun Zou, Li Ran
Bilateral primary breast cancer (BPBC) patients have a worse prognosis. Tools for accurately predicting mortality risk in patients with BPBC are lacking in clinical practice. We aimed to develop a clinically useful prediction model for the death of BPBC patients. A total of 19,245 BPBC patients from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2015 were randomly divided into the training set ( n  = 13,471) and test set (5,774). Models for predicting the 1-, 3- and 5-year death risk of BPBC patients were developed...
March 26, 2023: Biotechnology & Genetic Engineering Reviews
Ran Hao, Lei Zhang, Yangming Si, Peng Zhang, Yipeng Wang, Bangchao Li, Jie Hu, Yixin Qi
BACKGROUND: Metastasis is the leading cause of mortality in patients with breast cancer (BC). Studies demonstrate that circular RNAs (circRNAs) were involved in BC progression, while the molecular mechanisms remain largely unclear. METHODS: The microArray circRNA profiles were used to explore the differential expression circRNAs in BC and paracancerous normal tissues, and the quantitative reverse transcription-polymerase chain reaction was used to validate their expression level in clinical samples and cell lines...
March 25, 2023: Cancer Cell International
Min Yang, Ying Zhang, Min Li, Xinglong Liu, Mohammad Darvishi
No abstract text is available yet for this article.
March 25, 2023: Cancer Cell International
Lin Sun, Jiajia Liu, Meng Guo, Jiaqi Xu, Dan Wang
RATIONALE: Chinese women topped the list of new breast cancers, the first diagnosed gastric metastasis and bone metastasis is extremely infrequent. The clinical and pathological diagnosis of metastatic breast cancer is difficult. To our knowledge, this is the first reported case of the first diagnosis of breast cancer with both gastric metastasis and bone metastasis. CASE REPORT: The female patient was found to have abdominal distension for 15 days with nausea and vomiting...
March 25, 2023: BMC Women's Health
Masoumeh Safdari-Molan, Esmat Mehrabi, Roghaiyeh Nourizadeh, Reza Eghdam-Zamiri
INTRODUCTION: Worry about cancer recurrence is identified as the most common psychological burdens experienced by cancer patients and survivors. The present study aimed to determine the predictors of worry about cancer recurrence among women with breast cancer. MATERIALS AND METHODS: This cross-sectional study was conducted on 166 women with breast cancer undergoing chemotherapy and radiotherapy, who referred to private and public oncology centers in Tabriz, Iran using the convenience sampling...
March 25, 2023: BMC Women's Health
Kenneth Elder, Julia Matheson, Carolyn Nickson, Georgia Box, Jennifer Ellis, Arlene Mou, Clair Shadbolt, Allan Park, Jia Tay, Allison Rose, Gregory Bruce Mann
PURPOSE: Mammography (MG) is the standard imaging in surveillance of women with a personal history of breast cancer or DCIS (PHBC), supplemented with ultrasound. Contrast Enhanced Mammography (CEM) has higher sensitivity than MG and US. We report the performance of CEM compared with MG ± US. METHODS: A retrospective study of patients undergoing their first surveillance CEM in an Australian hospital setting between June 2006 and October 2020. Cases where a patient was recalled for assessment were identified, recording radiology, pathology and treatment details...
March 25, 2023: Breast Cancer Research and Treatment
Thomas Grinda, Elie Rassy, Barbara Pistilli
Antibody drug-conjugates (ADCs) have revolutionized the treatment of many types of cancer, including breast cancer. Recently, two new ADCs have been approved, trastuzumab deruxtecan and sacituzumab govitecan; both have demonstrated impressive improvements in overall survival, trastuzumab deruxtecan in all three subtypes of metastatic breast cancer and sacituzumab govitecan in luminal and triple negative metastatic breast cancer. These drugs are the results of significant progress and innovation in the construction of the three components of an ADC, the monoclonal antibody, the payload, and the linker, and of the discovery of new target antigens...
March 25, 2023: Current Treatment Options in Oncology
Nikitha Naomi Dsouza, Varun Alampady, Krishnaprasad Baby, Swastika Maity, Bharath Harohalli Byregowda, Yogendra Nayak
The "Thalidomide tragedy" is a landmark in the history of the pharmaceutical industry. Despite limited clinical trials, there is a continuous effort to investigate thalidomide as a drug for cancer and inflammatory diseases such as rheumatoid arthritis, lepromatous leprosy, and COVID-19. This review focuses on the possibilities of targeting inflammation by repurposing thalidomide for the treatment of idiopathic pulmonary fibrosis (IPF). Articles were searched from the Scopus database, sorted, and selected articles were reviewed...
March 25, 2023: Inflammopharmacology
Guang-Yi Sun, Jing Zhang, Bing-Zhi Wang, Hao Jing, Hui Fang, Yu Tang, Yong-Wen Song, Jing Jin, Yue-Ping Liu, Yuan Tang, Shu-Nan Qi, Bo Chen, Ning-Ning Lu, Ning Li, Ye-Xiong Li, Jian-Ming Ying, Shu-Lian Wang
BACKGROUND: Tumour-infiltrating lymphocytes (TILs) represent a robust biological prognostic biomarker in triple-negative breast cancer (TNBC); however, the contribution of different subsets of immune cells is unclear. We investigated the prognostic value of immune markers, including stromal TILs (sTILs), CD8+ T and FOPX3+ T cells, PD-1 and PD-L1 in non-metastatic TNBC. METHODS: In total, 259 patients with Stage I-III TNBC were reviewed. The density of sTILs along with the presence of total (t), stromal (s), and intratumoral (i) CD8+ T cells and FOPX3+ T cells were evaluated by haematoxylin and eosin and immunohistochemical staining...
March 25, 2023: British Journal of Cancer
A Youkharibache, E Ramelli, G Pavon, M Atlan, D Letourneur, S Cristofari
INTRODUCTION: Cytosteatonecrosis (CTN) is a frequent postoperative complication after breast autologous reconstruction using DIEP (deep inferior epigastric perforator) flap. CTN radiological diagnostic reveals different types of lesions, as nodes or extended fat necrosis, which become in some cases infected, or pass for tumor recurrence after breast cancer treatment. CTN is caused by intraoperative ischemia of the flap, and no current method can prevent postoperative CTN development after DIEP breast reconstruction...
March 23, 2023: Annales de Chirurgie Plastique et Esthétique
Maria G Fencer, Kelly A Krupa, Gabrielle C Bleich, Sherry Grumet, Firas G Eladoumikdachi, Shicha Kumar, Maria J Kowzun, Lindsay B Potdevin
BACKGROUND: This study aims to capture clinical and surgical practice patterns of patients with deleterious mutations in partner and localizer of BRCA2 (PALB2), checkpoint kinase 2 (CHEK2) and ataxia telangiesctasia mutated (ATM) genes. MATERIALS AND METHODS: This study is a retrospective chart review of patients with PALB2, CHEK2 or ATM mutations. Patient demographics, testing indications, management decisions, and surveillance strategies were recorded. RESULTS: Sixty-two patients were found to have deleterious mutations: 14 (23%) with a PALB2 mutation, 30 (48%) with a CHEK2 mutation, and 18 (29%) patients with an ATM mutation...
February 16, 2023: Clinical Breast Cancer
Yue Sun, Chengjun Zhu, Feng Xu, Shiyun Cui, Xiaoxiang Guan
Triple-negative breast cancer is a sub-type of clinically and molecularly heterogeneous malignant disease with a worse prognosis and earlier recurrence than HER2-amplified or hormone-receptor positive breast cancer. Because of the lack of personalized therapy, genetic information is essential to early diagnosing, identifying the high risk of recurrence, guiding therapeutic management, and monitoring treatment efficiency. Circulating tumor DNA (ctDNA) is a novel noninvasive, timely, and tumor specified biomarker that reliably reflects the comprehensive tumor genetic profiles...
March 2, 2023: Clinical Breast Cancer
Shih-Hung Richard Young, Yi-En Chang, Wei-Chung Vivian Yang, Buo-Jia Lu, Szu-Yuan Chou, Chi-Huang Chen
OBJECTIVE: What is the more efficient and safer protocol during controlled ovarian hyperstimulation (COH) for early-stage breast cancer patients seeking emergency fertility preservation before adjuvant chemo/radiotherapy? MATERIALS AND METHODS: This retrospective, case-series study involved two early-stage (Ia) breast cancer patients that requested for fertility preservation within 3 weeks. Random start/dual stimulation protocols with aromatase inhibitor (AI) were used to maximize oocyte yield and suppress serum estradiol (E2) level...
March 2023: Taiwanese Journal of Obstetrics & Gynecology
Siyuan Hao, Jingjie Zuo, Haowu Huang, Wenqiu Li, Huiling Guo, Mingxing Liu, Hongda Zhu, Hongmei Sun
In recent years, reactive oxygen species (ROS)-mediated cancer therapies have been widely recognized for their high selectivity and good biological safety. However, due to the difficulties of endogenous tumor microenvironment (TME), penetration of tumor tissues and integration of multimodal tumor ablation, the treatment with traditional therapies could not achieve satisfactory tumor inhibition effects. Here, a doxorubicin (DOX)-glucose oxidase (GOx) dual-loaded and poly (2-ethyl-2-oxazoline) (PEOz) decorated magnetic polydopamine nanoparticles (Fe3 O4 [email protected]@PEOz, FDPGP) were constructed for tumor ablation...
March 23, 2023: International Journal of Biological Macromolecules
Yuzhu Zhang, Jing Chen, Dazhao Mi, Jun Ling, Huachao Li, Peng He, Ning Liu, Qianjun Chen, Yihua Chen, Luqi Huang
Triple-negative breast cancer (TNBC) has a poor prognosis due to the lack of specific and highly effective therapeutic agents. Cancer stem cells (CSCs) are one of the main factors contributing to TNBC relapse and metastasis. Therefore, targeting CSCs selectively with small molecules is a novel strategy for drug development. In this study, the natural product harmine (HM) was identified as a hit compound from 2632 natural product monomers based on phenotypic screening of a 2D assay and patient-derived organoid (PDO) model that was established from a patient who had multiple drug resistance and various visceral and contralateral breast metastases...
March 23, 2023: Cancer Letters
Yufan Wang, Alexandra L McCarthy, Sandra C Hayes, Louisa G Gordon, Vivian Chiu, Tom G Bailey, Elizabeth Stewart, Haitham Tuffaha
While there is good evidence that exercise is an effective adjunct therapy to cancer care, little is known about its value for money. The aim of this systematic review is to explore the available evidence pertaining to the cost-effectiveness of exercise interventions following cancer. A search of eight online databases (CINAHL, the Cochrane Library (NHSEED), Econlit, Embase, PsycInfo, PubMed, Scopus, Web of science) was first conducted on 26 March 2021 and updated on 8 March 2022. Only economic evaluations with results in the form of incremental cost-effectiveness ratio (ICER) were included...
March 23, 2023: Preventive Medicine
Savannah Roy, Stephanie Lakritz, Anna R Schreiber, Elizabeth Molina, Peter Kabos, Marie Wood, Anthony Elias, Lavanya Kondapalli, Cathy J Bradley, Jennifer R Diamond
BACKGROUND: Triple-negative breast cancer (TNBC) is a subtype of breast cancer associated with an aggressive clinical course. Adjuvant chemotherapy reduces the risk of recurrence and improves survival in patients with node-positive TNBC. The benefit of anthracycline plus taxane (ATAX) regimens compared with non-anthracycline-containing, taxane-based regimens (TAX) in older women with node-positive TNBC is not well characterised. METHODS: Using the Surveillance, Epidemiology, and End Results-Medicare database, we identified 1106 women with node-positive TNBC diagnosed at age 66 years and older between 2010 and 2015...
February 28, 2023: European Journal of Cancer
Tianyu Jiao, Fuyan Li, Yi Cui, Xiao Wang, Butuo Li, Feng Shi, Yuwei Xia, Qing Zhou, Qingshi Zeng
BACKGROUND: Brain metastasis (BM) is a serious neurological complication of cancer of different origins. The value of deep learning (DL) to identify multiple types of primary origins remains unclear. PURPOSE: To distinguish primary site of BM and identify the best DL models. STUDY TYPE: Retrospective. POPULATION: A total of 449 BM derived from 214 patients (49.5% for female, mean age 58 years) (100 from small cell lung cancer [SCLC], 125 from non-small cell lung cancer [NSCLC], 116 from breast cancer [BC], and 108 from gastrointestinal cancer [GIC]) were included...
March 25, 2023: Journal of Magnetic Resonance Imaging: JMRI
Lulian Pang, Wen Li, Senbang Yao, Yanyan Jing, Xiangxiang Yin, Huaidong Cheng
BACKGROUND: Cancer-related cognitive impairment (CRCI) is a frequent consequence in breast cancer survivors after chemotherapy and lowers their quality of life (QOL). Psychological distress is frequently experienced by breast cancer survivors. There are currently few studies investigating the role of psychological distress in the genesis of CRCI. METHODS: In total, 122 breast cancer survivors after standard chemotherapy within a year were recruited and assessed using the Psychological Distress Thermometer (DT)...
March 25, 2023: Cancer Medicine
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