Toshio Kinoshita, Hitomi Yuzawa, Kazuhiko Natori, Ryo Wada, Shintaro Yao, Kensuke Yano, Katsuya Akitsu, Hideki Koike, Masaya Shinohara, Tadashi Fujino, Hideaki Shimada, Takanori Ikeda
BACKGROUND: Dealing with chemotherapy-related cardiac dysfunction (CTRCD) remains a significant problem complicated by the difficulty in early detection of cardiotoxicity. Electrocardiogram (ECG) is expected to be the most realistic methodology due to lower cost-performance and non-invasiveness. We investigated the long-term visual fluctuations in the ECG waveforms in patients with chronic doxorubicin (DOX)-induced cardiotoxicity to identify ECG indices for the early detection of cardiotoxicity...
November 16, 2020: Journal of Cardiology
Dongmin Kim, Pil-Sung Yang, Gregory Y H Lip, Boyoung Joung
Atrial fibrillation (AF) is considered a risk factor for dementia, especially in the elderly. However, the association between the two diseases is not well identified in different age subgroups. The association of incident AF with the development of dementia was assessed from 1 January 2005, to 31 December 2013, in 428,262 participants from a longitudinal cohort (the Korea National Health Insurance Service-Health Screening cohort). In total, 10,983 participants were diagnosed with incident AF during the follow-up period...
November 14, 2020: Journal of Clinical Medicine
Ezgi Kalaycıoğlu, Mustafa Çetin, Ali Gökhan Özyıldız, Tuncay Kırış
OBJECTIVES: Previous studies have demonstrated that increased aortic root diameter (ARD) is frequently associated with increased cardiovascular (CV) events and is a predictor of stroke. Two-dimensional speckle tracking echocardiography (2D-STE) provides a better evaluation of left atrial (LA) functions. Left atrial mechanical dispersion is a useful predictor of new-onset atrial fibrillation (AF) independent of LA enlargement and dysfunction. We aimed to investigate the relationship between ARD and LA mechanical functions...
November 16, 2020: Herz
Luis A Ruiz, Leyre Serrano, Pedro P España, Lorea Martinez-Indart, Ainhoa Gómez, Beatriz González, Amaia Artaraz, Rafael Zalacain
OBJETIVES: To assess the incidence, related factors, timing and duration of new- onset atrial fibrillation in a cohort of consecutive patients diagnosed with pneumococcal pneumonia. METHODS: Observational study including all immunocompetent adults hospitalized for pneumococcal pneumonia. Patients were classified by time (atrial fibrillation recognized on emergency room arrival or developed during hospitalization) and duration (paroxysmal or persistent). Patients were followed-up for 6 months after discharge...
November 12, 2020: Journal of Infection
Ana Pardo Sanz, Luisa Salido Tahoces, Rodrigo Ortega Pérez, Eduardo González Ferrer, Ángel Sanchez Recalde, José Luis Zamorano Gómez
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has led to a paradigm shift in healthcare worldwide. Little is known about the impact on the cardiovascular system, and the incidence and consequences of new onset of atrial fibrillation (AF) in infected patients remain unclear. The aim of this study was to analyze the cardiovascular outcomes of patients with new-onset AF and coronavirus disease 2019 (COVID-19) infection. METHODS: This observational study analyzed a sample of 160 consecutive patients hospitalized due to COVID-19...
November 3, 2020: Cardiology Journal
Jung Joon Cha, Kyung Yul Lee, Hyemoon Chung, In Soo Kim, Eui Young Choi, Pil Ki Min, Young Won Yoon, Byoung Kwon Lee, Bum Kee Hong, Se Joong Rim, Hyuck Moon Kwon, Jong Youn Kim
In cryptogenic stroke patients, early detection of new-onset atrial fibrillation (AF) and recurrent stroke is required to prevent poor clinical outcomes. Therefore, we investigated the predictors of new-onset AF and recurrent stroke in cryptogenic stroke patients without previously diagnosed AF. In total, 390 patients who were diagnosed with stroke and non-sustained atrial tachycardia (NSAT) on 24-hour Holter monitoring were followed up to assess new-onset AF and recurrent stroke. The 5-year event-free survival as well as the predictors of recurrent stroke or new-onset AF were investigated...
November 2020: Yonsei Medical Journal
Yoichiro Nagao, Makoto Nakajima, Yuichiro Inatomi, Yasuyuki Ito, Yanosuke Kouzaki, Kuniyasu Wada, Toshiro Yonehara, Tadashi Terasaki, Yoichiro Hashimoto, Yukio Ando
PURPOSE: There is scant data related to prehospital delay in cases of acute ischemic stroke from multicenter studies conducted after change of the therapeutic window of intravenous tissue plasminogen activator (iv-tPA) administration to within 4.5 h of onset. We investigated factors causing prehospital delay and their associations with clinical outcomes using data from a regional multicenter stroke registry. METHODS: Data from the multicenter regional stroke registry were analyzed...
November 2020: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Aya Saito, Hiraku Kumamaru, Hiroaki Miyata, Noboru Motomura
BACKGROUND: We recently reported early postoperative results comparing use of anastomosis-assist device (Device) with side-biting clamp for ascending aorta during coronary artery bypass grafting (CABG) except for transient neurological complications that occurred less often with Device. Here, we evaluated perioperative safety of Device against aorta no-touch technique (No-touch). METHODS: We evaluated patients receiving isolated off-pump CABG with either Device or No-touch approach in 2014-2016 from Japan Adult Cardiovascular Surgery Database...
October 13, 2020: Annals of Thoracic Surgery
Victor Bazan, Ignacio Vicente, Lourdes Lozano, Roger Villuendas, Marta González, Raquel Adeliño, Felipe Bisbal, Axel Sarrias, Jorge Abad, José Sanz-Santos, Ferran Padilla, Antoni Bayés-Genís
Obstructive sleep apnea-hypopnea syndrome (OSA) compromises the efficacy of atrial fibrillation (AF) control strategies. Continuous positive airway pressure (CPAP) may ameliorate arrhythmia control especially in early AF stages (new-onset AF). We investigated a practical screening strategy to determine the likelihood of CPAP indication in new-onset AF patients. Seventy-seven consecutive patients with new-onset (< 1 month) AF were prospectively evaluated. Of them, 4 were excluded due to previously diagnosed OSA...
October 12, 2020: American Journal of Cardiology
Erwin Chiquete, Valeria Sandoval-Rodríguez, Miguel García-Grimshaw, Amado Jiménez-Ruiz, Juan J Gómez-Piña, Eduardo Ruiz-Ruiz, Guillermo Ramírez-García, Fernando Flores-Silva, Carlos Cantú-Brito, Ana Ochoa-Guzmán, José L Ruiz-Sandoval
BACKGROUND: The recognition of stroke symptoms by patients or bystanders directly affects the outcomes of patients with acute cerebrovascular disease. OBJECTIVE: The objective of the study was to assess the predictive value of the medical his- tory and clinical features recognized by the patients' bystanders to classify neurovascular syndromes in pre-hospital settings. METHODS: We included 150 stroke patients of two Mexican referral centers: 50 with acute ischemic stroke (AIS), 50 with intracerebral hemorrhage (ICH), and 50 with subarachnoid hemorrhage (SAH)...
May 7, 2020: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
Kilian Griñán, Adrià Arboix, Joan Massons, Laura Díez, Enric Vergés, Francisco Gil, Jordi Arboix-Alió, María-José Sánchez-López, Luís García-Eroles
BACKGROUND: There is little information about the early clinical features of cardioembolic stroke before complementary examinations. OBJECTIVE: The aim of this study was to identify risk factors, clinical features, and early outcomes of cardioembolic stroke. METHODS: Retrospective study based on prospectively collected data available from a university medical center hospitalbased stroke registry. Consecutive patients diagnosed with cardioembolic infarction were selected and compared to those diagnosed with an atherothrombotic stroke...
May 7, 2020: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
Z F Xu, Y P Ling, Z Q Cui, H Zhao, Y C Gong, Y H Fu, H Yang, F Wan
OBJECTIVE: To explore the feasibility, safety and mid-term outcome of minimally invasive cardiac surgery coronary artery bypass grafting (MICS CABG) surgery. METHODS: Data of patients who underwent MICS CABG between November 2015 and November 2017 in Peking University Third Hospital were retrospectively analyzed. Results were compared with the patients who underwent off-pump coronary aortic bypass grafting (OPCABG) surgery over the same period. The two groups were matched in propensity score matching method according to age, gender, left ventricular ejection fraction, body mass index, severity of coronary artery disease, smoking, diabetes mellitus, hypertension, hyperlipidemia, renal insufficiency, history of cerebrovascular accident, and history of chronic obstructive pulmonary disease (COPD)...
October 18, 2020: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Ragab A Mahfouz, Mohamed El-Shetry, Abdelfattah Frere, Mohamed Safwat
Purpose: To investigate the association between 24-h blood pressure variability (BPV) and atrial electromechanical delay (EMD) in patients with ST segment elevation myocardial infarction (STEMI) who developed new-onset atrial fibrillation (NOAF). Materials and Methods: A total of 175 STEMI patients (age 56.6 ± 10.5 years) who underwent primary percutaneous coronary intervention were subjected to in-hospital 24-h ambulatory BP monitoring, comprehensive echocardiography, and assessment of atrial EMD...
August 2020: Pulse (Basel, Switzerland)
Märit Jensen, Eckhard Schlemm, Bastian Cheng, Iris Lettow, Fanny Quandt, Florent Boutitie, Martin Ebinger, Matthias Endres, Jochen B Fiebach, Jens Fiehler, Ivana Galinovic, Vincent Thijs, Robin Lemmens, Keith W Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z Simonsen, Christian Gerloff, Götz Thomalla
Background: Hemorrhagic transformation (HT) is an important complication of intravenous thrombolysis with alteplase. HT can show a wide range from petechiae to parenchymal hematoma with mass effect with varying clinical impact. We studied clinical and imaging characteristics of patients with HT and evaluated whether different types of HT are associated with functional outcome. Methods: We performed a post-hoc analysis of WAKE-UP, a multicenter, randomized, placebo-controlled trial of MRI-guided intravenous alteplase in unknown onset stroke...
2020: Frontiers in Neurology
Armaghan Raeouf, Siddarth Goyal, Nicole Van Horne, Jeremy Traylor
A spontaneous spinal epidural hematoma (SSEH) is a rare condition of intraspinal bleeding in the epidural space. It is often associated with disorders of anticoagulation, intraspinal tumors, vascular malformations, and pertinent to this case, anticoagulation therapy. This surgical emergency requires early diagnosis and management in order to minimize permanent neurologic deficits. We report the case of a 72-year-old female with a past medical history of paroxysmal atrial fibrillation treated with rivaroxaban who presented to the emergency department with acute-onset, midline, lower back pain with no known trauma or injury to the area...
September 12, 2020: Curēus
Jussi Jaakkola, Samuli Jaakkola, K E Juhani Airaksinen, Annastiina Husso, Tatu Juvonen, Mika Laine, Marko Virtanen, Pasi Maaranen, Matti Niemelä, Timo Mäkikallio, Mikko Savontaus, Tuomas Tauriainen, Antti Valtola, Antti Vento, Markku Eskola, Peter Raivio, Fausto Biancari
Whether the subtype of atrial fibrillation affects outcomes after transcatheter aortic valve replacement for aortic stenosis is unclear. The nationwide FinnValve registry included 2130 patients who underwent primary after transcatheter aortic valve replacement for aortic stenosis during 2008-2017. Altogether, 281 (13.2%) patients had pre-existing paroxysmal atrial fibrillation, 651 (30.6%) had pre-existing non-paroxysmal atrial fibrillation and 160 (7.5%) were diagnosed with new-onset atrial fibrillation during the index hospitalization...
2020: PloS One
Mohsen Khatami, Marita Knudsen Pope, Sophie Le Page, Petra Radic, Valentina Schirripa, Irene Grundvold, Dan Atar
There is a considerable periprocedural risk of thromboembolic events in atrial fibrillation patients undergoing cardioversion, and treatment with anticoagulants is therefore a hallmark of cardioversion safety. Based on retrospective subgroup analyses and prospective studies, non-vitamin K anticoagulants are at least as efficient as vitamin K-antagonists in preventing thromboembolic complications after cardioversion. The risk of thromboembolic complications after cardioversion very much depends on the comorbidities in a given patient, and especially heart failure, diabetes, and age >75 years carry a markedly increased risk...
September 8, 2020: Cardiology
Harry O Eyituoyo, Nkechi C Arinze, Rieta N Aben, Felix Sogade
Atrial fibrillation is the most common dysrhythmia, affecting about 6 million people in the United States. Atrial fibrillation has been shown to be an independent risk factor for stroke. Atrial tachycardia are common findings on Holter monitoring in the general population and may be associated with the development of atrial remodeling and atrial fibrillation inducibility. Studies have shown that atrial tachycardia is associated with the development of atrial fibrillation and subsequent stroke. The American Heart Association current guidelines recommend the use of oral anticoagulants in patients with atrial fibrillation and an elevated CHA2DS2-VASc ≥2 in men or ≥3 in women...
July 27, 2020: Curēus
Jedrzej Kosiuk, Katharina Langenhan, Gerhard Hindricks, Andreas Bollmann, Nikolaos Dagres
BACKGROUND: The beneficial effect of remote ischemic preconditioning (RIP) on electrophysiological parameters resulting in lower inducibility and sustainability of atrial fibrillation (AF) in patients with paroxysmal AF has been recently demonstrated in a randomized trial. However, the potential clinical impact of RIP on persistent AF (CAF) has not been investigated. Therefore, we designed a randomized trial set in a setting of electrical cardioversion (CV) of early onset CAF. AIM: The aim of the study is to answer the following questions: I) Does RIP have impact on rate of spontaneous conversion into sinus rhythm (SR) within 24 h after first RIP intervention? II) Does RIP have the potential to improve the acute outcome of CV following a standardized protocol? METHODS: The presented study is a two-armed randomized, placebo-controlled, double-blinded, multi-center trial in a cohort of 588 patients with early onset CAF referred for electrical CV...
August 23, 2020: Journal of Cardiology
Xianhui Meng, Ming Liu, Peng Xiong, Jian Chen, Lin Yang, Xiuling Liu
In order to solve the problem that the early onset of paroxysmal atrial fibrillation is very short and difficult to detect, a detection algorithm based on sparse coding of Riemannian manifolds is proposed. The proposed method takes into account that the nonlinear manifold geometry is closer to the real feature space structure, and the computational covariance matrix is used to characterize the heart rate variability (RR interval variation), so that the data is in the Riemannian manifold space. Sparse coding is applied to the manifold, and each covariance matrix is represented as a sparse linear combination of Riemann dictionary atoms...
August 25, 2020: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
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