keyword
https://read.qxmd.com/read/38523497/association-between-brain-fog-cardiac-injury-and-quality-of-life-at-work-after-hospitalization-due-to-covid-19
#1
JOURNAL ARTICLE
Żaneta Chatys-Bogacka, Iwona Mazurkiewicz, Joanna Słowik, Agnieszka Słowik, Leszek Drabik, Marcin Wnuk
BACKGROUND: To evaluate incidence and search for possible predictors of brain fog and quality of life at work (QoL-W) among low-to-moderate risk subjects previously hospitalized due to COVID-19. MATERIAL AND METHODS: Participants aged ≥18 retrospectively reported 8 brain fog symptoms pre-COVID-19, at 0-4, 4-12 and >12 weeks post-infection via validated clinical questionnaire. The QoL-W was assessed with a 4-point Likert scale where 0, 1, 2, and 3 meant no, mild, moderate, and severe impairment in performing activities at work, respectively...
March 22, 2024: Medycyna Pracy
https://read.qxmd.com/read/38512023/association-of-impaired-left-ventricular-mitral-filling-from-4d-flow-cardiac-mri-and-prognosis-of-hypertrophic-cardiomyopathy
#2
JOURNAL ARTICLE
Hichem Sakhi, Gilles Soulat, Damian Craiem, Umit Gencer, Jérôme Lamy, Valentina Stipechi, Tania Puscas, Jean-Sébastien Hulot, Albert Hagege, Elie Mousseaux
Purpose To investigate whether the peak early filling rate normalized to the filling volume (PEFR/FV) estimated from four-dimensional (4D) flow cardiac MRI may be used to assess impaired left ventricular (LV) filling and predict clinical outcomes in individuals with hypertrophic cardiomyopathy (HCM). Materials and Methods Cardiac MRI with a 4D flow sequence and late gadolinium enhancement (LGE), as well as echocardiography, was performed in 88 individuals: 44 participants with HCM from a French prospective registry (ClinicalTrials...
April 2024: Radiology. Cardiothoracic imaging
https://read.qxmd.com/read/38510713/loss-of-cardiac-splicing-regulator-rbm20-is-associated-with-early-onset%C3%A2-atrial-fibrillation
#3
JOURNAL ARTICLE
Oliver B Vad, Elisavet Angeli, Martin Liss, Gustav Ahlberg, Laura Andreasen, Ingrid E Christophersen, Camilla C Hansen, Sophie Møller, Ylva Hellsten, Stig Haunsoe, Arnljot Tveit, Jesper H Svendsen, Michael Gotthardt, Pia R Lundegaard, Morten S Olesen
We showed an association between atrial fibrillation and rare loss-of-function (LOF) variants in the cardiac splicing regulator RBM20 in 2 independent cohorts. In a rat model with loss of RBM20 , we demonstrated altered splicing of sarcomere genes ( NEXN , TTN , TPM1, MYOM1 , and LDB3 ), and differential expression in key cardiac genes. We identified altered sarcomere and mitochondrial structure on electron microscopy imaging and found compromised mitochondrial function. Finally, we demonstrated that 3 novel LOF variants in RBM20 , identified in patients with atrial fibrillation, lead to significantly reduced splicing activity...
February 2024: JACC. Basic to Translational Science
https://read.qxmd.com/read/38508836/secondary-stroke-prevention-in-people-with-atrial-fibrillation-treatments-and-trials
#4
REVIEW
David J Seiffge, Virginia Cancelloni, Lorenz Räber, Maurizio Paciaroni, Andreas Metzner, Paulus Kirchhof, Urs Fischer, David J Werring, Ashkan Shoamanesh, Valeria Caso
Atrial fibrillation is one of the most common cardiac arrhythmias and is a major cause of ischaemic stroke. Recent findings indicate the importance of atrial fibrillation burden (device-detected, subclinical, or paroxysmal and persistent or permanent) and whether atrial fibrillation was known before stroke onset or diagnosed after stroke for the risk of recurrence. Secondary prevention in patients with atrial fibrillation and stroke aims to reduce the risk of recurrent ischaemic stroke. Findings from randomised controlled trials assessing the optimal timing to introduce direct oral anticoagulant therapy after a stroke show that early start (ie, within 48 h for minor to moderate strokes and within 4-5 days for large strokes) seems safe and could reduce the risk of early recurrence...
April 2024: Lancet Neurology
https://read.qxmd.com/read/38501295/influencing-factors-of-futile-recanalization-after-endovascular-intervention-in-patients-with-acute-basilar-artery-occlusion
#5
JOURNAL ARTICLE
Yi Yan, Kemeng Zhang, Wansi Zhong, Shenqiang Yan, Bing Zhang, Jianhua Cheng, Min Lou
OBJECTIVES: To explore the influence factors for futile recanalization following endovascular treatment (EVT) in patients with acute basilar artery occlusion (BAO). METHODS: Clinical data of patients with acute BAO, who underwent endovascular treatment within 24 h of onset from January 2017 to November 2022, were retrospectively analyzed. The futile recanalization was defined as modified Thrombolysis in Cerebral Infarction (mTICI)≥2b or 3 after successful reperfusion, but the modified Rankin Scale score >2 at 90d after EVT...
March 18, 2024: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://read.qxmd.com/read/38479951/association-of-antiarrhythmic-drug%C3%A2-therapy-with-syncope-and-pacemaker%C3%A2-implantation-in-patients-with%C3%A2-atrial-fibrillation
#6
JOURNAL ARTICLE
Yun Gi Kim, Hyoung Seok Lee, Hoseob Kim, Mina Kim, Joo Hee Jeong, Yun Young Choi, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim
BACKGROUND: Early rhythm control therapy mainly with antiarrhythmic drugs (AADs) for new-onset atrial fibrillation (AF) reduces major adverse cardiovascular events. However, negative dromotropic effects of AADs via ion channel blocking may cause bradyarrhythmias. OBJECTIVES: This study aimed to evaluate the association between AAD use and the risk of pacemaker implantation or syncope in patients with new-onset AF receiving early rhythm control therapy with AADs...
March 19, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38470020/half-dose-direct-oral-anticoagulation-versus-warfarin-for-atrial-fibrillation-following-cardiac-surgery
#7
JOURNAL ARTICLE
Sabet W Hashim, Susan Collazo, Amanda Greco, Jeff F Mather, Raymond G McKay
BACKGROUND: Optimal anticoagulation strategies have not been defined for patients with atrial fibrillation following cardiac surgery. METHODS: From a total cohort of 228 patients with pre-existing or new onset atrial fibrillation following coronary artery bypass grafting and/or valve surgery, we compared in-hospital and 30-day outcomes in 119 patients treated with low-dose aspirin and a half-dose direct oral anticoagulant (DOAC) versus 109 treated with low-dose aspirin and warfarin...
March 12, 2024: Journal of Cardiovascular Surgery
https://read.qxmd.com/read/38458077/diabetes-status-genetic-susceptibility-and-incident-arrhythmias-a-prospective-cohort-study-of-457-151-participants
#8
JOURNAL ARTICLE
Lei Dai, Yuyue Zuo, Yanling Lv, Hesong Zeng, Liangkai Chen
AIMS: The association of diabetes onset age and duration with incident arrhythmias remains unclear. This study evaluates the association of diabetes onset age and duration with incident arrhythmias and assesses modifications by the genetic predisposition to atrial fibrillation (AF). METHODS: We included 457,151 participants from the UK Biobank study. Multivariable Cox regression models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) were used for the association between diabetes status, genetic predisposition, and risk of incident arrhythmias...
March 1, 2024: Diabetes & Metabolic Syndrome
https://read.qxmd.com/read/38451520/recurrence-of-atrial-fibrillation-in-patients-with-new-onset-postoperative-atrial-fibrillation-after-coronary-artery-bypass-grafting
#9
JOURNAL ARTICLE
Florian E M Herrmann, Amar Taha, Susanne J Nielsen, Andreas Martinsson, Emma C Hansson, Gerd Juchem, Anders Jeppsson
IMPORTANCE: New-onset postoperative atrial fibrillation (POAF) occurs in approximately 30% of patients undergoing coronary artery bypass grafting (CABG). It is unknown whether early recurrence is associated with worse outcomes. OBJECTIVE: To test the hypothesis that early AF recurrence in patients with POAF after CABG is associated with worse outcomes. DESIGN, SETTING, AND PARTICIPANTS: This Swedish nationwide cohort study used prospectively collected data from the SWEDEHEART (Swedish Web System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies) registry and 3 other mandatory national registries...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38447184/clinical-benefits-of-surgical-ablation-during-isolated-aortic-valve-replacement-a-nationwide-study
#10
JOURNAL ARTICLE
Ji Seong Kim, Jinhee Kim, Yoonjin Kang, Suk Ho Sohn, Yewon Lee, Sue Hyun Kim, Ho Young Hwang, Kyung Hwan Kim, Mi-Sook Kim, Jae Woong Choi
OBJECTIVES: To compare the early- and long-term clinical outcomes of concomitant surgical ablation (SA) for atrial fibrillation (AF) during isolated aortic valve replacement (AVR) using data from the Korean National Health Insurance Service Database. METHODS: Of 23,332 adult patients who underwent AVR between 2003 and 2019, those with underlying AF with or without concomitant surgical ablation were extracted, and propensity score matching (PSM) analysis was performed...
March 6, 2024: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/38426116/combination-of-early-rhythm-control-and-healthy-lifestyle-on-the-risk-of-stroke-in-elderly-patients-with-new-onset-atrial-fibrillation-a-nationwide-population-based-cohort-study
#11
JOURNAL ARTICLE
Woo-Hyun Lim, So-Ryoung Lee, Eue-Keun Choi, Seung-Woo Lee, Kyung-Do Han, Seil Oh, Gregory Y H Lip
BACKGROUND: The impact of early rhythm control (ERC) combined with healthy lifestyle (HLS) on the risk of ischemic stroke in elderly patients with atrial fibrillation (AF) remains unaddressed. OBJECTIVE: To evaluate the impact of combined ERC and HLS on the risk of stroke in elderly patients with new-onset AF. METHODS: Using the Korean National Health Insurance Service database, we included patients aged ≥75 years with new-onset AF from January 2009 to December 2016 ( n  = 41,315)...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38414084/increased-susceptibility-to-new-onset-atrial-fibrillation-in-diabetic-women-with-poor-sleep-behaviour-traits-findings-from-the-prospective-cohort-study-in-the-uk-biobank
#12
JOURNAL ARTICLE
Siwei Chen, Zhou Liu, Shaohua Yan, Zhongyan Du, Wenke Cheng
BACKGROUND: Diabetic individuals often encounter various sleep-related challenges. Although the association between sleep duration and atrial fibrillation (AF) have been explored, the association of other sleep traits with the incidence of AF remains unclear. A comprehensive understanding of these traits is essential for a more accurate assessment of sleep conditions in patients with diabetes and the development of novel AF prevention strategies. METHODS: This study involved 23,785 patients with diabetes without any pre-existing cardiovascular disease, drawn from the UK Biobank...
February 27, 2024: Diabetology & Metabolic Syndrome
https://read.qxmd.com/read/38398336/factors-associated-with-early-mortality-in-acute-type-a-aortic-dissection-a-single-centre-experience
#13
JOURNAL ARTICLE
Panagiotis Doukas, Nicola Dalibor, András Keszei, Jelle Frankort, Julia Krabbe, Rachad Zayat, Michael J Jacobs, Alexander Gombert, Payam Akhyari, Arash Mehdiani
BACKGROUND: Acute aortic dissection type A (AADA) is a surgical emergency with relevant mortality and morbidity despite improvements in current management protocols. Identifying patients at risk of a fatal outcome and controlling the factors associated with mortality remain of paramount importance. METHODS: In this retrospective observational study, we reviewed the medical records of 117 patients with AADA, who were referred to our centre and operated on between 2005 and 2021...
February 10, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38362141/examining-the-outcomes-of-hybrid-coronary-revascularization-in-acute-stemi-patients-from-2015-to-2022
#14
JOURNAL ARTICLE
Mozhgan Bahramian, Seyed Ali Moezi Bady, Maryam Bahramian, Ahmad Amouzeshi
BACKGROUND: The global rise of chronic diseases, especially cardiovascular disease (CVD), poses a significant public health challenge, being a leading cause of death and disability worldwide. In Iran, the surge in CVD incidence and its risk factors, along with a decrease in the age of onset, has notably increased the reliance on coronary artery bypass grafting (CABG) as a life-saving intervention. Staged hybrid coronary revascularization (HCR), which combines percutaneous coronary intervention with delayed CABG, offers a novel approach for patients with complex coronary artery disease, potentially improving survival and reducing complications...
2024: Journal of Interventional Cardiology
https://read.qxmd.com/read/38320384/the-relationship-between-atrial-cardiopathy-biomarkers-and-prognosis-of-patients-with-acute-ischemic-stroke-after-endovascular-treatment
#15
JOURNAL ARTICLE
Yixin Zhao, Yuye Ning, Lei Lei, Qin Liu, Mengmeng Li, Xiangyu Lei, Wanying Chen, Yiting Hu, Ting Xie, Jiaxin Luan, Haoyu Yang, Guogang Luo
Thromboembolism is a possible consequence of underlying atrial cardiopathy, which can occur even before the onset of atrial fibrillation. Our objective was to examine the association between biomarkers of atrial cardiopathy and outcomes of acute ischemic stroke (AIS) following endovascular treatment (EVT). We conducted a retrospective study that collected data from patients with AIS who underwent EVT and compared the outcomes between those with and without atrial cardiopathy. Neurological function was assessed using the modified Rankin Scale (mRS), with an mRS score >2 indicating poor function at day 90...
February 5, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38318998/survival-outcomes-of-tavr-and-self-expanding-versus-balloon-expandable-valves-in-patients-with-advanced-cardiac-dysfunction
#16
JOURNAL ARTICLE
Anthony Matta, Thibault Lhermusier, Patrick Ohlmann, Levai Laszlo, Vanessa Nader, Francisco Campelo Parada, Meyer Elbaz, Jerome Roncalli, Didier Carrié
AIMS: There is a growing body of literature on long-term outcomes post-transcatheter aortic valve replacement (TAVR), but to our knowledge, few research have focused on patients with advanced cardiac dysfunction. This challenging category of patients was excluded from the Partner 3 clinical trial. There are no data to guide the choice of valve type in patients with severely depressed ejection fraction. This study evaluates the safety, efficacy, and outcomes of TAVR in patients with severe aortic stenosis and left ventricular ejection fraction (LVEF) ≤ 35%...
February 6, 2024: ESC Heart Failure
https://read.qxmd.com/read/38286174/from-atrial-fibrillation-management-to-atrial-myopathy-assessment-the-evolving-concept-of-left-atrium-disease-in-hypertrophic-cardiomyopathy
#17
REVIEW
Carlo Fumagalli, Chiara Zocchi, Michele Ciabatti, Alessandra Milazzo, Francesco Cappelli, Stefano Fumagalli, Maurizio Pieroni, Iacopo Olivotto
Hypertrophic cardiomyopathy (HCM) is the most prevalent genetically inherited cardiovascular disorder in adults and a significant cause of heart failure and sudden cardiac death. Historically, atrial fibrillation (AF) has been considered a critical aspect in HCM patients as it is considered a marker of disease progression, escalates the frequency of heart failure hospitalizations, increases the risk of thromboembolic events and worsens quality of life and outcome. Increasing evidence suggests that AF is the result of a subtle, long-standing process which starts early in the history of HCM...
January 27, 2024: Canadian Journal of Cardiology
https://read.qxmd.com/read/38270932/why-is-early-onset-atrial-fibrillation-uncommon-in-patients-with-duchenne-muscular-dystrophy-insights-from-the-mdx-mouse
#18
JOURNAL ARTICLE
My-Nhan Nguyen, Charlotte Hooper, Matilde Stefanini, Besarte Vrellaku, Ricardo Carnicer, Matthew J Wood, Jillian N Simon, Barbara Casadei
BACKGROUND: A reduction in both dystrophin and neuronal nitric oxide synthase (NOS1) secondary to microRNA-31 (miR-31) upregulation contributes to the atrial electrical remodelling that underpins human and experimental atrial fibrillation (AF). By contrast, patients with Duchenne Muscular Dystrophy (DMD), who lack dystrophin and NOS1 and, at least in the skeletal muscle, have raised miR-31 expression, do not have increase susceptibility to AF in the absence of left ventricular (LV) dysfunction...
January 25, 2024: Cardiovascular Research
https://read.qxmd.com/read/38249829/prevalence-of-cardiovascular-disease-and-rate-of-major-adverse-cardiovascular-events-in-severe-alpha-1-antitrypsin-deficiency-copd
#19
JOURNAL ARTICLE
Paul Ellis, Emily Bailey, Radmila Choate, Kristen E Holm, Robert A Sandhaus, Alice M Turner, Michael Newnham
AIM: Alpha-1 antitrypsin deficiency is an autosomal co-dominant condition that predisposes individuals to early-onset emphysema. As with COPD, AATD-COPD is associated with pulmonary exacerbations, which impacts on overall mortality and quality of life. Though there is evidence that COPD is associated with a higher prevalence of cardiovascular disease and major adverse cardiovascular events (MACE), it is unclear if this is true for patients with AATD-COPD. METHODS: Prevalence of cardiovascular disease was determined in two separate severe AATD cohorts: AlphaNet, USA and the Birmingham AATD registry, UK...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38236317/association-between-coronary-artery-disease-testing-in-patients-with-new-onset-heart-failure-and-heart-failure-readmission-and-mortality
#20
JOURNAL ARTICLE
Cheng-Wei Huang, Siamak Kohan, In-Lu Amy Liu, Janet S Lee, Nicole C Baghdasaryan, Joon S Park, Jessica D Vallejo, Christopher C Subject, Huong Nguyen, Ming-Sum Lee
BACKGROUND: In patients with new-onset heart failure (HF), coronary artery disease (CAD) testing remains underutilized. Whether widespread CAD testing in patients with new-onset HF leads to improved outcomes remains to be determined. OBJECTIVE: We sought to examine whether CAD testing, and its timing, among patients hospitalized with new-onset HF with reduced ejection fraction (HFrEF), is associated with improved outcomes. DESIGN: Retrospective cohort study...
January 18, 2024: Journal of General Internal Medicine
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