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JOURNAL ARTICLE
R M Lacombe, P Martigny, D Pelletier, B D Barst, M Guillemette, M Amyot, K H Elliott, R A Lavoie
Mercury (Hg) is a ubiquitous and pervasive environmental contaminant with detrimental effects on wildlife, which originates from both natural and anthropogenic sources. Its distribution within ecosystems is influenced by various biogeochemical processes, making it crucial to elucidate the factors driving this variability. To explore these factors, we employed an innovative method to use northern gannets (Morus bassanus) as biological samplers of regurgitated fish in the Gulf of St. Lawrence. We assessed fish total Hg (THg) concentrations in relation to their geographical catch location as well as to pertinent biotic and anthropogenic factors...
April 2, 2024: Science of the Total Environment
#2
REVIEW
Julie Lacombe, Mathieu Ferron
Vitamin K is an essential micronutrient and a cofactor for the enzyme γ-glutamyl carboxylase, which adds a carboxyl group to specific glutamic acid residues in proteins transiting through the secretory pathway. Higher vitamin K intake has been linked to a reduced incidence of type 2 diabetes (T2D) in humans. Preclinical work suggests that this effect depends on the γ-carboxylation of specific proteins in β-cells, including endoplasmic reticulum Gla protein (ERGP), implicated in the control of intracellular Ca2+ levels...
February 29, 2024: Trends in Endocrinology and Metabolism: TEM
#3
JOURNAL ARTICLE
Sara Boccalini, Charles Mayard, Hugo Lacombe, Marjorie Villien, Salim Si-Mohamed, François Delahaye, Loic Boussel, Ricardo P J Budde, Matteo Pozzi, Philippe Douek
BACKGROUND AND PURPOSE: The contribution of cardiac computed tomography (CT) for the detection and characterization of prosthetic heart valve (PHV) complications is still limited due mainly to artifacts. Computed tomography systems equipped with photon-counting detectors (PCDs) have the potential to overcome these limitations. Therefore, the aim of the study was to compare image quality of PHV with PCD-CT and dual-energy dual-layer CT (DEDL-CT). MATERIALS AND METHODS: Two metallic and 3 biological PHVs were placed in a tube containing diluted iodinated contrast inside a thoracic phantom and scanned repeatedly at different angles on a DEDL-CT and PCD-CT...
February 28, 2024: Investigative Radiology
#4
JOURNAL ARTICLE
Rachel Sacks-Davis, Daniela K van Santen, Anders Boyd, Jim Young, Ashleigh Stewart, Joseph S Doyle, Andri Rauch, Catrina Mugglin, Marina Klein, Marc van der Valk, Colette Smit, Inmaculada Jarrin, Juan Berenguer, Karine Lacombe, Maria-Bernarda Requena, Linda Wittkop, Olivier Leleux, Fabrice Bonnet, Dominique Salmon, Gail V Matthews, Rebecca Guy, Natasha K Martin, Tim Spelman, Maria Prins, Mark Stoove, Margaret Hellard
BACKGROUND: Reinfection after successful treatment with direct-acting antivirals is hypothesised to undermine efforts to eliminate hepatitis C virus (HCV) infection among people with HIV. We aimed to assess changes in incidence of HCV reinfection among people with HIV following the introduction of direct-acting antivirals, and the proportion of all incident cases attributable to reinfection. METHODS: We pooled individual-level data on HCV reinfection in people with HIV after spontaneous or treatment-induced clearance of HCV from six cohorts contributing data to the International Collaboration on Hepatitis C Elimination in HIV Cohorts (InCHEHC) in Australia, Canada, France, the Netherlands, Spain, and Switzerland between Jan 1, 2010, and Dec 31, 2019...
January 12, 2024: Lancet HIV
#5
JOURNAL ARTICLE
Maria-Bernarda Requena, Camelia Protopopescu, Ashleigh C Stewart, Daniela K van Santen, Marina B Klein, Inmaculada Jarrin, Juan Berenguer, Linda Wittkop, Dominique Salmon, Andri Rauch, Maria Prins, Marc van der Valk, Rachel Sacks-Davis, Margaret E Hellard, Patrizia Carrieri, Karine Lacombe
BACKGROUND: Among people living with HIV and hepatitis C virus (HCV), people who inject drugs (PWID) have historically experienced higher mortality rates. Direct-acting antivirals (DAA), which have led to a 90 % HCV cure rate independently of HIV co-infection, have improved mortality rates. However, DAA era mortality trends among PWID with HIV/HCV remain unknown. Using data from the International Collaboration on Hepatitis C Elimination in HIV Cohorts (InCHEHC), we compared pre/post-DAA availability mortality changes in three groups: PWID, men who have sex with men (MSM), and all other participants...
January 6, 2024: International Journal on Drug Policy
#6
JOURNAL ARTICLE
Sara Nutley, Binh K Nguyen, Robert Scott Mackin, Philip S Insel, Duygu Tosun, Meryl Butters, Paul Aisen, Rema Raman, Andrew J Saykin, Arthur W Toga, Clifford Jack, Michael W Weiner, Craig Nelson, Michelle Kassel, Maria Kryza-Lacombe, Joseph Eichenbaum, Rachel L Nosheny, Carol A Mathews
Hoarding disorder (HD) is a debilitating neuropsychiatric condition that affects 2%-6% of the population and increases in incidence with age. Major depressive disorder (MDD) co-occurs with HD in approximately 50% of cases and leads to increased functional impairment and disability. However, only one study to date has examined the rate and trajectory of hoarding symptoms in older individuals with a lifetime history of MDD, including those with current active depression (late-life depression; LLD). We therefore sought to characterize this potentially distinct phenotype...
November 23, 2023: American Journal of Geriatric Psychiatry
#7
JOURNAL ARTICLE
Daniela K van Santen, Ashleigh Stewart, Joseph S Doyle, Mark A Stoové, Jason Asselin, Marina B Klein, Jim Young, Juan Berenguer, Inmaculada Jarrin, Karine Lacombe, Linda Wittkop, Olivier Leleux, Dominique Salmon, Fabrice Bonnet, Andri Rauch, Catrina Mugglin, Gail Matthews, Maria Prins, Colette Smit, Anders Boyd, Marc van der Valk, Rachel Sacks-Davis, Margaret E Hellard
No abstract text is available yet for this article.
December 8, 2023: International Journal of Epidemiology
#8
JOURNAL ARTICLE
W M N K Jayathilake, M A de Laat, M Furr, C Risco, V A Lacombe
Hyperinsulinemia is the key feature of equine metabolic syndrome (EMS) which leads to debilitating sequelae. Hyperinsulinemia-associated laminitis (HAL) is one of the major sequelae of EMS, although the pathophysiological mechanisms are not well elucidated. Using an equine model, we hypothesized that expression of inflammatory markers would be increased in digital lamellae and striated muscle following prolonged hyperinsulinemia. Healthy Standardbred horses (5.4 ± 1.9 years) were alternately assigned to a prolonged euglycemic-hyperinsulinemic clamp (pEHC) or control group (n=4 per group)...
December 1, 2023: Veterinary Journal
#9
JOURNAL ARTICLE
Gilles Wandeler, Adria Ramirez Mena, Charles Kouanfack, Louise Fortes, Albert Gautier Ndione, Nabil Debzi, Karine Lacombe, Christine Katlama, Didier K Ekouevi
No abstract text is available yet for this article.
September 2023: Journal of Virus Eradication
#10
JOURNAL ARTICLE
Thomas Husson, François Lecoquierre, Gaël Nicolas, Anne-Claire Richard, Alexandra Afenjar, Séverine Audebert-Bellanger, Catherine Badens, Frédéric Bilan, Varoona Bizaoui, Anne Boland, Marie-Noëlle Bonnet-Dupeyron, Elise Brischoux-Boucher, Céline Bonnet, Marie Bournez, Odile Boute, Perrine Brunelle, Roseline Caumes, Perrine Charles, Nicolas Chassaing, Nicolas Chatron, Benjamin Cogné, Estelle Colin, Valérie Cormier-Daire, Rodolphe Dard, Benjamin Dauriat, Julian Delanne, Jean-François Deleuze, Florence Demurger, Anne-Sophie Denommé-Pichon, Christel Depienne, Anne Dieux, Christèle Dubourg, Patrick Edery, Salima El Chehadeh, Laurence Faivre, Patricia Fergelot, Mélanie Fradin, Aurore Garde, David Geneviève, Brigitte Gilbert-Dussardier, Cyril Goizet, Alice Goldenberg, Evan Gouy, Anne-Marie Guerrot, Anne Guimier, Inès Harzalla, Delphine Héron, Bertrand Isidor, Didier Lacombe, Xavier Le Guillou Horn, Boris Keren, Alma Kuechler, Elodie Lacaze, Alinoë Lavillaureix, Daphné Lehalle, Gaëtan Lesca, James Lespinasse, Jonathan Levy, Stanislas Lyonnet, Godeliève Morel, Nolwenn Jean-Marçais, Sandrine Marlin, Luisa Marsili, Cyril Mignot, Sophie Nambot, Mathilde Nizon, Robert Olaso, Laurent Pasquier, Laurine Perrin, Florence Petit, Veronique Pingault, Amélie Piton, Fabienne Prieur, Audrey Putoux, Marc Planes, Sylvie Odent, Chloé Quélin, Sylvia Quemener-Redon, Mélanie Rama, Marlène Rio, Massimiliano Rossi, Elise Schaefer, Sophie Rondeau, Pascale Saugier-Veber, Thomas Smol, Sabine Sigaudy, Renaud Touraine, Frederic Tran Mau-Them, Aurélien Trimouille, Julien Van Gils, Clémence Vanlerberghe, Valérie Vantalon, Gabriella Vera, Marie Vincent, Alban Ziegler, Olivier Guillin, Dominique Campion, Camille Charbonnier
Variants of uncertain significance (VUS) are a significant issue for the molecular diagnosis of rare diseases. The publication of episignatures as effective biomarkers of certain Mendelian neurodevelopmental disorders has raised hopes to help classify VUS. However, prediction abilities of most published episignatures have not been independently investigated yet, which is a prerequisite for an informed and rigorous use in a diagnostic setting. We generated DNA methylation data from 101 carriers of (likely) pathogenic variants in ten different genes, 57 VUS carriers, and 25 healthy controls...
October 23, 2023: European Journal of Human Genetics: EJHG
#11
Aurélie de Thonel, Johanna K Ahlskog, Kevin Daupin, Véronique Dubreuil, Jérémy Berthelet, Carole Chaput, Geoffrey Pires, Camille Leonetti, Ryma Abane, Lluís Cordón Barris, Isabelle Leray, Anna L Aalto, Sarah Naceri, Marine Cordonnier, Carène Benasolo, Matthieu Sanial, Agathe Duchateau, Anniina Vihervaara, Mikael C Puustinen, Federico Miozzo, Patricia Fergelot, Élise Lebigot, Alain Verloes, Pierre Gressens, Didier Lacombe, Jessica Gobbo, Carmen Garrido, Sandy D Westerheide, Laurent David, Michel Petitjean, Olivier Taboureau, Fernando Rodrigues-Lima, Sandrine Passemard, Délara Sabéran-Djoneidi, Laurent Nguyen, Madeline Lancaster, Lea Sistonen, Valérie Mezger
No abstract text is available yet for this article.
September 28, 2023: Nature Communications
#12
JOURNAL ARTICLE
Q Richier, T Hueso, P Tiberghien, K Lacombe
No abstract text is available yet for this article.
September 7, 2023: La Revue de Médecine Interne
#13
JOURNAL ARTICLE
Mona Loutfy, Ashley Lacombe-Duncan, Alice Tseng, Yasmeen Persad, Angela Underhill, V Logan Kennedy, Ian Armstrong, Raymond Fung, Amy Bourns, Quang Nguyen, Sue Hranilovic, Thea Weisdorf, L Y L Chan, Hannah Kia, Roberta Halpenny, Harshita Iyer, Nirubini Jeyarajah, George Kovchazov, Jennifer McCully, Kimberly K Scarsi
BACKGROUND: Feminizing hormone therapy (FHT) is essential to many trans women. Concern about negative drug interactions between FHT and ART can be an ART adherence barrier among trans women with HIV. OBJECTIVES: In this single-centre, parallel group, cross-sectional pilot study, we measured serum oestradiol concentrations in trans women with HIV taking FHT and unboosted integrase strand transfer inhibitor (INSTI)-based ART versus trans women without HIV taking FHT...
September 8, 2023: Journal of Antimicrobial Chemotherapy
#14
JOURNAL ARTICLE
M Port, J-F Barquinero, D Endesfelder, J Moquet, U Oestreicher, G Terzoudi, F Trompier, A Vral, Y Abe, L Ainsbury, L Alkebsi, S A Amundson, C Badie, A Baeyens, A S Balajee, K Balázs, S Barnard, C Bassinet, L A Beaton-Green, C Beinke, L Bobyk, P Brochard, K Brzoska, M Bucher, B Ciesielski, C Cuceu, M Discher, M C D Oca, I Domínguez, S Doucha-Senf, A Dumitrescu, P N Duy, F Finot, G Garty, S A Ghandhi, E Gregoire, V S T Goh, I Güçlü, L Hadjiiska, R Hargitai, R Hristova, K Ishii, E Kis, M Juniewicz, R Kriehuber, J Lacombe, Y Lee, M Lopez Riego, K Lumniczky, T T Mai, N Maltar-Strmečki, M Marrale, J S Martinez, A Marciniak, N Maznyk, S W S McKeever, P K Meher, M Milanova, T Miura, O Monteiro Gil, A Montoro, M Moreno Domene, A Mrozik, R Nakayama, G O'Brien, D Oskamp, P Ostheim, J Pajic, N Pastor, C Patrono, M Pujol-Canadell, M J Prieto Rodriguez, M Repin, A Romanyukha, U Rößler, L Sabatier, A Sakai, H Scherthan, S Schüle, K M Seong, O Sevriukova, S Sholom, S Sommer, Y Suto, T Sypko, T Szatmári, M Takahashi-Sugai, K Takebayashi, A Testa, I Testard, A Tichy, S Triantopoulou, N Tsuyama, M Unverricht-Yeboah, M Valente, O Van Hoey, R C Wilkins, A Wojcik, M Wojewodzka, Lee Younghyun, D Zafiropoulos, M Abend
Tools for radiation exposure reconstruction are required to support the medical management of radiation victims in radiological or nuclear incidents. Different biological and physical dosimetry assays can be used for various exposure scenarios to estimate the dose of ionizing radiation a person has absorbed. Regular validation of the techniques through inter-laboratory comparisons (ILC) is essential to guarantee high quality results. In the current RENEB inter-laboratory comparison, the performance quality of established cytogenetic assays [dicentric chromosome assay (DCA), cytokinesis-block micronucleus assay (CBMN), stable chromosomal translocation assay (FISH) and premature chromosome condensation assay (PCC)] was tested in comparison to molecular biological assays [gamma-H2AX foci (gH2AX), gene expression (GE)] and physical dosimetry-based assays [electron paramagnetic resonance (EPR), optically or thermally stimulated luminescence (LUM)]...
June 1, 2023: Radiation Research
#15
JOURNAL ARTICLE
Sara Boccalini, Riham Dessouky, Pierre-Antoine Rodesch, Hugo Lacombe, Yoad Yagil, Elias Lahoud, Klaus Erhard, Bernhard Brendel, Philippe Coulon, Jean-Baptiste Langlois, Frederic Chaput, Stephane Parola, Loic Boussel, Frederic Lerouge, Salim Si-Mohamed, Philippe C Douek
PURPOSE: The purpose of this study was to investigate the feasibility of gadolinium-K-edge-angiography (angio-Gd-K-edge) with gadolinium-based contrast agents (GBCAs) as obtained with spectral photon counting CT (SPCCT) in atherosclerotic rabbits. MATERIALS AND METHODS: Seven atherosclerotic rabbits underwent angio-SPCCT acquisitions with two GBCAs, with similar intravenous injection protocol. Conventional and angio-Gd-K-edge images were reconstructed with the same parameters...
May 27, 2023: Diagnostic and Interventional Imaging
#16
JOURNAL ARTICLE
Julie Lacombe, Kevin Guo, Jessica Bonneau, Denis Faubert, Florian Gioanni, Alexis Vivoli, Sarah M Muir, Soraya Hezzaz, Vincent Poitout, Mathieu Ferron
Vitamin K is a micronutrient necessary for γ-carboxylation of glutamic acids. This post-translational modification occurs in the endoplasmic reticulum (ER) and affects secreted proteins. Recent clinical studies implicate vitamin K in the pathophysiology of diabetes, but the underlying molecular mechanism remains unknown. Here, we show that mouse β cells lacking γ-carboxylation fail to adapt their insulin secretion in the context of age-related insulin resistance or diet-induced β cell stress...
May 11, 2023: Cell Reports
#17
JOURNAL ARTICLE
M Abend, S A Amundson, C Badie, K Brzoska, R Kriehuber, J Lacombe, M Lopez-Riego, K Lumniczky, D Endesfelder, G O'Brien, S Doucha-Senf, S A Ghandhi, R Hargitai, E Kis, L Lundholm, D Oskamp, P Ostheim, S Schüle, D Schwanke, I Shuryak, C Siebenwith, M Unverricht-Yeboah, A Wojcik, J Yang, F Zenhausern, M Port
Early and high-throughput individual dose estimates are essential following large-scale radiation exposure events. In the context of the Running the European Network for Biodosimetry and Physical Dosimetry (RENEB) 2021 exercise, gene expression assays were conducted and their corresponding performance for dose-assessment is presented in this publication. Three blinded, coded whole blood samples from healthy donors were exposed to 0, 1.2 and 3.5 Gy X-ray doses (240 kVp, 1 Gy/min) using the X-ray source Yxlon...
April 14, 2023: Radiation Research
#18
JOURNAL ARTICLE
Valeriy V Ginzburg, Enza Fazio, Carmelo Corsaro
Water is one of the most important compounds on Earth, yet its material properties are still poorly understood. Here, we use a recently developed two-state, two-(time)scale (TS2) dynamic mean-field model combined with the two-state Sanchez-Lacombe (SL) thermodynamic theory in order to describe the equation of state (density as a function of temperature and pressure) and diffusivity of liquid water. In particular, it is shown that in a relatively wide temperature and pressure range (160 K < T < 360 K; 0 < P < 100 MPa), density and self-diffusion obey a special type of dynamic scaling, similar to the "τTV" scaling of Casalini and Roland, but with the negative exponent γ ...
March 11, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#19
JOURNAL ARTICLE
Cas J Isfordink, Anders Boyd, Rachel Sacks-Davis, Daniela K van Santen, Colette Smit, Marianne Martinello, Mark Stoove, Juan Berenguer, Linda Wittkop, Marina B Klein, Andri Rauch, Dominique Salmon, Karine Lacombe, Ashleigh Stewart, Janke Schinkel, Joseph S Doyle, Margaret Hellard, Marc van der Valk, Gail V Matthews
BACKGROUND: Individuals with HIV and hepatitis C virus (HCV) who remain untreated with direct-acting antivirals can contribute to HCV transmission and HCV-related mortality. We aimed to compare rates of uptake of direct-acting antivirals following unrestricted access to this treatment in high-income countries and examine factors associated with remaining untreated. METHODS: This multinational, prospective cohort study used data from the International Collaboration on Hepatitis C Elimination in HIV Cohorts (InCHEHC)...
April 2023: Lancet. Public Health
#20
JOURNAL ARTICLE
Cindy Bergeron, Kathryn Jane Potter, Valerie Boudreau, Bouchra Ouliass, Anne Bonhoure, Julie Lacombe, Marjolaine Mailhot, Annick Lavoie, Mathieu Ferron, Guylaine Ferland, Rémi Rabasa-Lhoret
Patients with Cystic Fibrosis (CF) are at high risk of fat-soluble vitamin deficiencies, even with supplementation. The contribution of a suboptimal vitamin K status to respiratory and endocrine pathophysiology in CF has been inadequately characterized. Cross-sectional study in adult CF patients (≥ 18 years old) from the Montreal Cystic Fibrosis Cohort. Vitamin K1 (VK1) was measured with high performance liquid chromatography (HPLC), using fasted serum samples collected during an oral glucose tolerance test (OGTT: 2h with plasma glucose & insulin every 30 min) (n = 168)...
January 21, 2023: Applied Physiology Nutrition and Metabolism
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