Walaa A El-Dakroury, Moataz B Zewail, Gihan F Asaad, Heba M I Abdallah, Marwa E Shabana, Abdelrahman R Said, Ahmed S Doghish, Hadeer A Azab, Dalia H Amer, Ahmed E Hassan, Alaa S Sayed, Ghada M Samra, Al-Aliaa M Sallam
The targeting and mucoadhesive features of chitosan (CS)-linked solid lipid nanoparticles (SLNs) were exploited to efficiently deliver fexofenadine (FEX) into the colon, forming a novel and potential oral therapeutic option for ulcerative colitis (UC) treatment. Different FEX-CS-SLNs with varied molecular weights of CS were prepared and optimized. Optimized FEX-CS-SLNs exhibited 229 ± 6.08 nm nanometric size, 36.3 ± 3.18 mV zeta potential, 64.9 % EE, and a controlled release profile...
February 2, 2024: European Journal of Pharmaceutics and Biopharmaceutics