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JOURNAL ARTICLE
Graziela Perri, Vanessa Garcia Vilas Boas, Maria Renata Sales Nogueira, Edgard José Franco Mello Júnior, Ana Lucia Coelho, Edwin M Posadas, Cory Hogaboam, Karen A Cavassani, Ana Paula Campanelli
Interleukin (IL)-33 is an important cytokine in the tumour microenvironment; it is known to promote the growth and metastasis of solid cancers, such as gastric, colorectal, ovarian and breast cancer. Our group demonstrated that the IL-33/ST2 pathway enhances the development of squamous cell carcinoma (SCC). Conversely, other researchers have reported that IL-33 inhibits tumour progression. In addition, the crosstalk between IL-33, cancer cells and immune cells in SCC remains unknown. The aim of this study was to investigate the effect of IL-33 on the biology of head and neck SCC lines and to evaluate the impact of IL-33 neutralisation on the T cell response in a preclinical model of SCC...
April 25, 2024: Cancer Immunology, Immunotherapy: CII
#42
JOURNAL ARTICLE
Yong Chen, Yanyan Ji, Lin Shen, Ying Li, Yue Ren, Hongcan Shi, Yue Li, Yunjiang Wu
PURPOSE: Core 1β1,3-galactosyltransferase 1 (C1GALT1) exhibits elevated expression in multiple cancers. The present study aimed to elucidate the clinical significance of C1GALT1 aberrant expression and its impact on radiosensitivity in lung adenocarcinoma (LUAD). METHODS: The C1GALT1 expression and its clinical relevance were investigated through public databases and LUAD tissue microarray analyses. A549 and H1299 cells with either C1GALT1 knockdown or overexpression were further assessed through colony formation, gamma-H2A histone family member X immunofluorescence, 5-ethynyl-2'-deoxyuridine incorporation, and flow cytometry assays...
April 25, 2024: Journal of Cancer Research and Clinical Oncology
#43
JOURNAL ARTICLE
Sudhir Kumar Rawal, Ashish Khanna, Amitabh Singh, Tarun Jindal, S K Raghunath, Bhuwan Kumar, Ravi Taori, Sarbartha Kumar Pratihar, Vivek Vasudeo, Nikhil Saurabh, Mujahid Ali, Ishan Malla, Kinju Adhikari
OBJECTIVE: To report outcomes of multicentre series of penile cancer patients undergoing Robot Assisted Video Endoscopic Inguinal Lymph Node dissection(RA-VEIL ) . MATERIAL AND METHODS: In this retrospective analysis from 3 tertiary care centres in India , consecutive intermediate /high risk carcinoma penis(CaP) patients with non-palpable inguinal lymphadenopathy and /or non-bulky (<3cm ) mobile inguinal lymphadenopathy undergoing RA-VEIL were included . Patients with matted/ bulky (> 3cm ) and fixed lymphadenopathy were excluded ...
April 25, 2024: Journal of Endourology
#44
JOURNAL ARTICLE
Joanna L Langner, Frederick Millard, Vera Vavinskaya, Haiyan Zhang, Nuphat Yodkhunnatham, Aditya Bagrodia
A 41-year-old man presented to his primary care physician with a 1-month history of left neck adenopathy in the context of a history of nonseminomatous germ cell tumors (NSGCTs). In 2011, the patient was treated for stage IB (T2N0M0S0) right-sided NSGCTs of the testis, which were 95% embryonal and 5% yolk sac tumors. He underwent a right radical orchiectomy and was followed until 2022 without recurrence. In the work-up for his adenopathy, laboratory results for human chorionic gonadotropin, lactate dehydrogenase, and α-fetoprotein were normal...
April 11, 2024: Oncology (Williston Park, NY)
#45
JOURNAL ARTICLE
Maria Stefania Latrofa, Marco Cereda, Viviane Noll Louzada-Flores, Filipe Dantas-Torres, Domenico Otranto
Leishmaniasis is a vector-borne disease caused by many Leishmania spp. which infect humans and other mammalian hosts. Leishmania infantum is the main agent of canine leishmaniasis (CanL) whose diagnosis is usually confirmed by serological and molecular tests. This study aimed to evaluate the clinical and analytical sensitivities of a lab-on-chip (LOC) real-time PCR applied on the portable Q3-Plus V2 platform (Q3 qPCR) in the detection of L. infantum . The Q3 qPCR performance was assessed by comparing the quantification cycle (Cq) values with those obtained using the qPCR run on a CFX96 Real-Time System (CFX96 qPCR)...
April 25, 2024: Journal of Clinical Microbiology
#46
JOURNAL ARTICLE
Jun-Ichi Kurashina, Yasuhiro Shimojima, Dai Kishida, Takanori Ichikawa, Takeshi Uehara, Yoshiki Sekijima
We report a case of eosinophilic granulomatosis with polyangiitis (EGPA) in a 75-year-old man who developed mononeuritis multiplex and purpura in the lower legs concomitantly presenting with lymphadenopathies. Biopsied lymph node tissue pathologically demonstrated fibrinoid necrotizing vasculitis with perivascular eosinophil infiltration, resulting in EGPA diagnosis. Additionally, abundant IgG4-positive plasma cell infiltration exhibiting >70% IgG4/IgG ratio, without storiform pattern fibrosis and obliterative phlebitis, was observed in the biopsied lymph node...
April 25, 2024: Modern rheumatology case reports
#47
JOURNAL ARTICLE
He-Sheng He, Yuan-Feng Wei, Xin-Yue Ji, You-Hai Xu, Yu-Qiong Yang, Xiao-Ke Jin
OBJECTIVE: To explore the clinical manifestations, pathological features, immunophenotype, as well as diagnosis, treatment and prognosis of patients with CD4- CD56+ blastic plasmacytoid dendritic cell neoplasm (BPDCN), in order to further understand the rare disease. METHODS: The clinical data, laboratory examinations and treatment regimens of two patients with CD4- CD56+ BPDCN in the First Affiliated Hospital of Wannan Medical College were retrospectively analyzed...
April 2024: Zhongguo Shi Yan Xue Ye Xue za Zhi
#48
JOURNAL ARTICLE
Azin Ghaffari, Mitra Mehrazma, Shahrzad Ossareh
IgG4-related disease (IgG4-RD) is a chronic systemic inflammatory disease, characterized by tissue infiltration of lymphocytes and IgG4-secreting plasma cells, presenting by fibrosis of different tissues, which is usually responsive only to oral steroids therapy. Kidneys are the most commonly involved organs, exhibiting renal insufficiency, tubulointerstitial nephritis, and glomerulonephritis. Here, we describe a patient with acute renal insufficiency who was presented with edema, weakness, anemia and multiple lymphadenopathies...
March 2024: Iranian Journal of Kidney Diseases
#49
JOURNAL ARTICLE
Bin-Sheng Wang, Chen-Li Zhang, Xiang Cui, Qiang Li, Lei Yang, Zhi-Yun He, Ze Yang, Miao-Miao Zeng, Nong Cao
BACKGROUND: Gastric cancer, characterized by a multifactorial etiology and high heterogeneity, continues to confound researchers in terms of its pathogenesis. Curcumin, a natural anticancer agent, exhibits therapeutic promise in gastric cancer. Its effects include promoting cell apoptosis, curtailing tumor angiogenesis, and enhancing sensitivity to radiation and chemotherapy. Long noncoding RNAs (lncRNAs) have garnered significant attention as biomarkers for early screening, diagnosis, treatment, and drug response because of their remarkable specificity and sensitivity...
April 15, 2024: World Journal of Gastrointestinal Oncology
#50
JOURNAL ARTICLE
Eric Toshiyuki Nakamura, Amanda Park, Marina Alessandra Pereira, Daniel Kikawa, Francisco Tustumi
BACKGROUND: Heat shock proteins (HSPs) are molecular chaperones that play an important role in cellular protection against stress events and have been reported to be overexpressed in many cancers. The prognostic significance of HSPs and their regulatory factors, such as heat shock factor 1 (HSF1) and CHIP, are poorly understood. AIM: To investigate the relationship between HSP expression and prognosis in esophageal and esophagogastric cancer. METHODS: A systematic review was conducted in accordance with PRISMA recommendations (PROSPERO: CRD42022370653), on Embase, PubMed, Cochrane, and LILACS...
April 15, 2024: World Journal of Gastrointestinal Oncology
#51
Abdulla Alzibdeh, Issa Mohamad, Lina Wahbeh, Ramiz Abuhijlih, Fawzi Abuhijla
BACKGROUND: Para-aortic lymph nodes (PALNs) are common sites for the regional spread of cervical squamous cell carcinoma (SCC). CASE SUMMARY: We report the case of a 36-year-old woman who presented with cervical SCC with multiple bulky PALNs, largest measured 4.5 cm × 5 cm × 10 cm. The patient was treated with radical intent with definitive chemoradiation using sequential dose-escalated adaptive radiotherapy, followed by maintenance chemotherapy. The patient achieved a complete response; she has been doing well since the completion of treatment with no evidence of the disease for 2 years...
April 6, 2024: World Journal of Clinical Cases
#52
Leyuan Ma, Ranjani Ramasubramanian, Naveen K Mehta, Benjamin Cossette, Duncan M Morgan, Ina Sukaj, Elisa Bergaggio, Stephan Kadauke, Regina M Myers, Luca Paruzzo, Guido Ghilardi, Tomasz M Grzywa, Austin Cozzone, Stephen J Schuster, Noelle Frey, Libin Zhang, Parisa Yousefpour, Wuhbet Abraham, Heikyung Suh, Marco Ruella, Stephan A Grupp, Roberto Chiarle, K Dane Wittrup, Darrell J Irvine
Chimeric antigen receptor (CAR) T cell therapy targeting CD19 elicits remarkable clinical efficacy in B-cell malignancies, but many patients relapse due to failed expansion and/or progressive loss of CAR-T cells. We recently reported a strategy to potently restimulate CAR-T cells in vivo , enhancing their functionality by administration of a vaccine-like stimulus comprised of surrogate peptide ligands for a CAR linked to a lymph node-targeting amphiphilic PEG-lipid (termed CAR-T-vax). Here, we demonstrate a general strategy to generate and optimize peptide mimotopes enabling CAR-T-vax generation for any CAR...
April 17, 2024: bioRxiv
#53
Sarcoidosis With Multiple Bone Lesions Mimicking Advanced Lung Cancer With Multiple Bone Metastases.
Takuya Ogaito, Yukio Kawagishi, Atsushi Muto, Akihiro Kikushima
Bone lesions in sarcoidosis are more common than previously known. A 59-year-old female with a history of sarcoidosis was referred due to suspected lung cancer. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) revealed numerous bone lesions in addition to abnormal uptake by pulmonary nodules and mediastinal lymph nodes, which mimicked metastatic advanced lung cancer. Biopsy of bone lesions detected epithelioid cell granuloma consistent with bone sarcoidosis. Moreover, prednisolone treatment was tried to exclude malignant disease...
March 2024: Curēus
#54
Adam Mylonakis, Michail Vailas, Panagiotis Sakarellos, Lysandros Karydakis, Eleandros Kyros, Spyridon Davakis, Alexandros Papalampros, Evaggelos Felekouras
This case study reports a rare case of a non-functioning metastatic pancreatic neuroendocrine tumor (pNET) transforming into a functioning pNET. A 59-year-old male, previously treated with distal pancreatectomy, splenectomy, lymph node dissection, liver metastasectomy, and pharmacotherapy, presented with weakness, hypoglycemia, and daily episodes of watery diarrhea. A functioning neuroendocrine liver metastasis expressing insulin and gastrin was identified. Surgical intervention, including left lateral hepatectomy and microwave ablation of multiple intrahepatic lesions, resulted in symptom resolution and uneventful recovery...
March 2024: Curēus
#55
EDITORIAL
Yan-Bo Yu
In this editorial, we comment on the article by Wang et al published in the recent issue of the World Journal of Gastroenterology in 2023. We focused on identifying risk factors for lymph node metastasis (LNM) in superficial esophageal squamous cell carcinoma (SESCC) patients and how to construct a simple and reliable clinical prediction model to assess the risk of LNM in SESCC patients, thereby helping to guide the selection of an appropriate treatment plan. The current standard treatment for SESCC is radical esophagectomy with lymph node dissection...
April 7, 2024: World Journal of Gastroenterology: WJG
#56
JOURNAL ARTICLE
Wichan Dankaona, Pornpiroon Nooroong, Napassorn Poolsawat, Chutchai Piewbang, Somporn Techangamsuwan, Panat Anuracpreeda
Canine circovirus (CanineCV) is a contagious virus that causes severe gastroenteritis, diarrhea, respiratory disease, and vasculitis, often resulting in fatality among infected dogs. In this study, a recombinant Capsid protein (rCap) of CanineCV was expressed in the Escherichia coli ( E. coli ) Rosetta (DE3) pLysS host cell, followed by affinity purification, and then analyzed by SDS-PAGE, revealing a molecular weight of approximately 31 kDa. The antigenicity of the CanineCV rCap protein was confirmed through recognition by a rabbit anti-CanineCV rCap protein polyclonal antibody (PoAb)...
2024: Frontiers in Veterinary Science
#57
Shunsuke Furukawa, Masatsugu Hiraki, Takeshi Oda, Yukihiko Takahashi, Ryuichiro Samejima
Although rarely used in laparoscopic surgery, computed tomography (CT)-guided marking is useful for targeting small lesions. The present study describes the performance of laparoscopic resection with preoperative CT-guided marking for lateral lymph node recurrence of rectal cancer. A 48-year-old man underwent laparoscopic low anterior resection with D3 lymph node dissection for rectal cancer (postoperative diagnosis, stage IIIb). Postoperative adjuvant chemotherapy was then administered. Solitary lymph node recurrence was observed in the left lateral region after 6 months...
June 2024: Oncology Letters
#58
REVIEW
Weifeng Tang, Jian Wang, Ting Dai, Hao Qiu, Chao Liu, Shuchen Chen, Zhendong Hu
Non-small cell lung cancer (NSCLC) is increasing dramatically. It is believed that energy metabolism-related genes could play an important role in etiology of NSCLC. In this study, we sought to assess the correlation between three LEPR single nucleotide polymorphisms (rs1137101, rs1137100 and rs6588147) with NSCLS susceptibility. In total, 1193 NSCLC cases and 1056 controls were included. SNPscan™ genotyping method was used to analyze the genotypes of LEPR polymorphisms. Compared to rs6588147 GG in LEPR gene, this study identified a protective role of LEPR rs6588147 GA and GA/AA for the occurrence of NSCLC (GA vs...
April 2024: Cancer Medicine
#59
MULTICENTER STUDY
James Lucocq, Jake Hawkyard, Beate Haugk, Omar Mownah, Krishna Menon, Takaki Furukawa, Yosuke Inoue, Yuki Hirose, Naoki Sasahira, Michael Feretis, Anita Balakrishnan, Carlo Ceresa, Brian Davidson, Rupaly Pande, Bobby Dasari, Lulu Tanno, Dimitrios Karavias, Jack Helliwell, Alistair Young, Quentin Nunes, Tomas Urbonas, Michael Silva, Alex Gordon-Weeks, Jenifer Barrie, Dhanny Gomez, Stijn Van Laarhoven, Francis Robertson, Hossain Nawara, Joseph Doyle, Ricky Bhogal, Ewen Harrison, Marcus Roalso, Debora Ciprani, Somaiah Aroori, Bathiya Ratnayake, Jonathan Koea, Gabriele Capurso, Ruben Bellotti, Stefan Stättner, Tareq Alsaoudi, Neil Bhardwaj, Srujan Rajesh, Fraser Jeffery, Saxon Connor, Andrew Cameron, Nigel Jamieson, Amy Sheen, Anubhav Mittal, Jas Samra, Anthony Gill, Keith Roberts, Kjetil Søreide, Sanjay Pandanaboyana
BACKGROUND: The clinical impact of adjuvant chemotherapy after resection for adenocarcinoma arising from intraductal papillary mucinous neoplasia is unclear. The aim of this study was to identify factors related to receipt of adjuvant chemotherapy and its impact on recurrence and survival. METHODS: This was a multicentre retrospective study of patients undergoing pancreatic resection for adenocarcinoma arising from intraductal papillary mucinous neoplasia between January 2010 and December 2020 at 18 centres...
April 3, 2024: British Journal of Surgery
#60
JOURNAL ARTICLE
Zhenwei Liang, Jixin Zhang, Lei Chen, Jinghua Liu, Fumin Wang, Yuhong Shao, Xiuming Sun, Luzeng Chen
OBJECTIVE: This retrospective study involving a large dataset of unilateral multifocal papillary thyroid carcinoma (UM-PTC) sought to identify factors that predict central lymph node metastases (CLNM) in patients. METHODS: We identified a cohort of 158 patients who underwent cervical ultrasonography followed by UM-PTC diagnosis based on postoperative pathology. The relationship between CLNM and UM-PTC clinical ultrasound features was evaluated using univariate and multivariate analyses...
April 24, 2024: Asia-Pacific Journal of Clinical Oncology
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