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Geriatric

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https://read.qxmd.com/read/32227563/long-non-coding-rna-colon-cancer-associated-transcript-1-regulates-tumor-cell-proliferation-and-invasion-of-non-small-cell-lung-cancer-through-suppressing-mir-152
#1
Na Li, Weiwei Hao, Junfang Yang, Yali Guo, Yonggang Guo, Ying Du
AIM: Lung cancer serves as one of the most common cancers in the world, and approximately 50% of non-small-cell lung cancer (NSCLC) patients are found to be aged >70 when diagnosed. In this study, we aimed to explore the effect of long non-coding RNAs colon cancer-associated transcript-1 (CCAT1) in NSCLC. METHODS: A total of 72 clinical samples from older NSCLC patients were collected for analysis. The relative mRNA level of CCAT1 was detected through real-time polymerase chain reaction...
March 30, 2020: Geriatrics & Gerontology International
https://read.qxmd.com/read/32227494/caution-should-be-exercised-for-the-detection-of-sars-cov-2-especially-in-the-elderly
#2
YajunYuan, Nan Wang, Xueqing Ou
In December 2019, a pneumonia outbreak, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first identified in Wuhan, China and presented a major threat to public health. Nationwide, there were more than 70,000 confirmed cases, and 2500 deaths. Most patients were elderly, with severe disease. For acute respiratory infection, RT-PCR is routinely used to detect causative viruses in respiratory secretions. Coronavirus RNA can be detected from nose and throat swabs, sputum and other lower respiratory tract secretions, blood and feces...
March 30, 2020: Journal of Medical Virology
https://read.qxmd.com/read/32227400/number-of-functional-teeth-more-strongly-predicts-all-cause-mortality-than-number-of-present-teeth-in-japanese-older-adults
#3
Kenji Maekawa, Tomoko Ikeuchi, Shoji Shinkai, Hirohiko Hirano, Masahiro Ryu, Katsushi Tamaki, Hirofumi Yatani, Takuo Kuboki, Aya Kimura-Ono, Takeshi Kikutani, Takashi Suganuma, Yasunori Ayukawa, Tomoya Gonda, Toru Ogawa, Masanori Fujisawa, Shoichi Ishigaki, Yutaka Watanabe, Akihiko Kitamura, Yu Taniguchi, Yoshinori Fujiwara, Ayako Edahiro, Yuki Ohara, Junichi Furuya, Junko Nakajima, Kento Umeki, Kentaro Igarashi, Yasuhiro Horibe, Yoshihiro Kugimiya, Yasuhiko Kawai, Hideo Matsumura, Tetsuo Ichikawa, Shuji Ohkawa
AIM: Previous studies on the association between intraoral conditions and mortality in community-dwelling older individuals reported that fewer present teeth (PT) are significant risk factors for mortality. However, how the number of PT relative to the number of functional teeth (FT), including both present and rehabilitated teeth, influences mortality has not been investigated fully. This study examined the impact of the number of FT on mortality among community-dwelling Japanese older adults...
March 29, 2020: Geriatrics & Gerontology International
https://read.qxmd.com/read/32227289/the-evolving-complexity-of-treating-hormone-receptor-positive-human-epidermal-growth-factor-receptor-2-her2-negative-breast-cancer-special-considerations-in-older-breast-cancer-patients-part-ii-metastatic-disease
#4
REVIEW
Addie Hill, Eutiquio Gutierrez, Jennifer Liu, Sarah Sammons, Gretchen Kimmick, Mina S Sedrak
Breast cancer is a disease of aging, and the incidence of breast cancer is projected to increase dramatically as the global population ages. The majority of breast cancers that occur in older adults are hormone-receptor positive, human epidermal growth factor receptor-2 (HER2)-negative phenotypes, with favorable tumor biology; yet, because of underrepresentation in clinical trials, less evidence is available to guide the complex care for this population. Providing care for older patients with metastatic breast cancer, with coexisting medical conditions, increased risk of treatment toxicity, and frailty, remains a clinical challenge in oncology...
March 30, 2020: Drugs & Aging
https://read.qxmd.com/read/32227283/blood-pressure-and-long-term-mortality-in-older-patients-results-of-the-fiesole-misurata-follow-up-study
#5
Giulia Rivasi, Ersilia Lucenteforte, Giada Turrin, Daniela Balzi, Matteo Bulgaresi, Nicola Nesti, Antonella Giordano, Martina Rafanelli, Niccolò Lombardi, Roberto Bonaiuti, Alfredo Vannacci, Alessandro Mugelli, Mauro Di Bari, Tahir Masud, Andrea Ungar
BACKGROUND: Optimal blood pressure (BP) control can prevent major adverse health events, but target values are still controversial, especially in older patients with comorbidities, frailty and disability. AIMS: To evaluate mortality according to BP values in a cohort of older adults enrolled in the Fiesole Misurata Study, after a 6-year follow-up. METHODS: Living status as of December 31, 2016 was obtained in 385 subjects participating in the Fiesole Misurata Study...
March 30, 2020: Aging Clinical and Experimental Research
https://read.qxmd.com/read/32226684/efficacy-and-tolerability-of-ashwagandha-root-extract-in-the-elderly-for-improvement-of-general-well-being-and-sleep-a-prospective-randomized-double-blind-placebo-controlled-study
#6
Sunil B Kelgane, Jaysing Salve, Prasanthi Sampara, Khokan Debnath
Background Ashwagandha is an excellent adaptogen that is being used since ancient times in Ayurvedic medicine. Traditionally, it is used for various ailments and general well-being, including the treatment of geriatric patients. Managing quality of life (QoL) remains a challenge for the elderly population, especially joint pain management, sleep, and general well-being. With a growing global elderly population, QoL management with efficient medication and supplementation is the major healthcare requirement...
February 23, 2020: Curēus
https://read.qxmd.com/read/32224618/diagnostic-impact-of-csf-biomarkers-in-a-local-hospital-memory-clinic-revisited
#7
Leo Boelaarts, Jos F M de Jonghe, Philip Scheltens
BACKGROUND/AIMS: Research guidelines on predicting and diagnosing Alzheimer's disease (AD) acknowledge cerebrospinal fluid (CSF) levels as pivotal biomarkers. We studied the usefulness of CSF biomarkers in the diagnostic workup of patients in a geriatric outpatient memory clinic of a community-based hospital, attempted to determine a cutoff age for the use of CSF biomarkers in this group of patients, and compared the total τ/Aβ ratio as an alternative CSF diagnostic rule with the usual rules for interpreting CSF levels...
March 30, 2020: Dementia and Geriatric Cognitive Disorders
https://read.qxmd.com/read/32224019/enteral-and-parenteral-order-writing-survey-a-collaborative-evaluation-between-the-academy-of-nutrition-and-dietetics-dietitians-in-nutrition-support-dietetics-practice-group-and-the-american-society-for-parenteral-and-enteral-nutrition-aspen-dietetics-practice
#8
Sarah Peterson, Stephanie Dobak, Wendy Phillips, Ainsley Malone, Carol Ireton-Jones, Amanda Haney, Mary Rybicki, Peggi Guenter
INTRODUCTION: In 2014 and 2017, the Centers for Medicare and Medicaid Services authorized nutrition-related ordering privileges for registered dietitian nutritionists (RDNs) in hospital and long-term care settings, respectively. Despite this practice advancement, information describing current parenteral nutrition (PN) and enteral nutrition (EN) ordering practices is lacking. Dietitians in Nutrition Support, a dietetic practice group of the Academy of Nutrition and Dietetics and the Dietetics Practice Section of the American Society of Parenteral and Enteral Nutrition (ASPEN) utilized a survey to describe PN and EN ordering practices among RDNs in the United States...
March 24, 2020: Journal of the Academy of Nutrition and Dietetics
https://read.qxmd.com/read/32223768/fast-nosocomial-spread-of-sars-cov2-in-a-french-geriatric-unit-lyon-study-group-on-covid-19-infection
#9
Philippe Vanhems
Lyon Study Group on Covid19 infection (Geriatric section- Alphabetic order): Adrait, A, Benoist F, Castel-Kremer E, Chuzeville M, Dupin AC, Doh S, Kim B, Favrelle L, Hilliquin D, Kanafer N, Marion E, Martin-Gaujard G, Moyenin Y, Paulet-Lafuma H, Ricanet A, Saadatian-Elahi M, Vanhems P.
March 30, 2020: Infection Control and Hospital Epidemiology
https://read.qxmd.com/read/32223742/the-modified-functional-comorbidity-index-performed-better-than-the-charlson-index-and-original-functional-comorbidity-index-in-predicting-functional-outcome-in-geriatric-rehabilitation-a-prospective-observational-study
#10
Anouk D Kabboord, Deborah Godfrey, Adam L Gordon, John R F Gladman, Monica Van Eijk, Romke van Balen, Wilco P Achterberg
BACKGROUND: In the inpatient rehabilitation of older patients, estimating to what extent the patient may functionally recover (functional prognosis), is important to plan the rehabilitation programme and aid discharge planning. Comorbidity is very common in older patients. However, the role of comorbidity in making a functional prognosis is not clearly defined. The aim of this study was to investigate a modified and weighted Functional Comorbidity Index (w-FCI) in relation to functional recovery and compare its predictive performance with that of the Charlson comorbidity index (CCI) and the original Functional Comorbidity Index (FCI)...
March 29, 2020: BMC Geriatrics
https://read.qxmd.com/read/32223535/exploring-new-use-of-cannabis-among-older-adults
#11
Jennifer Baumbusch, Isabel Sloan Yip
Objectives : In Canada, cannabis prohibition ended in October 2018. Older adults are the fastest growing group of cannabis users and are out-pacing other groups as new users. Clinical evidence indicates that cannabis may be helpful for select medicinal purposes in this population. Yet there is limited research about older adults experiences of starting to use cannabis in later life. The purpose of this study was to begin to address this gap. Methods : This study employed qualitative description. A convenience sample of Canadian community-dwelling older adults who were new users of cannabis were recruited...
March 29, 2020: Clinical Gerontologist
https://read.qxmd.com/read/32223397/blood-pressure-drop-rate-after-standing-up-is-associated-with-frailty-and-number-of-falls-in-geriatric-outpatients
#12
Arjen Mol, Lois Robin Nicolle Slangen, Marijke C Trappenburg, Esmee M Reijnierse, Richard J A van Wezel, Carel G M Meskers, Andrea B Maier
Background The relationship between orthostatic hypotension and clinical outcome in older adults is poorly understood. Blood pressure drop rate (ie, speed of blood pressure drop) may particularly reflect the imposed challenge to the baroreflex and the associated clinical outcome (ie, frailty and number of falls). This study aimed to compare orthostatic blood pressure drop rate and drop magnitude with regard to their association with frailty and number of falls. Methods and Results Blood pressure was measured continuously during a standardized active stand task in 168 patients (mean age 81...
April 7, 2020: Journal of the American Heart Association
https://read.qxmd.com/read/32222409/association-of-hernia-with-subsequent-aortic-aneurysm-in-geriatric-patients
#13
Kuo-Chuan Hung, Ying-Jen Chang, Cheuk-Kwan Sun, Jhi-Joung Wang, Yi-Chen Chen, Shih-Feng Weng, Chin-Chen Chu
OBJECTIVE: Although inguinal hernia and aortic aneurysm share similar pathogenic mechanisms of collagen and elastin destruction, their clinical association in geriatric patients is inconclusive. We assessed the association between hernia and the subsequent occurrence of aortic aneurysm in geriatric patients. METHODS: Adult patients with hernias between 2000 and 2012 were identified from a longitudinal claims database of 1 million beneficiaries from Taiwan's National Health Insurance program, and a control group of patients without hernia were matched by propensity score in a ratio of 1:3...
February 29, 2020: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/32222360/the-enhancing-quality-of-prescribing-practices-for-older-veterans-discharged-from-the-emergency-department-equipped-potentially-inappropriate-medication-dashboard-a-suitable-alternative-to-the-in-person-academic-detailing-and-standardized-feedback-reports-of
#14
Zachary Burningham, George L Jackson, Jessica Kelleher, Melissa Stevens, Isis Morris, Joy Cohen, Gerald Maloney, Camille P Vaughan
PURPOSE: The Enhancing Quality of Prescribing Practices for Older Veterans Discharged From the Emergency Department (EQUIPPED) program is a quality improvement initiative that combines education, clinical decision support (ie, geriatric pharmacy order sets), and in-person academic detailing coupled with audit and feedback in an effort to improve appropriate prescribing to older veterans discharged from the emergency department. Although the EQUIPPED program is effective at reducing the prescribing of potentially inappropriate medications, the reliance on in-person academic detailing may be a limitation for broader dissemination...
March 25, 2020: Clinical Therapeutics
https://read.qxmd.com/read/32222314/interventions-to-improve-older-adults-emergency-department-patient-experience-a-systematic-review
#15
REVIEW
Michelle J Berning, Lucas Oliveira J E Silva, Nataly Espinoza Suarez, Laura E Walker, Patricia Erwin, Christopher R Carpenter, Fernanda Bellolio
STUDY OBJECTIVE: To summarize interventions that impact the experience of older adults in the emergency department (ED) as measured by patient experience instruments. METHODS: This is a systematic review to evaluate interventions aimed to improve geriatric patient experience in the ED. We searched Ovid CENTRAL, Ovid EMBASE, Ovid MEDLINE and PsycINFO from inception to January 2019. The main outcome was patient experience measured through instruments to assess patient experience or satisfaction...
March 12, 2020: American Journal of Emergency Medicine
https://read.qxmd.com/read/32222309/geriatric-psychiatry
#16
EDITORIAL
Dan G Blazer, Susan K Schultz
No abstract text is available yet for this article.
May 2020: Clinics in Geriatric Medicine
https://read.qxmd.com/read/32222301/electroconvulsive-therapy-in-geriatric-psychiatry-a-selective-review
#17
REVIEW
Justin P Meyer, Samantha K Swetter, Charles H Kellner
Electroconvulsive therapy (ECT) remains an important treatment of geriatric patients. ECT treats severe depression, mania, psychosis, catatonia, and comorbid depression and agitation in dementia. ECT also serves a crucial role in treating urgent illness requiring expedient recovery, such as catatonia, or in patients with severe suicidal ideation or intent. ECT is even more effective in the elderly than in mixed-age adult populations. ECT is a safe treatment option with few medical contraindications. Cognitive effects are largely transient, even in patients with preexisting cognitive impairment...
May 2020: Clinics in Geriatric Medicine
https://read.qxmd.com/read/32222286/-medication-management-of-hypertension-and-heart-failure-in-older-patients-what-happens-to-therapeutic-changes-after-hospitalization
#18
A Bouterige, J Mercier, Z Makaroff, P Krolak-Salmon, C Mouchoux, T Novais
PURPOSE: The objective of this study was to objectivize if the cardiovascular therapeutic changes performed during hospitalization of older patients with hypertension and/or heart failure (HF), were maintained in ambulatory 3 month after hospitalization. METHODS: This is a longitudinal study conducted in a geriatric unit. Patients over 65 years with hypertension and/or HF, who had at least one change in cardiovascular medicaton during hospitalization, and who accepted the 3-month follow-up were included in the longitudinal study...
March 25, 2020: Annales de Cardiologie et D'angéiologie
https://read.qxmd.com/read/32221871/-ambulatory-care-for-geriatric-patients
#19
Jana Hummel
No abstract text is available yet for this article.
March 2020: MMW Fortschritte der Medizin
https://read.qxmd.com/read/32221721/transcranial-doppler-could-help-to-differentiate-the-types-of-dementia-a-pilot-study-when-csf-biomarkers-are-not-available
#20
Valeria Battistella, V D Camara, C B Nogueira, F H G Porto, L Jamaci, C V Guillermo, J M N Osvaldo, J A Souza
Our objective was to find a mean flow velocity (MFV) cut-off point to differentiate between normal and cognitive impaired patients using Clinical Dementia Rating (CDR) as a comparison method. To evaluate MFV (in cm/s) and pulsatility index (PI) from the left middle cerebral artery (MCA) and basilar artery using transcranial Doppler in a pilot study from an outpatient cognition unit and compare with cognitively normal older adults (at the age of sixty or older) from the Geriatric Ambulatory of Fluminense Federal University...
March 27, 2020: Journal of Neural Transmission
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