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JOURNAL ARTICLE
Raunak Milton, Guna Pratheep Kalanjiyam, Rajasekaran S, Ajoy Prasad Shetty, Rishi Mugesh Kanna
Incidental dural tears being a familiar complication in spine surgery could result in dreaded postoperative outcomes. Though the literature pertaining to their incidence and management is vast, it is limited by the retrospective study designs and smaller case series. Hence, we performed a prospective study in our institute to determine the incidence, surgical risk factors, complications and surgical outcomes in patients with unintended durotomy during spine surgery over a period of one year. The overall incidence in our study was 2...
June 2023: Journal of Clinical Orthopaedics and Trauma
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JOURNAL ARTICLE
Shanmuganathan Rajasekaran, Gowdaman Vasudevan, Murugesh Easwaran, Narmatha Devi Ps, Sri Vijay Anand K S, Raveendran Muthurajan, Chitraa Tangavel, Chandhan Murugan, Pushpa B T, Ajoy Prasad Shetty, Rishi Mugesh Kanna
BACKGROUND: The majority of literature on bacterial flora in the disc stands disadvantaged in utilizing traditional culture methods and targeting a single bacterium, Cutibacterium acnes. PURPOSE: Our objective was to document the diversity in the bacterial flora between normal and degenerated discs for shortlisting potential pathogens using next-generation genomic tools. STUDY DESIGN: Experimental case-control study. METHODS: 16S metagenome sequencing was employed to profile bacterial diversity in magnetic resonance imaging normal healthy discs from brain-dead organ voluntary donors (n=20) and 40 degenerated disc samples harvested during surgery (Modic [MC]=20 and non-Modic [NMC]=20)...
June 25, 2023: Spine Journal: Official Journal of the North American Spine Society
#43
JOURNAL ARTICLE
A S Vinutha, R Rajasekaran
As an alternative to antibiotics, Antimicrobial Peptides (AMPs) possess unique properties including cationic, amphipathic and their abundance in nature, but the exact characteristics of AMPs against bacterial membranes are still undetermined. To estimate the structural stability and functional activity of AMPs, the Pseudin AMPs (Pse-1, Pse-2, Pse-3, and Pse-4) from Hylid frog species, Pseudis paradoxa, an abundantly discovered source for AMPs were examined. We studied the intra-peptide interactions and thermal denaturation stability of peptides, as well as the geometrical parameters and secondary structure profiles of their conformational trajectories...
June 27, 2023: Journal of Computer-aided Molecular Design
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JOURNAL ARTICLE
Pradeep Yuvaraj, Krupa S Chacko, Rony Roy, Rahina Abubacker, Aravind Kumar Rajasekaran
Background and objective Temporal processing abilities help perceive signal changes over time. Efficient temporal processing is necessary for pitch perception, voice identification, and speech perception. It plays a significant role in language development. Internal redundancy of the central auditory nervous plays a role in processing sensory information. There is a need to gain more insights into the maturation of neural hardwiring that supports binaural temporal processing at a young age. The purpose of the present study was to evaluate the difference between monaural and binaural temporal processing in children aged 7-11 years...
June 2023: Curēus
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JOURNAL ARTICLE
J M Muretta, D Rajasekaran, Y Blat, S Little, M Myers, C Nair, B Burdekin, S L Yuen, N Jimenez, P Guhathakurta, A Wilson, A R Thompson, N Surti, D Connors, P Chase, D Harden, C M Barbieri, L Adam, D D Thomas
Small molecules that bind to allosteric sites on target proteins to alter protein function are highly sought in drug discovery. High-throughput screening (HTS) assays are needed to facilitate the direct discovery of allosterically active compounds. We have developed technology for high-throughput time-resolved fluorescence lifetime detection of fluorescence resonance energy transfer (FRET), which enables the detection of allosteric modulators by monitoring changes in protein structure. We tested this approach at the industrial scale by adapting an allosteric FRET sensor of cardiac myosin to high-throughput screening (HTS), based on technology provided by Photonic Pharma and the University of Minnesota, and then used the sensor to screen 1...
June 10, 2023: SLAS Discovery
#46
JOURNAL ARTICLE
Nithya Gajendran, Santhanasabapathy Rajasekaran, Stephan N Witt
The Parkinson's disease (PD) associated protein, alpha-synuclein (α-syn/SNCA), is highly expressed in aggressive melanomas. The goal of this study was to reveal possible mechanism(s) of α-syn involvement in melanoma pathogenesis. Herein, we asked whether α-syn modulates the expression of the pro-oncogenic adhesion molecules L1CAM and N-cadherin. We used two human melanoma cell lines (SK-MEL-28, SK-MEL-29), SNCA-knockout (KO) clones, and two human SH-SY5Y neuroblastoma cell lines. In the melanoma lines, loss of α-syn expression resulted in significant decreases in the expression of L1CAM and N-cadherin and concomitant significant decreases in motility...
June 7, 2023: Scientific Reports
#47
JOURNAL ARTICLE
Neethu Francis, Ravikesavan Rajasekaran, Veera Ranjani Rajagopalan, S Vinothini Bakya, Raveendran Muthurajan, Ashwini Girish Kumar, Senthil Alagarswamy, Iyanar Krishnamoorthy, Chitdeshwari Thiyagarajan
Proso millet ( Panicummiliaceum L.) is a short-duration C4 crop that is drought tolerant and nutritionally rich and can grow well in marginal lands. Though the crop has many climate-resilient traits like tolerance to drought and heat, its yield is lower than that of common cereals like rice, wheat, and maize. Being an underutilized crop, the molecular resources in the crop are limited. The main aim of the present study was to develop and characterize contrasting mutants for yield and generate functional genomic information for the trait in proso millet...
2023: Frontiers in Plant Science
#48
JOURNAL ARTICLE
Vibhu K Viswanathan, Ajoy P Shetty, Nimish Rai, Nancy Sindhiya, Surabhi Subramanian, Shanmuganathan Rajasekaran
BACKGROUND CONTEXT: Computed tomography-based vertebral attenuation values (CT-based HU) have been shown to correlate with T-scores on DEXA scan; and have been acknowledged as an independent factor for predicting fragility fractures. Most patients undergoing lumbar surgeries require CT as part of their preoperative evaluation. PURPOSE: The current study was thus planned to evaluate the role of lumbar CT as an opportunistic investigation in determining BMD preoperatively in patients undergoing lumbar fusion...
October 2023: Spine Journal: Official Journal of the North American Spine Society
#49
JOURNAL ARTICLE
Rijul S Kshirsagar, Jacob G Eide, Aman Prasad, Ryan M Carey, Karthik Rajasekaran, Jason A Brant, Jason G Newman, James N Palmer, Nithin D Adappa
Objectives Although adjuvant radiotherapy may be indicated in patients with sinonasal squamous cell carcinoma (SNSCC) following primary surgery, some patients choose to forgo recommended postoperative radiation therapy (PORT). This study aimed to elucidate factors associated with patient refusal of recommended PORT in SNSCC and examine overall survival. Methods Retrospective analysis of patients with SNSCC treated with primary surgery from the National Cancer Database diagnosed between 2004 and 2016...
June 2023: Journal of Neurological Surgery. Part B, Skull Base
#50
JOURNAL ARTICLE
Rishi M Kanna, Ajoy P Shetty, S Rajasekaran
The presence of thick sub-cutaneous fat and bulky paraspinal musculature mandates extensive surgical dissection in obese patients undergoing open Transforaminal lumbar interbody fusion surgery. Securing a 'converging' pedicle screw trajectory becomes difficult by the counterforces of the erector spinae muscles and thick sub-cutaneous fat in obese patients, especially at the L5-S1 level. We describe the use of a limited standard posterior midline exposure and a separate, far lateral 'satellite' incision to insert pedicle screws in an optimal trajectory in obese patients...
July 2023: World neurosurgery: X
#51
JOURNAL ARTICLE
R Kannan, S Rajasekaran, S Daison Stallon, R Anand
This manuscript proposes an improved indirect instantaneous torque control (IITC) based torque sharing function (TSF) method of switched reluctance motor (SRM) drives in electric vehicles (EVs) using a hybrid system. The proposed hybrid techniques are joint performance of both Reptile Search Algorithm (RSA) and Honey Badger Algorithm (HBA), hence it is named as Enhanced RSA (ERSA) method. Here, an IITC method of SRMs for EVs is utilized. It achieves the requirements of the vehicle, like minimum torque ripple, improved speed range, high effectiveness, and maximal torque per ampere (MTPA)...
April 6, 2023: ISA Transactions
#52
JOURNAL ARTICLE
Joseph S Lu, Austin C Cao, David Shimunov, Lova Sun, John N Lukens, Alexander Lin, Roger B Cohen, Devraj Basu, Steven B Cannady, Karthik Rajasekaran, Gregory S Weinstein, Robert M Brody
OBJECTIVES: To describe swallowing and feeding-tube outcomes in patients with high-risk oropharyngeal cancer treated with trimodality therapy (TMT), including transoral robotic surgery (TORS) and adjuvant chemoradiotherapy. METHODS: A chart review was conducted on patients with HPV+ OPSCC receiving TMT with TORS at an academic medical center from March 2010 to March 2021. Data collected included demographics, treatment, feeding tube placement, functional oral intake scale (FOIS) scores, and swallowing-language pathology (SLP) evaluations...
May 2, 2023: Laryngoscope
#53
JOURNAL ARTICLE
Hemant Deepak Shewade, Asha Frederick, G Kiruthika, Madhanraj Kalyanasundaram, Joshua Chadwick, T Daniel Rajasekar, K Gayathri, R Vijayaprabha, R Sabarinathan, Jeyashree Kathiresan, P K Bhavani, S Aarthi, K V Suma, Delphina Peter Pathinathan, Raghavan Parthasarathy, M Bhavani Nivetha, Jerome G Thampi, Deiveegan Chidambaram, Tarun Bhatnagar, S Lokesh, Shanmugasundaram Devika, Timothy S Laux, Stalin Viswanathan, R Sridhar, K Krishnamoorthy, M Sakthivel, S Karunakaran, S Rajkumar, M Ramachandran, K D Kanagaraj, M Kaleeswari, V P Durai, R Saravanan, A Sugantha, S Zufire Hassan Mohamed Khan, P Sangeetha, R Vasudevan, R Nedunchezhian, M Sankari, N Jeevanandam, S Ganapathy, V Rajasekaran, T Mathavi, A R Rajaprakash, Lakshmi Murali, U Pugal, K Sundaralingam, S Savithri, S Vellasamy, D Dheenadayal, P Ashok, K Jayasree, R Sudhakar, K P Rajan, N Tharageshwari, D Chokkalingam, S M Anandrajkumar, T S Selvavinayagam, C Padmapriyadarshini, Ranjani Ramachandran, Manoj V Murhekar
To reduce TB deaths in resource-limited settings, a differentiated care strategy can be used to triage patients with high risk of severe illness (i.e., those with very severe undernutrition, respiratory insufficiency, or inability to stand without support) at diagnosis and refer them for comprehensive assessment and inpatient care. Globally, there are few examples of implementing this type of strategy in routine program settings. Beginning in April 2022, the Indian state of Tamil Nadu implemented a differentiated care strategy called Tamil Nadu- Kasanoi Erappila Thittam (TN-KET) for all adults aged 15 years and older with drug-susceptible TB notified by public facilities...
April 28, 2023: Global Health, Science and Practice
#54
Julianne Michael, Elizabeth VanSickle, Marlie Vipond, Abby Dalman, Jeremy Prokop, Charles E Schwartz, Surender Rajasekaran, André S Bachmann, Magalie Barth, Clément Prouteau, Yotam Almagor, Lina Berkun, Gheona Alterescu, Caleb P Bupp
Recent identification of four additional polyaminopathies, including Bachmann-Bupp syndrome, have benefited from previous research on Snyder-Robinson syndrome in order to advance from research to treatment more quickly. As a result of the discovery of these conditions, the potential for treatment within this pathway, and for other possible unidentified polyaminopathies, the International Center for Polyamine Disorders (ICPD) was created to help promote understanding of these conditions, research opportunities, and appropriate care for families...
April 4, 2023: Medical Sciences: Open Access Journal
#55
JOURNAL ARTICLE
Zhilin Ji, Yue Li, Weiqiang Dou, Yaru Zhu, Yin Shi, Yuefen Zou
OBJECTIVE: To investigate the feasibility of ultra-short echo time (UTE) magnetic resonance imaging (MRI) in the assessment of cartilage endplate (CEP) damage and further evaluate the relationship between total endplate score (TEPS) and lumbar intervertebral disc (IVD) degeneration for chronic low back pain patients. MATERIALS AND METHODS: IVD were measured in 35 patients using UTE imaging at 3T MR. Subtracted UTE images between short and long TEs were obtained to depict anatomy of CEP...
April 20, 2023: BMC Medical Imaging
#56
JOURNAL ARTICLE
T Sivaruban, Pandiarajan Srinivasan, S Barathy, Rajasekaran Isack, Nikita Kluge
A new species, Cheleocloeon vaigaiensis sp. n., is described from Southern India based on larvae, imagines and subimagines of both sexes associated by rearing. This new Oriental species is most closely related to the Afrotropical species Cheleocloeon clavifolium Kluge 2016. Formerly, the genus Cheleocloeon Wuillot & Gillies 1993 was known only from Africa, Madagascar and Arabia; this is the first report of this genus from the Oriental Region.
November 17, 2022: Zootaxa
#57
JOURNAL ARTICLE
Nikita Kluge, T Sivaruban, Pandiarajan Srinivasan, S Barathy, Rajasekaran Isack
A new synonymy to Labiobaetis pulchellus (Müller-Liebenau & Hubbard, 1985) (= L. soldani Kubendran et al. 2014, syn. n.) is established based on examination of imagines reared from larvae in India and Sri Lanka. This species belongs to the tricolor group, which comprises Holarctic species L. tricolor (Tshernova, 1928), L. propinquus (Walsh, 1863), L. calcaratus (Keffermüller, 1972), and some Oriental species.
April 12, 2023: Zootaxa
#58
JOURNAL ARTICLE
Pandiarajan Srinivasan, T Sivaruban, S Barathy, Rajasekaran Isack
Three new species of Caenis Stephens viz., Caenis kaegies sp. n., C. venkataramani sp. n., and C. arunachalami sp. n., are described based on larvae and reared subimagines and/or imagines from Madurai, Tamil Nadu. Two more species of Caenis are recognized and described (from eggs and imagoes) but are not formally named. Additional characters are mentioned for C. americani Srinivasan, Sivaruban, Barathy, Malzacher & Isack, 2021 and C. maduraiensis Balasubramanian & Muthukatturaja, 2021. The egg morphology of all the known species of Caenis from Tamil Nadu is described...
March 27, 2023: Zootaxa
#59
JOURNAL ARTICLE
Pandiarajan Srinivasan, T Sivaruban, S Barathy, Rajasekaran Isack
Tricorythus meenakshi sp. n., is described based on all the stages from Tamil Nadu, Southern India. This new Indian species is most closely related to the Afrotropical species T. discolor Burmeister and T. tener Kluge. The new species can be separated from others in the genus by: In male imago, i) body dorsally with a colorless median stripe from head to abdomen; ii) femur and base of the tibia of all legs dark, rest mostly colorless; and iii) penis shape; and in the larva, i) body slender with a light median stripe as in adult; ii) protoptera dark in both sexes; iii) mouthparts details; iv) tarsal claws denticulation; and v) shape of denticles on hind margins of abdominal terga...
December 21, 2022: Zootaxa
#60
JOURNAL ARTICLE
Nikita Kluge, Pandiarajan Srinivasan, T Sivaruban, S Barathy, Rajasekaran Isack
According to the classification proposed in the previous publication by Kluge, the genus Teloganodes Eaton 1882 is divided into three subgenera distinguished only by tergalii number: the subgenus Teloganodes (with 5 pairs of tergalii on uromeres II-VI), the subgenus Dudgeodes Sartori in Sartori et al. 2008 (with 4 pairs of tergalii on uromeres II-V) and the subgenus Derlethina Sartori in Sartori et al. 2008 (with 3 pairs of tergalii on uromeres II-IV). All three subgenera are represented in Southern India. Based on the new material, additional descriptions are given to the following species: T...
February 23, 2023: Zootaxa
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