Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#41
JOURNAL ARTICLE
Balamurugan Packialakshmi, David M Burmeister, Joseph A Anderson, Judah Morgan, Georgetta Cannon, Juliann G Kiang, Yuanyi Feng, Sang Lee, Ian J Stewart, Xiaoming Zhou
Hemorrhage is a leading cause of death in trauma. Tourniquets are effective at controlling extremity hemorrhage and have saved lives. However, tourniquets can cause ischemia reperfusion injury of limbs, leading to systemic inflammation and other adverse effects, which results in secondary damage to the kidney, lung, and liver. A clinically relevant animal model is critical to understanding the pathophysiology of this process and developing therapeutic interventions. Despite the importance of animal models, tourniquet-induced lower limb ischemia/reperfusion (TILLIR) models to date lack a hemorrhage component...
2023: Frontiers in Physiology
#42
JOURNAL ARTICLE
Ji Hyun Park, Masayoshi Tanaka, Takafumi Nakano, Ester Licastro, Yoshihiko Nakamura, Wenlu Li, Elga Esposito, Emiri T Mandeville, Sherry Hsiang-Yi Chou, MingMing Ning, Eng H Lo, Kazuhide Hayakawa
BACKGROUND: Transplantation of mitochondria is increasingly explored as a novel therapy in central nervous system (CNS) injury and disease. However, there are limitations in safety and efficacy because mitochondria are vulnerable in extracellular environments and damaged mitochondria can induce unfavorable danger signals. METHODS: Mitochondrial O-GlcNAc-modification was amplified by recombinant O-GlcNAc transferase (OGT) and UDP-GlcNAc. O-GlcNAcylated mitochondrial proteins were identified by mass spectrometry and the antiglycation ability of O-GlcNAcylated DJ1 was determined by loss-of-function via mutagenesis...
November 25, 2023: Commun Med (Lond)
#43
JOURNAL ARTICLE
Marijan Tepes, Ivan Krezic, Hrvoje Vranes, Ivan Maria Smoday, Luka Kalogjera, Helena Zizek, Vlasta Vukovic, Katarina Oroz, Katarina Kasnik Kovac, Zrinko Madzar, Mislav Rakic, Blazenka Miskic, Suncana Sikiric, Ivan Barisic, Sanja Strbe, Marko Antunovic, Luka Novosel, Ivana Kavelj, Josipa Vlainic, Ivan Dobric, Mario Staresinic, Anita Skrtic, Sven Seiwerth, Alenka Boban Blagaic, Predrag Sikiric
Given in reperfusion, the use of stable gastric pentadecapeptide BPC 157 is an effective therapy in rats. It strongly counteracted, as a whole, decompression/reperfusion-induced occlusion/occlusion-like syndrome following the worst circumstances of acute abdominal compartment and intra-abdominal hypertension, grade III and grade IV, as well as compression/ischemia-occlusion/occlusion-like syndrome. Before decompression (calvariectomy, laparotomy), rats had long-lasting severe intra-abdominal hypertension, grade III (25 mmHg/60 min) (i) and grade IV (30 mmHg/30 min; 40 mmHg/30 min) (ii/iii), and severe occlusion/occlusion-like syndrome...
November 2, 2023: Pharmaceuticals
#44
William Denney Zimmerman, Melissa Pergakis, Ghasan Ahmad, Nicholas A Morris, Jamie Podell, Wan-Tsu Chang, Melissa Motta, Hegang Chen, Gaurav Jindal, Uttam Bodanapally, J Marc Simard, Neeraj Badjatia, Gunjan Y Parikh
BACKGROUND & PURPOSE: Ischemia affecting two thirds of the MCA territory predicts development of malignant cerebral edema. However, early infarcts are hard to diagnose on conventional head CT. We hypothesize that high-energy (190keV) virtual monochromatic images (VMI) from dual-energy CT (DECT) imaging enables earlier detection of secondary injury from malignant cerebral edema (MCE). METHODS: Consecutive LHI patients with NIHSS ≥ 15 and DECT within 10 hours of reperfusion from May 2020 to March 2022 were included...
November 10, 2023: Research Square
#45
JOURNAL ARTICLE
Wenbin Gao, Liping Zhang, Ziru Li, Tong Wu, Chunhui Lang, Michael W Mulholland, Weizhen Zhang
BACKGROUND AIMS: Hepatic ischemia-reperfusion (IR) injury is the most common complication that occurs in liver surgery and hemorrhagic shock. ATP citrate lyase (Acly) plays a pivotal role in chromatin modification via generating acetyl-CoA for histone acetylation to influence biological processes. We aim to examine the roles of Acly, which is highly expressed in hepatocytes, in liver IR injury. APPROACH: The functions of Acly in hepatic IR injury were examined in the mouse model with hepatocytes-specific knockout of Acly...
November 20, 2023: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#46
JOURNAL ARTICLE
Zan Jie Feng, Liu Song Wang, Xuan Ma, Kai Li, Xin Yao Li, Yi Tang, Ci Jun Peng
BACKGROUND: Hepatic ischemia-reperfusion (I/R) injury involves inflammatory necrosis of liver cells as a significant pathological mechanism. Catapol possesses anti-inflammatory activity that is extracted from the traditional Chinese medicine, Rehmannia glutinosa. METHODS: The liver function and histopathology, Oxidative stress, and aseptic inflammatory responses were assessed in vivo, and the strongest dose group was selected. For mechanism, the expression of miR-410-3p, HMGB1, and TLR-4/NF-κB signaling pathways was detected...
November 16, 2023: Molecular Immunology
#47
JOURNAL ARTICLE
Nikhil R Shah, Brianna L Spencer, Kathryn M Maselli, Keyonna M Williams, Vikram Sood, Samir K Gadepalli, Arul S Thirumoorthi
INTRODUCTION: Extracorporeal membrane oxygenation cannulation strategies vary between adults and children. Femoral approach is common in adults and extremity morbidity is well-documented. Aside from limb ischemia, complications in children are theorized and have yet to be studied. This study aims to comprehensively evaluate implications of pediatric femoral cannulation. METHODS: This is a single-center retrospective review of children <21 years, undergoing femoral venoarterial (VA) or venovenous (VV) cannulation between 2015 and 2022...
November 17, 2023: Perfusion
#48
JOURNAL ARTICLE
Shimaa K Mohamed, Amany A E Ahmed, Abeer Elkhoely
Cerebral ischemia reperfusion (I/R) is one of the neurovascular diseases which leads to severe brain deterioration. Haemorrhagic transformation (HT) is the main complication of ischemic stroke. It exacerbates by reperfusion, causing a more deleterious effect on the brain and death. The current study explored the protective effect of sertraline (Sert) against cerebral I/R in rats by inhibiting HT, together with the molecular pathways involved in this effect. Forty-eight wister male rats were divided into 4 groups: Sham, Sert + Sham, I/R, and Sert + I/R...
November 13, 2023: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
#49
JOURNAL ARTICLE
Xiao-Xiao Ma, Hai-Yi Xie, Pin-Pin Hou, Xiao-Jing Wang, Wei Zhou, Zhen-Hong Wang
Cerebral ischemia/reperfusion (I/R) injury increases blood-brain barrier (BBB) permeability, leading to hemorrhagic transformation and brain edema. Normobaric oxygen (NBO) is a routine clinical treatment strategy for this condition. However, its neuroprotective effects remain controversial. This study investigated the effect of different NBO concentrations on I/R injury and explores the involvement of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in the underlying mechanism. A mouse middle cerebral artery occlusion (MCAO) model, and an oxygen and glucose deprivation (OGD) model featuring mouse brain microvascular endothelial cells (ECs) called bEnd...
November 11, 2023: Molecular Neurobiology
#50
REVIEW
Bin Jiang, Xiaojie Wang, Jianping Ma, Aminah Fayyaz, Li Wang, Pei Qin, Yuchuan Ding, Xunming Ji, Sijie Li
BACKGROUND AND PURPOSE: Stroke is a leading cause of global morbidity and mortality, indicating the necessity and urgency of effective prevention and treatment. Remote ischemic conditioning (RIC) is a convenient, simple, non-intrusive, and effective method that can be easily added to the treatment regime of stroke patients. Animal experiments and clinical trials have proved the neuroprotective effects of RIC on brain injury including (examples of neuroprotective effects). This neuroprotection is achieved by raising brain tolerance to ischemia, increasing local cerebral blood perfusion, promoting collateral circulations, neural regeneration, and reducing the incidence of hematomas in brain tissue...
April 2024: CNS Neuroscience & Therapeutics
#51
JOURNAL ARTICLE
Andreas Kumar, Kim Connelly, Keyur Vora, Kevin R Bainey, Andrew Howarth, Jonathon Leipsic, Suzanne Betteridge-LeBlanc, Frank S Prato, Howard Leong-Poi, Anthony Main, Rony Atoui, Jacqueline Saw, Eric Larose, Michelle M Graham, Marc Ruel, Rohan Dharmakumar
Myocardial infarction (MI) remains a leading cause of morbidity and mortality. In atherothrombotic MI (ST-elevation MI and type 1 non-ST-elevation MI), coronary artery occlusion leads to ischemia. Subsequent cardiomyocyte necrosis evolves over time as a wavefront within the territory at risk. The spectrum of ischemia and reperfusion injury is wide: it can be minimal in aborted MI or myocardial necrosis can be large and complicated by microvascular obstruction and reperfusion hemorrhage. Established risk scores and infarct classifications help with patient management but do not consider tissue injury characteristics...
October 26, 2023: Canadian Journal of Cardiology
#52
REVIEW
Stefanie Scheid, Ulrich Goebel, Felix Ulbrich
Cerebral injury is a leading cause of long-term disability and mortality. Common causes include major cardiovascular events, such as cardiac arrest, ischemic stroke, and subarachnoid hemorrhage, traumatic brain injury, and neurodegenerative as well as neuroinflammatory disorders. Despite improvements in pharmacological and interventional treatment options, due to the brain's limited regeneration potential, survival is often associated with the impairment of crucial functions that lead to occupational inability and enormous economic burden...
October 18, 2023: Cells
#53
JOURNAL ARTICLE
Lan Fu, Lin-Na Guan, Hongye Zuo
This study aims to summarize the changes of functional diffusion kurtosis imaging (DKI) parameters in the bilateral hippocampal CA1 region of the hemorrhagic shock reperfusion (HSR) model of rats and their correlation with cognitive dysfunction. Adult male Sprague-Dawley rats (9-10 weeks of age, weighing 350-400 g) were randomized into the HSR group (n = 30) and the sham-operated group (Sham) (n = 30). Rats in the HSR group and the Sham group were subdivided into five time points (1, 2, 4, 8, and 12 weeks) for examination...
October 25, 2023: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
#54
JOURNAL ARTICLE
Li Zhang, Hao Luo, Chao Li, Hua Teng, Brianna Powell, Mei Lu, Michael Chopp, Zheng Gang Zhang
UNLABELLED: Stroke is a leading cause of death and disability worldwide, mainly affecting the elderly. Unfortunately, current treatments for acute ischemic stroke warrant improvement. To date, tissue plasminogen activator (tPA) is of limited use in stroke patients mainly due to its narrow therapeutic window and potential for hemorrhagic complication. The adjuvant treatment with Vepoloxamer, a purified amphipathic polymer has been shown to enhance the thrombolytic efficacy of tPA treatment in young adult male rats after embolic stroke...
2023: Frontiers in Neurology
#55
JOURNAL ARTICLE
Bei Guo, Huimeng Song, Jiahui Fan, Bin Wang, Lingyi Chen, Qiandai Hu, Yanling Yin
Stroke is reported to be the second leading cause of death worldwide, among which ischemic stroke has fourfold greater incidence than intracerebral hemorrhage. Excitotoxicity induced by NMDAR plays a central role in ischemic stroke-induced neuronal death. However, intervention targeted NMDARs against ischemic stroke has failed, which may result from the complex composition of NMDARs and the dynamic changes of their subunits. In this current study, the levels of NR1, NR2A and NR2B subunits of NMDARs were observed upon different time points during the reperfusion after 1 h ischemia with the western blot assay...
October 16, 2023: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
#56
JOURNAL ARTICLE
I I Lisnyy, K A Zakalska, A A Burlaka, S A Lysykh, O V Efimenko
BACKGROUND: The intermittent Pringle maneuver remains the major technique for controlling hemorrhage during liver surgery. Nevertheless, this procedure involves a risk of triggering a cascade of pathological changes resulting in the ischemia-reperfusion injury (I/R) effect. The pharmacological prevention of this I/R injury represents a promising approach. The aim of the study was to compare the effects of pharmacological preconditioning with sevoflurane and propofol-based intravenous anesthesia on the postoperative function of the liver as the primary end-point...
October 11, 2023: Experimental Oncology
#57
RANDOMIZED CONTROLLED TRIAL
Rolf Ankerlund Blauenfeldt, Niels Hjort, Jan Brink Valentin, Anne-Mette Homburg, Boris Modrau, Birgitte Forsom Sandal, Martin Faurholdt Gude, Kristina Dupont Hougaard, Dorte Damgaard, Marika Poulsen, Tove Diedrichsen, Marie Louise Schmitz, Paul von Weitzel-Mudersbach, Alex Alban Christensen, Krystian Figlewski, Erik Lerkevang Grove, Margrét Katrín Hreiðarsdóttir, Henning Morthorst Lassesen, Daniel Wittrock, Søren Mikkelsen, Ulla Væggemose, Palle Juelsgaard, Hans Kirkegaard, Martin Rostgaard-Knudsen, Niels Degn, Sigrid Breinholt Vestergaard, Andreas Gammelgaard Damsbo, Ane Bull Iversen, Janne Kærgård Mortensen, Jesper Petersson, Thomas Christensen, Anne Brink Behrndtz, Hans Erik Bøtker, David Gaist, Marc Fisher, David Charles Hess, Søren Paaske Johnsen, Claus Ziegler Simonsen, Grethe Andersen
IMPORTANCE: Despite some promising preclinical and clinical data, it remains uncertain whether remote ischemic conditioning (RIC) with transient cycles of limb ischemia and reperfusion is an effective treatment for acute stroke. OBJECTIVE: To evaluate the effect of RIC when initiated in the prehospital setting and continued in the hospital on functional outcome in patients with acute stroke. DESIGN, SETTING, AND PARTICIPANTS: This was a randomized clinical trial conducted at 4 stroke centers in Denmark that included 1500 patients with prehospital stroke symptoms for less than 4 hours (enrolled March 16, 2018, to November 11, 2022; final follow-up, February 3, 2023)...
October 3, 2023: JAMA
#58
REVIEW
Yajin Zhao, Kimberly Main, Tanroop Aujla, Shaf Keshavjee, Mingyao Liu
Organ transplantation remains the only treatment option for patients with end-stage organ dysfunction. However, there are numerous limitations that challenge its clinical application, including the shortage of organ donations, the quality of donated organs, injury during organ preservation and reperfusion, primary and chronic graft dysfunction, acute and chronic rejection, infection, and carcinogenesis in post-transplantation patients. Acute and chronic inflammation and cell death are two major underlying mechanisms for graft injury...
September 17, 2023: Cells
#59
JOURNAL ARTICLE
Zhen-Ni Guo, Yang Qu, Reziya Abuduxukuer, Peng Zhang, Lijuan Wang, Ying Liu, Rui-Hong Teng, Jian-Hua Gao, Feng Jin, Hai-Feng Wang, Yu Cao, Yong-Quan Xue, Jun-Feng Zhao, Magdy H Selim, Thanh N Nguyen, Yi Yang
BACKGROUND: Previous studies have revealed that remote ischemic conditioning (RIC) may have a neuroprotective function. However, the potential benefit of RIC for patients with ICH remain unclear. OBJECTIVE: The primary aim of this study is to assess the safety and efficacy of RIC for patients with ICH. METHODS: The Safety and Efficacy of RIC for Spontaneous ICH (SERIC-ICH) is an ongoing prospective, randomized, multicenter, parallel-controlled, and blinded-endpoint clinical trial...
September 26, 2023: European Stroke Journal
#60
JOURNAL ARTICLE
Enes Karaman, Gozde Ozge Onder, Ozge Goktepe, Erol Karakas, Ozge Cengiz Mat, Demet Bolat, Eda Koseoglu, Kardelen Tur, Munevver Baran, Mustafa Ermis, Esra Balcioglu, Arzu Yay
Ovarian ischemia is a gynecological emergency that occurs as a result of ovarian torsion, affects women of reproductive age, and reduces ovarian reserve. The current study was designed to investigate the effect of boric acid taken in different ways on histopathological changes, autophagy, oxidative stress, and DNA damage caused by ischemia and reperfusion in the ovary of adult female rats. We established seven groups of 70 adult female rats: untreated control, intraperitoneal boric acid group (IpBA), oral boric acid group (OBA), ischemia/reperfusion group (ischemia/2 h reperfusion; OIR), ischemia/reperfusion and local boric acid group (OIR + LBA), ischemia/reperfusion and intraperitoneal boric acid group (OIR + IpBA), and ischemia/reperfusion and oral boric acid group (OIR + OBA)...
September 25, 2023: Biological Trace Element Research
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
