Katherine Pfister, Victoria Young, Brendon Frankel, Anne Silva Barbosa, Jordan Burton, Joanna Bons, Bob Zhang, Takuto Chiba, Rebecca Uhlean, Eric Goetzman, Birgit Schilling, Sunder Sims-Lucas
Acute Kidney Injury (AKI) is extremely prevalent among hospitalizations and presents a significant risk for the development of chronic kidney disease and increased mortality. Ischemia caused by shock, trauma, and transplant are common causes of AKI. To attenuate ischemic AKI therapeutically, we need a better understanding of the physiological and cellular mechanisms underlying damage. Instances of ischemia are most damaging in Proximal Tubule Epithelial Cells (PTECs) where hypoxic signaling cascades, and perhaps more rapidly, posttranslational modifications (PTMs), act in concert to change cellular metabolism...
May 2, 2024: American Journal of Physiology. Renal Physiology