Menghang Xia, Ruili Huang, Qiang Shi, Windy A Boyd, Jinghua Zhao, Nuo Sun, Julie R Rice, Paul E Dunlap, Amber J Hackstadt, Matt F Bridge, Marjolein V Smith, Sheng Dai, Wei Zheng, Pei-Hsuan Chu, David Gerhold, Kristine L Witt, Michael DeVito, Jonathan H Freedman, Christopher P Austin, Keith A Houck, Russell S Thomas, Richard S Paules, Raymond R Tice, Anton Simeonov
BACKGROUND: A central challenge in toxicity testing is the large number of chemicals in commerce that lack toxicological assessment. In response, the Tox21 program is re-focusing toxicity testing from animal studies to less expensive and higher throughput in vitro methods using target/pathway-specific, mechanism-driven assays. OBJECTIVES: Our objective was to use an in-depth mechanistic study approach to prioritize and characterize the chemicals affecting mitochondrial function...
July 2018: Environmental Health Perspectives