Bo Wang, Sheng Zhang, Zi-Tao Shen, Ting Hou, Yi-Han Zhao, Meng-Sheng Huang, Jian Li, Huan Chen, Peng-Hui Hu, Zi-Jiang Luo, Shuai Yuan, Feng-Min Wang, Wei Li, Chang Shu, Xing-Hua Xia, Ya Ding
Enzyme-prodrug therapies have shown unique advantages in efficiency, selectivity, and specificity of in vivo prodrug activation. However, precise spatiotemporal control of both the enzyme and its substrate at the target site, preservation of enzyme activity, and in situ substrate depletion due to low prodrug delivery efficiency continue to be great challenges. Here, we propose a novel core-shell reactor partitioning enzyme and prodrug by ZIF-8, which integrates an enzyme with its substrate and increases the drug loading capacity (DLC) using a prodrug as the building ligand to form a Zn-prodrug shell...
October 26, 2023: Angewandte Chemie