Daniel Gabriel Pons, Joana Vilanova-Llompart, Auba Gaya-Bover, Marina Alorda-Clara, Jordi Oliver, Pilar Roca, Jorge Sastre-Serra
Breast cancer is the most common malignancy in women of developed countries. The aim of this study was to investigate the effects of the phytoestrogen genistein on the inflammatory profile in three breast cancer cell lines with different oestrogen receptors alpha (ERα) and beta (ERβ) ratio. MCF-7 (high ERα/ERβ ratio), T47D (low ERα/ERβ ratio), and MDA-MB-231 (ERα-negative) cells were treated with 1 µM of genistein for 48 h (cell proliferation and ROS production) or 4 h (mRNA expression of 18S, ERα, ERβ, pS2, Sirtuin1, IL-1β, NF-κB, COX-2, TGFβ1, PPARγ)...
April 4, 2019: International Journal of Food Sciences and Nutrition