Zhigang Shen, Tao Dong, Hongmei Yong, Chuyin Deng, Changxiu Chen, Xintian Chen, Miaolei Chen, Sufang Chu, Junnian Zheng, Zhongwei Li, Jin Bai
Glioblastoma (GBM) is the most common malignant primary brain tumor. Despite comprehensive treatment with traditional surgery, radiotherapy, and chemotherapy, the median survival rate is <14.6% and the 5-year survival rate is only 5%. FBXO22, a substrate receptor of the SCF ubiquitin ligases, has been reported to play a promoting role in melanoma, liver cancer, cervical cancer, and other cancers. However, the function of FBXO22 in GBM has not been reported. In the present study, we demonstrate that FBXO22 is highly expressed in glioma and is positively correlated with worse pathological features and shorter survival of GBM patients...
March 23, 2024: Cell Death Discovery