Anna K Le Fevre, Sharelle Taylor, Neva H Malek, Denise Horn, Christopher W Carr, Omar A Abdul-Rahman, Sherindan O'Donnell, Trent Burgess, Marie Shaw, Jozef Gecz, Nicole Bain, Kerry Fagan, Matthew F Hunter
Mutations in FOXP1, located at 3p13, have been reported in patients with global developmental delay (GDD), intellectual disability (ID), and speech defects. Mutations in FOXP2, located at 7q31, are well known to cause developmental speech and language disorders, particularly developmental verbal dyspraxia (DVD). FOXP2 has been shown to work co-operatively with FOXP1 in mouse development. An overlap in FOXP1 and FOXP2 expression, both in the songbird and human fetal brain, has suggested that FOXP1 may also have a role in speech and language disorders...
December 2013: American Journal of Medical Genetics. Part A