Xiaoxue Yin, Xiaoxia Wei, Ruqaiya Al Shamsi, Fatima S Ali, Faiza Al Kindi, Xingming Zhang, Jiayu Liang, Xiuyi Pan, Mohammed Al Masqari, Linmao Zheng, Qiao Zhou, Abbas Agaimy, Ni Chen
Leiomyoma is the most prevalent benign tumor of the female reproductive system. Benign metastasizing leiomyoma (BML) is a rare phenomenon that presents at distant sites, typically the lungs, exhibiting histopathological features similar to the primary uterine tumor in the absence of malignancy features in both. Fumarate hydratase-deficient uterine leiomyoma (FH-d UL) is an uncommon subtype among uterine smooth muscle tumors (0.5-2%), showing distinctive histomorphology and FH inactivation. The majority of FH-d ULs are sporadic, caused by somatic FH inactivation, while a minority of cases occur in the context of the hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome caused by germline FH inactivation...
April 20, 2024: Virchows Archiv: An International Journal of Pathology