keyword
https://read.qxmd.com/read/33091898/computational-modelling-of-modern-cancer-immunotherapy
#1
Damijan Valentinuzzi, Robert Jeraj
Modern cancer immunotherapy has revolutionised oncology and carries the potential to radically change the approach to cancer treatment. However, numerous questions remain to be answered to understand immunotherapy response better and further improve the benefit for future cancer patients. Computational models are promising tools that can contribute to accelerated immunotherapy research by providing new clues and hypotheses that could be tested in future trials, based on preceding simulations in addition to the empirical rationale...
October 22, 2020: Physics in Medicine and Biology
https://read.qxmd.com/read/33091175/the-role-of-b-cells-in-multiple-sclerosis-and-related-disorders
#2
REVIEW
Giancarlo Comi, Amit Bar-Or, Hans Lassmann, Antonio Uccelli, Hans-Peter Hartung, Xavier Montalban, Per Solberg Sørensen, Reinhard Hohlfeld, Stephen L Hauser
The success of clinical trials of selective B-cell depletion in patients with relapsing multiple sclerosis (RMS) and primary progressive MS (PPMS) have led to a conceptual shift in the understanding of MS pathogenesis, away from the classical model in which T cells were the sole central actors, and towards a more complex paradigm with B cells having an essential role in both the inflammatory and neurodegenerative components of the disease process. The role of B cells in MS was selected as the topic of the 27th Annual meeting of the European Charcot Foundation...
October 9, 2020: Annals of Neurology
https://read.qxmd.com/read/33090846/interactive-rhythms-in-the-wild-in-the-brain-and-in-silico
#3
Marianna Anichini, Marianne de Heer Kloots, Andrea Ravignani
There are some historical divisions in methods, rationales, and purposes between studies on comparative cognition and behavioural ecology. In turn, the interaction between these two branches and studies from mathematics, computation, and neuroscience is not usual. In this short piece, we attempt to build bridges among these disciplines. We present a series of interconnected vignettes meant to illustrate what a more interdisciplinary approach looks like when successful, and its advantages. Concretely, we focus on a recent topic, namely animal rhythms in interaction, studied under different approaches...
September 2020: Canadian Journal of Experimental Psychology
https://read.qxmd.com/read/33090616/perceptions-of-provider-s-epistemic-authority-in-response-to-variant-of-uncertain-significance-related-recommendations
#4
Sukh Makhnoon, Maureen Mork, Banu Arun, Robert J Volk, Susan K Peterson
Uncertain genetic information such as variants of uncertain significance (VUS) is often encountered by patients in clinical cancer genetic testing. Although healthcare providers facilitate patient's understanding of VUS-associated empirical risk and its medical implications, patients' understanding and perceptions of risk often differ and may be based on subjective evaluations such as their perception of provider's epistemic authority (EA). This study examines the hypothesis that individuals attribute greater EA to genetic counselors (GCs) (compared to gastrointestinal oncologists) and to providers who recommend more active VUS-related recommendations (compared to inactive)...
October 8, 2020: Journal of Genetic Counseling
https://read.qxmd.com/read/33090355/the-use-and-perceived-usefulness-of-an-online-toolbox-targeted-at-employers-miles-intervention-for-enhancing-successful-return-to-work-of-cancer-survivors
#5
M A Greidanus, A E de Rijk, M H W Frings-Dresen, C M Tiedtke, S Brouwers, A G E M de Boer, S J Tamminga
PURPOSE: The MiLES intervention is a web-based intervention targeted at employers with the objective of enhancing successful return to work (RTW) of cancer survivors. The aim of this study is to gain insight into the employers' use and perceived usefulness of the MiLES intervention. METHODS: Employer representatives (e.g. Human Resource managers and supervisors) were given access to the MiLES intervention, which contains, among others, interactive videos, conversation checklists and tailored tips...
October 22, 2020: Journal of Occupational Rehabilitation
https://read.qxmd.com/read/33090120/ethical-considerations-in-animal-research-the-principle-of-3r-s
#6
Lorenza Díaz, Elena Zambrano, María E Flores, Mariela Contreras, José C Crispín, Gabriela Alemán, César Bravo, Alejandra Armenta, Victor J Valdés, Armando Tovar, Gerardo Gamba, Jorge Barrios-Payán, Norma A Bobadilla
In the last century, progress in the knowledge of human diseases, their diagnosis and treatment have grown exponentially, due in large part to the introduction and use of laboratory animals. Along with this important progress, the need to provide training and guidance to the scientific community in all aspects related to the proper use of experimental animals has been indispensable. Animal research committees play a primary role in evaluating experimental research protocols, from their feasibility to the rational use of animals, but above all in seeking animal welfare...
May 7, 2020: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/33090115/performance-cost-effectiveness-and-representativeness-of-facebook-recruitment-to-suicide-prevention-research-online-survey-study
#7
Sylvia Lee, Michelle Torok, Fiona Shand, Nicola Chen, Lauren McGillivray, Alexander Burnett, Mark Erik Larsen, Katherine Mok
BACKGROUND: Researchers are increasingly using social media advertisements to recruit participants because of their many advantages over traditional methods. Although there is growing evidence for the effectiveness and cost-effectiveness of social media recruitment in the health sciences, no studies have yet examined this in the context of suicide prevention, which remains to be a highly stigmatized and sensitive topic. OBJECTIVE: This study aims to recruit a general community sample to complete a survey on suicide literacy, stigma, and risk via Facebook advertisements...
October 22, 2020: JMIR Mental Health
https://read.qxmd.com/read/33089650/review-article-systematic-literature-review-of-leadership-in-emergency-departments
#8
REVIEW
Samuel Wilson, Andrew Rixon, Stephanie Hartanto, Peter White, Simon Judkins
Emergency medicine (EM) is a discipline with complex leadership demands. However, studies of EM physician leadership and ED leadership are in their infancy. As such, there is a lack of clarity about the forms, antecedents, enablers, barriers and consequences of EM physician leadership. A systematic review of the scientific literature was conducted to reveal the different conceptualisations of EM physician leadership, the activities involved in the practice of leadership, and the knowledge and skills of effective ED leaders...
October 21, 2020: Emergency Medicine Australasia: EMA
https://read.qxmd.com/read/33089623/international-expert-perspectives-on-the-principles-and-components-of-effective-intervention-for-adults-who-stutter
#9
Amy Connery, Rose Galvin, Arlene McCurtin
BACKGROUND: While evidence-based practice is widely endorsed by researchers, clinicians and professional bodies as a guiding framework for the provision of quality care to clients, the reliance on efficacy evidence may overshadow the benefits of other knowledge forms in supporting intervention design and evaluation. Due consideration needs to be given to varied forms of evidence, including practice and patient evidence. Stuttering intervention for adults is one area in which there is a significant shortage of practice-based research literature...
October 22, 2020: International Journal of Language & Communication Disorders
https://read.qxmd.com/read/33089443/administration-of-exogenous-hormones-and-the-implications-for-cigarette-smoking-related-behaviors
#10
REVIEW
Alicia Allen, Stephanie Mallahan, Alexis Ortega, Heather Miller, Ahlam Saleh, Andrea E Bonny
PURPOSE OF REVIEW: Preclinical evidence indicates progesterone and estrogen influence drug-taking behaviors, including nicotine/tobacco. However, clinical research on this relationship is less clear. This lack of clarity may be due to measuring naturally occurring endogenous hormones to examine this relationship, which introduces substantial error. Therefore, the goal of this review is to examine the link between the delivery of exogenous hormones and cigarette smoking-related behavior...
October 22, 2020: Current Psychiatry Reports
https://read.qxmd.com/read/33089215/encapsulation-of-mesenchymal-stem-cells-dissecting-the-underlying-mechanism-of-mesenchymal-stem-cell-transplantation-therapy
#11
COMMENT
Kyohei Kin, Takao Yasuhara, Isao Date
Mesenchymal stem cells (MSCs) are widely considered good candidates for cell transplantation therapy. Various central nervous system disorders have been suggested as suitable targets for MSC transplantation therapy. In this context, a great deal of basic and clinical research has been conducted to explore its clinical uses. Although depression is one of the most common diseases in the world, the response rate to the currently available treatment is insufficient and new treatments are much needed. Despite the fact that MSC transplantation therapy has the potential to elicit an antidepressant effect, few studies have been conducted on this topic to date and the underlying mechanism remains poorly understood...
2020: Neuroscience insights
https://read.qxmd.com/read/33089022/practical-considerations-for-postarrest-targeted-temperature-management
#12
REVIEW
Isabelle Mullen, Benjamin S Abella
Out-of-hospital cardiac arrest remains a major challenge worldwide, with survival to discharge rates of <20% in the great majority of countries. Advancements in prehospital care, including increasing deployment of automated external defibrillators and improvements in bystander cardiopulmonary resuscitation, have led to more victims achieving return of spontaneous circulation (ROSC), yet the majority of patients with ROSC suffer in-hospital mortality or significant neurologic injuries that persist after discharge...
October 2020: Turkish Journal of Emergency Medicine
https://read.qxmd.com/read/33088988/software-for-bioprinting
#13
REVIEW
Catherine Pakhomova, Dmitry Popov, Eugenii Maltsev, Iskander Akhatov, Alexander Pasko
The bioprinting of heterogeneous organs is a crucial issue. To reach the complexity of such organs, there is a need for highly specialized software that will meet all requirements such as accuracy, complexity, and others. The primary objective of this review is to consider various software tools that are used in bioprinting and to reveal their capabilities. The sub-objective was to consider different approaches for the model creation using these software tools. Related articles on this topic were analyzed. Software tools are classified based on control tools, general computer-aided design (CAD) tools, tools to convert medical data to CAD formats, and a few highly specialized research-project tools...
2020: International journal of bioprinting
https://read.qxmd.com/read/33088936/critical-assessment-of-islamic-endowment-funds-waqf-literature-lesson-for-government-and-future-directions
#14
Raditya Sukmana
In this paper, the literature on Islamic endowment funds (awqaf) was surveyed. The data suggest that banking, accountability, law, and norms constitute most of the coverage in this body of literature. The finance topic, with 35% coverage, dominated the literature, whereas history (with 6% coverage) recorded the least interest. In this sample, the second most popular theme was related to economic development (25% coverage). Also discovered was that 59% of the papers employed a normative approach, and the balance adopted an empirical approach...
October 2020: Heliyon
https://read.qxmd.com/read/33088880/a-stance-data-set-on-polarized-conversations-on-twitter-about-the-efficacy-of-hydroxychloroquine-as-a-treatment-for-covid-19
#15
Ece C Mutlu, Toktam Oghaz, Jasser Jasser, Ege Tutunculer, Amirarsalan Rajabi, Aida Tayebi, Ozlem Ozmen, Ivan Garibay
At the time of this study, the SARS-CoV-2 virus that caused the COVID-19 pandemic has spread significantly across the world. Considering the uncertainty about policies, health risks, financial difficulties, etc. the online media, especially the Twitter platform, is experiencing a high volume of activity related to this pandemic. Among the hot topics, the polarized debates about unconfirmed medicines for the treatment and prevention of the disease have attracted significant attention from online media users...
December 2020: Data in Brief
https://read.qxmd.com/read/33088806/regulating-the-performance-of-lithium-ion-battery-focus-on-the-electrode-electrolyte-interface
#16
REVIEW
Dongni Zhao, Shiyou Li
The development of lithium-ion battery (LIB) has gone through nearly 40 year of research. The solid electrolyte interface film in LIBs is one of most vital research topics, its behavior affects the cycle life and safety of LIBs significantly. Progress in understanding the interfacial layer on the negative and positive electrodes in LIBs has been the focus of considerable research in the past few decades, but there remains a number of problem to be understood at the fundamental level, and there is still a great deal of controversy regarding the composition and formation mechanism of the interfacial film...
2020: Frontiers in Chemistry
https://read.qxmd.com/read/33088745/introduction-and-implementation-of-early-clinical-exposure-in-undergraduate-medical-training-to-enhance-learning
#17
Kapil Gupta, Gurpreet Singh Gill, Rajiv Mahajan
Context: Conventional medical curricula have created an impenetrable wall between the preclinical and clinical years of training, thus submerging relevance of basic sciences in clinical setup. Recently, the Medical Council of India has introduced a number of changes and updates in the medical education, including "early clinical exposure" (ECE) in newly proposed competency-based medical education. ECE does not replace the basic and clinical sciences but enriches and contextualizes that learning, therefore motivating the students to develop a better insight into medical profession...
July 2020: International Journal of Applied and Basic Medical Research
https://read.qxmd.com/read/33088291/theoretical-and-practical-challenges-of-proportionate-universalism-a-review
#18
REVIEW
Florence Francis-Oliviero, Linda Cambon, Jérôme Wittwer, Michael Marmot, François Alla
Objective: In 2010, the principle of proportionate universalism (PU) has been proposed as a solution to reduce health inequalities. It had a great resonance but does not seem to have been widely applied and no guidelines exist on how to implement it.The two specific objectives of this scoping review were: (1) to describe the theoretical context in which PU was established, (2) to describe how researchers apply PU and related methodological issues. Methods: We searched for all articles published until 6th of February 2020, mentioning "Proportionate Universalism" or its synonyms "Targeted universalism" OR "Progressive Universalism" as a topic in all Web of Science databases...
2020: Pan American Journal of Public Health
https://read.qxmd.com/read/33088215/linc01089-is-a-tumor-suppressive-lncrna-in-gastric-cancer-and-it-regulates-mir-27a-3p-tet1-axis
#19
Xufeng Guo, Ming Li
Background: Gastric cancer (GC) is one of the most common malignancies around the world. Recently, the role of long non-coding RNA (lncRNA) in cancer biology has become a hot research topic. This work aimed to explore the biological function and underlying mechanism of LINC01089 in GC. Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was employed to investigate the expression of LINC01089 in GC tissues and cells. The relationship between the expression level of LINC01089 and the clinicopathological parameters of GC was assessed...
2020: Cancer Cell International
https://read.qxmd.com/read/33088058/effect-of-two-desensitizing-agents-on-dentin-hypersensitivity-a-randomized-split-mouth-clinical-trial
#20
Angambakkam Rajasekaran PradeepKumar, Venkatnagaraj Viswanath, Kamna Singh, Kuzhanchinathan Manigandan, HaseenaBegum Iqbal, Anil Kishen
Background: Clinical research is important to evaluate the effect of desensitizing agents. Aims: This randomized clinical trial evaluated the immediate and 1 week desensitizing effect of two desensitizing agents Uno Topical Gel and Profluorid. Materials and Methods: Thirtyfive patients with teeth presenting with dentin hypersensitivity were included in this clinical trial. Each quadrant in a patient was randomly assigned to one of two groups: Uno Topical Gel or Profluorid Varnish...
November 2019: Journal of Conservative Dentistry: JCD
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