Ali Mroueh, Walaa Fakih, Adrien Carmona, Antonin Trimaille, Kensuke Matsushita, Benjamin Marchandot, Abdul Wahid Qureshi, Dal-Seong Gong, Cyril Auger, Laurent Sattler, Antje Reydel, Sébastien Hess, Walid Oulehri, Olivier Vollmer, Jean-Marc Lessinger, Nicolas Meyer, Michael-Paul Pieper, Laurence Jesel, Magnus Bäck, Valérie Schini-Kerth, Olivier Morel
BACKGROUND: COVID-19 is associated with increased risk of cardiovascular complications. Although cytokines have a predominant role in endothelium damage, the precise molecular mechanisms are far from being elucidated. OBJECTIVES: The present study hypothesizes that inflammation in COVID-19 patients contributes to endothelial dysfunction through redox sensitive SGLT2 overexpression and investigates the protective effect of SGLT2 inhibition by empagliflozin. METHODS: Human plasma samples were collected from acute, sub-acute and long COVID-19 patients (n=100), non-COVID-19 patients with cardiovascular risk factors (n=50), and healthy volunteers (n=25)...
October 3, 2023: Journal of Thrombosis and Haemostasis: JTH