keyword
https://read.qxmd.com/read/38522056/nbs-superfood-a-promising-adjunctive-therapy-in-critically-ill-icu-patients-with-omicron-variant-of-covid-19
#41
JOURNAL ARTICLE
Mehrdad Mosadegh, Aref Khalkhali, Yousef Erfani, Manije Nezamdoost, Seyyed Hamid Hashemi, Farid Azizi Jalilian, Nastaran Ansari, Shahab Mahmoudvand, Mojgan Mamani, Elham Abdoli, Razieh Amini, Gholamreza Kalvandi
This clinical trial aimed to assess the impact of Nutrition Bio-shield superfood (NBS) on clinical status among critically ill ICU patients suffering from acute respiratory distress syndrome (ARDS) due to the Omicron variant of COVID-19. A total of 400 patients with confirmed Omicron-related ARDS were randomly assigned to either the intervention group (n = 200) or the control group (n = 200). Patients in the intervention group received 1.5 g of NBS powder daily for 2 weeks in addition to standard antiviral treatment, while the control group received a placebo alongside standard antiviral therapy...
March 24, 2024: AMB Express
https://read.qxmd.com/read/38521944/breath-metabolomics-for-diagnosis-of-acute-respiratory-distress-syndrome
#42
JOURNAL ARTICLE
Shiqi Zhang, Laura A Hagens, Nanon F L Heijnen, Marry R Smit, Paul Brinkman, Dominic Fenn, Tom van der Poll, Marcus J Schultz, Dennis C J J Bergmans, Ronny M Schnabel, Lieuwe D J Bos
BACKGROUND: Acute respiratory distress syndrome (ARDS) poses challenges in early identification. Exhaled breath contains metabolites reflective of pulmonary inflammation. AIM: To evaluate the diagnostic accuracy of breath metabolites for ARDS in invasively ventilated intensive care unit (ICU) patients. METHODS: This two-center observational study included critically ill patients receiving invasive ventilation. Gas chromatography and mass spectrometry (GC-MS) was used to quantify the exhaled metabolites...
March 23, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38521771/ripk1-inhibitor-ameliorates-pulmonary-injury-by-modulating-the-function-of-neutrophils-and-vascular-endothelial-cells
#43
JOURNAL ARTICLE
Tao Yang, Cai-Gui Xiang, Xiao-Han Wang, Qing-Qing Li, Shu-Yue Lei, Kai-Rong Zhang, Jing Ren, Hui-Min Lu, Chun-Lan Feng, Wei Tang
Acute lung injury (ALI) is an acute and progressive hypoxic respiratory failure that could progress to acute respiratory distress syndrome (ARDS) with a high mortality rate, thus immediate medical attention and supportive care are necessary. The pathophysiology of ALI is characterized by the disruption of the alveolar-capillary barrier and activation of neutrophils, leading to lung tissue damage. The receptor-interacting protein kinase 1 (RIPK1) has emerged as a promising target for the treatment of multiple inflammatory diseases, but the role of RIPK1 in the ALI remains poorly understood...
March 23, 2024: Cell Death Discovery
https://read.qxmd.com/read/38518606/inhibition-the-ubiquitination-of-enac-and-na-k-atpase-with-erythropoietin-promotes-alveolar-fluid-clearance-in-sepsis-induced-acute-respiratory-distress-syndrome
#44
JOURNAL ARTICLE
Ye Gao, Fei Cao, Xinyi Tian, Qianping Zhang, Congcong Xu, Bowen Ji, Ye-An Zhang, Linan Du, Jun Han, Li Li, Siyu Zhou, Yuqiang Gong, Binyu Ying, Fang Gao-Smith, Shengwei Jin
Sepsis-induced acute respiratory distress syndrome (ARDS) causes significant fatalities worldwide and lacks pharmacological intervention. Alveolar fluid clearance (AFC) plays a pivotal role in the remission of ARDS and is markedly impaired in the pathogenesis of ARDS. Here, we demonstrated that erythropoietin could effectively ameliorate lung injury manifestations and lethality, restore lung function and promote AFC in a rat model of lipopolysaccharide (LPS)-induced ARDS. Moreover, it was proven that EPO-induced restoration of AFC occurs through triggering the total protein expression of ENaC and Na,K-ATPase channels, enhancing their protein abundance in the membrane, and suppressing their ubiquitination for degeneration...
March 21, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38516615/use-of-inhaled-epoprostenol-in-patients-with-covid-19-receiving-humidified-high-flow-nasal-oxygen-is-associated-with-progressive-respiratory-failure
#45
JOURNAL ARTICLE
Andrew P Michelson, Patrick G Lyons, Nguyet M Nguyen, Daniel Reynolds, Rachel McDonald, Colleen A McEvoy, Vladimir Despotovic, Steven L Brody, Marin H Kollef, Bryan D Kraft
BACKGROUND: The clinical benefit of using inhaled epoprostenol (iEpo) through a humidified high-flow nasal cannula (HHFNC) remains unknown for patients with COVID-19. RESEARCH QUESTION: Can iEpo prevent respiratory deterioration for patients with positive SARS-CoV-2 findings receiving HHFNC? STUDY DESIGN AND METHODS: This multicenter retrospective cohort analysis included patients aged 18 years or older with COVID-19 pneumonia who required HHFNC treatment...
December 2023: CHEST Crit Care
https://read.qxmd.com/read/38516360/surge-capacity-of-taipei-s-regional-emergency-medical-system-during-covid-19-a-system-dynamics-approach
#46
JOURNAL ARTICLE
Chih Chang Chen, Su Ying Hung
BACKGROUND: The community transmission of COVID-19 has caused the breakdown of the regional emergency medical system (REMS), impacting the rights and care of regional patients with acute and severe conditions. This study proposes a model for the surge capacity of REMS to plan for readiness and preparedness during challenging events that overload capacity. METHODS: The surge capacity of REMS during the COVID-19 pandemic was studied. The data collection included 26 hospitals that received the data...
2024: Emergency Medicine International
https://read.qxmd.com/read/38516357/prone-position-in-the-mechanical-ventilation-of-acute-respiratory-distress-syndrome-children-a-systematic-review-and-meta-analysis
#47
REVIEW
Wen Qin, Lei Mao, Yue Shen, Li Zhao
BACKGROUND: Prone position has been well recognized for the treatment of adult acute respiratory distress syndrome (ARDS). We aimed to evaluate the role of prone position in the mechanical ventilation in children with ARDS, to provide evidence to the treatment and care of children with ARDS. METHODS: We searched the Pubmed et al. databases by computer until January 23, 2024 for randomized controlled trials (RCTs) on the role of prone position in the mechanical ventilation in children with ARDS...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38515193/clustering-covid-19-ards-patients-through-the-first-days-of-icu-admission-an-analysis-of-the-ciberesucicovid-cohort
#48
MULTICENTER STUDY
Adrian Ceccato, Carles Forne, Lieuwe D Bos, Marta Camprubí-Rimblas, Aina Areny-Balagueró, Elena Campaña-Duel, Sara Quero, Emili Diaz, Oriol Roca, David De Gonzalo-Calvo, Laia Fernández-Barat, Anna Motos, Ricard Ferrer, Jordi Riera, Jose A Lorente, Oscar Peñuelas, Rosario Menendez, Rosario Amaya-Villar, José M Añón, Ana Balan-Mariño, Carme Barberà, José Barberán, Aaron Blandino-Ortiz, Maria Victoria Boado, Elena Bustamante-Munguira, Jesús Caballero, Cristina Carbajales, Nieves Carbonell, Mercedes Catalán-González, Nieves Franco, Cristóbal Galbán, Víctor D Gumucio-Sanguino, Maria Del Carmen de la Torre, Ángel Estella, Elena Gallego, José Luis García-Garmendia, José Garnacho-Montero, José M Gómez, Arturo Huerta, Ruth Noemí Jorge-García, Ana Loza-Vázquez, Judith Marin-Corral, Amalia Martínez de la Gándara, María Cruz Martin-Delgado, Ignacio Martínez-Varela, Juan Lopez Messa, Guillermo Muñiz-Albaiceta, María Teresa Nieto, Mariana Andrea Novo, Yhivian Peñasco, Juan Carlos Pozo-Laderas, Felipe Pérez-García, Pilar Ricart, Ferran Roche-Campo, Alejandro Rodríguez, Victor Sagredo, Angel Sánchez-Miralles, Susana Sancho-Chinesta, Lorenzo Socias, Jordi Solé-Violan, Fernando Suarez-Sipmann, Luis Tamayo-Lomas, José Trenado, Alejandro Úbeda, Luis Jorge Valdivia, Pablo Vidal, Jesus Bermejo, Jesica Gonzalez, Ferran Barbe, Carolyn S Calfee, Antonio Artigas, Antoni Torres
BACKGROUND: Acute respiratory distress syndrome (ARDS) can be classified into sub-phenotypes according to different inflammatory/clinical status. Prognostic enrichment was achieved by grouping patients into hypoinflammatory or hyperinflammatory sub-phenotypes, even though the time of analysis may change the classification according to treatment response or disease evolution. We aimed to evaluate when patients can be clustered in more than 1 group, and how they may change the clustering of patients using data of baseline or day 3, and the prognosis of patients according to their evolution by changing or not the cluster...
March 21, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38512478/pancytopenia-with-aplastic-anemia-in-systemic-lupus-erythematosus-case-series-and-literature-review
#49
REVIEW
Zaid Al-Ghazawi, Amwaj Al-Farajat, Ahmad A Toubasi, Hind B Abu Tawileh, Aya Qteish, Tariq N Aladily, Fatima Alnaimat
Aplastic anemia (AA) is a rare, potentially catastrophic hematopoiesis failure manifested by pancytopenia and bone marrow aplasia. AA occurrence in Systemic Lupus Erythematosus (SLE) patients is extremely rare. The diagnosis may be delayed due to other possible pancytopenia etiologies. Confirmation of peripheral cytopenias diagnosis necessitates a bone marrow aspiration. The management of AA is challenging, and the literature reported using glucocorticoids, danazol, plasmapheresis, cyclophosphamide, intravenous immunoglobulin, and cyclosporine...
March 21, 2024: Rheumatology International
https://read.qxmd.com/read/38512400/electrical-impedance-tomography-guided-positive-end-expiratory-pressure-titration-in-ards-a-systematic-review-and-meta-analysis
#50
Nickjaree Songsangvorn, Yonghao Xu, Cong Lu, Ori Rotstein, Laurent Brochard, Arthur S Slutsky, Karen E A Burns, Haibo Zhang
PURPOSE: Assessing efficacy of electrical impedance tomography (EIT) in optimizing positive end-expiratory pressure (PEEP) for acute respiratory distress syndrome (ARDS) patients to enhance respiratory system mechanics and prevent ventilator-induced lung injury (VILI), compared to traditional methods. METHODS: We carried out a systematic review and meta-analysis, spanning literature from January 2012 to May 2023, sourced from Scopus, PubMed, MEDLINE (Ovid), Cochrane, and LILACS, evaluated EIT-guided PEEP strategies in ARDS versus conventional methods...
March 21, 2024: Intensive Care Medicine
https://read.qxmd.com/read/38512359/estimation-of-the-transpulmonary-pressure-from-the-central-venous-pressure-in-mechanically-ventilated-patients
#51
JOURNAL ARTICLE
Federico Franchi, Emanuele Detti, Alberto Fogagnolo, Savino Spadaro, Gabriele Cevenini, Gennaro Cataldo, Tommaso Addabbo, Cesare Biuzzi, Daniele Marianello, Carlo Alberto Volta, Fabio Silvio Taccone, Sabino Scolletta
Transpulmonary pressure (PL ) calculation requires esophageal pressure (PES ) as a surrogate of pleural pressure (Ppl), but its calibration is a cumbersome technique. Central venous pressure (CVP) swings may reflect tidal variations in Ppl and could be used instead of PES , but the interpretation of CVP waveforms could be difficult due to superposition of heartbeat-induced pressure changes. Thus, we developed a digital filter able to remove the cardiac noise to obtain a filtered CVP (f-CVP). The aim of the study was to evaluate the accuracy of CVP and filtered CVP swings (ΔCVP and Δf-CVP, respectively) in estimating esophageal respiratory swings (ΔPES ) and compare PL calculated with CVP, f-CVP and PES; then we tested the diagnostic accuracy of the f-CVP method to identify unsafe high PL levels, defined as PL >10 cmH2 O...
March 21, 2024: Journal of Clinical Monitoring and Computing
https://read.qxmd.com/read/38511721/increased-platelet-to-red-blood-cell-transfusion-ratio-associated-with-acute-kidney-injury-in-children-with-life-threatening-bleeding
#52
JOURNAL ARTICLE
Rachel Vaizer, Christine M Leeper, Liling Lu, Cassandra D Josephson, Julie C Leonard, Joshua B Brown, Philip C Spinella
INTRODUCTION: Transfusion may increase the risk of organ failure through immunomodulatory effects. The primary objective of this study was to assess for patient or transfusion-related factors that are independently associated with the risk of acute kidney injury (AKI) and acute respiratory distress syndrome (ARDS) in a cohort of children with life-threatening bleeding from all etiologies. METHODS: In a secondary analysis of the prospective observational massive transfusion in children (MATIC) study, multivariable logistic regression was performed in an adjusted analysis to determine if blood product ratios or deficits were independently associated with AKI or ARDS in children with life-threatening bleeding...
March 21, 2024: Transfusion
https://read.qxmd.com/read/38511227/cpap-versus-nippv-postextubation-in-preterm-neonates-a-comparative-effectiveness-study
#53
JOURNAL ARTICLE
Amit Mukerji, Brooke Read, Junmin Yang, Michelle Baczynski, Eugene Ng, Michael Dunn, Guillaume Ethier, Ayman Abou Mehrem, Marc Beltempo, Christine Drolet, Orlando da Silva, Deepak Louis, Brigitte Lemyre, Jehier Afifi, Balpreet Singh, Rebecca Sherlock, Miroslav Stavel, Edith Masse, Jaideep Kanungo, Jonathan Wong, Jaya Bodani, Faiza Khurshid, Kyong-Soon Lee, Sajit Augustine, Caio Barbosa de Oliveira, Hala Makary, Alana Newman, Cecil Ojah, Prakesh S Shah
BACKGROUND AND OBJECTIVES: Nasal intermittent positive pressure ventilation (NIPPV) has been shown to be superior to nasal continuous positive airway pressure (CPAP) postextubation in preterm neonates. However, studies have not permitted high CPAP pressures or rescue with other modes. We hypothesized that if CPAP pressures >8 cmH2O and rescue with other modes were permitted, CPAP would be noninferior to NIPPV. METHODS: We conducted a pragmatic, comparative-effectiveness, noninferiority study utilizing network-based real-world data from 22 Canadian NICUs...
March 21, 2024: Pediatrics
https://read.qxmd.com/read/38510887/right-to-left-intra-cardiac-shunt-in-a-covid-19-patient-leading-to-stroke-and-poor-prognosis-a-case-report-and-review-of-the-literature
#54
Ahmad Damlakhy, Husam Barham, Mohammad Omar, Zohaib Khan, Montaser Elkholy
Coronavirus disease 2019 (COVID-19) often presents with a wide range of complications, including respiratory distress, acute respiratory distress syndrome (ARDS), and hypercoagulable states with resultant cerebrovascular incidents. Intra- and extra-pulmonological shunts can further complicate patient courses, leading to persistent hypoxemia and paradoxical emboli, resulting in potentially life-threatening consequences, necessitating a comprehensive, multidisciplinary approach to patient care. Here we present the case of a 73-year-old male who experienced severe persistent hypoxemic respiratory failure, superimposed methicillin-resistant  Staphylococcus aureus (MRSA) pneumonia, and stroke with a previously undiagnosed patent foramen ovale (PFO) contributing to his clinical presentation...
February 2024: Curēus
https://read.qxmd.com/read/38510776/effect-of-aviptadil-a-novel-therapy-on-clinical-outcomes-of-patients-with-viral-related-severe-ards-a-retrospective-observational-study
#55
JOURNAL ARTICLE
Supriya Sampley, Deepak Bhasin, Kavita Sekhri, Harpal Singh, Onkar Gupta
BACKGROUND: Dealing with life-threatening viral acute respiratory distress syndrome (ARDS) has always been challenging and with the recent COVID pandemic experience, there is still the need of newer therapies to alleviate mortality. Aviptadil, has shown significant beneficial results in covid. We share our experience with this molecule by doing a retrospective study to evaluate the effect of this drug on clinical outcomes in viral-related Ards patients. MATERIALS AND METHODS: In this study, all patients with severe viral-related Ards received Aviptadil along with the conventional treatment...
January 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38509522/overexpression-of-wnt5a-promoted-the-protective-effect-of-mesenchymal-stem-cells-on-lipopolysaccharide-induced-endothelial-cell-injury-via-activating-pi3k-akt-signaling-pathway
#56
JOURNAL ARTICLE
Manliang Guo, Shiqi Li, Chuan Li, Xueyan Mao, Liru Tian, Xintong Yang, Caixia Xu, Mian Zeng
BACKGROUND: Lung endothelial barrier injury plays an important role in the pathophysiology of acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Mesenchymal stem cells (MSCs) therapy has shown promise in ARDS treatment and restoration of the impaired barrier function. It has been reported that Wnt5a shows protective effects on endothelial cells. Therefore, the study aimed to investigate whether overexpression of Wnt5a could promote the protective effects of MSCs on Lipopolysaccharide (LPS)-induced endothelial cell injury...
March 20, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38509149/plasma-renin-as-a-novel-prognostic-biomarker-of-sepsis-associated-acute-respiratory-distress-syndrome
#57
JOURNAL ARTICLE
Anjali Chakradhar, Rebecca M Baron, Mayra Pinilla Vera, Prasad Devarajan, Lakhmir Chawla, Peter C Hou
Sepsis-associated acute respiratory distress syndrome (ARDS) is a life-threatening condition in critical care medicine for which there is a substantial need for early prognostic biomarkers of outcome. The present study seeks to link plasma renin levels and 30-day mortality in sepsis-associated ARDS patients treated at our institution. The Registry of Critical Illness (RoCI) prospectively enrolled patients from the intensive care units (ICU) within a single academic medical center, and a convenience sample of patients with sepsis-associated ARDS was analyzed from this cohort...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38509095/comparison-of-mortality-and-outcomes-of-four-respiratory-viruses-in-the-intensive-care-unit-a-multicenter-retrospective-study
#58
MULTICENTER STUDY
Baptiste Grangier, Charles-Hervé Vacheron, Donatien De Marignan, Jean-Sebastien Casalegno, Sandrine Couray-Targe, Audrey Bestion, Florence Ader, Jean-Christophe Richard, Emilie Frobert, Laurent Argaud, Thomas Rimmele, Anne-Claire Lukaszewicz, Frédéric Aubrun, Frédéric Dailler, Jean-Luc Fellahi, Julien Bohe, Vincent Piriou, Bernard Allaouchiche, Arnaud Friggeri, Florent Wallet
This retrospective study aimed to compare the mortality and burden of respiratory syncytial virus (RSV group), SARS-CoV-2 (COVID-19 group), non-H1N1 (Seasonal influenza group) and H1N1 influenza (H1N1 group) in adult patients admitted to intensive care unit (ICU) with respiratory failure. A total of 807 patients were included. Mortality was compared between the four following groups: RSV, COVID-19, seasonal influenza, and H1N1 groups. Patients in the RSV group had significantly more comorbidities than the other patients...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38508704/fever-low-back-pain-and-skin-ulcerations
#59
JOURNAL ARTICLE
Linrong He, Yongpeng Ge, Xiaoming Shu
No abstract text is available yet for this article.
March 20, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38507979/a-pretrain-finetune-approach-for-improving-model-generalizability-in-outcome-prediction-of-acute-respiratory-distress-syndrome-patients
#60
JOURNAL ARTICLE
Songlu Lin, Meicheng Yang, Chengyu Liu, Zhihong Wang, Xi Long
BACKGROUND: Early prediction of acute respiratory distress syndrome (ARDS) of critically ill patients in intensive care units (ICUs) has been intensively studied in the past years. Yet a prediction model trained on data from one hospital might not be well generalized to other hospitals. It is therefore essential to develop an accurate and generalizable ARDS prediction model adaptive to different hospital or medical centers. METHODS: We analyzed electronic medical records of 200,859 and 50,920 hospitalized patients within 24 h after being diagnosed with ARDS from the Philips eICU Institute (eICU-CRD) and the Medical Information Mart for Intensive Care (MIMIC-IV) dataset, respectively...
March 2, 2024: International Journal of Medical Informatics
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