journal
Journals Endocrinology, Diabetes & Meta...

Endocrinology, Diabetes & Metabolism

https://read.qxmd.com/read/37899666/the-association-between-obesity-with-treatment-duration-icu-length-of-stay-and-the-risk-of-death-in-critically-ill-patients-with-covid-19
#21
JOURNAL ARTICLE
Maryam Gholamalizadeh, Mohammad Attari, Mahdi Mousavi, Soheila Shekari, Zahra Salimi, Asma Rajabi Harsini, Mobina Zeinolabedin, Amin Barzkar, Zahra Mahmoudi, Farkhondeh Alami, Samaneh Mirzaei Dahka, Somayeh Gholami, Masoume Rahvar, Masoume Pourtaleb, Sara Khoshdooz, Naser Kalantari, Saeid Doaei
BACKGROUND: Despite the confirmed association between higher BMI with increased risk of the acute respiratory distress syndrome (ARDS), the association between obesity with mortality in critically ill patients with coronavirus disease 2019 (COVID-19) is not clear. The present study aimed to investigate the association between obesity with treatment duration, ICU length of stay, and the risk of death in critically ill patients with COVID-19. METHODS: This case-control study was performed on 223 patients with COVID-19 including 148 surviving patients as the control group and 75 eventually dead patients as the case group in Rasht, Iran...
October 29, 2023: Endocrinology, Diabetes & Metabolism
https://read.qxmd.com/read/37872876/metabolic-dysregulation-and-gut-dysbiosis-linked-to-hyperandrogenism-in-female-mice
#22
JOURNAL ARTICLE
Annie Chen, Alex Handzel, Lillian Sau, Laura Cui, Scott T Kelley, Varykina G Thackray
INTRODUCTION: Polycystic ovary syndrome (PCOS) is a common endocrine pathology in women. In addition to infertility, women with PCOS have metabolic dysregulation which predisposes them to Type 2 diabetes, cardiovascular disease and non-alcoholic fatty liver disease. Moreover, women with PCOS have changes in their gut microbial community that may be indicative of dysbiosis. While hyperandrogenism is associated with both the development of metabolic dysfunction and gut dysbiosis in females, the mechanisms involved are not well understood...
October 23, 2023: Endocrinology, Diabetes & Metabolism
https://read.qxmd.com/read/37807699/increased-risk-of-poor-clinical-outcome-in-covid-19-patients-with-diabetes-mellitus-and-in-hospital-mortality-predictors-a%C3%A2-retrospective-cohort-from-a-tertiary-hospital-in-indonesia
#23
JOURNAL ARTICLE
Md Ikhsan Mokoagow, Dante Saksono Harbuwono, Ida Ayu Kshanti, C Martin Rumende, Imam Subekti, Kuntjoro Harimurti, Khie Chen, Hamzah Shatri
AIM: To determine association between diabetes in confirmed cases of COVID-19 and intensive care admission and in-hospital mortality, evaluate several laboratory parameters as mortality predictor and develop predictors of in-hospital mortality among diabetics with COVID-19. METHODS: This retrospective cohort recruited all cases of COVID-19 hospitalized in Fatmawati General Hospital from March to October 2020. Inclusion criterion was RT-PCR confirmed cases of COVID-19 who aged 18 years and older while exclusion criteria were incomplete medical record or cannot be found and pregnant women...
October 9, 2023: Endocrinology, Diabetes & Metabolism
https://read.qxmd.com/read/37775939/relationship-between-salivary-levels-of-interleukin-8-and-hba1c-in-patients-with-type-2-diabetes
#24
JOURNAL ARTICLE
Masoomeh Shirzaiy, Zohreh Dalirsani, Payam Peymankar, Mahboobeh Taherizadeh
INTRODUCTION: Diabetes mellitus is a metabolic disease, which genetic and environmental factors play a role in its pathogenesis. Cytokines as important elements in the immune system have diverse expressions in different individuals and societies and are effective in the pathogenesis of diabetes. This study investigated the relationship between blood sugar control and salivary levels of interleukin-8 (IL-8) in patients with type 2 diabetes. METHODS: This cross-sectional study was conducted on 73 subjects (35 diabetic and 38 healthy individuals)...
September 29, 2023: Endocrinology, Diabetes & Metabolism
https://read.qxmd.com/read/37771199/human-gut-microbiome-therapeutic-opportunities-for-metabolic-syndrome-hype-or-hope
#25
REVIEW
Angela Horvath, Kristina Zukauskaite, Olha Hazia, Irina Balazs, Vanessa Stadlbauer
Shifts in gut microbiome composition and metabolic disorders are associated with one another. Clinical studies and experimental data suggest a causal relationship, making the gut microbiome an attractive therapeutic goal. Diet, intake of probiotics or prebiotics and faecal microbiome transplantation (FMT) are methods to alter a person's microbiome composition. Although FMT may allow establishing a proof of concept to use microbiome modulation to treat metabolic disorders, studies show mixed results regarding the effects on metabolic parameters as well as on the composition of the microbiome...
September 28, 2023: Endocrinology, Diabetes & Metabolism
https://read.qxmd.com/read/37749959/sociodemographic-factors-affecting-glycaemic-control-in-finnish-paediatric-patients-with-type-1-diabetes
#26
JOURNAL ARTICLE
Riina Pironetti, Marja-Terttu Saha, Tiina Luukkaala, Päivi Keskinen
AIMS: Socioeconomic problems may present significant challenges when trying to reach optimal glycaemic control in paediatric patients with type 1 diabetes. We examined sociodemographic factors affecting metabolic control in patients in one of the biggest paediatric diabetes clinics in Finland. METHODS: One hundred ninety-one children (age 2-15 years; median 11 years; 47% female) with type 1 diabetes and their families were recruited during outpatient visits in the paediatric diabetes clinic of Tampere University Hospital, Finland...
September 25, 2023: Endocrinology, Diabetes & Metabolism
https://read.qxmd.com/read/37743677/progression-of-diabetic-nephropathy-and-vitamin-d-serum-levels-a-pooled-analysis-of-7722-patients
#27
REVIEW
Yomna E Dean, Sameh Samir Elawady, Wangpan Shi, Ahmed A Salem, Arinnan Chotwatanapong, Haya Ashraf, Tharun Reddi, Prashant Obed Reddy Dundi, Waleed Yasser Habash, Mohamed Yasser Habash, Safaa Ahmed, Hana M Samir, Ahmed Elsayed, Aryan Arora, Abhinav Arora, Abdelrahman Elsayed, Tamer Mady, Yousef Tanas, Yusef Hazimeh, Mohamed Alazmy, Hani Aiash
BACKGROUND AND AIM: Low serum Vitamin D levels have been associated with diabetic nephropathy (DN). Our study aimed to analyse the serum levels of vitamin D in patients suffering from DN and the subsequent changes in serum vitamin D levels as the disease progresses. METHODS: PubMed, Embase, SCOPUS and Web of Science were searched using keywords such as '25 hydroxyvitamin D' and 'diabetic nephropathy'. We included observational studies that reported the association between the serum 25 hydroxy vitamin D levels and diabetic nephropathy without restriction to age, gender, and location...
September 24, 2023: Endocrinology, Diabetes & Metabolism
https://read.qxmd.com/read/37723884/maternal-dexamethasone-exposure-does-not-affect-glucose-tolerance-but-alters-renal-haemodynamics-in-f-1-rats-in-a-sex-dependent-manner
#28
JOURNAL ARTICLE
Slava A Malatiali, Narayana Kilarkaje, Maie Al-Bader
INTRODUCTION: Prenatal programming with dexamethasone increases the risk of the development of hyperglycaemia and insulin resistance, leading to diabetes in adulthood. Dexamethasone also causes a decline in renal glomerular filtration in the adult offspring. Sodium-glucose cotransporter-2 (SGLT2) plays a significant role in regulating blood glucose and renal haemodynamics in diabetic patients. However, the role of SGLT2 in dexamethasone-induced programming and the putative sex-dependent effects on the changes named earlier is unknown...
September 18, 2023: Endocrinology, Diabetes & Metabolism
https://read.qxmd.com/read/37715520/catabolism-of-fats-and-branched-chain-amino-acids-in-children-with-type-1-diabetes-association-with-glycaemic-control-and-total-daily-insulin-dose
#29
JOURNAL ARTICLE
Grace Hendrix, Yuliya Lokhnygina, Megan Ramaker, Olga Ilkayeva, Michael Muehlbauer, William Evans, Lisa Rasbach, Robert Benjamin, Michael Freemark, Pinar Gumus Balikcioglu
OBJECTIVE: Hyperglycaemia in Type 1 diabetes (T1D) results from an absolute insulin deficiency. However, insulin resistance (IR) may exacerbate glycaemic instability in T1D and contribute to long-term cardiovascular complications. We previously showed that IR in teenagers with obesity is associated with sex-dependent derangements in the catabolism of branched-chain amino acids (BCAA) and fatty acids. Here we hypothesized that byproducts of BCAA and fatty acid metabolism may serve as biomarkers or determinants of glycaemic control and IR in prepubertal or early pubertal children with T1D...
September 16, 2023: Endocrinology, Diabetes & Metabolism
https://read.qxmd.com/read/37715339/which-people-with-diabetes-are-treated-with-a-disposable-half-unit-insulin-pen-a-real-world-retrospective-database-study-in-spain
#30
JOURNAL ARTICLE
F Javier Ampudia-Blasco, Natalia Duque, Esther Artime, Elena Caveda, Erik Spaepen, Silvia Díaz-Cerezo, Miriam Rubio- de Santos, Daniel Callejo Velasco, M Pilar Bahíllo-Curieses
INTRODUCTION: Insulin lispro 100 units/mL Jr KwikPen is the first prefilled, disposable, half-unit insulin pen that delivers 0.5-30 units in increments of 0.5 units for the treatment of patients with diabetes. This study describes the profile of patients in Spain who initiated insulin therapy with Jr KwikPen in a real-world setting. METHODS: This retrospective, observational study based on IQVIA's electronic medical records database included patients with Type 1 (T1D) or Type 2 (T2D) diabetes who initiated therapy with Jr KwikPen between May 2018 and December 2020...
September 15, 2023: Endocrinology, Diabetes & Metabolism
https://read.qxmd.com/read/37698290/association-of-a-single-nucleotide-polymorphism-in-sod2-with-susceptibility-for-the-development-of-diabetic-nephropathy-in-patients-with-type-2-diabetes-a-saudi-population-study
#31
JOURNAL ARTICLE
Samar Sultan, Meshari Alharbi, Nuha Alrayes, Nehad Makki, Hanan Faruqui, Lama Basuni, Amani Alhozali, Reham Abdulnoor, Anwar Borai, Abdullah Almalki, Abdullah Alzahrani, Reem Alamoudi, Mazin Almaghrabi
INTRODUCTION: One of the complications of diabetes mellitus (DM) is diabetic nephropathy (DN), which plays a significant role in the progression of end-stage renal disease. Oxidative stress is implicated in DN pathogenesis, and genetic variations in antioxidant enzymes such as superoxide dismutase 2 (SOD2) and catalase (CAT) may contribute to the susceptibility. This study aimed to investigate the potential association between single nucleotide polymorphisms (SNPs) in antioxidant enzymes, specifically SOD2 rs4880 and CAT rs769217, and the risk of T2D and susceptibility to DN within the Saudi population...
September 12, 2023: Endocrinology, Diabetes & Metabolism
https://read.qxmd.com/read/37697708/incidental-versus-symptomatic-nonfunctioning-pituitary-adenomas-are-they-different
#32
JOURNAL ARTICLE
Vanessa Guerreiro, Fernando Mendonça, Helena Urbano Ferreira, Paula Freitas, Josué Pereira, Irene Bernardes, Jorge Pinheiro, Tiago Guimarães, Davide Carvalho
BACKGROUND: Nonfunctioning pituitary adenomas (NFPAs) constitute one of the most common tumours in the sellar region and are often discovered only when associated with compressive symptoms. With the frequent use of brain imaging, there has been an increase in the prevalence of incidentally discovered NFPAs. AIM: We aim to determine the prevalence of incidental diagnosis with NPAs observed over a decade and compare the analytical, clinical and treatment differences between those who were diagnosed either incidentally or symptomatically...
September 11, 2023: Endocrinology, Diabetes & Metabolism
https://read.qxmd.com/read/37621219/thyroid-dysfunction-and-glycaemic-control-among-type-2-diabetes-mellitus-patients-in-ghana-a-comparative-cross-sectional-study
#33
JOURNAL ARTICLE
Samuel Asamoah Sakyi, Bright Ameyaw, Edwin Ferguson Laing, Richard Anthony, Richard K Dadzie Ephraim, Alfred Effah, Afia Agyapomaa Kwayie, Ebenezer Senu, Enoch Odame Anto, Emmanuel Acheampong, Bright Oppong Afranie, Benjamin Amoani, Stephen Opoku
INTRODUCTION: Thyroid disorders and diabetes mellitus coexist and are prevalent endocrinopathies among adult population. Thyroid dysfunction contributes to metabolic imbalances, increase beta-cell apoptosis and glucose intolerance. There is paucity of data and contradicting findings on how thyroid dysfunction influence glycaemic control. Therefore, we evaluated thyroid dysfunction and glycaemic control among Type 2 diabetes mellitus (T2DM) patients in Ghana. METHODS: A comparative cross-sectional study was conducted among 192 T2DM patients from Effia Nkwanta Regional Hospital...
August 25, 2023: Endocrinology, Diabetes & Metabolism
https://read.qxmd.com/read/37605374/serum-uric-acid-to-high-density-lipoprotein-ratio-as-a-novel-indicator-of-inflammation-is-correlated-with-the-presence-and-severity-of-metabolic-syndrome-a-large-scale-study
#34
JOURNAL ARTICLE
Rana Kolahi Ahari, Amin Mansoori, Toktam Sahranavard, Monireh Sadat Miri, Sara Feizi, Habibollah Esmaily, Majid Ghayour-Mobarhan
INTRODUCTION: We investigated the association of serum uric acid to high-density lipoprotein ratio (UHR) with the presence and severity of metabolic syndrome (MetS) among MASHAD cohort participants. METHODS: In this cross-sectional study, according to International Diabetes Federation criteria, the cohort participants were divided into MetS (+) and MetS (-) groups. MetS (+) were classified into Group 1 (those with 3 MetS criteria), Group 2 (those with 4 MetS criteria) and Group 3 (those with 5 MetS criteria)...
August 21, 2023: Endocrinology, Diabetes & Metabolism
https://read.qxmd.com/read/37505196/mechanism-of-action-of-gut-microbiota-and-probiotic-lactobacillus-rhamnosus-gg-on-skeletal-remodeling-in-mice
#35
REVIEW
Abdul Malik Tyagi
INTRODUCTION: Gut microbiota (GM) is the collection of small organisms such as bacteria, fungi, bacteriophages and protozoans living in the intestine in symbiotics relation within their host. GM regulates host metabolism by various mechanisms. METHODS: This review aims to consolidate current information for physicians on the effect of GM on bone health. For this, an online search of the literature was conducted using the keywords gut microbiota, bone mass, osteoporosis, Lactobacillus and sex steroid...
July 28, 2023: Endocrinology, Diabetes & Metabolism
https://read.qxmd.com/read/37496158/effect-of-biological-variation-in-hba1c-and-blood-glucose-on-the-diagnosis-of-prediabetes
#36
JOURNAL ARTICLE
James M Hempe, Shengping Yang, Daniel S Hsia
INTRODUCTION: People with a low or high haemoglobin glycation index (HGI) have lower or higher HbA1c than other people with the same FPG. This study compared the prevalence of prediabetes based on FPG, 2hOGTT and HbA1c in people with low, moderate or high HGI. METHODS: Prediabetes was diagnosed based on ADA cutpoints in 10,488 NHANES participants without self-reported diabetes. HGI was calculated as the difference between a participant's observed HbA1c and a predicted HbA1c where predicted HbA1c = 0...
July 26, 2023: Endocrinology, Diabetes & Metabolism
https://read.qxmd.com/read/37491893/medication-adherence-and-health-related-quality-of-life-among-people-with-diabetes-in-bangladesh-a-cross-sectional-study
#37
JOURNAL ARTICLE
Sabrina Ahmed, K M Saif-Ur-Rahman, Raja Ram Dhungana, Gantsetseg Ganbaatar, Fatema Ashraf, Yuichiro Yano, Katsuyuki Miura, M S A Mansur Ahmed
INTRODUCTION: Good adherence to anti-diabetic medications is an important protective factor for decreasing diabetes-related complications and disabilities but its association with health-related quality of life (HRQoL) is understudied. The current study aimed to assess an association between medication adherence to anti-diabetic drugs and HRQoL among people with diabetes in Dhaka city, Bangladesh. METHODS: We conducted a cross-sectional study among 480 people with diabetes aged between 50 and 70 years, who attended a tertiary-level hospital in Dhaka city...
July 25, 2023: Endocrinology, Diabetes & Metabolism
https://read.qxmd.com/read/37469128/the-effects-of-macro-algae-supplementation-on-serum-lipid-glycaemic-control-and-anthropometric-indices-a-systematic-review-and-meta-analysis-of-clinical-trials
#38
REVIEW
Shahla Rezaei, Saeid Doaei, Reza Tabrizi, Saeed Ghobadi, Morteza Zare, Maryam Gholamalizadeh, Zohreh Mazloom
INTRODUCTION: Macro-algae products have been shown to ameliorate the metabolic disorders state. Thus, highlighting their function as supplementary therapeutic agents can be a novel strategy for clinical therapies. This systematic review and meta-analysis of clinical trials aimed to summarize the effect of macro-algae consumption on serum lipid profile, glycaemic control and anthropometric factors. METHODS: In this systematic review and meta-analysis, a comprehensive search was performed for relevant studies published up to May 2023...
July 19, 2023: Endocrinology, Diabetes & Metabolism
https://read.qxmd.com/read/37431844/investigating-the-impact-of-metformin-on-severity-of-covid-19-in-patients-with-type-2-diabetes-mellitus-focusing-on-laboratory-findings
#39
JOURNAL ARTICLE
Rana Taheri, Seyedeh Zahra Shahrokhi, Zahra Amjadi, Faranak Kazerouni
BACKGROUND: In the terrifying pandemic caused by SARS-CoV-2, diabetic patients exhibiting more severe outcomes and mortality rate is high among them. Based on recent studies, metformin as the most prescribed drug for T2DM treatment may improve severe outcomes in diabetic patients infected with SARS-CoV-2. On the other hand, abnormal laboratory findings can help to differentiate between the severe and non-severe form of COVID-19. According to the mentioned issues, the effect of metformin on severity of COVID-19 was examined in T2DM patients with SARS-CoV-2 infection...
July 11, 2023: Endocrinology, Diabetes & Metabolism
https://read.qxmd.com/read/37403247/effect-of-elettaria-cardamomum-l-on-hormonal-changes-and-spermatogenesis-in-the-propylthiouracil-induced-hypothyroidism-male-balb-c-mice
#40
JOURNAL ARTICLE
Bahar Atabaki, Naser Mirazi, Abdolkarim Hosseini, Abdolrahman Sarihi, Zahra Izadi, Alireza Nourian
INTRODUCTION: Spermatogenesis is significantly influenced by the thyroid gland. Thyroid disorders can be caused by a variety of factors. Traditionally, Ellettaria cardamomum has been used to treat a variety of ailments. The effects of E. cardamomum extract (ECE) on spermatogenesis in hypothyroid mice were investigated in this study. METHODS: In this study 42 male mice, weighing (25-35 g) were randomly divided in six groups: control group (taking normal saline, 0...
July 4, 2023: Endocrinology, Diabetes & Metabolism
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