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RANDOMIZED CONTROLLED TRIAL
Philip C Schouten, Sandra Schmidt, Kerstin Becker, Holger Thiele, Peter Nürnberg, Lisa Richters, Corinna Ernst, Isabelle Treilleux, Jacques Medioni, Florian Heitz, Carmela Pisano, Yolanda Garcia, Edgar Petru, Sakari Hietanen, Nicoletta Colombo, Ignace Vergote, Shoji Nagao, Sabine C Linn, Eric Pujade-Lauraine, Isabelle Ray-Coquard, Philipp Harter, Eric Hahnen, Rita K Schmutzler
IMPORTANCE: Testing for homologous recombination deficiency is required for the optimal treatment of high-grade epithelial ovarian cancer. The search for accurate biomarkers is ongoing. OBJECTIVE: To investigate whether progression-free survival (PFS) and overall survival (OS) of patients with high-grade epithelial ovarian cancer treated with maintenance olaparib or placebo differed between patients with a tumor BRCA-like genomic profile and patients without a tumor BRCA-like profile...
April 1, 2024: JAMA Network Open
#42
JOURNAL ARTICLE
Davide Ciardiello, Erika Martinelli, Teresa Troiani, Gianluca Mauri, Daniele Rossini, Giulia Martini, Stefania Napolitano, Vincenzo Famiglietti, Sara Del Tufo, Gianluca Masi, Daniele Santini, Antonio Avallone, Filippo Pietrantonio, Sara Lonardi, Massimo Di Maio, Maria Giulia Zampino, Nicola Fazio, Alberto Bardelli, Salvatore Siena, Chiara Cremolini, Andrea Sartore-Bianchi, Fortunato Ciardiello
IMPORTANCE: The available evidence regarding anti-epidermal growth factor receptor (EGFR) inhibitor rechallenge in patients with refractory circulating tumor DNA (ctDNA) RAS/BRAF wild-type (wt) metastatic colorectal cancer (mCRC) is derived from small retrospective and prospective studies. OBJECTIVE: To evaluate the efficacy of anti-EGFR rechallenge in patients with refractory ctDNA RAS/BRAF wt mCRC. DESIGN, SETTING, AND PARTICIPANTS: This nonrandomized controlled trial used a pooled analysis of individual patient data from patients with RAS/BRAF wt ctDNA mCRC enrolled in 4 Italian trials (CAVE, VELO, CRICKET, and CHRONOS) and treated with anti-EGFR rechallenge between 2015 and 2022 (median [IQR] follow-up, 28...
April 1, 2024: JAMA Network Open
#43
JOURNAL ARTICLE
Leah Roberts, Mark H Hoofnagle, Brady Bushover, Ariana N Gobaud, Christina A Mehranbod, Carolyn Fish, Christopher N Morrison
IMPORTANCE: Interstate gun flow has critical implications for gun violence prevention, as gun transfers across state lines can undermine local gun control policies. OBJECTIVE: To identify possible gun trafficking routes along interstate highways in the US. DESIGN, SETTING, AND PARTICIPANTS: This repeated-measures, ecological, cross-sectional study used data from the Bureau of Alcohol, Tobacco, Firearms and Explosives from January 1, 2010, to December 31, 2019, to examine associations between interstate connections via 13 highways that each spanned at least 1000 miles and interstate traced gun transfer counts for the 48 contiguous United States...
April 1, 2024: JAMA Network Open
#44
MULTICENTER STUDY
Paola Ilaria Bianchi, Marco Vincenzo Lenti, Clarissa Petrucci, Giulia Gambini, Nicola Aronico, Matteo Varallo, Carlo Maria Rossi, Elena Pozzi, Elena Groppali, Francesca Siccardo, Giulia Franchino, Gian Vincenzo Zuccotti, Grazia Di Leo, Chiara Zanchi, Fernanda Cristofori, Ruggiero Francavilla, Marina Aloi, Giulia Gagliostro, Monica Montuori, Sara Romaggioli, Caterina Strisciuglio, Marco Crocco, Noemi Zampatti, Angela Calvi, Renata Auricchio, Costantino De Giacomo, Silvia Maria Elena Caimmi, Carolina Carraro, Annamaria Staiano, Sabrina Cenni, Mauro Congia, Enrico Schirru, Francesca Ferretti, Carolina Ciacci, Nicoletta Vecchione, Mario Andrea Latorre, Semela Resuli, Giusy Cinzia Moltisanti, Giulia Maria Abruzzese, Andrea Quadrelli, Simone Saglio, Pietro Canu, Damiano Ruggeri, Annalisa De Silvestri, Catherine Klersy, Gian Luigi Marseglia, Gino Roberto Corazza, Antonio Di Sabatino
IMPORTANCE: The extent and factors associated with risk of diagnostic delay in pediatric celiac disease (CD) are poorly understood. OBJECTIVES: To investigate the diagnostic delay of CD in childhood, and to assess factors associated with this delay. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, retrospective, cross-sectional study (2010-2019) of pediatric (aged 0-18 years) patients with CD from 13 pediatric tertiary referral centers in Italy...
April 1, 2024: JAMA Network Open
#45
JOURNAL ARTICLE
Kenneth Vanbrabant, Debby Van Dam, Eva Bongaerts, Yannick Vermeiren, Hannelore Bové, Niels Hellings, Marcel Ameloot, Michelle Plusquin, Peter Paul De Deyn, Tim S Nawrot
IMPORTANCE: Ambient air pollution is a worldwide problem, not only related to respiratory and cardiovascular diseases but also to neurodegenerative disorders. Different pathways on how air pollutants could affect the brain are already known, but direct evidence of the presence of ambient particles (or nanoparticles) in the human adult brain is limited. OBJECTIVE: To examine whether ambient black carbon particles can translocate to the brain and observe their biodistribution within the different brain regions...
April 1, 2024: JAMA Network Open
#46
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 1, 2024: JAMA Network Open
#47
JOURNAL ARTICLE
Sumil K Thakrar
No abstract text is available yet for this article.
April 1, 2024: JAMA Network Open
#48
JOURNAL ARTICLE
Arjun Gupta, Paul Nguyen, Danielle Kain, Andrew G Robinson, Amit A Kulkarni, David H Johnson, Carolyn J Presley, Anne H Blaes, Gabrielle B Rocque, Ishani Ganguli, Christopher M Booth, Timothy P Hanna
IMPORTANCE: Patients with stage IV non-small cell lung cancer (NSCLC) experience substantial morbidity and mortality. Contact days (ie, the number of days with health care contact outside the home) measure how much of a person's life is consumed by health care, yet little is known about patterns of contact days for patients with NSCLC. OBJECTIVE: To describe the trajectories of contact days in patients with stage IV NSCLC and how trajectories vary by receipt of cancer-directed treatment in routine practice...
April 1, 2024: JAMA Network Open
#49
JOURNAL ARTICLE
Si-Hong Shen, Liao Peng, Xiao Zeng, Jie Zhang, Hong Shen, De-Yi Luo
IMPORTANCE: Interstitial cystitis (IC) is a debilitating condition. Although viral infection is a potential etiological cause, few studies have detected the effect of antiviral treatment. OBJECTIVE: To determine the efficacy and safety of intravesical interferon instillation compared with hyaluronic acid in female patients with IC. DESIGN, SETTING, AND PARTICIPANTS: This double-masked, randomized phase 2/3 clinical trial with parallel group design was implemented from October 2022 to April 2023 and had a 6-month follow-up period...
April 1, 2024: JAMA Network Open
#50
JOURNAL ARTICLE
Robert D Brook, Sanjay Rajagopalan, Sadeer Al-Kindi
IMPORTANCE: Reducing exposure to fine particulate matter (<2.5 μm [PM2.5]) air pollution improves cardiopulmonary morbidity and mortality. However, the public health relevance of air quality index (AQI) activity guidelines under present-day environmental conditions in the US has not been critically assessed. OBJECTIVE: To evaluate the public health relevance of following PM2.5 AQI activity guidance in preventing serious atherosclerotic cardiovascular disease (ASCVD) and pulmonary events among adults in the US...
April 1, 2024: JAMA Network Open
#51
JOURNAL ARTICLE
Joshua T B Williams, Kate Kurlandsky, Kristin Breslin, M Joshua Durfee, Amy Stein, Laura Hurley, Jo Ann Shoup, Liza M Reifler, Matthew F Daley, Bruno J Lewin, Kristin Goddard, Michelle L Henninger, Jennifer C Nelson, Gabriela Vazquez-Benitez, Kayla E Hanson, Candace C Fuller, Eric S Weintraub, Michael M McNeil, Simon J Hambidge
IMPORTANCE: Pregnant people and infants are at high risk of severe COVID-19 outcomes. Understanding changes in attitudes toward COVID-19 vaccines among pregnant and recently pregnant people is important for public health messaging. OBJECTIVE: To assess attitudinal trends regarding COVID-19 vaccines by (1) vaccination status and (2) race, ethnicity, and language among samples of pregnant and recently pregnant Vaccine Safety Datalink (VSD) members from 2021 to 2023...
April 1, 2024: JAMA Network Open
#52
JOURNAL ARTICLE
Christopher E Gaw, Kristina B Metzger, Melissa R Pfeiffer, Benjamin E Yerys, Rhonda C Boyd, Daniel J Corwin, Allison E Curry
IMPORTANCE: Mood disorders are prevalent among adolescents and young adults, and their onset often coincides with driving eligibility. The understanding of how mood disorders are associated with youth driving outcomes is limited. OBJECTIVE: To examine the association between the presence of a mood disorder and rates of licensing, crashes, violations, and suspensions among adolescents and young adults. DESIGN, SETTING, AND PARTICIPANTS: This cohort study was conducted among New Jersey residents who were born 1987 to 2000, age eligible to acquire a driver's license from 2004 to 2017, and patients of the Children's Hospital of Philadelphia network within 2 years of licensure eligibility at age 17 years...
April 1, 2024: JAMA Network Open
#53
JOURNAL ARTICLE
Melisa M Shah, Bryan R Spencer, Jade James-Gist, James M Haynes, Leora R Feldstein, Susan L Stramer, Jefferson M Jones, Sharon H Saydah
IMPORTANCE: Long-term symptoms, lasting more than 4 consecutive weeks after acute COVID-19 disease, are an important consequence of SARS-CoV-2 infection. Many prior studies have lacked a non-SARS-CoV-2-infected control population to distinguish background prevalence of symptoms from the direct impact of COVID-19 disease. OBJECTIVE: To examine the prevalence of long-term physical and mental health symptoms associated with SARS-CoV-2 infection in a large population of blood donors based on self-report and serologic test results...
April 1, 2024: JAMA Network Open
#54
JOURNAL ARTICLE
Paula M Trief, Hui Wen, Brian Burke, Diane Uschner, Barbara J Anderson, Xun Liu, Jane Bulger, Ruth S Weinstock
IMPORTANCE: Youth-onset type 2 diabetes is associated with poor glycemic control and early onset of complications. Identification of psychosocial factors associated with poor glycemic control is needed to inform efficacious interventions. OBJECTIVE: To identify psychosocial factors associated with glycated hemoglobin (HbA1c) levels in young adults with youth-onset type 2 diabetes. DESIGN, SETTING, AND PARTICIPANTS: For the iCount cohort study, HbA1c levels were measured twice (at baseline [T1] and at 1 year [T2]) during the last years (2017-2019) of the observational phase of the multicenter Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY2) study...
April 1, 2024: JAMA Network Open
#55
JOURNAL ARTICLE
Caelan Taggart, Andreas Roos, Erik Kadesjö, Atul Anand, Ziwen Li, Dimitrios Doudesis, Kuan Ken Lee, Anda Bularga, Ryan Wereski, Matthew T H Lowry, Andrew R Chapman, Amy V Ferry, Anoop S V Shah, Anton Gard, Bertil Lindahl, Gustaf Edgren, Nicholas L Mills, Dorien M Kimenai
IMPORTANCE: Whether the diagnostic classifications proposed by the universal definition of myocardial infarction (MI) to identify type 1 MI due to atherothrombosis and type 2 MI due to myocardial oxygen supply-demand imbalance have been applied consistently in clinical practice is unknown. OBJECTIVE: To evaluate the application of the universal definition of MI in consecutive patients with possible MI across 2 health care systems. DESIGN, SETTING, AND PARTICIPANTS: This cohort study used data from 2 prospective cohorts enrolling consecutive patients with possible MI in Scotland (2013-2016) and Sweden (2011-2014) to assess accuracy of clinical diagnosis of MI recorded in hospital records for patients with an adjudicated diagnosis of type 1 or type 2 MI...
April 1, 2024: JAMA Network Open
#56
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 1, 2024: JAMA Network Open
#57
JOURNAL ARTICLE
Mariana P Socal, Joshua M Sharfstein
No abstract text is available yet for this article.
April 1, 2024: JAMA Network Open
#58
JOURNAL ARTICLE
Marcos Mills, Michelle Gleason, Michael Lin, Nikolay Braykov, Sherry Smith, Michael Fundora, Alaa Aljiffry
No abstract text is available yet for this article.
April 1, 2024: JAMA Network Open
#59
JOURNAL ARTICLE
Megan E Deaner, Johnathan Rausch, Parker Entrup, O Trent Hall
No abstract text is available yet for this article.
April 1, 2024: JAMA Network Open
#60
JOURNAL ARTICLE
Katherine Callaway Kim, Scott D Rothenberger, Mina Tadrous, Inmaculada Hernandez, Walid F Gellad, Joshua W Devine, Tina B Hershey, Lisa M Maillart, Katie J Suda
IMPORTANCE: Drug shortages are a chronic and worsening issue that compromises patient safety. Despite the destabilizing impact of the COVID-19 pandemic on pharmaceutical production, it remains unclear whether issues affecting the drug supply chain were more likely to result in meaningful shortages during the pandemic. OBJECTIVE: To estimate the proportion of supply chain issue reports associated with drug shortages overall and with the COVID-19 pandemic. DESIGN, SETTING, AND PARTICIPANTS: This longitudinal cross-sectional study used data from the IQVIA Multinational Integrated Data Analysis database, comprising more than 85% of drug purchases by US pharmacies from wholesalers and manufacturers, from 2017 to 2021...
April 1, 2024: JAMA Network Open
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