JAMA Network Open

IMPORTANCE: Suicide is a substantial public health concern that involves various recognized contributing factors. Sensory impairments, specifically visual impairment, are deemed potential risk factors. Nonetheless, comprehensive information about associated risk levels and underlying determinants remains limited. OBJECTIVE: To investigate the association between visual impairment and different aspects of suicide, including the assessment of risk levels and exploration of potential contributing factors...

IMPORTANCE: Cerebral small vessel diseases (CSVDs) account for one-fifth of stroke cases. Numerous familial cases remain unresolved after routine screening of known CSVD genes. OBJECTIVE: To identify novel genes and mechanisms associated with familial CSVD. DESIGN, SETTING, AND PARTICIPANTS: This 2-stage study involved linkage analysis and a case-control study; linkage analysis and whole exome and genome sequencing were used to identify candidate gene variants in 2 large families with CSVD (9 patients with CSVD)...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

IMPORTANCE: Organized screening outreach can reduce differences in colorectal cancer (CRC) incidence and mortality between demographic subgroups. Outcomes associated with additional outreach, beyond universal outreach, are not well known. OBJECTIVE: To compare CRC screening completion by race and ethnicity, age, and sex after universal automated outreach and additional personalized outreach. DESIGN, SETTING, AND PARTICIPANTS: This observational cohort study included screening-eligible individuals aged 50 to 75 years assessed during 2019 in a community-based organized CRC screening program within the Kaiser Permanente Northern California (KPNC) integrated health care delivery setting...

IMPORTANCE: Sydenham chorea is the most common acquired chorea of childhood worldwide; however, treatment is limited by a lack of high-quality evidence. OBJECTIVES: To evaluate historical changes in the clinical characteristics of Sydenham chorea and identify clinical and treatment factors at disease onset associated with chorea duration, relapsing disease course, and functional outcome. DATA SOURCES: The systematic search for this meta-analysis was conducted in PubMed, Embase, CINAHL, Cochrane Library, and LILACS databases and registers of clinical trials from inception to November 1, 2022 (search terms: [Sydenham OR Sydenham's OR rheumatic OR minor] AND chorea)...

IMPORTANCE: Genetic researchers must have access to databases populated with data from diverse ancestral groups to ensure research is generalizable or targeted for historically excluded communities. OBJECTIVE: To determine genetic researchers' interest in doing research with diverse ancestral populations, which database stewards offer adequate samples, and additional facilitators for use of diverse ancestral data. DESIGN, SETTING, AND PARTICIPANTS: This survey study was conducted from June to December 2022 and was part of an exploratory sequential mixed-methods project in which previous qualitative results informed survey design...

IMPORTANCE: Posttraumatic stress disorder (PTSD) is marked by the contrasting symptoms of hyperemotional reactivity and emotional numbing (ie, reduced emotional reactivity). Comprehending the mechanism that governs the transition between neutral and negative emotional states is crucial for developing targeted therapeutic strategies. OBJECTIVES: To explore whether individuals with PTSD experience a more pronounced shift between neutral and negative emotional states and how the intensity of emotional numbing symptoms impacts this shift...

IMPORTANCE: Inflammatory bowel disease (IBD) is associated with adverse clinical outcomes, including chronic kidney disease and mortality, due in part to chronic inflammation. Little is known about the effects of anti-tumor necrosis factor (TNF) therapy on kidney disease progression and mortality among patients with new-onset IBD. OBJECTIVE: To examine the association of incident use of TNF inhibitors with subsequent decline in kidney function and risk of all-cause mortality...

IMPORTANCE: Fibroids are benign neoplasms associated with severe gynecologic morbidity. There are no strategies to prevent fibroid development. OBJECTIVE: To examine associations of hypertension, antihypertensive treatment, anthropometry, and blood biomarkers with incidence of reported fibroid diagnosis in midlife. DESIGN, SETTING, AND PARTICIPANTS: The Study of Women's Health Across the Nation is a prospective, multisite cohort study in the US...

IMPORTANCE: Randomized clinical trials (RCTs) with neoadjuvant immune checkpoint inhibitors (ICIs) plus chemotherapy (ICI-chemotherapy) for patients with early-stage non-small cell lung cancer (NSCLC) have reported consistent associations with event-free survival (EFS) and pathologic complete response (pCR) pending longer follow-up for overall survival data. OBJECTIVE: To assess the pooled benefit of ICI-chemotherapy in 2-year EFS and pCR among patients with NSCLC and examine the impact of clinical, pathologic, and treatment-related factors...

No abstract text is available yet for this article.

IMPORTANCE: Physical diseases co-occur with late-life depression (LLD). The influence of physical diseases and the subjective perception of physical health (PPH) on treatment outcome in LLD, however, is not well understood. OBJECTIVE: To assess the association of physical diseases and PPH with the outcomes of 2 different types of psychotherapy in LLD. DESIGN, SETTING, AND PARTICIPANTS: This post hoc secondary analysis of a multicenter, observer-blinded, controlled, parallel-group randomized clinical trial assessed participants 60 years or older with moderate to severe depression recruited at 7 psychiatric-psychotherapeutic outpatient trial sites in Germany from October 1, 2018, to November 11, 2020...

IMPORTANCE: It is unclear whether nonfunctional adrenal tumors (NFATs) are associated with fractures. OBJECTIVE: To analyze fracture frequencies in individuals with NFATs. DESIGN, SETTING, AND PARTICIPANTS: A national retrospective cohort study was conducted in patients with NFATs diagnosed in Sweden between January 1, 2005, and December 31, 2019, and control participants without adrenal tumors followed up until death or the end of 2019. Individuals with a diagnosis of adrenal hormonal excess or previous malignant tumors were excluded...

IMPORTANCE: Timely tests are warranted to assess the association between generative artificial intelligence (GenAI) use and physicians' work efforts. OBJECTIVE: To investigate the association between GenAI-drafted replies for patient messages and physician time spent on answering messages and the length of replies. DESIGN, SETTING, AND PARTICIPANTS: Randomized waiting list quality improvement (QI) study from June to August 2023 in an academic health system...

IMPORTANCE: Delayed appendicitis diagnosis is associated with worse outcomes. Appendicitis hospital care costs associated with delayed diagnosis are unknown. OBJECTIVE: To determine whether delayed appendicitis diagnosis was associated with increased appendicitis hospital care costs. DESIGN, SETTING, AND PARTICIPANTS: This cohort study used data from patients receiving an appendectomy aged 18 to 64 years in 5 states (Florida, Maryland, Massachusetts, New York, Wisconsin) that were captured in the Healthcare Cost and Utilization Project State Inpatient and Emergency Department databases for the years 2016 and 2017 with no additional follow-up...

IMPORTANCE: The overall prevalence of mitral valve replacement (MVR) or MV repair at the time of cardiac surgery in the setting of isolated anterior mitral leaflet degenerative pathologic status in the US population is unknown. OBJECTIVE: To investigate the prevalence of MVR and MV repair using the Society of Thoracic Surgeons' Adult Cardiac Surgery Database. DESIGN, SETTING, AND PARTICIPANTS: In a cross-sectional study, all patients diagnosed with isolated anterior mitral leaflet degenerative regurgitation who underwent either surgical MVR or MV repair between July 1, 2011, and June 30, 2022, were identified...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

IMPORTANCE: Although cardiovascular disease (CVD) is a known risk factor for depression, evidence is lacking regarding whether and to what extent a spouse's CVD is associated with the subsequent mental health of individuals. OBJECTIVE: To examine the association between CVD onset in spouses and subsequent depression. DESIGN, SETTING, AND PARTICIPANTS: This cohort study examined 277 142 matched married couples enrolled in the Japan Health Insurance Association health insurance program between April 2015 and March 2022, covering approximately 40% of the working-age population in Japan...