Xiao-Ning Yuan, You-Cheng Shao, Xiao-Qing Guan, Qin Liu, Meng-Fei Chu, Ze-Lin Yang, Hui Li, Sai Zhao, Yi-Hao Tian, Jing-Wei Zhang, Lei Wei
BACKGROUND: The carcinogenic transcription factor c-Myc is the most aggressive oncogene, which drive malignant transformation and dissemination of triple-negative breast cancer (TNBC). Recruitment of many cofactors, especially WDR5, a protein that nucleates H3K4me chromatin modifying complexes, play a pivotal role in regulating c-Myc-dependent gene transcription, a critical process for c-Myc signaling to function in a variety of biological and pathological contexts. For this reason, interrupting the interaction between c-Myc and the synergistic factor WDR5 may become the most promising new strategy for treating c-Myc driven TNBC...
March 26, 2024: Biochimica et Biophysica Acta. Molecular Cell Research