Journals Hematology, Transfusion and Ce...

Hematology, Transfusion and Cell Therapy
Tiago Henrique Monteiro, Ítalo de Jesus da Rocha Ferreira, Antonio Carlos Fonseca Pontes Junior, Humberto Sanches Chocair, Jeniffer Dantas Ferreira
INTRODUCTION: It has been estimated that the proportion of blood donors in Brazil is below 2.0 %, lower than that recommended by the World Health Organization, which is between 3 % and 5 % of the population. OBJECTIVE: The aim of this study was to analyze the factors that can influence blood donation. METHOD: This is an integrative review, whose bibliographic search was carried out through the Virtual Health Library, considering scientific articles indexed in the Latin American and Caribbean Literature in the Health Sciences database...
November 22, 2023: Hematology, Transfusion and Cell Therapy
Carina Maria Pinto, Camila Marques Bertolucci, Alef Rafael Severino, Juliana Fernanda Dos Santos Tosi, Maura R V Ikoma-Colturato
Acute megakaryoblastic leukemia is characterized by heterogeneous biology and clinical behavior. Immunophenotypic characteristics include the expression of megakaryocytic differentiation markers (e.g. CD41, CD42a, CD42b, CD61) associated with immaturity markers (CD34, CD117, HLA-DR) and myeloid markers (e.g. CD13, CD33) and even with lymphoid cross-lineage markers (e.g. CD7, CD56). Although the diagnostic immunophenotype has already been well described, given the rarity of the disease, its immunophenotypic heterogeneity and post-therapeutic instability, there is no consensus on the combination of monoclonal markers to detect minimal/measurable residual disease (MRD)...
November 17, 2023: Hematology, Transfusion and Cell Therapy
Md Shahid Ansari, Dinesh Jain, Sandeep Budhiraja
BACKGROUND: Blood component transfusions are a common and often necessary medical practice during the epidemics of dengue. Transfusions are required for patients when they developed severe dengue fever or thrombocytopenia of 10×109 /L or less. This study therefore investigated the risk factors, performance and effectiveness of eight different machine-learning algorithms to predict blood component transfusion requirements in confirmed dengue cases admitted to hospital. The objective was to study the risk factors that can help to predict blood component transfusion needs...
November 17, 2023: Hematology, Transfusion and Cell Therapy
Kaio José Santos de Andrade, Luís Fábio Barbosa Botelho, Rodolfo Froes Calixto, Manuela Gomes de Oliveira, Leina Yukari Etto, Luiz Victor Maia Loureiro
Autologous hematopoietic stem cell transplantation (Auto-HSCT) is widely used in the treatment of patients with hematological neoplasms. Since these cells circulate in small quantities in the periphery, the use of regimens that promote their mobilization is essential. In this study, we retrospectively evaluated the efficacy and safety of using intermediate doses of cytarabine (1.6 g/m²) + filgrastim (10 mcg/kg/day) in the mobilization of stem cells in 157 patients treated by the Unified Health System at the Hematology and Bone Marrow Transplant Service of the Hospital Real Português de Beneficência, in Recife, Pernambuco...
October 29, 2023: Hematology, Transfusion and Cell Therapy
María Queralt Salas, Luis Gerardo Rodríguez-Lobato, Paola Charry, Maria Suárez-Lledó, Alexandra Pedraza, María Teresa Solano, Jordi Arcarons, Joan Cid, Miquel Lozano, Laura Rosiñol, Jordi Esteve, Enric Carreras, Francesc Fernández-Avilés, Carmen Martínez, Montserrat Rovira
We investigated the predictive capacity of six prognostic indices [Karnofsky Performance Status (KPS), Hematopoietic Cell Transplant-Specific Comorbidity Index (HCT-CI), Disease Risk Index (DRI), European Bone Marrow Transplantation (EBMT) and Revised Pre-Transplantation Assessment of Mortality (rPAM) Scores and Endothelial Activation and Stress Index (EASIX)] in 205 adults undergoing post-transplant cyclophosphamide (PTCy)-based allo-HCT. KPS, HCT-CI, DRI and EASIX grouped patients into higher and lower risk strata...
October 12, 2023: Hematology, Transfusion and Cell Therapy
Alexis A Franco, Viviana Lotero, Pamela Rodríguez, Estefania Beltran, Eliana Manzi, Angela Devia-Zapata, Diego Medina-Valencia
INTRODUCTION: Acute myeloid leukemia is a challenging disease, due to a poor prognosis in developing countries. Herein, we aim to describe the clinical characteristics and outcomes after chemotherapy and transplantation. METHODS: A retrospective analytic observational study was performed with patients under 18 years of age with newly diagnosed acute myeloid leukemia treated at a referral center in Colombia. Two groups were compared: induction therapy (IT) and induction therapy plus consolidation (IT + C)...
October 11, 2023: Hematology, Transfusion and Cell Therapy
Lucas Certain, João Vitor Cerávolo Rostirola, Gabriela Cerávolo Rostirola, Juliana Silva Pereira, Isabella Gonçalves, Karize Ribeiro Gabrigna, Filipe Duo Speri, Matheus Ferreira Mendes, Tainá Serena Mottin, Israel da Silva, Jussara Aparecida Rodrigues, Juliana de Cássia Schevenin, Ana Barbara Regiani de Oliveira, Amanda Bonamichi Franceli, Camila Emanuele Camargo Lisboa, Bruno Deltreggia Benites
INTRODUCTION: Hemorrhagic shock is the main cause of death in the prehospital environment, which highlights the need to standardize measures aiming at bleeding control and volume replacement in this environment. In Brazil, the first prehospital packed red blood cell transfusion service started in September 2020, in Bragança Paulista, state of São Paulo. OBJECTIVES: Describe the trends and characteristics of patients who received prehospital transfusions prior to hospital treatment during the first year of operation...
October 7, 2023: Hematology, Transfusion and Cell Therapy
Claudia Morales-Olvera, Fernando Pérez-Jacobo
No abstract text is available yet for this article.
September 14, 2023: Hematology, Transfusion and Cell Therapy
Marcia Garnica, Edvan De Queiroz Crusoe, Glaciano Ribeiro, Rosane Bittencourt, Roberto José Pessoa Magalhães, Karla Richter Zanella, Abrahão Elias Hallack Neto, Juliana Souza Lima, Caroline Bonamin Solo, Emmanuella Graciott Souza, Andre Magalhaes Fernandes, Angelo Maiolino, Vania Hungria
INTRODUCTION: This study evaluated outcomes and risk factors for COVID-19 in 91 Brazilian multiple myeloma (MM) patients between April 2020 and January 2022. RESULTS: Of the 91 MM patients diagnosed with COVID-19, 64% had comorbidities and 66% required hospitalization due to COVID-19, with 44% needing ventilatory support and 37% intensive care. Age (OR 2.02; 95%CI 1.02 - 7.7) and hypertension OR 4.5; 95%CI 1.3 - 15.5) were independently associated with hospitalization and certain MM therapies (corticosteroids and monoclonal drugs) were associated with ventilatory support (OR 4...
September 13, 2023: Hematology, Transfusion and Cell Therapy
Priti Desai, Anisha Navkudkar, Sunil Rajadhyaksha
INTRODUCTION: In serological testing, determination of ABO grouping requires both antigen typing for A and B antigens and screening of serum or plasma for A and B antibodies. Lack of corroboration between the results of the cell and serum groupings identifies a discrepancy. Analysis of ABO blood group discrepancies was performed to determine the incidence of these discrepancies among healthy blood donors and oncology patients. MATERIALS AND METHODS: ABO discrepancies found during testing of blood samples from blood donors and patients in an oncology centre in the period from January 2015 to December 2018 were analysed...
September 6, 2023: Hematology, Transfusion and Cell Therapy
Cristian Maximiliano Seehaus, Natalia Schutz, Erika Brulc, Gonzalo Ferini, Jorge Arbelbide, Dorotea Fantl, Ana Lisa Basquiera
INTRODUCTION: The treatment of elderly multiple myeloma (MM) patients with autologous stem cell transplantation (ASCT) is a controversial procedure. Most clinical trials evaluating the safety and efficacy of ASCT have primarily included patients younger than 65 years. DESIGN AND METHODS: This was a retrospective analysis of patients with MM who underwent ASCT between 2008 and 2018. Patients at or over 65 years were compared with patients under 65 years. We analyzed treatment-related mortality (TRM), response rate, progression-free survival (PFS) and overall survival (OS)...
September 5, 2023: Hematology, Transfusion and Cell Therapy
Valderez Ravaglio Jamur, Mateus de Oliveira Lisboa, Ana Paula Azambuja, Paulo Roberto Slud Brofman
No abstract text is available yet for this article.
August 29, 2023: Hematology, Transfusion and Cell Therapy
Deivide de Sousa Oliveira, Daniel Girão Britto, Gabriella Fidelis de Sá, Ana Carolina Nogueira Rocha Lima, João Victor Araújo Silva, Antonio Vinícius Barros de Araújo, Rejane Cavalcante Rebelo, Larissa Ciarlini Varandas Sales, Marcus Fábio Tavares de Abreu, Ednardo Ramos de Meneses
INTRODUCTION: Dengue is the most fatal virus disease spread by mosquito bites and Aedes aegypti is the main transmitting agent. It is an endemic disease in the tropical and subtropical regions, currently affecting more than 100 countries. Although most patients present mild forms of the disease, a considerable proportion of individuals has severe alterations in the blood count. The aim of this study was to evaluate the consumption pattern of blood components in epidemic and non-epidemic periods and to verify if there was an impact on dengue cases and the death rate...
August 28, 2023: Hematology, Transfusion and Cell Therapy
Lais Moreira Lopes, Marcio Nucci, Rodrigo Doyle Portugal
INTRODUCTION: High-dose cytarabine is considered standard of care as consolidation chemotherapy in adults with acute myeloid leukemia (AML) who are not eligible for allogeneic hematopoietic cell transplantation, but may be associated with significant toxicity. We evaluated the toxicity associated with high-dose cytarabine given as consolidation in AML patients treated at a Brazilian public hospital. METHODS: We retrospectively reviewed the charts of all patients with AML treated between 2008 and 2020 who obtained complete remission (CR) after one cycle of induction chemotherapy and received consolidation with at least one cycle of high-dose cytarabine (defined as 3 g/m2 every 12 h days 1, 3 and 5)...
August 28, 2023: Hematology, Transfusion and Cell Therapy
Stephen E Langabeer
No abstract text is available yet for this article.
August 28, 2023: Hematology, Transfusion and Cell Therapy
Daiane Keller Cecconello, Fabiane Spagnol, Ana Paula Alegretti, Diogo André Pilger, Mariela Granero Farias
INTRODUCTION AND OBJECTIVE: Flow Cytometry (FC) is one of the techniques, which allows the identification and characterization of platelets. The detection of absent or reduced expression of the glycoproteins is the main objective of this technique. Abnormalities of glycoproteins lead to hemorrhagic syndromes. Among the main diseases, the Bernard-Soulier syndrome (BSS) and Glanzmann thrombasthenia (GT) stand out. We aimed to show a FC-based platelet assessment test for diagnostic use, which measures the expression of markers in normal patients, and evaluate these markers in patients with platelet disorders...
August 28, 2023: Hematology, Transfusion and Cell Therapy
Eduardo Cerello Chapchap, Murilo Marques Almeida Silva, Ronaldo Hueb Baroni, Aderson da Silva Araujo, Reijane Alves de Assis, Sandra Regina Loggetto, Antonio Fabron Junior, Monica Pinheiro de Almeida Verissimo, Giorgio Roberto Baldanzi, Kleber Yotsumoto Fertrin, Fernando Tricta, Antonio Giulio Piga, Nelson Hamerschlak
INTRODUCTION: Despite knowledge advances on extramedullary haematopoiesis (EMH) in thalassemic patients, the real picture remains an open issue. OBJECTIVES: To assess EMH prevalence in patients with thalassemia major (TM) and intermedia (TI), to describe magnetic resonance imaging (MRI) findings and to explore clinical risk factors. METHODS: In this cross-sectional study, images and clinical records of 184 consecutive patients with thalassemia who underwent T2* MRI between 2004 and 2011 were reviewed...
August 26, 2023: Hematology, Transfusion and Cell Therapy
Sergio Cabibbo, Giovanna Oriella Manenti, Agostino Antolino, Massimo Poidomani, Raffaele Elia, Giuseppe Palumbo, Francesco DiRaimondo
INTRODUCTION: Polycythaemia vera patients can present with arterial or venous vascular occlusive events such as thrombosis or cardiovascular disease; disease-related symptoms may significantly impact on the quality of life. The aim of this study was to evaluate the efficacy and safety of erythrocytapheresis compared to phlebotomy in the treatment of polycythaemia patients. METHODS: This study reports the findings of a retrospective analysis of 40 polycythaemia vera patients diagnosed according to published guidelines and treated either with erythrocytapheresis or phlebotomy over a four-year period...
August 24, 2023: Hematology, Transfusion and Cell Therapy
Dahra Teles Cruz, Marina C V Conrado, Alfredo Mendrone, Carla L Dinardo
No abstract text is available yet for this article.
August 23, 2023: Hematology, Transfusion and Cell Therapy
Mojtaba Karimi, Mohammad Bahadoram, Ladan Mafakher, Mohammadhossein Rastegar
INTRODUCTION: Sickle cell disease (SCD) is a common hemoglobinopathy worldwide that causes painful crises and hospitalization of patients. These attacks decrease survival and cause chronic end-organ damage in these patients. HYPOTHESIS: For this reason, finding new treatment approaches could be helpful. METHOD: In this study, Imatinib was applied as a mast cell inhibitor to reduce pain crises in these patients. Seven patients resistant to hydroxyurea and folic acid treatment and who had at least four painful crises per year with hospitalization were enrolled in this study with treatment with Imatinib (100 mg, twice daily)...
August 10, 2023: Hematology, Transfusion and Cell Therapy
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