journal
https://read.qxmd.com/read/38312439/valproate-risperidone-and-paliperidone-a-case-of-valproate-induced-hyperammonemic-encephalopathy
#21
Kyle Wesselman, Vincent Cavaliere, Rakesh Goyal, Eric Anderson
Hyperammonemia is a well-known adverse effect of valproate that can progress to a potentially fatal condition known as valproate-induced hyperammonemic encephalopathy (VHE). VHE is more common when valproate is used in combination therapy with other antiepileptic medications. A growing number of case reports have pointed to a possible interaction with the antipsychotic risperidone leading to an increased risk of VHE. We present a case of VHE in which a 20-year-old male patient with bipolar affective disorder developed VHE when on concomitant valproate, risperidone, and paliperidone palmitate...
February 2024: Mental Health Clinician
https://read.qxmd.com/read/38312438/impact-of-covid-19-quarantines-on-clozapine-induced-constipation-experience-of-utilizing-a-clozapine-induced-constipation-protocol-at-a-state-forensic-psychiatric-facility
#22
JOURNAL ARTICLE
Bridgette M Gleisner, O Greg Deardorff, Yifei Liu, Megan G Trout, Joshua R Wood, Roger W Sommi, Niels C Beck
OBJECTIVE: Since 2017, Fulton State Hospital (FSH) has implemented a clozapine-induced constipation protocol. In March 2020, FSH initiated unit quarantines to minimize the spread of coronavirus disease (COVID-19). The objective of this study was to evaluate the impact of these quarantines on medical referrals for constipation, the Bristol Stool Chart ratings, utilization of as-needed (PRN) laxatives, and adherence rates with scheduled constipation medication regimens. METHODS: Patients on the clozapine-induced constipation protocol from May 1, 2019 to December 31, 2020, were included, with 10-month pre- and mid-quarantine implementation...
February 2024: Mental Health Clinician
https://read.qxmd.com/read/38312437/the-impact-of-early-direct-contact-experiences-on-reducing-mental-health-stigma-among-student-pharmacists-a-pilot-study
#23
JOURNAL ARTICLE
Amber R Tran, Saumyaa A Patel, Lindsey J Loera, Tawny Smith, Samantha Catanzano
INTRODUCTION: Mental health-related stigma is a barrier to treatment and recovery for serious mental illnesses (SMIs). Educational training programs demonstrate positive changes in health professional students' attitudes and stigma toward SMI; however, student pharmacists have minimal opportunity to directly engage with the SMI population. This study aims to assess and compare student pharmacists' stigma related to SMI before and after participating in a pilot series of direct-contact workshop experiences...
February 2024: Mental Health Clinician
https://read.qxmd.com/read/38058599/management-of-off-condition-in-parkinson-disease
#24
JOURNAL ARTICLE
Jessa Koch
Parkinson disease (PD) impacts nearly 1 million individuals in the United States. Nearly every patient with PD will require therapy with dopamine in the form of levodopa as the disease progresses. In more advanced stages of the disease, patients will experience motor fluctuations and require adjustment to their medication regimens to maintain good control of their symptoms. During the last 10 years, several new therapeutic treatment options have come to the market to treat motor fluctuations and improve patient quality of life...
December 2023: Mental Health Clinician
https://read.qxmd.com/read/38058598/impact-of-sex-on-antidepressant-discontinuation-in-groups-of-similar-cytochrome-p450-phenotypes
#25
JOURNAL ARTICLE
Dylan L Kosaski, Kristin C Cole, Jessica A Wright, Razan M El Melik, Simon Kung, Wayne T Nicholson, Jonathan G Leung
INTRODUCTION: Although there are studies assessing reasons for antidepressant discontinuation, little is known about the impact of sex differences or cytochrome P450 phenotypes. Our objective is to assess discontinuation rates between males and females and whether CYP450 phenotype influences discontinuation. METHODS: This is a retrospective review of patients previously enrolled in the Right Drug, Right Dose, Right Time: Using Genomic Data to Individualize Treatment database with major depressive disorder...
December 2023: Mental Health Clinician
https://read.qxmd.com/read/38058597/impact-of-traditional-versus-nontraditional-initiation-dosing-schedule-of-paliperidone-palmitate-on-30-day-readmission-and-safety
#26
JOURNAL ARTICLE
Erika Kim, Andrew Williams, Justin Chang, Niyati Butala, Matthew Firek
INTRODUCTION: Paliperidone palmitate (PP), a second-generation long-acting injectable antipsychotic, requires 2 injections upon initiation. Due to the fast-paced nature of the inpatient setting, the second dose may be administered earlier than recommended by labeled use despite the lack of evidence that evaluates this practice. METHODS: This was a retrospective chart review that investigated the outcomes associated with the timing of the second PP initiation dose with the aim of comparing patients who received the second PP dose fewer than 3 days after the first injection with those who received it between 3 and 11 days after the first injection...
December 2023: Mental Health Clinician
https://read.qxmd.com/read/38058596/concurrent-opioid-and-alcohol-withdrawal-management
#27
JOURNAL ARTICLE
Michelle Colvard
Concurrent alcohol and opioid withdrawal syndrome is a common and challenging clinical scenario with little published evidence or guidance to inform pharmacotherapy strategies. Concurrent use of benzodiazepines and opioid agonists, which are considered first-line agents for management of each withdrawal syndrome independently, is controversial and often avoided in clinical practice. Strategies to provide effective, simultaneous medication treatment of alcohol and opioid withdrawal while optimizing patient safety are demonstrated through 3 patient cases...
December 2023: Mental Health Clinician
https://read.qxmd.com/read/38058595/ethnopsychopharmacology-clinical-and-scientific-writing-pearls
#28
JOURNAL ARTICLE
Jonathan G Leung
The concept of ethnopsychopharmacology aims to predict or explain the pharmacologic response to psychiatric medications based on the influence of biologic and nonbiologic factors. Interactions involving these factors are complex and influence patient outcomes in health care. Pharmacists and other clinicians working in patient care environments, research, or medical education should engage in lifelong learning to enhance ethnopsychopharmacologic knowledge gaps, which ultimately may improve and individualize care across diverse populations...
December 2023: Mental Health Clinician
https://read.qxmd.com/read/38058594/concepts-for-selection-and-utilization-of-psychiatric-medications-in-pregnancy
#29
JOURNAL ARTICLE
P Brittany Vickery
Psychiatric illness may develop or relapse during pregnancy, and understanding best practices is paramount. In 2017, the British Association for Psychopharmacology (BAP) consensus guidance on the use of psychotropic medication preconception, in pregnancy, and postpartum was released. The BAP guidelines provide concise evidence and additional insight and flexibility for use of psychiatric medication. Key takeaways of these guidelines are highlighted serving as a concise reference for practitioners. Additionally, practice points, such as recommendations for rapid tranquilization and the role of long-acting injectable antipsychotic medications as well as additional insights to the growing body of literature associated with psychiatric medications in pregnancy since 2017 are summarized...
December 2023: Mental Health Clinician
https://read.qxmd.com/read/38058593/antidepressant-prescribing-in-transgender-and-nonbinary-individuals-diagnosed-with-gender-dysphoria-and-mood-or-anxiety-disorders
#30
JOURNAL ARTICLE
Casey M Tiefenthaler, Kelly C Lee
INTRODUCTION: Transgender and nonbinary (TGNB) individuals are highly stigmatized members of society and are significantly at higher risk of having mood or anxiety-related disorders compared to non-TGNB individuals. METHODS: In this retrospective cohort study, antidepressant prescribing data were collected from TGNB adults diagnosed with gender dysphoria (GD) and mood or anxiety-related disorder between January 2005 and October 2021. The primary outcome was to compare the number of active outpatient antidepressant prescriptions at the time of GD diagnosis between gender identities...
December 2023: Mental Health Clinician
https://read.qxmd.com/read/38131059/exploring-real-world-symptom-impact-and-improvement-in-well-being-domains-for-tardive-dyskinesia-in-vmat2-inhibitor-treated-patients-via-clinician-survey-and-chart-review
#31
JOURNAL ARTICLE
Jonathan M Meyer, Craig Chepke, Rimal B Bera, M Mercedes Pérez-Rodríguez, Leslie Lundt, Ericha G Franey, Rahul Dhanda, Betsy Benning, Morgan Bron, Chuck Yonan
INTRODUCTION: Two vesicular monoamine transporter 2 (VMAT2) inhibitors are approved in the United States (US) for the treatment of tardive dyskinesia (TD). There is a paucity of information on the impact of VMAT2 inhibitor treatment on patient social and physical well-being. The study objective was to elucidate clinician-reported improvement in symptoms and any noticeable changes in social or physical well-being in patients receiving VMAT2 inhibitors. METHODS: A web-based survey was offered to physicians, nurse practitioners, and physician assistants based in the US who prescribed valbenazine for TD within the past 24 months...
October 2023: Mental Health Clinician
https://read.qxmd.com/read/38131058/efficacy-and-safety-of-pharmacotherapy-in-chronic-insomnia-a-review-of-clinical-guidelines-and-case-reports
#32
REVIEW
Alejandro Del Rio Verduzco, Ahva Salari, Parna Haghparast
INTRODUCTION: Chronic insomnia affects 5% to 10% of the US population, increasing the demand for treatment options and the corresponding research to prove their validity.1 This review compares recommendations from 3 clinical guidelines and summarizes hypnotic medications, including their newly reported side effects not mentioned in the guidelines. In addition, we aim to provide an overview of what pharmacotherapies are available for prescribers and patients. METHODS: A literature search was conducted for articles published prior to January 10, 2022, and case reports and clinical studies were retrieved from PubMed and Google Scholar...
October 2023: Mental Health Clinician
https://read.qxmd.com/read/38131057/predictors-of-persistence-and-adherence-to-deutetrabenazine-among-patients-with-huntington-disease-or-tardive-dyskinesia
#33
JOURNAL ARTICLE
Daniel O Claassen, Rajeev Ayyagari, Viviana García-Horton, Su Zhang, Sam Leo
INTRODUCTION: Deutetrabenazine is approved for treatment of Huntington disease (HD)-related chorea and tardive dyskinesia (TD) in adults. Factors associated with deutetrabenazine persistence and adherence are not well understood. METHODS: Claims data from the Symphony Health Solutions Integrated Dataverse (2017-2019) were analyzed to identify real-world predictors of deutetrabenazine persistence and adherence in adults with HD or TD in the United States. Predictive models for persistence and adherence that considered patient demographics, payer type, comorbidities, treatment history, and health care resource use were developed...
October 2023: Mental Health Clinician
https://read.qxmd.com/read/38131056/intranasal-ketamine-as-a-treatment-for-psychiatric-complications-of-long-covid-a-case-report
#34
Kaitlyn Baldwin, Annabelle Wanson, Lee-Anne Gilecki, Courtney Dalton, Evyn Peters, Katelyn Halpape
BACKGROUND: Neuropsychiatric symptoms associated with long COVID are a growing concern. A proposed pathophysiology is increased inflammatory mediators. There is evidence that typical serotonergic antidepressants have limited efficacy in the presence of inflammation. Although ketamine has shown promise in MDD, there is limited evidence supporting the use of ketamine to treat depressive symptoms associated with long COVID. CASE REPORT: This case took place on an inpatient psychiatry unit in a Canadian hospital...
October 2023: Mental Health Clinician
https://read.qxmd.com/read/38131055/consumer-perception-knowledge-and-uses-of-cannabidiol
#35
JOURNAL ARTICLE
Cambrey Nguyen, Karen E Moeller, Michael McGuire, Brittany L Melton
INTRODUCTION: The legalization of cannabidiol (CBD) across the United States, in varying degrees, has made CBD easily accessible to consumers for complementary and medical purposes. However, there is a paucity of scientific evidence on the benefits and risks of commercially available CBD. In the literature, 2 studies have gathered consumer perceptions and attitudes on cannabis products, specifically CBD, using survey-based questionnaires. This study aimed to build on the aforementioned studies in obtaining consumer perception and knowledge of CBD products using a national survey-based questionnaire...
October 2023: Mental Health Clinician
https://read.qxmd.com/read/38131054/impact-of-board-certified-psychiatric-pharmacists-on-improving-urinary-tract-infection-antibiotic-appropriateness-at-an-acute-psychiatric-hospital
#36
JOURNAL ARTICLE
Mohammad Adam Hamad, Andrew Williams, Jamie Kneebusch, Niyati Butala
INTRODUCTION: Urinary tract infections (UTIs) are one of the most common indications for antibiotic use; patients with psychiatric disorders have a greater risk for UTI compared with patients without these disorders. However, there is little guidance on how best to manage antibiotic therapy in psychiatric hospitals. This study assessed the impact of a Board Certified Psychiatric Pharmacist (BCPP)-driven guideline on managing UTI treatment in an acute psychiatric hospital. METHODS: The guideline was developed by the psychiatric pharmacy team and distributed to internists, psychiatrists, and pharmacists...
October 2023: Mental Health Clinician
https://read.qxmd.com/read/38131053/barriers-to-access-to-psychiatric-medications-in-missouri-county-jails
#37
JOURNAL ARTICLE
Jessica K Burval, Courtney A Iuppa, Carrie R Kriz, Shelby E Lang, Leigh Anne Nelson, Nicole A Gramlich, Ellie S R Elliott, Roger W Sommi
INTRODUCTION: Objectives of this study were to characterize barriers to receiving psychiatric medications for people who are incarcerated, to compare barriers before competency restoration to those after competency restoration, and to characterize psychiatric medication formularies. METHODS: A survey of county jails in Missouri was completed between October 2021 and February 2022. Survey questions were answered by medical department personnel, nurses, or a person responsible for medication oversight...
October 2023: Mental Health Clinician
https://read.qxmd.com/read/37860591/offering-a-combined-resident-research-training-program-and-pharmacy-student-elective-may-help-improve-resident-publication-rates
#38
JOURNAL ARTICLE
Geoffrey Brown, Stephanie Seyse, Ashley Woodruff
No abstract text is available yet for this article.
August 2023: Mental Health Clinician
https://read.qxmd.com/read/37860590/comparison-of-inpatient-psychiatric-medication-management-in-gender-diverse-youth-with-cisgender-peers
#39
JOURNAL ARTICLE
Nina Carrillo, Maren McGurran, Brittany L Melton, Karen E Moeller
INTRODUCTION: The primary objective was to determine if gender diverse (GD) youth receive different psychotropic prescribing compared with cisgender (CG) peers with the same diagnosis. Secondary objectives include evaluation of readmission rates and the effect of gender-affirming hormone therapy (GAHT) on psychiatric outcomes in transgender (TG) patients. METHODS: A total of 255 GD youth patients were retrospectively matched to CG controls based on age, primary discharge diagnosis, and year of admission...
August 2023: Mental Health Clinician
https://read.qxmd.com/read/37860589/comment-on-opioid-antagonists-to-prevent-olanzapine-induced-weight-gain-a-systematic-review
#40
JOURNAL ARTICLE
Mark S Todtenkopf, Christoph U Correll, Marni E Harris-White, Michael J Doane, David McDonnell
No abstract text is available yet for this article.
August 2023: Mental Health Clinician
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