Olga Araújo, Ricardo P Casaroli-Marano, José Hernández-Rodríguez, Marc Figueras-Roca, Vanesa Budi, Montse Morató, Halbert Hernández-Negrín, José Ríos, Alfredo Adan, Gerard Espinosa, Laura Pelegrín, Ricard Cervera
OBJECTIVE: To compare multimodal structural and functional diagnostic methods in patients with systemic lupus erythematosus (SLE) treated with hydroxychloroquine, to identify the best complementary approach for detecting subclinical retinal toxicity. METHODS: A cross-sectional, unicentric study was conducted on patients with SLE treated with hydroxychloroquine. Each patient underwent a comprehensive ophthalmic evaluation, comprising structural tests (spectral-domain optical coherence tomography (SD-OCT), en face OCT, en face OCT angiography (OCTA), fundus autofluorescence (FAF)) and functional tests (automated perimetry for visual field (VF) testing, multifocal electroretinography (mfERG))...
March 18, 2024: BMJ Open Ophthalmology
Ji Eun Diana Han, Anuradhaa Subramanian, Wen Hwa Lee, Jesse Coker, Alastair K Denniston, Krishnarajah Nirantharakumar, Nicola Jaime Adderley
OBJECTIVE: Despite significant advances in clinical care and understanding of the underlying pathophysiology, age-related macular degeneration (AMD)-a major cause of global blindness-lacks effective treatment to prevent the irreversible degeneration of photoreceptors leading to central vision loss. Limited studies suggest phosphodiesterase type 5 (PDE5) inhibitors, such as sildenafil, may prevent AMD by increasing retinal blood flow. This study explores the potential association between sildenafil use and AMD risk in men with erectile dysfunction using UK data...
March 15, 2024: BMJ Open Ophthalmology
Geoffrey K Broadhead, John Grigg, Peter J McCluskey, Thomas Hong, Timothy E Schlub, Eugenia Chu, Andrew A Chang
OBJECTIVE: To assess the long-term efficacy and safety of oral saffron, a natural antioxidant, in treating mild/moderate age-related macular degeneration (AMD). METHODS AND ANALYSIS: Open-label, extension trial of 93 adults (>50 years) with mild/moderate AMD and vision >20/70 Snellen equivalent in at least 1 eye. Exclusion criteria included confounding visual lesions or significant gastrointestinal disease impairing absorption.Participants were given oral saffron supplementation (20 mg/day) for 12 months...
March 13, 2024: BMJ Open Ophthalmology
Clare Quigley, Kirk A J Stephenson, Paul F Kenna, Lorraine Cassidy
BACKGROUND: We investigated Leber hereditary optic neuropathy (LHON) families for variation in peripapillary retinal nerve fibre layer thickness and perfusion, and associated optic nerve dysfunction. METHOD: A group of LHON-affected patients (n=12) and their asymptomatic maternal relatives (n=16) underwent examination including visual acuity (VA), visual-evoked-potential and optic nerve imaging including optical coherence tomography (OCT) and OCT angiography of the peripapillary retinal nerve fibre layer (RNFL)...
March 11, 2024: BMJ Open Ophthalmology
Raymond Matthew Bellis, Yang Fei, Brandon Le, Gerardo Ledesma-Gil, Oscar Otero-Marquez, Yuehong Tong, Katy Tai, Richard B Rosen, Gareth M C Lema, Roland Theodore Smith
PURPOSE: Subretinal drusenoid deposits (SDDs) in age-related macular degeneration (AMD) are associated with systemic vascular diseases that compromise ocular perfusion. We demonstrate that SDDs are associated with decreased ellipsoid zone (EZ) thickness, further evidence of hypoxic damage. METHODS: Post hoc analysis of a cross-sectional study. 165 AMD subjects (aged 51-100; 61% women). Spectral-domain optical coherence tomography was obtained in both eyes...
March 9, 2024: BMJ Open Ophthalmology
Patricia Domsa, Éva M Bankó, Judit Körtvélyes, Christof Meigen, Rita Széchey, Krisztina Lantos, Zoltán Zsolt Nagy, Adrienne Csutak
OBJECTIVE: To assess the efficacy of myopia control spectacle lenses (defocus incorporated multiple segments/DIMS) in slowing myopia progression among a diverse Central European paediatric population and investigate the contribution of baseline parameters on treatment outcomes. METHODS AND ANALYSIS: This retrospective observational study included 62 individuals aged 4-17 years (mean±SD: 10.21±2.70) with progressing myopia but without ocular pathology with a range of -0...
March 7, 2024: BMJ Open Ophthalmology
Zulkarnain Abubakar, Amal Chalik Sjaaf, Tjahjono Darminto Gondhowiardjo, Moh Anfasa Giffari Makkaraka
OBJECTIVE: This review aimed to identify and summarise how value-based healthcare (VBHC) is implemented in the field of ophthalmology. METHODS: A scoping review was conducted by searching empirical and non-empirical articles from from electronic databases (PubMed, Science Direct, ProQuest and Scopus) and other methods starting January 2006 (the year Porter and Teisberg introduced VBHC) up to 31 December 2023. RESULTS: 1.081 records were screened, and 12 articles (8 empirical studies and 4 non-empirical articles) were used for data extraction...
March 1, 2024: BMJ Open Ophthalmology
Jonas Müller, Xiaoqin Chen, Arne Ohlendorf, Lihua Li, Siegfried Wahl
OBJECTIVE: This study investigated the agreement between objective wavefront-based refraction and subjective refraction in myopic children. It also assessed the impact of cyclopentolate and refraction levels on the agreement. METHODS: A total of 84 eyes of myopic children aged 6-13 years were included in the analysis. Non-cycloplegic and cycloplegic objective wavefront-based refraction were determined and cycloplegic subjective refraction was performed for each participant...
March 1, 2024: BMJ Open Ophthalmology
Anne Xuan-Lan Nguyen, Dipti Satvi Venkatesh, Ankita Biyani, Sanyam Ratan, Gun Min Youn, Albert Y Wu
PURPOSE: The purpose of this study is to assess the research productivity and gender of award recipients of ophthalmology research awards in international societies. METHODS: This is a retrospective, observational study. The study population included award recipients of research awards from 36 ophthalmologic societies (listed on the International Council of Ophthalmology database) in 99 years (1922-2021). A gender-specific pronoun and a photograph of each award recipient were extracted from professional websites to assign their gender...
February 27, 2024: BMJ Open Ophthalmology
Fatma Omar, Kayleigh McCluskey, Eden Mashayo, Ai Chee Yong, Damaris Mulewa, Christine Graham, Carlos Price-Sanchez, Omar Othman, Ronnie Graham, Ving Fai Chan
OBJECTIVES: To assess needs and views regarding eye health and empowerment from craftswomen's perspectives to develop a theory of change (ToC) for a women-targeted eyecare programme. MATERIAL AND METHODS: Eighteen stakeholders participated in a 2-day consultation workshop in Zanzibar. The composition was (1) 15 women and 3 men; (2) Unguja (n=8), Pemba (n=6) and Tanzania mainland (n=4) and (3) craftswomen (n=14) and governmental stakeholders (n=4). Thematic analysis determined the craftswomen's needs and views regarding eye health and empowerment and subsequently inputs, activities, outputs, outcomes and impact to develop the programme's initial ToC...
February 23, 2024: BMJ Open Ophthalmology
Laura Giurgola, Umberto Rodella, Claudio Gatto, Orietta Rossi, Claudia Honisch, Eugenio Ragazzi, Paolo Ruzza, Stefano Ferrari, Jana D'Amato Tóthová
PURPOSE: To prove the safety and performance of the hypothermic corneal storage medium "Corneal Chamber" and the rinsing solution "PSS-L" in support of the new Conformité Européenne (CE) certification process in accordance with the Medical Device Regulation. METHODS: Fifteen (n=15) human donor corneas and 11 (n=11) porcine corneas were evaluated for the following parameters: endothelial cell density (ECD) and mortality, percentage of hexagonal cells (HEX%), coefficient of cellular area variation (CV%) and corneal transparency at Day 0 and after 14±1 days of storage in Corneal Chamber medium at 2-8°C...
February 22, 2024: BMJ Open Ophthalmology
Alexander Tanner, Mandeep S Sagoo, Omar A Mahroo, Jose S Pulido
BACKGROUND: Large genomic databases enable genetic evaluation in terms of haploinsufficiency and prevalence of missense and synonymous variants. We explored these parameters in ocular tumour-associated genes. METHODS: A curated list of ocular tumour-associated genes was assessed using the genomic databases Genome Aggregation Database (gnomAD) and DatabasE of genomiC varIation and Phenotype in Humans using Ensembl Resources (DECIPHER) and compared with breast and lung cancer-associated gene lists...
February 21, 2024: BMJ Open Ophthalmology
Sonia Seen-Hang Chan, Kai Yip Choi, Henry Ho-Lung Chan
OBJECTIVE: Full-field electroretinogram (ffERG) is an objective test to determine the electroretinal activities in response to light stimulation for investigating retinal physiology and diagnosing retinal diseases. This study aimed to establish a reference data set of photopic electroretinogram (ERG) of Chinese preschool children in Hong Kong to facilitate clinical and research studies. METHODS AND ANALYSIS: Preschool children aged 3-7 years with normal vision were recruited from local kindergartens...
February 21, 2024: BMJ Open Ophthalmology
Ryutaro Yamanishi, Erisa Yotsukura, Akiko Hanyuda, Miki Uchino, Kenya Yuki, Kazuno Negishi, Nobufumi Yasuda, Isao Saito, Tadahiro Kato, Kazuhiko Arima, Kiyoshi Aoyagi, Kozo Tanno, Kazumasa Yamagishi, Isao Muraki, Taiki Yamaji, Motoki Iwasaki, Manami Inoue, Shoichiro Tsugane, Norie Sawada
OBJECTIVE: This population-based, cross-sectional study was performed to investigate the relationship between a history of glaucoma and subjective happiness. METHODS AND ANALYSIS: We conducted a cross-sectional questionnaire-based survey of 92 397 Japanese men and women aged 40-74 who participated in the Japan Public Health Center-based Prospective Study for the Next Generation study. A multivariable logistic regression model was used to estimate the ORs of glaucoma associated with subjective happiness and their two-sided 95% CIs...
February 19, 2024: BMJ Open Ophthalmology
Kevin Gillmann, Dana M Hornbeak
BACKGROUND/AIM: While intraocular pressure (IOP) remains the only modifiable risk factor for glaucoma progression, the ultimate goal of glaucoma management is to preserve patients' functional vision and quality of life. To this end, minimally invasive glaucoma surgeries (MIGSs) aim to reduce IOP with minimal eye trauma. Commonly used MIGS devices include iStent technologies, which have well-documented IOP-reducing potential and favourable safety profiles. However, no study concluded on their effect on the rates of visual field (VF) changes...
February 15, 2024: BMJ Open Ophthalmology
Nikolaos Dervenis, Panagiotis Dervenis, Eleftherios Agorogiannis
Age-related macular degeneration is a major cause of blindness, and the development of anti-vascular endothelial growth factor (VEGF) intravitreal treatments has revolutionised the management of the disease. At the same time, new challenges and unmet needs arose due to the limitations of the current therapeutic options. Neovascularisation development during the course of the disease has a complex pathogenetic mechanism, and several biomarkers and their association with treatment outcomes have been investigated...
February 10, 2024: BMJ Open Ophthalmology
Yaxuan Wu, Ronghua Shi, He Chen, Zicheng Zhang, Siqi Bao, Jia Qu, Meng Zhou
OBJECTIVE: Evidence from observational studies has reported possible associations between the gut microbiome (GM) and glaucoma. However, the causal effect of GM on glaucoma risk remains to be determined. METHODS AND ANALYSIS: We conducted two-sample bidirectional Mendelian randomisation (MR) analyses to explore the causal association between GM and glaucoma. Genome-wide association study summary statistics of 196 GM taxa (n=18 340) and glaucoma (18 902 cases and 358 375 controls) were obtained from MiBioGen and FinnGen Consortium...
January 29, 2024: BMJ Open Ophthalmology
Winston Chamberlain, Charles C Lin, Jennifer Y Li, William Gensheimer, Jameson Clover, Bennie H Jeng, Nicole Varnado, Sarah Abdelrahman, Benjamin F Arnold, Thomas M Lietman, Jennifer Rose-Nussbaumer
BACKGROUND: It remains uncertain which endothelial keratoplasty (EK) technique yields the best outcomes while maintaining safety, particularly in eyes with coexisting ocular conditions. Moreover, the impact of endothelial cell loss (ECL) on long-term graft survival requires further investigation. Adjuvant ripasudil, a rho kinase inhibitor, may address the challenge of ECL in corneal transplantation. This paper presents the protocol for the Descemet Endothelial Thickness Comparison Trial 1 (DETECT 1), a multicentre, outcome-masked, randomised, placebo-controlled, four-arm clinical trial...
January 29, 2024: BMJ Open Ophthalmology
Mohit Parekh, Alexander George Wallace, Matteo Airaldi, Alessandro Ruzza, Stefano Ferrari, Vito Romano, Sajjad Ahmad
OBJECTIVE: To evaluate the Descemet membrane endothelial keratoplasty (DMEK) preparation performance of trainee surgeons in an ex vivo human donor cornea DMEK wet lab simulation setting. METHODS: Human donor corneoscleral rims unsuitable for transplantation were obtained from Moorfields Lions Eye Bank. At the wet lab, graft stripping was performed by scoring the peripheral endothelium. The trypan blue positive cells (TBPC) and cell density (cells/mm2 -reticule count) were counted manually before and after stripping...
January 25, 2024: BMJ Open Ophthalmology
Chang Ki Yoon, Hyeong Gon Yu
OBJECTIVE: Although central serous chorioretinopathy (CSC) treatment using selective retinal therapy (SRT) has presented favourable outcomes, no long-term studies with a real-world clinical practice regimen have been conducted. METHODS AND ANALYSIS: We performed a long-term assessment of CSC treatment using SRT with real-time feedback (RTF) technology. 50 patients (53 eyes) with CSC and more than a 1-month symptom duration were recruited and treated with SRT using a 1...
January 22, 2024: BMJ Open Ophthalmology
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