Miriam Kolko, Rikke Faergemann Hansen, Louise G Dal, Emma Sabelström, Magnus Brandel, Andreas Hoiberg Bentsen, Anne Cathrine Falch-Joergensen
BACKGROUND: Self-treatment with glaucoma medication (eye drops) has been associated with adherence challenges. Poor adherence results in worse outcomes in terms of visual field loss. OBJECTIVE: To investigate patterns in medication adherence among Danish patients with glaucoma in relation to selected predictors of adherence, long-term adherence patterns, and long-term societal economic consequences of poor adherence. METHODS AND ANALYSIS: This register-based study included 30 100 glaucoma patients followed for 10 years between 2000 and 2018...
April 15, 2024: BMJ Open Ophthalmology
Koji Nitta, Kae Sugihara, Akiko Narita, Tomoko Naito, Takako Miki, Maki Katai, Shiro Mizoue, Keiji Yoshikawa, Masaki Tanito, Kazuhisa Sugiyama
BACKGROUND/AIMS: This study aimed to investigate and compare the efficacy and safety of first-line and second-line selective laser trabeculoplasty (SLT) in Japanese patients with normal-tension glaucoma (NTG). METHODS: 100 patients with NTG were enrolled in this study. Patients were treated with SLT as a first-line or second-line treatment for NTG. Main outcome measures were intraocular pressure (IOP) reduction rate, outflow pressure improvement rate (ΔOP), success rate at 1 year and complications...
April 15, 2024: BMJ Open Ophthalmology
Fei Xiang, Ye Zhang, Qing Zhang, Xiaohua Pan, Hui Feng, Meijuan Zhang, Caixia Li, Qianqian Ji, Zhi Li, Shuning Li
OBJECTIVE: To investigate the characteristics of beta parapapillary atrophy (β-PPA) in patients with primary angle-closure suspect (PACS). METHODS AND ANALYSIS: In total, 215 and 259 eyes with PACS and non-PACS (NPACS), respectively, were enrolled in this observational, cross-sectional study. Stereoscopic fundus and optical coherence tomography images were used to characterise β-PPA; the former was also used to measure the major β-PPA parameters...
April 15, 2024: BMJ Open Ophthalmology
Gisela Haza Anissa, Rina La Distia Nora, Syska Widyawati, Ratna Sitompul, Prasandhya Astagiri Yusuf, Aria Kekalih
OBJECTIVE: The objective of this study is to determine the validity and reliability of the red filter meibography by smartphone compared with infrared in assessing meibomian gland drop-out. METHODS AND ANALYSIS: An analytical cross-sectional study was done with a total of 35 subjects (68 eyes) with suspected MGD based on symptoms and lid morphological abnormalities. Meibomian glands were photographed using two smartphones (Samsung S9 and iPhone XR) on a slit-lamp with added red filter...
April 12, 2024: BMJ Open Ophthalmology
Endalew Mulugeta Worku, Sofonias Addis Fekadu, Bersufekad Wubie Alemie, Merkineh Markos Lorato
OBJECTIVE: This study aimed to assess the prevalence and associated factors of corneal opacity among adults in Kolladiba town, Northwest Ethiopia. METHODS AND ANALYSIS: A community-based cross-sectional study was conducted using a systematic random sampling technique. A total of 846 adult individuals were recruited for the study. Ethical approval was obtained from the University of Gondar School of Medicine Ethical Review Committee. A standardised, semistructured questionnaire plus an ocular examination were used to collect the data...
April 11, 2024: BMJ Open Ophthalmology
Menghan Li, Ya Shi, Qiuying Chen, Guangyi Hu, Jiamin Xie, Luyao Ye, Ying Fan, Jianfeng Zhu, Jiangnan He, Xun Xu
OBJECTIVE: This study aimed to investigate the influence of peripapillary atrophy (PPA) area and axial elongation on the longitudinal changes in macular choroidal thickness (ChT) in young individuals with myopia. METHODS AND ANALYSIS: In this longitudinal investigation, 431 eyes-342 categorised as non-high myopia (non-HM) and 89 as HM-were examined for 2 years. Participants were examined with swept-source optical coherence tomography. The macular ChT, PPA area and axial length (AL) were measured at baseline and follow-up visits...
April 8, 2024: BMJ Open Ophthalmology
Rizwana I Khan, Kealan McElhinney, Andrew Dickson, Ronan P Kileen, Conor Murphy, Donncha F O'Brien
OBJECTIVE: Preclinical validation study to assess the feasibility and accuracy of electromagnetic image-guided systems (EM-IGS) in orbital surgery using high-fidelity physical orbital anatomy simulators. METHODS: EM-IGS platform, clinical software, navigation instruments and reference system (StealthStation S8, Medtronic) were evaluated in a mock operating theatre at the Royal Victoria Eye and Ear Hospital, a tertiary academic hospital in Dublin, Ireland. Five high-resolution 3D-printed model skulls were created using CT scans of five anonymised patients with an orbital tumour that previously had a successful orbital biopsy or excision...
April 4, 2024: BMJ Open Ophthalmology
Stefania B Diniz, Elana Meer, John M Nesemann, Nicholas J Jackson, Daniel B Rootman
PURPOSE: Effective visual perceptual processing is one of the many components of surgical competence. Human face identification is most efficient when viewed upright. However, it is not yet clear how this perception sensitivity impacts eyelid symmetry. This study investigates surgeons' and laypeople's accuracy and efficiency in perceiving eyelid asymmetry from different spatial perspectives. METHODS: A prospective psychometric experiment was conducted where oculoplastic surgeons were recruited from the American Society of Ophthalmic Plastic and Reconstructive Surgery and the Brazilian Oculoplastic Surgery Society, and control participants were recruited via crowdsourcing (Amazon's Mechanical Turk)...
April 4, 2024: BMJ Open Ophthalmology
Faisal Aljahdali, Waleed Khayyat, Abdulelah T BinYamin, Sultan A Al-Qahtani, Mohammed D Alghamdi, Ali Saleh Alsudais, Husain A Alalgum, Halah Bin Helayel, Mohammed AlMutlak
BACKGROUND: Pterygium is a common ocular surface disorder that requires surgical intervention for treatment. Conjunctival autografts are preferred over simple excision due to lower recurrence rates. This systematic review and meta-analysis compared the modified sutureless glue-free (MSGF) method with conventional sutures (CS) for conjunctival autograft fixation in primary pterygium surgery. METHODS: A comprehensive search was conducted in MEDLINE, Embase, CENTRAL, Google Scholar and ClinicalTrials...
April 1, 2024: BMJ Open Ophthalmology
Sheikh M A Mannaf, Md Shafiqul Islam, M Nazrul Islam, Md Mizanur Rahman, Salma Parvin, Siddiqur Rahman, Bipul Kumer De Sarker
BACKGROUND: To delineate the epidemiological landscape of glaucoma using a population-based sample representative of Bangladesh. METHODS: Using multistage stratified cluster random sampling, households were selected to identify individuals ≥35 years across all 8 divisions of Bangladesh. Sampling frames were derived from the 2011 national census. Fifty-eight study examination sites were set up for comprehensive eye evaluations, including intraocular pressure, gonioscopy and visual field testing when indicated...
March 27, 2024: BMJ Open Ophthalmology
Oscar Kallay, Rayane Sadad, Ahmed Zafzafi, Elie Motulsky
OBJECTIVE: To compare sustainability, financial implications and surgical efficiency of two phacoemulsification cassette systems for cataract surgery: a machine with single-use cassettes and another with daily, reusable ones. METHODS: Observational study involving retrospective cataract surgery data collection at the Centre Médical de l'Alliance, Braine-l'Alleud, Belgium, a tertiary eye care centre. Information on cassette weight, quantities and transport volume was obtained from routine procedures and purchasing records...
March 26, 2024: BMJ Open Ophthalmology
Olga Araújo, Ricardo P Casaroli-Marano, José Hernández-Rodríguez, Marc Figueras-Roca, Vanesa Budi, Montse Morató, Halbert Hernández-Negrín, José Ríos, Alfredo Adan, Gerard Espinosa, Laura Pelegrín, Ricard Cervera
OBJECTIVE: To compare multimodal structural and functional diagnostic methods in patients with systemic lupus erythematosus (SLE) treated with hydroxychloroquine, to identify the best complementary approach for detecting subclinical retinal toxicity. METHODS: A cross-sectional, unicentric study was conducted on patients with SLE treated with hydroxychloroquine. Each patient underwent a comprehensive ophthalmic evaluation, comprising structural tests (spectral-domain optical coherence tomography (SD-OCT), en face OCT, en face OCT angiography (OCTA), fundus autofluorescence (FAF)) and functional tests (automated perimetry for visual field (VF) testing, multifocal electroretinography (mfERG))...
March 18, 2024: BMJ Open Ophthalmology
Ji Eun Diana Han, Anuradhaa Subramanian, Wen Hwa Lee, Jesse Coker, Alastair K Denniston, Krishnarajah Nirantharakumar, Nicola Jaime Adderley
OBJECTIVE: Despite significant advances in clinical care and understanding of the underlying pathophysiology, age-related macular degeneration (AMD)-a major cause of global blindness-lacks effective treatment to prevent the irreversible degeneration of photoreceptors leading to central vision loss. Limited studies suggest phosphodiesterase type 5 (PDE5) inhibitors, such as sildenafil, may prevent AMD by increasing retinal blood flow. This study explores the potential association between sildenafil use and AMD risk in men with erectile dysfunction using UK data...
March 15, 2024: BMJ Open Ophthalmology
Geoffrey K Broadhead, John Grigg, Peter J McCluskey, Thomas Hong, Timothy E Schlub, Eugenia Chu, Andrew A Chang
OBJECTIVE: To assess the long-term efficacy and safety of oral saffron, a natural antioxidant, in treating mild/moderate age-related macular degeneration (AMD). METHODS AND ANALYSIS: Open-label, extension trial of 93 adults (>50 years) with mild/moderate AMD and vision >20/70 Snellen equivalent in at least 1 eye. Exclusion criteria included confounding visual lesions or significant gastrointestinal disease impairing absorption.Participants were given oral saffron supplementation (20 mg/day) for 12 months...
March 13, 2024: BMJ Open Ophthalmology
Clare Quigley, Kirk A J Stephenson, Paul F Kenna, Lorraine Cassidy
BACKGROUND: We investigated Leber hereditary optic neuropathy (LHON) families for variation in peripapillary retinal nerve fibre layer thickness and perfusion, and associated optic nerve dysfunction. METHOD: A group of LHON-affected patients (n=12) and their asymptomatic maternal relatives (n=16) underwent examination including visual acuity (VA), visual-evoked-potential and optic nerve imaging including optical coherence tomography (OCT) and OCT angiography of the peripapillary retinal nerve fibre layer (RNFL)...
March 11, 2024: BMJ Open Ophthalmology
Raymond Matthew Bellis, Yang Fei, Brandon Le, Gerardo Ledesma-Gil, Oscar Otero-Marquez, Yuehong Tong, Katy Tai, Richard B Rosen, Gareth M C Lema, Roland Theodore Smith
PURPOSE: Subretinal drusenoid deposits (SDDs) in age-related macular degeneration (AMD) are associated with systemic vascular diseases that compromise ocular perfusion. We demonstrate that SDDs are associated with decreased ellipsoid zone (EZ) thickness, further evidence of hypoxic damage. METHODS: Post hoc analysis of a cross-sectional study. 165 AMD subjects (aged 51-100; 61% women). Spectral-domain optical coherence tomography was obtained in both eyes...
March 9, 2024: BMJ Open Ophthalmology
Patricia Domsa, Éva M Bankó, Judit Körtvélyes, Christof Meigen, Rita Széchey, Krisztina Lantos, Zoltán Zsolt Nagy, Adrienne Csutak
OBJECTIVE: To assess the efficacy of myopia control spectacle lenses (defocus incorporated multiple segments/DIMS) in slowing myopia progression among a diverse Central European paediatric population and investigate the contribution of baseline parameters on treatment outcomes. METHODS AND ANALYSIS: This retrospective observational study included 62 individuals aged 4-17 years (mean±SD: 10.21±2.70) with progressing myopia but without ocular pathology with a range of -0...
March 7, 2024: BMJ Open Ophthalmology
Zulkarnain Abubakar, Amal Chalik Sjaaf, Tjahjono Darminto Gondhowiardjo, Moh Anfasa Giffari Makkaraka
OBJECTIVE: This review aimed to identify and summarise how value-based healthcare (VBHC) is implemented in the field of ophthalmology. METHODS: A scoping review was conducted by searching empirical and non-empirical articles from from electronic databases (PubMed, Science Direct, ProQuest and Scopus) and other methods starting January 2006 (the year Porter and Teisberg introduced VBHC) up to 31 December 2023. RESULTS: 1.081 records were screened, and 12 articles (8 empirical studies and 4 non-empirical articles) were used for data extraction...
March 1, 2024: BMJ Open Ophthalmology
Jonas Müller, Xiaoqin Chen, Arne Ohlendorf, Lihua Li, Siegfried Wahl
OBJECTIVE: This study investigated the agreement between objective wavefront-based refraction and subjective refraction in myopic children. It also assessed the impact of cyclopentolate and refraction levels on the agreement. METHODS: A total of 84 eyes of myopic children aged 6-13 years were included in the analysis. Non-cycloplegic and cycloplegic objective wavefront-based refraction were determined and cycloplegic subjective refraction was performed for each participant...
March 1, 2024: BMJ Open Ophthalmology
Anne Xuan-Lan Nguyen, Dipti Satvi Venkatesh, Ankita Biyani, Sanyam Ratan, Gun Min Youn, Albert Y Wu
PURPOSE: The purpose of this study is to assess the research productivity and gender of award recipients of ophthalmology research awards in international societies. METHODS: This is a retrospective, observational study. The study population included award recipients of research awards from 36 ophthalmologic societies (listed on the International Council of Ophthalmology database) in 99 years (1922-2021). A gender-specific pronoun and a photograph of each award recipient were extracted from professional websites to assign their gender...
February 27, 2024: BMJ Open Ophthalmology
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