Proapa Islam, John A Ice, Sanmi E Alake, Pelumi Adedigba, Bethany Hatter, Kara Robinson, Stephen L Clarke, Ashlee N Ford Versypt, Jerry Ritchey, Edralin A Lucas, Brenda J Smith
Targeting the gut-bone axis with probiotics and prebiotics is considered as a promising strategy to reduce the risk of osteoporosis. Gut-derived short chain fatty acids (SCFA) mediate the effects of probiotics on bone via Tregs, but it is not known whether prebiotics act through a similar mechanism. We investigated how 2 different prebiotics, tart cherry (TC) and fructooligosaccharide (FOS), affect bone, and whether Tregs are required for this response. Eight-wk-old C57BL/6 female mice were fed with diets supplemented with 10% w/w TC, FOS, or a control diet (Con; AIN-93M) diet, and they received an isotype control or CD25 Ab to suppress Tregs...
May 2024: JBMR Plus