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Journals Research and Practice in Throm...

Research and Practice in Thrombosis and Haemostasis

https://read.qxmd.com/read/38384985/bleeding-events-in-thrombotic-antiphospholipid-syndrome-prevalence-severity-and-associated-damage-accrual
#1
JOURNAL ARTICLE
Pedro Gaspar, Prabal Mittal, Hannah Cohen, David A Isenberg
BACKGROUND: Life-long anticoagulation increases bleeding risk in patients with antiphospholipid syndrome (APS). The Damage Index for Antiphospholipid Syndrome does not include bleeding events in damage accrual. OBJECTIVES: We aimed to characterize the prevalence, severity, and damage associated with bleeding events in patients with APS. METHODS: This was a single-center retrospective analysis of patients with thrombotic APS (2006 Sydney criteria)...
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38379712/validation-of-a-fibrinogen-%C3%AE-enzyme-linked-immunosorbent-assay-using-a-new-monoclonal-antibody-effects-of-bariatric-surgery
#2
JOURNAL ARTICLE
Nadja Bødker Pedersen, Else-Marie Bladbjerg, Claus Bogh Juhl, Anette Larsen, Anna-Marie Bloch Münster, Moniek P M de Maat, Yaseelan Palarasah
BACKGROUND: Fibrinogen γ' is a naturally occurring 20-amino-acid splice variant of the fibrinogen γ chain. Animal studies link variations in fibrinogen to obesity, but it is unknown how fibrinogen γ' is associated with obesity in humans. OBJECTIVES: To develop and validate an enzyme-linked immunosorbent assay (ELISA) for fibrinogen γ' quantification in human plasma and analyze fibrinogen γ' before and after bariatric surgery. METHODS: We generated C-terminal fibrinogen γ' specific mouse monoclonal antibodies and developed a γ' ELISA...
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38379711/contractility-defects-hinder-glycoprotein-vi-mediated-platelet-activation-and-affect-platelet-functions-beyond-clot-contraction
#3
JOURNAL ARTICLE
Martin Kenny, Alice Y Pollitt, Smita Patil, Dishon W Hiebner, Albert Smolenski, Natalija Lakic, Robert Fisher, Reema Alsufyani, Sebastian Lickert, Viola Vogel, Ingmar Schoen
BACKGROUND: Active and passive biomechanical properties of platelets contribute substantially to thrombus formation. Actomyosin contractility drives clot contraction required for stabilizing the hemostatic plug. Impaired contractility results in bleeding but is difficult to detect using platelet function tests. OBJECTIVES: To determine how diminished myosin activity affects platelet functions, including and beyond clot contraction. METHODS: Using the myosin IIA-specific pharmacologic inhibitor blebbistatin, we modulated myosin activity in platelets from healthy donors and systematically characterized platelet responses at various levels of inhibition by interrogating distinct platelet functions at each stage of thrombus formation using a range of complementary assays...
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38371336/venous-thromboembolism-and-amyotrophic-lateral-sclerosis-the-venous-thrombo-embolism-and-sclerosis-lateral-amyotrophic-study
#4
JOURNAL ARTICLE
Audrey Barnabe, Steeve Genestet, Christophe Gut-Gobert, Chloé Rivalain, Jean-Baptiste Noury, Marion Goret, Aude Barnier, Claire De Moreuil, Benjamin Espinasse, Raphaël Le Mao, Christophe Leroyer, Francis Couturaud, Cécile Tromeur
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease. Given the inflammatory nature of ALS and the high number of ALS-related clinical circumstances (eg, prolonged immobilization and infections), patients with ALS may have a high risk of venous thromboembolism (VTE). OBJECTIVES: To determine the annual incidence rate of VTE and the predictors of VTE in patients with ALS. METHODS: We analyzed a prospective cohort of patients with ALS diagnosed between 2009 and 2019 followed in the Brest University Hospital ALS Centre...
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38371335/hemophagocytic-lymphohistiocytosis-is-associated-with-deficiency-and-closed-conformation-of-adamts-13
#5
JOURNAL ARTICLE
Amélie Launois, Sandrine Valade, Eric Mariotte, Lionel Galicier, Elie Azoulay, Elien Roose, Karen Vanhoorelbeke, Agnès Veyradier, Bérangère S Joly
BACKGROUND: A disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13 (ADAMTS-13) is the specific von Willebrand factor-cleaving protease and circulates in a closed and latent conformation due to a spacer/CUB1 domain interaction. ADAMTS-13 is allosterically activated after binding of its substrate or antibodies, inducing an open conformation. Recently, we suggested a potential role of plasmin (fibrinolysin) in hemostasis disorders reported in most patients with hemophagocytic lymphohistiocytosis (HLH), a rare and life-threatening condition related to a severe systemic inflammatory state...
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38371334/the-impact-of-child-specific-characteristics-on-warfarin-dosing-requirements
#6
JOURNAL ARTICLE
Yousif S Alakeel, Abdulraouf M Z Jijeh, Norah S BinSabbar, Meshary F Almeshary, Numan A Alabdan, Jawaher A Gramish, Mohammed A Al Essa
BACKGROUND: The influence of child characteristics on warfarin dosing has been reported; however, there is no consensus on the nature and extent of this effect. OBJECTIVES: To investigate the impacts of the demographic and clinical characteristics of children on the warfarin dose required to achieve a therapeutic international normalization ratio (INR). METHODS: This retrospective cohort study included children aged 3 months to 14 years old who were prescribed warfarin for 3 months or longer with a "stable INR...
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38356853/antiplatelet-period-drama-a-rush-of-blood-or-classic-crimson-tide
#7
JOURNAL ARTICLE
Kylee L Martens, Bethany Samuelson Bannow
No abstract text is available yet for this article.
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38356852/balancing-the-risks-of-recurrent-venous-thromboembolism-and-bleeding-with-extended-anticoagulation-oh-for-a-crystal-ball
#8
JOURNAL ARTICLE
Julia Czuprynska, Roopen Arya
No abstract text is available yet for this article.
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38327613/galectin-3-binding-protein-and-future-venous-thromboembolism
#9
JOURNAL ARTICLE
Ellen-Sofie Hansen, Magnus S Edvardsen, Pål Aukrust, Thor Ueland, John-Bjarne Hansen, Sigrid K Brækkan, Vânia M Morelli
No abstract text is available yet for this article.
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38327612/apixaban-overdose-in-children-case-report-and-proposed-management-a-brief-communication-from-the-pediatric-and-neonatal-thrombosis-and-hemostasis-ssc-of-isth
#10
Meredith Wiggins, Tina Biss, Leslie Raffini, Heleen Van Ommen, Anthony Chan, Christina Vanderpluym, Neil Goldenberg, Paul Monagle
BACKGROUND: Direct oral anticoagulants are commonly prescribed for adults and increasingly also for children requiring anticoagulation therapy. While household medications should not be accessible to children, accidental, and intentional overdoses occur. KEY CLINICAL QUESTION: How should apixaban overdose in children be managed?. CLINICAL APPROACH: We present a case of an accidental overdose with the factor Xa antagonist apixaban in a young child and propose an approach to the management of cases of apixaban overdose in children...
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38322151/ultrasound-evaluation-of-hemophilic-arthropathy-a-proposal-of-definitions-in-a-changing-landscape
#11
EDITORIAL
Roberta Gualtierotti, Luigi Piero Solimeno, Flora Peyvandi
The advent of novel effective treatments and the identification of the need to achieve a higher trough level for persons with hemophilia A and B have changed the landscape of management of these patients, allowing to change the target from survival and prevention of life-threatening complications to prevention of musculoskeletal complications and improvement of quality of life. Point-of-care musculoskeletal ultrasound imaging has also improved the early recognition of joint bleeding and the differential diagnosis of acute joint pain...
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38318153/site-directed-mutagenesis-of-tissue-factor-pathway-inhibitor-binding-exosite-d60a-on-factor-vii-results-in-a-new-factor-vii-variant-with-lower-coagulant-activity
#12
JOURNAL ARTICLE
Karnsasin Seanoon, Vorawat Kitiyanant, Panwajee Payongsri, Nongnuch Sirachainan, Pantep Angchaisuksiri, Ampaiwan Chuansumrit, Suradej Hongeng, Pansakorn Tanratana
BACKGROUND: Recombinant factor (F)VIIa (rFVIIa) has been approved by the US Food and Drug Administration for the treatment of hemophilia A and B with inhibitors and congenital FVII deficiency. Moreover, the investigational uses of rFVIIa are becoming of interest since it can be used to treat various clinical bleeding conditions. However, there is evidence showing that rFVIIa is a potent procoagulant agent that potentially leads to an increased risk of thrombotic complications. OBJECTIVES: To design a new rFVII with lower coagulant activity that could potentially be used as an alternative hemostatic agent aiming to minimize the risk of thrombogenicity...
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38318152/periodontitis-in-ischemic-stroke-impact-of-porphyromonas-gingivalis-on-thrombus-composition-and-ischemic-stroke-outcomes
#13
JOURNAL ARTICLE
Aurélien Freiherr Von Seckendorff, Mialitiana Solo Nomenjanahary, Julien Labreuche, Véronique Ollivier, Lucas Di Meglio, Sebastien Dupont, Mylène Hamdani, Nahida Brikci-Nigassa, Adrian Brun, Perrine Boursin, Michel Piotin, Mikael Mazighi, Benoit Ho-Tin-Noé, Jean-Philippe Desilles, Sandrine Delbosc
BACKGROUND: Periodontitis is associated with an increased risk of ischemic stroke, but the mechanisms underlying this association remain unclear. OBJECTIVES: Our objective was to determine whether Porphyromonas gingivalis (Pg), a periodontal bacterium, could be detected within thrombus aspirates, modify thrombus composition, and endovascular therapy responses. METHODS: The presence of Pg gingipain in 175 consecutive thrombi from patients with large vessel occlusion stroke enrolled in the multicenter research cohort compoCLOT was investigated by immunostaining...
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38314168/acute-ischemic-stroke-and-measurement-of-apixaban-and-rivaroxaban-an-observational-cohort-implementation-study
#14
JOURNAL ARTICLE
Erik Koldberg Amundsen, Hege Ihle-Hansen, Kristian Lundsgaard Kraglund, Guri Hagberg
BACKGROUND: Treatment with intravenous thrombolysis for acute ischemic stroke is contraindicated with intake of apixaban/rivaroxaban in the last 48 hours. Recent European Stroke Organization guidelines suggest that thrombolysis can be considered if anti-factor Xa activity (AFXa) is <0.5 × 103 IU/L with low-molecular-weight (LMWH) or unfractionated heparin (UFH) calibrated assays. Some centers also use apixaban/rivaroxaban-calibrated AFXa assays to identify patients with low drug concentrations...
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38292352/immunothrombosis-in-neurovascular-disease
#15
JOURNAL ARTICLE
Frederik Denorme, Abigail Ajanel, Robert A Campbell
A State of the Art lecture titled "Immunothrombosis in Neurovascular Diseases" was presented at the International Society on Thrombosis and Haemostasis Congress in 2023. Despite significant clinical advancements in stroke therapy, stroke remains a prominent contributor to both mortality and disability worldwide. Brain injury resulting from an ischemic stroke is a dynamic process that unfolds over time. Initially, an infarct core forms due to the abrupt and substantial blockage of blood flow. In the subsequent hours to days, the surrounding tissue undergoes gradual deterioration, primarily driven by sustained hypoperfusion, programmed cell death, and inflammation...
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38292351/bleeding-disorder-of-unknown-cause-unclassified-bleeding-disorders-at-us-hemophilia-treatment-centers
#16
JOURNAL ARTICLE
Callie Berkowitz, Kristi Kirkland, Alice Ma, Nigel S Key
No abstract text is available yet for this article.
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38292350/coagulopathy-and-adverse-outcomes-in-hospitalized-patients-with-covid-19-results-from-the-nor-solidarity-trial
#17
JOURNAL ARTICLE
Thor Ueland, Annika E Michelsen, Anders Aune Tveita, Trine Kåsine, Tuva B Dahl, Ane-Kristine Finbråten, Aleksander R Holten, Ole Henning Skjønsberg, Alexander Mathiessen, Katerina N Henriksen, Marius Trøseid, Trond Mogens Aaløkken, Bente Halvorsen, Anne Ma Dyrhol-Riise, Andreas Barratt-Due, Pål Aukrust
BACKGROUND: Several studies have examined parameters of increased thrombogenicity in COVID-19, but studies examining their association with long-term outcome and potential effects of antiviral agents in hospitalized patients with COVID-19 are scarce. OBJECTIVES: To evaluate plasma levels of hemostatic proteins during hospitalization in relation to disease severity, treatment modalities, and persistent pulmonary pathology after 3 months. METHODS: In 165 patients with COVID-19 recruited into the NOR-Solidarity trial (NCT04321616) and randomized to treatment with hydroxychloroquine, remdesivir, or standard of care, we analyzed plasma levels of hemostatic proteins during the first 10 days of hospitalization ( n  = 160) and at 3 months of follow-up ( n  = 100) by enzyme immunoassay...
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38292349/exploring-the-ex%C3%A2-vivo-effects-of-naja-mossambica-venom-on-the-ultrastructure-and-viscoelastic-properties-of-human-blood
#18
JOURNAL ARTICLE
Tanyaradzwa Chamboko, Jenna Love, Morné A Strydom, Janette Bester
BACKGROUND: Venomous snake bites have been listed as a neglected tropical disease by the World Health Organization. The Mozambique spitting cobra ( Naja mossambica) is found in Sub-Saharan African countries, and its venom has been identified to predominantly result in cytotoxic effects. However, there is limited evidence on the possible hemotoxic effects of this venom on human blood. OBJECTIVES: In this cross-sectional study, we investigated how Mozambique spitting cobra venom affects blood clot formation...
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38292348/risk-scores-for-major-bleeding-from-direct-oral-anticoagulants-comparing-predictive-performance-in-patients-with-atrial-fibrillation
#19
JOURNAL ARTICLE
Alessandra M Campos-Staffico, Juliet P Jacoby, Michael P Dorsch, Nita A Limdi, Geoffrey D Barnes, Jasmine A Luzum
BACKGROUND: Despite direct oral anticoagulants (DOACs) being safer than warfarin for stroke prevention in atrial fibrillation (AF), major bleeding concerns persist. Most bleeding risk scores predate DOAC approval. OBJECTIVES: This study aimed to compare the Age, history of Bleeding, and non-bleeding related Hospitalisation [ABH] score's performance-derived for DOAC-treated patients-with those of 5 other scores (Anticoagulation and Risk Factors in Atrial Fibrillation [ATRIA], Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio, Elderly [>65 years], Drugs/alcohol concomitantly [HAS-BLED], Hepatic, Hepatic or Renal Disease, Ethanol Abuse, Malignancy, Older Age, Reduced Platelet Count or Function, Re-Bleeding, Hypertension, Anemia, Genetic Factors, Excessive Fall Risk and Stroke [HEMORR2 HAGES], Outcomes Registry for Better Informed Treatment of Atrial Fibrillation [ORBIT-AF], and Congestive heart failure, Hypertension, Age ≥75 [doubled], Diabetes, Stroke [doubled]-Vascular disease, Age 65-74, Sex category [CHA2 DS2 -VASc]) in predicting DOAC-related major bleeding in patients with AF...
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38292347/association-of-laboratory-test-results-with-the-bleeding-history-in-patients-with-inherited-platelet-function-disorders-the-bleeding-assesment-tool-laboratory-tests-substudy-communication-from-the-platelet-physiology-isth-ssc
#20
JOURNAL ARTICLE
Paolo Gresele, Emanuela Falcinelli, Loredana Bury, Marie-Christine Alessi, Giuseppe Guglielmini, Céline Falaise, Gianmarco Podda, Mathieu Fiore, Francesco Mazziotta, Teresa Sevivas, Nuria Bermejo, Erica De Candia, Meera Chitlur, Michele P Lambert, Luca Barcella, Ana C Glembotsky, Marie Lordkipanidzé
BACKGROUND: In hemophilia and von Willebrand disease, the degree of alteration of laboratory assays correlates with bleeding manifestations. Few studies have assessed the predictive value for bleeding of laboratory assays in patients with inherited platelet function disorders (IPFDs). OBJECTIVES: To assess whether there is an association between platelet function assay results and bleeding history, as evaluated by the International Society on Thrombosis and Haemostasis (ISTH) bleeding assessment tool (BAT)...
January 2024: Research and Practice in Thrombosis and Haemostasis
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